Increase of CTGF mRNA expression by respiratory syncytial virus infection is abrogated by caffeine in lung epithelial cells

  • Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infection in early childhood. Underlying pathomechanisms of elevated pulmonary morbidity in later infancy are largely unknown. We found that RSV‐infected H441 cells showed increased mRNA expression of connective tissue growth factor (CTGF), a key factor in airway remodeling. Additional dexamethasone treatment led to further elevated mRNA levels, indicating additive effects. Caffeine treatment prevented RSV‐mediated increase in CTGF mRNA. RSV may be involved in airway remodeling processes by increasing CTGF mRNA expression. Caffeine might abrogate these negative effects and thereby help to restore lung homeostasis.

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Author:Steffen Kunzmann, Christine Krempl, Silvia Seidenspinner, Kirsten Glaser, Christian Speer, Markus Fehrholz
Pubmed Id:
Parent Title (English):Influenza and other respiratory viruses
Place of publication:Oxford [u. a.]
Document Type:Article
Year of Completion:2018
Date of first Publication:2018/04/16
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2018/05/24
Tag:CCN2; Caffeine; dexamethasone; lung remodeling; poly(I:C)
Page Number:5
First Page:1
Last Page:5
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0