High-energy proton imaging for biomedical applications

  • The charged particle community is looking for techniques exploiting proton interactions instead of X-ray absorption for creating images of human tissue. Due to multiple Coulomb scattering inside the measured object it has shown to be highly non-trivial to achieve sufficient spatial resolution. We present imaging of biological tissue with a proton microscope. This device relies on magnetic optics, distinguishing it from most published proton imaging methods. For these methods reducing the data acquisition time to a clinically acceptable level has turned out to be challenging. In a proton microscope, data acquisition and processing are much simpler. This device even allows imaging in real time. The primary medical application will be image guidance in proton radiosurgery. Proton images demonstrating the potential for this application are presented. Tomographic reconstructions are included to raise awareness of the possibility of high-resolution proton tomography using magneto-optics.

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Author:Matthias Prall, Marco Durante, Thomas Berger, Bartos Przybyla, Christian Graef, Philipp-M. Lang, Chiara LaTessa, Lev Shestov, Palma Simoniello, Chris R. Danly, Fesseha G. Mariam, Frank Edward Merrill, Paul Nedrow, Carl Wilde, Dmitry Varentsov
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/27282667
Parent Title (English):Scientific reports
Publisher:Macmillan Publishers Limited, part of Springer Nature
Place of publication:[London]
Document Type:Article
Year of Completion:2016
Date of first Publication:2016/06/10
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2018/05/24
Tag:Biomedical engineering; Preclinical research
Issue:Art. 27651
Page Number:11
First Page:1
Last Page:11
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Institutes:Wissenschaftliche Zentren und koordinierte Programme / Frankfurt Institute for Advanced Studies (FIAS)
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0