An exponential regression model reveals the continuous development of B cell subpopulations used as reference values in children

  • B lymphocytes are key players in humoral immunity, expressing diverse surface immunoglobulin receptors directed against specific antigenic epitopes. The development and profile of distinct subpopulations have gained awareness in the setting of primary immunodeficiency disorders, primary or secondary autoimmunity and as therapeutic targets of specific antibodies in various diseases. The major B cell subpopulations in peripheral blood include naïve (CD19+ or CD20+IgD+CD27−), non-switched memory (CD19+ or CD20+IgD+CD27+) and switched memory B cells (CD19+ or CD20+IgD−CD27+). Furthermore, less common B cell subpopulations have also been described as having a role in the suppressive capacity of B cells to maintain self-tolerance. Data on reference values for B cell subpopulations are limited and only available for older age groups, neglecting the continuous process of human B cell development in children and adolescents. This study was designed to establish an exponential regression model to produce continuous reference values for main B cell subpopulations to reflect the dynamic maturation of the human immune system in healthy children.

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Author:Christoph KönigsORCiDGND, Stephan Schultze-Straßer, Andrea Quaiser, Konrad Bochennek, Dirk Schwabe, Thomas KlingebielORCiDGND, Ulrike Köhl, Claudia Cappel, Udo RolleORCiDGND, Peter BaderORCiDGND, Melanie BremmGND, Sabine HüneckeGND, Shahrzad Bakhtiar
Pubmed Id:
Parent Title (English):Frontiers in Pediatrics
Publisher:Frontiers Media
Place of publication:Lausanne
Contributor(s):Marzia Duse
Document Type:Article
Year of Completion:2018
Date of first Publication:2018/05/04
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2018/05/29
Tag:B cell subpopulations; autoimmunity; exponential model; flow cytometry; reference values
Issue:Art. 121
Page Number:9
First Page:1
Last Page:9
Copyright: © 2018 Königs, Schultze-Strasser, Quaiser, Bochennek, Schwabe, Klingebiel, Koehl, Cappel, Rolle, Bader, Bremm, Huenecke and Bakhtiar. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0