Effects of medicines used to treat gastrointestinal diseases on the pharmacokinetics of co-administered drugs : a PEARRL review [Pharmacokinetic interactions with GI drugs]

  • Background: Drugs used to treat gastrointestinal diseases (GI drugs) are widely used either as prescription or over23 the-counter (OTC) medications and belong to both the ten most prescribed and ten most sold OTC medications worldwide. Current clinical practice shows that in many cases, these drugs are administered concomitantly with other drug products. Due to their metabolic properties and mechanisms of action, the drugs used to treat gastrointestinal diseases can change the pharmacokinetics of some co27 administered drugs. In certain cases, these interactions can lead to failure of treatment or to the occurrence of serious adverse events. The mechanism of interaction depends highly on drug properties and differs among therapeutic categories. Understanding these interactions is essential to providing recommendations for optimal drug therapy. Objective: To discuss the most frequent interactions between GI and other drugs, including identification of the mechanisms behind these interactions, where possible. Conclusion: Interactions with GI drugs are numerous and can be highly significant clinically. Whilst alterations in bioavailability due to changes in solubility, dissolution rate and metabolic interactions can be (for the most part) easily identified, interactions that are mediated through other mechanisms, such as permeability or microbiota, are less well understood. Future work should focus on characterizing these aspects.
Author:Chara Litou, Angela Effinger, Edmund Kostewicz, Karl Box, Nikoletta Fotaki, Jennifer B. DressmanGND
Place of publication:Frankfurt am Main
Document Type:Preprint
Year of Completion:2018
Year of first Publication:2018
Publishing Institution:Universit├Ątsbibliothek Johann Christian Senckenberg
Creating Corporation:Johann Wolfgang Goethe-Universit├Ąt Frankfurt am Main
Release Date:2018/07/23
Tag:Drug-Drug Interactions; GI pH; GI solubility; Pharmacokinetic Interactions; gastrointestinal drugs
Page Number:98
First Page:1
Last Page:98
Nebentitel: Pharmacokinetic interactions with GI drugs
Institutes:Biochemie, Chemie und Pharmazie / Pharmazie
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoDeutsches Urheberrecht