Endothelial cell metabolism in Atherosclerosis

  • Atherosclerosis and its sequelae, such as myocardial infarction and stroke, are the leading cause of death worldwide. Vascular endothelial cells (EC) play a critical role in vascular homeostasis and disease. Atherosclerosis as well as its independent risk factors including diabetes, obesity, and aging, are hallmarked by endothelial activation and dysfunction. Metabolic pathways have emerged as key regulators of many EC functions, including angiogenesis, inflammation, and barrier function, processes which are deregulated during atherogenesis. In this review, we highlight the role of glucose, fatty acid, and amino acid metabolism in EC functions during physiological and pathological states, specifically atherosclerosis, diabetes, obesity and aging.

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Author:Kosta Theodorou, Reinier Boon
URN:urn:nbn:de:hebis:30:3-473624
DOI:https://doi.org/10.3389/fcell.2018.00082
ISSN:2296-634X
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/30131957
Parent Title (English):Frontiers in cell and developmental biology
Publisher:Frontiers Media
Place of publication:Lausanne
Contributor(s):Salvatore Papa
Document Type:Article
Language:English
Year of Completion:2018
Date of first Publication:2018/08/07
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2018/10/30
Tag:aging; atherosclerosis; endothelial cells; hyperglycemia; hyperlipidemia; inflammation; metabolism
Volume:6
Issue:Art. 82
Page Number:9
First Page:1
Last Page:9
Note:
Copyright © 2018 Theodorou and Boon. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
HeBIS-PPN:440663628
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Open-Access-Publikationsfonds:Medizin
Licence (German):License LogoCreative Commons - Namensnennung 4.0