Generation of human induced pluripotent stem cell lines (hiPSC) from one bipolar disorder patient carrier of a DGKH risk haplotype and one non-risk-variant-carrier bipolar disorder patient

  • Fibroblasts were isolated from skin biopsies from two patients with bipolar I disorder. One patient was a 26 year old female carrying a risk haplotype in the DGKH (diacylglycerol kinase eta) gene and the other was a non-carrier 27 year old male. Patient fibroblasts were reprogrammed into human induced pluripotent stem cells (hiPSCs) by using a Sendai virus vector. DGKH-risk haplotype and non-risk haplotype hiPSCs showed expression of pluripotency markers and were able to differentiate into cells of the three germ layers. These cell models are useful to investigate the role of risk gene variants in bipolar disorder.
Metadaten
Author:Viola Stella Palladino, Nadia Omega Cipta Subrata, Andreas Geburtig-ChiocchettiORCiDGND, Rhiannon McNeillORCiD, Per HoffmannORCiDGND, Andreas ReifORCiDGND, Sarah Kittel-SchneiderORCiDGND
URN:urn:nbn:de:hebis:30:3-476861
DOI:https://doi.org/10.1016/j.scr.2018.09.008
ISSN:1876-7753
ISSN:1873-5061
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/30266033
Parent Title (English):Stem cell research
Publisher:Elsevier
Place of publication:Amsterdam [u. a.]
Document Type:Article
Language:English
Year of Completion:2018
Date of first Publication:2018/09/17
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2018/10/11
Volume:32
Page Number:6
First Page:104
Last Page:109
Note:
© 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).
Note:
Corrigendum erschienen in: Stem cell research, 36.2019, Art. 101419, doi:10.1016/j.scr.2019.101419
HeBIS-PPN:439212855
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Open-Access-Publikationsfonds:Medizin
Licence (German):License LogoCreative Commons - Namensnennung 4.0

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