Percutaneous left atrial appendage occlusion for the prevention of stroke in patients with atrial fibrillation : review and critical appraisal

  • The authors review the current status of percutaneous left atrial appendage (LAA) occlusion therapy in patients with atrial fibrillation with the goal to prevent ischemic stroke and systemic embolism and to reduce oral anticoagulation associated bleeding. While we cover the historical and also surgical background, and all tested devices, the main focus rests on the single currently U.S. Food and Drug Administration (FDA) approved LAA occluder, the WATCHMAN device, and its approval process. The authors also give a critical appraisal beyond the review of mere facts, trying to put the current data into perspective.

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Author:Peter Dieter Schellinger, Georgios Tsivgoulis, Thorsten Steiner, Martin Köhrmann
Pubmed Id:
Parent Title (English):Journal of stroke
Publisher:Korean Stroke Society
Place of publication:Seoul
Document Type:Article
Year of Completion:2018
Date of first Publication:2018/09/30
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2018/10/18
Tag:Atrial appendage occlusion; Atrial fibrillation; Brain ischemia; Intracranial hemorrhage; Stroke
Page Number:11
First Page:281
Last Page:291
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (English):License LogoCreative Commons - Namensnennung-Nicht kommerziell 4.0