Autophagic responses compensate mitochondrial impairments

  • Mitochondria are the "power plants" of eukaryotic cells involved cellular energy metabolism and lead the generation of most of the cellular "energy currency" adenosine triphosphate (ATP). In addition, they have other crucial functions including the control of programmed cell death, iron/sulfur cluster biogenesis and copper and calcium homeostasis. Mitochondrial dysfunction is deleterious and leads to degeneration, disease and aging. A number of individual pathways are active in keeping mitochondria functional over longer periods of time and thereby have a strong impact on lifespan. These mitochondrial quality control (mtQC) pathways occur at different molecular and cellular levels and are all limited in their capacity. They do not all work at the same time. Some of them are induced when others fail. Currently, the underlying molecular interaction of pathways and their regulation is only initially elucidated. ...

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Author:Vanessa Henkel, Verena Warnsmann, Heinz D. OsiewaczORCiDGND
Pubmed Id:
Parent Title (English):Aging
Publisher:Impact Journals, LLC
Place of publication:[s. l.]
Document Type:Article
Year of Completion:2017
Date of first Publication:2017/09/11
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2019/03/07
Tag:aging; general autophagy; mitochondrial quality control; mitophagy
Page Number:2
First Page:1947
Last Page:1948
Copyright: Henkel et al. This is an open‐access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Institutes:Biowissenschaften / Biowissenschaften
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Licence (German):License LogoCreative Commons - Namensnennung 3.0