μ-Rhythm extracted with personalized EEG filters correlates with corticospinal excitability in real-time phase-triggered EEG-TMS

  • Ongoing brain activity has been implicated in the modulation of cortical excitability. The combination of electroencephalography (EEG) and transcranial magnetic stimulation (TMS) in a real-time triggered setup is a novel method for testing hypotheses about the relationship between spontaneous neuronal oscillations, cortical excitability, and synaptic plasticity. For this method, a reliable real-time extraction of the neuronal signal of interest from scalp EEG with high signal-to-noise ratio (SNR) is of crucial importance. Here we compare individually tailored spatial filters as computed by spatial-spectral decomposition (SSD), which maximizes SNR in a frequency band of interest, against established local C3-centered Laplacian filters for the extraction of the sensorimotor μ-rhythm. Single-pulse TMS over the left primary motor cortex was synchronized with the surface positive or negative peak of the respective extracted signal, and motor evoked potentials (MEP) were recorded with electromyography (EMG) of a contralateral hand muscle. Both extraction methods led to a comparable degree of MEP amplitude modulation by phase of the sensorimotor μ-rhythm at the time of stimulation. This could be relevant for targeting other brain regions with no working benchmark such as the local C3-centered Laplacian filter, as sufficient SNR is an important prerequisite for reliable real-time single-trial detection of EEG features.

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Author:Natalie Schaworonkow, Pedro Caldana Gordon, Paolo Belardinelli, Ulf Ziemann, Til Ole Bergmann, Christoph Zrenner
URN:urn:nbn:de:hebis:30:3-486890
DOI:https://doi.org/10.3389/fnins.2018.00954
ISSN:1662-453X
ISSN:1662-4548
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/30618580
Parent Title (English):Frontiers in neuroscience
Publisher:Frontiers Research Foundation
Place of publication:Lausanne
Contributor(s):Arnaud Delorme
Document Type:Article
Language:English
Year of Completion:2018
Date of first Publication:2018/12/13
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2019/01/22
Tag:EEG-TMS; brain-state-dependent stimulation; corticospinal excitability; sensorimotor oscillations; spatial filtering
Volume:12
Issue:Art. 954
Page Number:6
First Page:1
Last Page:6
Note:
Copyright © 2018 Schaworonkow, Caldana Gordon, Belardinelli, Ziemann, Bergmann and Zrenner. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
HeBIS-PPN:446479063
Institutes:Wissenschaftliche Zentren und koordinierte Programme / Frankfurt Institute for Advanced Studies (FIAS)
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0