Advanced cell therapeutics are changing the clinical landscape : will mesenchymal stromal cells be a part of it?
- During the past 15 years there have been dramatic changes in the medical landscape, particularly in oncology and regenerative medicine. Cell therapies have played a substantial part in this progress. Cellular immunotherapies can use immune cells, such as T cells or natural killer cells that, after functional modification ex vivo, exert powerful anti-cancer effects when given to the patient. Innovative technologies, such as re-programming terminally differentiated cells into pluripotent stem cells or into other cell types and applying specific enzymes to more precisely edit the human genome, are paving the way towards more potent cell and gene therapies. Mesenchymal stromal cells are promising cellular immunotherapeutics, which also have potential for use in tissue engineering strategies and other regenerative medicine applications. However, substantial gaps in our knowledge of their biology and therapeutic efficacy present major challenges to their sustainable implementation in the clinical routine. In this article, progress in the field of cell therapeutics during the past 15 years will be briefly discussed, with a focus on mesenchymal stromal cells, highlighting the impact of this field on patient care.
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| Author: | Richard SchäferORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-489606 |
| DOI: | https://doi.org/10.1186/s12916-019-1289-6 |
| ISSN: | 1741-7015 |
| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/30832655 |
| Parent Title (English): | BMC medicine |
| Publisher: | BioMed Central ; Springer |
| Place of publication: | London ; Berlin ; Heidelberg |
| Document Type: | Article |
| Language: | English |
| Year of Completion: | 2019 |
| Date of first Publication: | 2019/03/05 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2019/03/28 |
| Tag: | Biotechnology; Cell therapy; Immunotherapy; Mesenchymal stromal cells; Regenerative medicine; Stem cells |
| Volume: | 17 |
| Issue: | Art. 53 |
| Page Number: | 3 |
| First Page: | 1 |
| Last Page: | 3 |
| Note: | Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| HeBIS-PPN: | 44805440X |
| Institutes: | Medizin / Medizin |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung 4.0 |
