Area postrema syndrome as frequent feature of Bickerstaff brainstem encephalitis

  • Objective: Area postrema (AP) syndrome (defined as: nausea and/or emesis and/or singultus at onset of brainstem dysfunction) comprises complex pathophysiologic mechanisms triggered by different entities. The first objective was to assess the frequency of AP syndrome as a clinical feature in brainstem encephalitis (BE). Finding an especially high prevalence of AP syndrome in Bickerstaff brainstem encephalitis (BBE), we also analyzed the frequency of AP syndrome in other autoimmune diseases with anti‐ganglioside antibodies (Guillain–Barré syndrome (GBS) and its variants). Methods: We systematically evaluated the prevalence of AP syndrome in BE in all patients treated at our university hospital during a 15‐year period. In a second step, BBE patients were compared to GBS and Miller Fisher syndrome (MFS) patients as clinical subtypes of a disease continuum without brainstem dysfunction. Results: We found AP syndrome in 8 of 21 BE patients, including 3 of 7 BBE and in 4 of 112 GBS/MFS patients. AP syndrome was as a frequent but under‐recognized feature of BE with a significant impact on patients’ well being. Interpretation: Manifestation of AP syndrome in BBE but also in GBS and its subtypes point toward a role of autoimmune antibodies that should be investigated in future studies. Considerable misdiagnosis or nonrecognition complicates diagnostic and therapeutic management. Therefore, AP syndrome should be considered in any episode of otherwise unexplained nausea, emesis, or singultus.
Metadaten
Author:Pia Susan ZeinerORCiD, Annemarie Brandhofe, Monika Müller-Eschner, Helmuth Steinmetz, Waltraud PfeilschifterORCiDGND
URN:urn:nbn:de:hebis:30:3-491856
DOI:https://doi.org/10.1002/acn3.666
ISSN:2328-9503
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/30564620
Parent Title (English):Annals of Clinical and Translational Neurology
Publisher:Wiley
Place of publication:Chichester [u. a.]
Document Type:Article
Language:English
Year of Completion:2018
Date of first Publication:2018/10/31
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2019/02/21
Volume:5
Issue:12
Page Number:9
First Page:1534
Last Page:1542
Note:
This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
HeBIS-PPN:446891320
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Open-Access-Publikationsfonds:Medizin
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0