Aberrant brain network topology in fronto‐limbic circuitry differentiates euthymic bipolar disorder from recurrent major depressive disorder

  • Introduction: Previous studies have established graph theoretical analysis of functional network connectivity (FNC) as a potential tool to detect neurobiological underpinnings of psychiatric disorders. Despite the promising outcomes in studies that examined FNC aberrancies in bipolar disorder (BD) and major depressive disorder (MDD), there is still a lack of research comparing both mood disorders, especially in a nondepressed state. In this study, we used graph theoretical network analysis to compare brain network properties of euthymic BD, euthymic MDD and healthy controls (HC) to evaluate whether these groups showed distinct features in FNC. Methods: We collected resting‐state functional magnetic resonance imaging (fMRI) data from 20 BD patients, 15 patients with recurrent MDD as well as 30 age‐ and gender‐matched HC. Graph theoretical analyses were then applied to investigate functional brain networks on a global and regional network level. Results: Global network analysis revealed a significantly higher mean global clustering coefficient in BD compared to HC. We further detected frontal, temporal and subcortical nodes in emotion regulation areas such as the limbic system and associated regions exhibiting significant differences in network integration and segregation in BD compared to MDD patients and HC. Participants with MDD and HC only differed in frontal and insular network centrality. Conclusion: In conclusion, our findings indicate that a significantly altered brain network topology in the limbic system might be a trait marker specific to BD. Brain network analysis in these regions may therefore be used to differentiate euthymic BD not only from HC but also from patients with MDD.
Metadaten
Author:Jannis Dvorak, Marietheres Hilke, Marco Trettin, Sofia Maria Wenzler, Marleen Hagen, Naddy Ghirmai, Maximilian Müller, Dominik Kraft, Andreas ReifORCiDGND, Viola Oertel-Knöchel
URN:urn:nbn:de:hebis:30:3-502569
DOI:https://doi.org/10.1002/brb3.1257
ISSN:2162-3279
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/31066228
Parent Title (English):Brain and behavior
Publisher:Wiley
Place of publication:Malden, Mass.
Document Type:Article
Language:English
Year of Completion:2019
Date of first Publication:2019/05/07
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2019/05/16
Tag:bipolar disorder; euthymic; fMRI; functional connectivity; graph theory; major depressive disorder; resting‐state
Volume:2019
Issue:e01257
Page Number:14
First Page:1
Last Page:14
Note:
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
HeBIS-PPN:452426316
Institutes:Psychologie und Sportwissenschaften / Psychologie
Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Open-Access-Publikationsfonds:Medizin
Licence (German):License LogoCreative Commons - Namensnennung 4.0