Redox regulation of Smac mimetic-induced cell death

  • Cell death and survival programs are controlled by the cellular redox state, which is typically dysregulated during oncogenesis. A recent study reports that the inhibition of antioxidant defenses resulting from glutathione depletion can prime acute lymphoblastic leukemia cells for death induced by Smac mimetics.

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Author:Simone FuldaORCiDGND
URN:urn:nbn:de:hebis:30:3-506739
DOI:https://doi.org/10.1080/23723556.2014.1000697
ISSN:2372-3556
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/27308489
Parent Title (English):Molecular & cellular oncology
Publisher:Taylor & Francis
Place of publication:London
Document Type:Article
Language:English
Year of Completion:2015
Date of first Publication:2015/01/23
Publishing Institution:Universit├Ątsbibliothek Johann Christian Senckenberg
Release Date:2019/07/11
Tag:Smac; apoptosis; cell death; leukemia; redox
Volume:2
Issue:4
Page Number:3
First Page:e1000697-1
Last Page:e1000697-2
Note:
This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
HeBIS-PPN:452969212
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universit├Ątspublikationen
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell 3.0