Redox regulation of Smac mimetic-induced cell death
- Cell death and survival programs are controlled by the cellular redox state, which is typically dysregulated during oncogenesis. A recent study reports that the inhibition of antioxidant defenses resulting from glutathione depletion can prime acute lymphoblastic leukemia cells for death induced by Smac mimetics.
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| Author: | Simone FuldaORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-506739 |
| DOI: | https://doi.org/10.1080/23723556.2014.1000697 |
| ISSN: | 2372-3556 |
| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/27308489 |
| Parent Title (English): | Molecular & cellular oncology |
| Publisher: | Taylor & Francis |
| Place of publication: | London |
| Document Type: | Article |
| Language: | English |
| Year of Completion: | 2015 |
| Date of first Publication: | 2015/01/23 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2019/07/11 |
| Tag: | Smac; apoptosis; cell death; leukemia; redox |
| Volume: | 2 |
| Issue: | 4 |
| Page Number: | 3 |
| First Page: | e1000697-1 |
| Last Page: | e1000697-2 |
| Note: | This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. |
| HeBIS-PPN: | 452969212 |
| Institutes: | Medizin / Medizin |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung-Nicht kommerziell 3.0 |
