SUMOylation in glioblastoma : a novel therapeutic target

  • Protein SUMOylation is a dynamic post-translational modification which is involved in a diverse set of physiologic processes throughout the cell. Of note, SUMOylation also plays a role in the pathobiology of a myriad of cancers, one of which is glioblastoma (GBM). Accordingly, herein, we review core aspects of SUMOylation as it relates to GBM and in so doing highlight putative methods/modalities capable of therapeutically engaging the pathway for treatment of this deadly neoplasm.

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Author:Brandon M. Fox, Andrew Janssen, Dagoberto Estevez-Ordonez, Florian GeßlerORCiDGND, Nunzio Vicario, Gustavo Chagoya, Galal Elsayed, Houman Sotoudeh, William Stetler, Gregory K. Friedman, Joshua D. BernstockORCiD
Pubmed Id:
Parent Title (English):International journal of molecular sciences
Publisher:Molecular Diversity Preservation International
Place of publication:Basel
Document Type:Article
Year of Completion:2019
Date of first Publication:2019/04/15
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2019/08/19
Tag:SUMO1-3; SUMOylation; glioblastoma (GBM); post-translational modifications (PTMs)
Issue:8, Art. 1853
Page Number:13
First Page:1
Last Page:13
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0