Regulation of eicosanoid pathways by microRNAs

  • Over the last years, many microRNAs (miRNAs) have been identified that regulate the formation of bioactive lipid mediators such as prostanoids and leukotrienes. Many of these miRNAs are involved in complex regulatory circuits necessary for the fine-tuning of biological functions including inflammatory processes or cell growth. A better understanding of these networks will contribute to the development of novel therapeutic strategies for the treatment of inflammatory diseases and cancer. In this review, we provide an overview of the current knowledge of miRNA regulation in eicosanoid pathways with special focus on novel miRNA functions and regulatory circuits of leukotriene and prostaglandin biosynthesis.

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Author:Meike J. Saul, Anne C. Emmerich, Dieter SteinhilberORCiDGND, Beatrix SüßGND
Pubmed Id:
Parent Title (English):Frontiers in pharmacology
Publisher:Frontiers Media
Place of publication:Lausanne
Contributor(s):Dan A. Dixon
Document Type:Article
Year of Completion:2019
Date of first Publication:2019/07/19
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2019/08/22
Tag:eicosanoids; inflammation; microRNA; new miRNA functions; prostaglandins
Issue:Art. 824
Page Number:11
First Page:1
Last Page:11
Copyright © 2019 Saul, Emmerich, Steinhilber and Suess. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Institutes:Medizin / Medizin
Wissenschaftliche Zentren und koordinierte Programme / Sonderforschungsbereiche / Forschungskollegs
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0