IL-18/IL-18BP and IL-22/IL-22BP : two interrelated couples with therapeutic potential

  • Interleukin (IL)-18 and IL-22 are key components of cytokine networks that play a decisive role in (pathological) inflammation, host defense, and tissue regeneration. Tight regulation of cytokine-driven signaling, inflammation, and immunoactivation is supposed to enable nullification of a given deleterious trigger without mediating overwhelming collateral tissue damage or even activating a cancerous face of regeneration. In fact, feedback regulation by specific cytokine opponents is regarded as a major means by which the immune system is kept in balance. Herein, we shine a light on the interplay between IL-18 and IL-22 and their opponents IL-18 binding protein (IL-18BP) and IL-22BP in order to provide integrated information on their biology, pathophysiological significance, and prospect as targets and/or instruments of therapeutic intervention.

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Author:Heiko Mühl, Malte Bachmann
Pubmed Id:
Parent Title (English):Cellular signalling
Publisher:Elsevier Science
Place of publication:Amsterdam [u. a.]
Document Type:Article
Year of Completion:2019
Date of first Publication:2019/08/08
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2019/08/26
Tag:Interleukin-22 binding protein
Cytokines; Inflammation; Interleukin-18; Interleukin-18 binding protein; Interleukin-22
Issue:Art. 109388
Page Number:14
First Page:1
Last Page:14
© 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0