IL-18/IL-18BP and IL-22/IL-22BP : two interrelated couples with therapeutic potential
- Interleukin (IL)-18 and IL-22 are key components of cytokine networks that play a decisive role in (pathological) inflammation, host defense, and tissue regeneration. Tight regulation of cytokine-driven signaling, inflammation, and immunoactivation is supposed to enable nullification of a given deleterious trigger without mediating overwhelming collateral tissue damage or even activating a cancerous face of regeneration. In fact, feedback regulation by specific cytokine opponents is regarded as a major means by which the immune system is kept in balance. Herein, we shine a light on the interplay between IL-18 and IL-22 and their opponents IL-18 binding protein (IL-18BP) and IL-22BP in order to provide integrated information on their biology, pathophysiological significance, and prospect as targets and/or instruments of therapeutic intervention.
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| Author: | Heiko MühlORCiDGND, Malte BachmannGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-508191 |
| DOI: | https://doi.org/10.1016/j.cellsig.2019.109388 |
| ISSN: | 1873-3913 |
| ISSN: | 0898-6568 |
| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/31401146 |
| Parent Title (English): | Cellular signalling |
| Publisher: | Elsevier Science |
| Place of publication: | Amsterdam [u. a.] |
| Document Type: | Article |
| Language: | English |
| Year of Completion: | 2019 |
| Date of first Publication: | 2019/08/08 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2019/08/26 |
| Tag: | Interleukin-22 binding protein Cytokines; Inflammation; Interleukin-18; Interleukin-18 binding protein; Interleukin-22 |
| Volume: | 63 |
| Issue: | Art. 109388 |
| Page Number: | 14 |
| First Page: | 1 |
| Last Page: | 14 |
| Note: | © 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/) |
| HeBIS-PPN: | 454003609 |
| Institutes: | Medizin / Medizin |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0 |
