Migration properties distinguish tumor cells of classical hodgkin lymphoma from anaplastic large cell lymphoma cells

  • Anaplastic large cell lymphoma (ALCL) and classical Hodgkin lymphoma (cHL) are lymphomas that contain CD30-expressing tumor cells and have numerous pathological similarities. Whereas ALCL is usually diagnosed at an advanced stage, cHL more frequently presents with localized disease. The aim of the present study was to elucidate the mechanisms underlying the different clinical presentation of ALCL and cHL. Chemokine and chemokine receptor expression were similar in primary ALCL and cHL cases apart from the known overexpression of the chemokines CCL17 and CCL22 in the Hodgkin and Reed-Sternberg (HRS) cells of cHL. Consistent with the overexpression of these chemokines, primary cHL cases encountered a significantly denser T cell microenvironment than ALCL. Additionally to differences in the interaction with their microenvironment, cHL cell lines presented a lower and less efficient intrinsic cell motility than ALCL cell lines, as assessed by time-lapse microscopy in a collagen gel and transwell migration assays. We thus propose that the combination of impaired basal cell motility and differences in the interaction with the microenvironment hamper the dissemination of HRS cells in cHL when compared with the tumor cells of ALCL.

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Author:Olga Goncharova, Nadine Flinner, Julia Bein, Claudia Döring, Emmanuel Donnadieu, Sandy Rikirsch, Marco Herling, Ralf Küppers, Martin-Leo Hansmann, Sylvia HartmannGND
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/31581676
Parent Title (English):Cancers
Place of publication:Basel
Document Type:Article
Year of Completion:2019
Date of first Publication:2019/10/02
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2019/10/14
Tag:anaplastic large cell lymphoma; cell motility; chemokine receptors; classical Hodgkin lymphoma; dissemination; gene expression; image analysis; rosetting T cells; segmentation
Issue:10, Art. 1484
Page Number:16
First Page:1
Last Page:16
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
Institutes:Informatik und Mathematik / Informatik
Medizin / Medizin
Wissenschaftliche Zentren und koordinierte Programme / Frankfurt Institute for Advanced Studies (FIAS)
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0