Autoantibodies in autoimmune liver disease—clinical and diagnostic relevance

  • Testing for liver-related autoantibodies should be included in the workup of patients with hepatitis or cholestasis of unknown origin. Although most of these autoantibodies are not disease specific, their determination is a prerequisite to diagnose autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC), and they are components of the diagnostic scoring system in these diseases. In primary sclerosing cholangitis (PSC), on the other hand, autoantibodies are frequently present but play a minor role in establishing the diagnosis. In PSC, however, data on antibodies suggest a link between disease pathogenesis and the intestinal microbiota. This review will focus on practical aspects of antibody testing in the three major autoimmune liver diseases AIH, PBC, and PSC.

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Author:Marcial Sebode, Christina Weiler-Normann, Timur Liwinski, Christoph Schramm
Pubmed Id:
Parent Title (English):Frontiers in immunology
Publisher:Frontiers Media
Place of publication:Lausanne
Contributor(s):Ralf Ludwig
Document Type:Article
Year of Completion:2018
Date of first Publication:2018/03/27
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2019/12/23
Tag:antimitochondrial antibodies; antinuclear antibodies; autoimmune hepatitis; primary biliary cholangitis; primary sclerosing cholangitis; serology; smooth muscle antibodies; soluble liver antigen/liver–pancreas antigen
Issue:Art. 609
Page Number:12
First Page:1
Last Page:12
Copyright: © 2018 Sebode, Weiler-Normann, Liwinski and Schramm. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Institutes:keine Angabe Fachbereich / Extern
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0