Chronic intestinal failure and short bowel syndrome in Crohn’s disease

  • Chronic intestinal failure (CIF) is a rare but feared complication of Crohn’s disease. Depending on the remaining length of the small intestine, the affected intestinal segment, and the residual bowel function, CIF can result in a wide spectrum of symptoms, from single micronutrient malabsorption to complete intestinal failure. Management of CIF has improved significantly in recent years. Advances in home-based parenteral nutrition, in particular, have translated into increased survival and improved quality of life. Nevertheless, 60% of patients are permanently reliant on parenteral nutrition. Encouraging results with new drugs such as teduglutide have added a new dimension to CIF therapy. The outcomes of patients with CIF could be greatly improved by more effective prevention, understanding, and treatment. In complex cases, the care of patients with CIF requires a multidisciplinary approach involving not only physicians but also dietitians and nurses to provide optimal intestinal rehabilitation, nutritional support, and an improved quality of life. Here, we summarize current literature on CIF and short bowel syndrome, encompassing epidemiology, pathophysiology, and advances in surgical and medical management, and elucidate advances in the understanding and therapy of CIF-related complications such as catheter-related bloodstream infections and intestinal failure-associated liver disease.

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Author:Aysegül Aksan, Karima Farrag, Irina Ursula BlumensteinORCiDGND, Oliver Schröder, Axel Uwe Dignass, Jürgen Stein
URN:urn:nbn:de:hebis:30:3-580781
DOI:https://doi.org/10.3748/wjg.v27.i24.3440
ISBN:1007-9327
ISSN:2219-2840
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/34239262
Parent Title (English):World journal of gastroenterology
Publisher:Baishideng Publishing Group Inc.
Place of publication:Beijing
Document Type:Article
Language:English
Date of Publication (online):2021/06/28
Date of first Publication:2021/06/28
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2021/07/12
Tag:Chronic intestinal failure; Crohn's disease; Inflammatory bowel disease; Intestinal failure-associated liver disease; Parenteral nutrition; Short bowel syndrome
Volume:27
Issue:24
Page Number:31
First Page:3440
Last Page:3465
HeBIS-PPN:484946307
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Open-Access-Publikationsfonds:Medizin
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0