Clinical outcome and risk factors of red blood cell transfusion in patients undergoing elective primary meningioma resection

  • Transfusion of red blood cells (RBC) in patients undergoing major elective cranial surgery is associated with increased morbidity, mortality and prolonged hospital length of stay (LOS). This retrospective single center study aims to identify the clinical outcome of RBC transfusions on skull base and non-skull base meningioma patients including the identification of risk factors for RBC transfusion. Between October 2009 and October 2016, 423 patients underwent primary meningioma resection. Of these, 68 (16.1%) received RBC transfusion and 355 (83.9%) did not receive RBC units. Preoperative anaemia rate was significantly higher in transfused patients (17.7%) compared to patients without RBC transfusion (6.2%; p = 0.0015). In transfused patients, postoperative complications as well as hospital LOS was significantly higher (p < 0.0001) compared to non-transfused patients. After multivariate analyses, risk factors for RBC transfusion were preoperative American Society of Anaesthesiologists (ASA) physical status score (p = 0.0247), tumor size (p = 0.0006), surgical time (p = 0.0018) and intraoperative blood loss (p < 0.0001). Kaplan-Meier curves revealed significant influence on overall survival by preoperative anaemia, RBC transfusion, smoking, cardiovascular disease, preoperative KPS ≤ 60% and age (elderly ≥ 75 years). We concluded that blood loss due to large tumors or localization near large vessels are the main triggers for RBC transfusion in meningioma patients paired with a potential preselection that masks the effect of preoperative anaemia in multivariate analysis. Further studies evaluating the impact of preoperative anaemia management for reduction of RBC transfusion are needed to improve the clinical outcome of meningioma patients.

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Author:Vanessa NeefORCiDGND, Sven König, Daniel MondenORCiD, Daniel DubinskiORCiDGND, Anika Benesch, Florian Jürgen RaimannORCiDGND, Florian PiekarskiORCiDGND, Michael Wilfried RonellenfitschORCiDGND, Patrick Nikolaus HarterORCiDGND, Christian SenftORCiDGND, Patrick MeybohmORCiDGND, Elke HattingenORCiDGND, Kai ZacharowskiORCiDGND, Volker Seifert, Peter BaumgartenORCiDGND
URN:urn:nbn:de:hebis:30:3-618920
DOI:https://doi.org/10.3390/cancers13143601
ISSN:2072-6694
Parent Title (English):Cancers
Publisher:MDPI
Place of publication:Basel
Document Type:Article
Language:English
Date of Publication (online):2021/07/18
Date of first Publication:2021/07/18
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2021/08/03
Tag:anaemia; meningioma; red blood cells; transfusion
Volume:13
Issue:14, art. 3601
Page Number:13
First Page:1
Last Page:13
HeBIS-PPN:486229386
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Open-Access-Publikationsfonds:Medizin
Licence (German):License LogoCreative Commons - Namensnennung 4.0