C6 ceramide (d18:1/6:0) as a novel treatment of cutaneous T cell lymphoma

  • Cutaneous T cell lymphomas (CTCLs) represent a heterogeneous group of T cell lymphomas that primarily affect the skin. The most frequent forms of CTCL are mycosis fungoides and Sézary syndrome. Both are characterized by frequent recurrence, developing chronic conditions and high mortality with a lack of a curative treatment. In this study, we evaluated the effect of short-chain, cell-permeable C6 Ceramide (C6Cer) on CTCL cell lines and keratinocytes. C6Cer significantly reduced cell viability of CTCL cell lines and induced cell death via apoptosis and necrosis. In contrast, primary human keratinocytes and HaCaT keratinocytes were less affected by C6Cer. Both keratinocyte cell lines showed higher expressions of ceramide catabolizing enzymes and HaCaT keratinocytes were able to metabolize C6Cer faster and more efficiently than CTCL cell lines, which might explain the observed protective effects. Along with other existing skin-directed therapies, C6Cer could be a novel well-tolerated drug for the topical treatment of CTCL.

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Author:Raphael Wilhelm, Timon Eckes, Gergely ImreORCiD, Stefan KippenbergerORCiDGND, Markus MeissnerORCiDGND, Dominique Jeanette ThomasORCiDGND, Sandra TrautmannGND, Jean-Philippe Merlio, Edith Chevret, Roland KaufmannGND, Josef PfeilschifterGND, Alexander Koch, Manuel Jäger
URN:urn:nbn:de:hebis:30:3-624793
DOI:https://doi.org/10.3390/cancers13020270
ISSN:2072-6694
Parent Title (English):Cancers
Publisher:MDPI
Place of publication:Basel
Document Type:Article
Language:English
Date of Publication (online):2021/01/13
Date of first Publication:2021/01/13
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2021/09/09
Tag:C6 ceramide; cutaneous T cell lymphoma; short-chain ceramide; skin
Volume:13
Issue:2, art. 270
Page Number:14
First Page:1
Last Page:14
Note:
This work was supported by the German Research Foundation (SFB 1039).
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0