Clinical assessment of W-band spectroscopy for non-invasive detection and monitoring of sustained hyperglycemia

  • HbA1c is the gold standard test for monitoring medium/long term glycemia conditions in diabetes care, which is a critical factor in reducing the risk of chronic diabetes complications. Current technologies for measuring HbA1c concentration are invasive and adequate assays are still limited to laboratory-based methods that are not widely available worldwide. The development of a non-invasive diagnostic tool for HbA1c concentration can lead to the decrease of the rate of undiagnosed cases and facilitate early detection in diabetes care. We present a preliminary validation diagnostic study of W-band spectroscopy for detection and monitoring of sustained hyperglycemia, using the HbA1c concentration as reference. A group of 20 patients with type 1 diabetes mellitus and 10 healthy subjects were non-invasively assessed at three different visits over a period of 7 months by a millimeter-wave spectrometer (transmission mode) operating across the full W-band. The relationship between the W-band spectral profile and the HbA1c concentration is studied using longitudinal and non-longitudinal functional data analysis methods. A potential blind discrimination between patients with or without diabetes is obtained, and more importantly, an excellent relation (R-squared = 0.97) between the non-invasive assessment and the HbA1c measure is achieved. Such results support that W-band spectroscopy has great potential for developing a non-invasive diagnostic tool for in-vivo HbA1c concentration monitoring in humans.

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Author:Aldo Moreno-OyervidesORCiD, M. Carmen Aguilera-Morillo, María José de la Cruz Fernández, Edurne Lecumberri Pascual, Lucía Llanos Jiménez, Viktor KrozerORCiDGND, Pablo AcedoORCiD
Parent Title (English):Biomedical optics express
Place of publication:Washington, DC
Document Type:Article
Date of Publication (online):2021/07/19
Date of first Publication:2021/07/19
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2022/06/15
Page Number:15
First Page:5008
Last Page:5022
Instituto de Salud Carlos III (DTS17/00135). Aldo Moreno-Oyervides thanks the Consejo Nacional de Ciencia y Tecnología de México (CONACYT) for financially supporting his doctoral education (PhD. Grant) associated to this work. This work has been supported by the Madrid Government (Comunidad de Madrid-Spain) under the Multiannual Agreement with UC3M in the line of Excellence of University Professors (EPUC3M26), and in the context of the V PRICIT (Regional Programme of Research and Technological Innovation).
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 51 Mathematik / 510 Mathematik
5 Naturwissenschaften und Mathematik / 53 Physik / 530 Physik
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoDeutsches Urheberrecht