Electrical stimulation in bone tissue engineering treatments

  • Electrical stimulation (EStim) has been shown to promote bone healing and regeneration both in animal experiments and clinical treatments. Therefore, incorporating EStim into promising new bone tissue engineering (BTE) therapies is a logical next step. The goal of current BTE research is to develop combinations of cells, scaffolds, and chemical and physical stimuli that optimize treatment outcomes. Recent studies demonstrating EStim’s positive osteogenic effects at the cellular and molecular level provide intriguing clues to the underlying mechanisms by which it promotes bone healing. In this review, we discuss results of recent in vitro and in vivo research focused on using EStim to promote bone healing and regeneration and consider possible strategies for its application to improve outcomes in BTE treatments. Technical aspects of exposing cells and tissues to EStim in in vitro and in vivo model systems are also discussed.

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Author:Liudmila LeppikORCiD, Karla Mychellyne Costa OliveiraORCiD, Mit Balvantray BhavsarORCiD, John Howard BarkerORCiD
URN:urn:nbn:de:hebis:30:3-637259
DOI:https://doi.org/10.1007/s00068-020-01324-1
ISSN:1863-9941
Parent Title (English):European journal of trauma and emergency surgery
Publisher:Springer Medizin
Place of publication:Heidelberg
Document Type:Article
Language:English
Date of Publication (online):2020/02/20
Date of first Publication:2020/02/20
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2022/11/18
Tag:Bone regeneration; Bone tissue engineering; Electrical stimulation; In vitro; In vivo
Volume:46
Issue:2
Page Number:14
First Page:231
Last Page:244
Note:
Open Access funding provided by Projekt DEAL.
Note:
This study was supported by the Friedrichsheim Foundation (Stiftung Friedrichsheim) based in Frankfurt/Main, Germany.
Institutes:Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0