Prevalence of colorectal cancer and its precursor lesions in symptomatic patients under 55 years of age undergoing total colonoscopy: results of a large retrospective, multicenter, controlled endoscopy study

  • Purpose: Colorectal cancer (CRC) is the second most common cancer in Germany. Around 60,000 people were diagnosed CRC in 2016 in Germany. Since 2019, screening colonoscopies are offered in Germany for men by the age of 50 and for women by the age of 55. It is recently discussed if women should also undergo a screening colonoscopy by the age of 50 and if there are any predictors for getting CRC. Methods: Colonoscopies of 1553 symptomatic patients younger than 55 years were compared with colonoscopies of 1075 symptomatic patients older than 55 years. We analyzed if there are any significant differences between those two groups in the prevalence of CRC and its precursor lesions or between symptomatic men and women. We evaluated if there is a correlation between abdominal symptoms and the prevalence of CRC. Results: In 164/1553 symptomatic patients, 194 (12.5%) polyps were detected. In total, six colorectal carcinomas (0.4%) were detected. There were no significant differences between men and women. In symptomatic patients ≥ 55 years, significantly more polyps were found (p<0.0001; 26.6% vs. 12.5%). Totally, 286 polyps (26.6%) were removed in 1075 symptomatic patients older than 55 years. Anorectal bleeding was the only abdominal symptom being a significant indicator for the prevalence of the occurrence of colon and rectum cancer in both groups (p=0.03, OR=2.73 95%-CI [1.11;6.70]), but with only low sensitivity (44%). Conclusion: Due to no significant differences in men and women, we recommend screening colonoscopies also for women by the age of 50.

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Author:Katharina Christina StratmannORCiDGND, Katarzyna Czerwinska, Sonja Natalie FilmannORCiDGND, Wolfgang TackeGND, Christoph Weber, Herbert Bock, Irina Ursula BlumensteinORCiDGND
Parent Title (English):International journal of colorectal disease
Place of publication:Berlin ; Heidelberg
Document Type:Article
Date of Publication (online):2021/03/05
Date of first Publication:2021/03/05
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2022/08/24
Tag:Colorectal cancer; Lesions; Total colonoscopy
Page Number:6
First Page:1695
Last Page:1700
Open Access funding enabled and organized by Projekt DEAL.
Institut: Medizin
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0