Daniel Klionsky, Giulia Petroni, Ravi K. Amaravadi, Eric H. Baehrecke, Andrea Ballabio, Patricia Boya, José Manuel Bravo-San Pedro, Ken Cadwell, Francesco Cecconi, Augustine M. K. Choi, Mary E. Choi, Charleen T. Chu, Patrice Codogno, Maria Isabel Colombo, Ana Maria Cuervo, Vojo Deretic, Ivan Đikić, Zvulun Elazar, Eeva-Liisa Eskelinen, Gian Maria Fimia, David A. Gewirtz, Douglas R. Green, Malene Hansen, Marja Jäättelä, Terje Johansen, Gábor Juhász, Vassiliki Karantza, Claudine Kraft, Guido Kroemer, Nicholas T. Ktistakis, Sharad Kumar, Carlos López Otín, Kay F. Macleod, Frank Madeo, Jennifer Martinez, Alicia Meléndez, Noboru Mizushima, Christian Münz, Josef Martin Penninger, Rushika M. Perera, Mauro Piacentini, Fulvio Reggiori, David C. Rubinsztein, Kevin M. Ryan, Junichi Sadoshima, Laura Santambrogio, Luca Scorrano, Hans-Uwe Simon, Anna Katharina Simon, Anne Simonsen, Alexandra Stolz, Nektarios Tavernarakis, Sharon A. Tooze, Tamotsu Yoshimori, Junying Yuan, Zhenyu Yue, Qing Zhong, Lorenzo Galluzzi, Federico Pietrocola
- Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.
Metadaten| Author: | Daniel KlionskyORCiDGND, Giulia Petroni, Ravi K. Amaravadi, Eric H. Baehrecke, Andrea BallabioORCiD, Patricia BoyaORCiD, José Manuel Bravo-San Pedro, Ken Cadwell, Francesco CecconiORCiDGND, Augustine M. K. Choi, Mary E. Choi, Charleen T. ChuORCiD, Patrice CodognoORCiD, Maria Isabel Colombo, Ana Maria CuervoORCiD, Vojo Deretic, Ivan ĐikićORCiDGND, Zvulun Elazar, Eeva-Liisa Eskelinen, Gian Maria FimiaORCiD, David A. GewirtzORCiDGND, Douglas R. Green, Malene Hansen, Marja Jäättelä, Terje JohansenORCiD, Gábor Juhász, Vassiliki Karantza, Claudine KraftORCiD, Guido KroemerORCiDGND, Nicholas T. Ktistakis, Sharad KumarORCiD, Carlos López OtínORCiDGND, Kay F. Macleod, Frank Madeo, Jennifer Martinez, Alicia Meléndez, Noboru MizushimaORCiD, Christian MünzORCiDGND, Josef Martin Penninger, Rushika M. PereraORCiD, Mauro PiacentiniORCiD, Fulvio ReggioriORCiD, David C. Rubinsztein, Kevin M. Ryan, Junichi Sadoshima, Laura Santambrogio, Luca Scorrano, Hans-Uwe Simon, Anna Katharina Simon, Anne SimonsenORCiD, Alexandra StolzORCiDGND, Nektarios TavernarakisORCiDGND, Sharon A. ToozeORCiD, Tamotsu YoshimoriORCiD, Junying Yuan, Zhenyu Yue, Qing ZhongORCiD, Lorenzo GalluzziORCiDGND, Federico PietrocolaORCiD |
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| URN: | urn:nbn:de:hebis:30:3-639054 |
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| DOI: | https://doi.org/10.15252/embj.2021108863 |
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| ISSN: | 1460-2075 |
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| Parent Title (English): | The EMBO journal |
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| Publisher: | EMBO Press ; Wiley |
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| Place of publication: | Heidelberg ; Hoboken, NJ [u.a.] |
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| Document Type: | Article |
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| Language: | English |
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| Date of Publication (online): | 2021/08/30 |
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| Date of first Publication: | 2021/08/30 |
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| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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| Release Date: | 2022/03/09 |
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| Tag: | aging; cancer; inflammation; metabolic syndromes; neurodegeneration |
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| Volume: | 40 |
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| Issue: | 19, e108863 |
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| Page Number: | 63 |
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| First Page: | 1 |
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| Last Page: | 63 |
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| HeBIS-PPN: | 493746560 |
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| Institutes: | Medizin / Medizin |
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| Fachübergreifende Einrichtungen / Buchmann Institut für Molekulare Lebenswissenschaften (BMLS) |
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| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
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| 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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| Sammlungen: | Universitätspublikationen |
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| Licence (German): |  Creative Commons - Namensnennung 4.0 |
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