Autophagy in major human diseases

  • Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.
Metadaten
Author:Daniel Klionsky, Giulia Petroni, Ravi K. Amaravadi, Eric H. Baehrecke, Andrea BallabioORCiD, Patricia Boya, José Manuel Bravo-San Pedro, Ken Cadwell, Francesco Cecconi, Augustine M. K. Choi, Mary E. Choi, Charleen T. Chu, Patrice Codogno, Maria Isabel Colombo, Ana Maria Cuervo, Vojo Deretic, Ivan ĐikićORCiDGND, Zvulun Elazar, Eeva-Liisa Eskelinen, Gian Maria Fimia, David A. GewirtzORCiDGND, Douglas R. Green, Malene Hansen, Marja Jäättelä, Terje Johansen, Gábor Juhász, Vassiliki Karantza, Claudine Kraft, Guido Kroemer, Nicholas T. Ktistakis, Sharad Kumar, Carlos Lopez-Otin, Kay F. Macleod, Frank Madeo, Jennifer Martinez, Alicia Meléndez, Noboru Mizushima, Christian Münz, Josef Martin Penninger, Rushika M. Perera, Mauro Piacentini, Fulvio Reggiori, David C. Rubinsztein, Kevin M. Ryan, Junichi Sadoshima, Laura Santambrogio, Luca Scorrano, Hans-Uwe Simon, Anna Katharina Simon, Anne Simonsen, Alexandra Stolz, Nektarios Tavernarakis, Sharon A. Tooze, Tamotsu Yoshimori, Junying Yuan, Zhenyu Yue, Qing ZhongORCiD, Lorenzo GalluzziORCiD, Federico PietrocolaORCiD
URN:urn:nbn:de:hebis:30:3-639054
DOI:https://doi.org/10.15252/embj.2021108863
ISSN:1460-2075
Parent Title (English):The EMBO journal
Publisher:EMBO Press ; Wiley
Place of publication:Heidelberg ; Hoboken, NJ [u.a.]
Document Type:Article
Language:English
Date of Publication (online):2021/08/30
Date of first Publication:2021/08/30
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2022/03/09
Tag:aging; cancer; inflammation; metabolic syndromes; neurodegeneration
Volume:40
Issue:19, e108863
Page Number:63
First Page:1
Last Page:63
HeBIS-PPN:493746560
Institutes:Medizin / Medizin
Fachübergreifende Einrichtungen / Buchmann Institut für Molekulare Lebenswissenschaften (BMLS)
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0