Secukinumab demonstrates sustained efficacy in clearing skin and improving patient-reported outcomes in patients with moderate-to-severe psoriasis through 2 years of treatment : results from the CLEAR study

  • Secukinumab is a fully human monoclonal antibody that selectively neutralizes interleukin 17A, a key cytokine involved in the development of psoriasis. Secukinumab has shown long-lasting efficacy and safety in the complete spectrum of psoriatic disease, including disease localized to nails, scalp, palms and soles, and joints (peripheral and axial arthritis). Given the chronic and relapsing nature of psoriasis, long-term data might help to fully characterize the efficacy and safety profile of secukinumab as well as its impact on quality of life.

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Author:Diamant ThaçiORCiD, Lluís Puig, Kristian ReichORCiDGND, Tsen-Fang Tsai, Stephen Tyring, Kulli Kingo, Michael Ziv, Andreas PinterORCiDGND, Ronald Vender, Aude Lacombe, Summer Xia, Vaishali Bhosekar, Isabelle Gilloteau, Adriana Guana, Andrew Blauvelt
URN:urn:nbn:de:hebis:30:3-507521
DOI:https://doi.org/10.1016/j.jaad.2019.04.045
ISSN:1097-6787
ISSN:0190-9622
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/31399223
Parent Title (English):Journal of the American Academy of Dermatology
Publisher:Elsevier
Place of publication:Amsterdam [u. a.]
Document Type:Article
Language:English
Year of Completion:2019
Date of first Publication:2019/08/06
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2019/11/11
Volume:81
Issue:6
Page Number:5
First Page:1405
Last Page:1409
Note:
2019 by the American Academy of Dermatology, Inc. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
HeBIS-PPN:456377166
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0

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