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Sex differences in psychiatric comorbidity and clinical presentation in youths with conduct disorder
(2021)
Konrad, Kerstin ; Kohls, Gregor ; Baumann, Sarah ; Bernhard, Anka ; Martinelli, Anne ; Ackermann, Katharina ; Smaragdi, Areti ; Gonzalez-Madruga, Karen ; Wells, Amy ; Rogers, Jack C. ; Pauli, Ruth ; Clanton, Roberta ; Baker, Rosalind ; Kersten, Linda ; Prätzlich, Martin ; Oldenhof, Helena ; Jansen, Lucres ; Kleeven, Anneke ; Bigorra, Aitana ; Hervás, Amaia ; Kerexeta-Lizeaga, Iñaki ; Sesma-Pardo, Eva ; Gonzalez-Torres, Miguel Angel ; Siklósi, Réka ; Dochnal, Roberta ; Kalogerakis, Zacharias ; Pirlympou, Mara ; Papadakos, Leonidas ; Cornwell, Harriet ; Scharke, Wolfgang ; Dikeos, Dimitris ; Fernández-Rivas, Aranzazu ; Popma, Arne ; Stadler, Christina ; Herpertz-Dahlmann, Beate ; De Brito, Stephane A. ; Fairchild, Graeme ; Freitag, Christine M.
Background: Conduct disorder (CD) rarely occurs alone but is typically accompanied by comorbid psychiatric disorders, which complicates the clinical presentation and treatment of affected youths. The aim of this study was to investigate sex differences in comorbidity pattern in CD and to systematically explore the ‘gender paradox’ and ‘delayed-onset pathway’ hypotheses of female CD.
Methods: As part of the FemNAT-CD multisite study, semistructured clinical interviews and rating scales were used to perform a comprehensive phenotypic characterization of 454 girls and 295 boys with CD (9–18 years), compared to 864 sex- and age-matched typically developing controls.
Results: Girls with CD exhibited higher rates of current major depression, anxiety disorders, post-traumatic stress disorder and borderline personality disorder, whereas boys with CD had higher rates of current attention-deficit/hyperactivity disorder. In line with the ‘gender paradox’ hypothesis, relative to boys, girls with CD showed significantly more lifetime psychiatric comorbidities (incl. Alcohol Use Disorder), which were accompanied by more severe CD symptoms. Female and male youths with CD also differed significantly in their CD symptom profiles and distribution of age-of-onset subtypes of CD (i.e. fewer girls with childhood-onset CD). In line with the ‘delayed-onset pathway’ hypothesis, girls with adolescent-onset CD showed similar levels of dimensional psychopathology like boys with childhood-onset CD, while boys with adolescent-onset CD had the lowest levels of internalizing psychopathology.
Conclusions: Within the largest study of CD in girls performed to date, we found compelling evidence for sex differences in comorbidity patterns and clinical presentation of CD. Our findings further support aspects of the ‘gender paradox’ and ‘delayed-onset pathway’ hypotheses by showing that girls with CD had higher rates of comorbid lifetime mental disorders and functional impairments, and they usually developed CD during adolescence. These novel data on sex-specific clinical profiles of CD will be critical in informing intervention and prevention programmes.
Sex differences in psychiatric comorbidity and clinical presentation in youths with conduct disorder
(2021)
Konrad, Kerstin ; Kohls, Gregor ; Baumann, Sarah ; Bernhard, Anka ; Martinelli, Anne ; Ackermann, Katharina ; Smaragdi, Areti ; Gonzalez-Madruga, Karen ; Wells, Amy ; Rogers, Jack C. ; Pauli, Ruth ; Clanton, Roberta ; Baker, Rosalind ; Kersten, Linda ; Prätzlich, Martin ; Oldenhof, Helena ; Jansen, Lucres ; Kleeven, Anneke ; Bigorra, Aitana ; Hervás, Amaia ; Kerexeta-Lizeaga, Iñaki ; Sesma-Pardo, Eva ; Gonzalez-Torres, Miguel Angel ; Siklósi, Réka ; Dochnal, Roberta ; Kalogerakis, Zacharias ; Pirlympou, Mara ; Papadakos, Leonidas ; Cornwell, Harriet ; Scharke, Wolfgang ; Dikeos, Dimitris ; Fernández-Rivas, Aranzazu ; Popma, Arne ; Stadler, Christina ; Herpertz-Dahlmann, Beate ; De Brito, Stephane A. ; Fairchild, Graeme ; Freitag, Christine M.
Background: Conduct disorder (CD) rarely occurs alone but is typically accompanied by comorbid psychiatric disorders, which complicates the clinical presentation and treatment of affected youths. The aim of this study was to investigate sex differences in comorbidity pattern in CD and to systematically explore the ‘gender paradox’ and ‘delayed-onset pathway’ hypotheses of female CD.
Methods: As part of the FemNAT-CD multisite study, semistructured clinical interviews and rating scales were used to perform a comprehensive phenotypic characterization of 454 girls and 295 boys with CD (9–18 years), compared to 864 sex- and age-matched typically developing controls.
Results: Girls with CD exhibited higher rates of current major depression, anxiety disorders, post-traumatic stress disorder and borderline personality disorder, whereas boys with CD had higher rates of current attention-deficit/hyperactivity disorder. In line with the ‘gender paradox’ hypothesis, relative to boys, girls with CD showed significantly more lifetime psychiatric comorbidities (incl. Alcohol Use Disorder), which were accompanied by more severe CD symptoms. Female and male youths with CD also differed significantly in their CD symptom profiles and distribution of age-of-onset subtypes of CD (i.e. fewer girls with childhood-onset CD). In line with the ‘delayed-onset pathway’ hypothesis, girls with adolescent-onset CD showed similar levels of dimensional psychopathology like boys with childhood-onset CD, while boys with adolescent-onset CD had the lowest levels of internalizing psychopathology.
Conclusions: Within the largest study of CD in girls performed to date, we found compelling evidence for sex differences in comorbidity patterns and clinical presentation of CD. Our findings further support aspects of the ‘gender paradox’ and ‘delayed-onset pathway’ hypotheses by showing that girls with CD had higher rates of comorbid lifetime mental disorders and functional impairments, and they usually developed CD during adolescence. These novel data on sex-specific clinical profiles of CD will be critical in informing intervention and prevention programmes.
Adam, Jaroslav ; Adamová, Dagmar ; Aggarwal, Madan Mohan ; Aglieri Rinella, Gianluca ; Agnello, Michelangelo ; Agrawal, Neelima ; Ahammed, Zubayer ; Ahmed, I. ; Ahn, Sang Un ; Aimo, Ilaria ; Aiola, Salvatore ; Ajaz, Muhammad ; Akindinov, Alexander ; Alam, Sk Noor ; Aleksandrov, Dmitry ; Alessandro, Bruno ; Alexandre, Didier ; Alfaro Molina, Jose Ruben ; Alici, Andrea ; Alkin, Anton ; Alme, Johan ; Alt, Torsten ; Altinpinar, Sedat ; Altsybeev, Igor ; Prado, Caio Alves Garcia ; Andrei, Cristian ; Andronic, Anton ; Anguelov, Venelin ; Anielski, Jonas ; Antičić, Tome ; Antinori, Federico ; Antonioli, Pietro ; Aphecetche, Laurent Bernard ; Appelshäuser, Harald ; Arcelli, Silvia ; Armesto, Néstor ; Arnaldi, Roberta ; Aronsson, Tomas Robert ; Arsene, Ionut Cristian ; Arslandok, Mesut ; Augustinus, Andre ; Averbeck, Ralf Peter ; Azmi, Mohd Danish ; Bach, Matthias ; Badalà, Angela ; Baek, Yong Wook ; Bagnasco, Stefano ; Bailhache, Raphaëlle ; Bala, Remu ; Baldisseri, Alberto ; Ball, Markus ; Baltasar Dos Santos Pedrosa, Fernando ; Baral, Rama Chandra ; Barbano, Anastasia Maria ; Barbera, Roberto ; Barile, Francesco ; Barnaföldi, Gergely Gábor ; Barnby, Lee Stuart ; Barret, Valerie ; Bartalini, Paolo ; Bartke, Jerzy ; Bartsch, Esther ; Basile, Maurizio ; Bastid, Nicole ; Basu, Sumit ; Bathen, Bastian ; Batigne, Guillaume ; Batista Camejo, Arianna ; Batyunya, Boris ; Bätzing, Paul Christoph ; Bearden, Ian Gardner ; Beck, Hans ; Bedda, Cristina ; Behera, Nirbhay Kumar ; Belikov, Iouri ; Bellini, Francesca ; Bello Martinez, Hector ; Bellwied, Rene ; Belmont, Ron ; Belmont-Moreno, Ernesto ; Belyaev, Vladimir ; Bencédi, Gyula ; Beolè, Stefania ; Berceanu, Ionela ; Bercuci, Alexandru ; Berdnikov, Yaroslav ; Berényi, Dániel ; Bertens, Redmer Alexander ; Berzano, Dario ; Betev, Latchezar ; Bhasin, Anju ; Bhat, Inayat Rasool ; Bhati, Ashok Kumar ; Bhattacharjee, Buddhadeb ; Bhom, Jihyun ; Bianchi, Livio ; Bianchi, Nicola ; Bianchin, Chiara ; Bielčík, Jaroslav ; Bielčíková, Jana ; Bilandzic, Ante ; Biswas, Saikat ; Bjelogrlic, Sandro ; Blanco, Fernando ; Blau, Dmitry S. ; Blume, Christoph ; Bock, Friederike ; Bogdanov, Alexey A. ; Bøggild, Hans ; Boldizsár, László ; Bombara, Marek ; Book, Julian ; Borel, Hervé ; Borissov, Alexander ; Borri, Marcello ; Bossú, Francesco ; Botje, Michiel ; Botta, Elena ; Böttger, Stefan ; Braun-Munzinger, Peter ; Bregant, Marco ; Breitner, Timo ; Broker, Theo Alexander ; Browning, Tyler Allen ; Broz, Michal ; Brücken, Erik Jens ; Bruna, Elena ; Bruno, Giuseppe Eugenio ; Budnikov, Dmitry ; Büsching, Henner ; Bufalino, Stefania ; Bunčić, Predrag ; Busch, Oliver ; Buthelezi, Edith Zinhle ; Buxton, Jesse Thomas ; Caffarri, Davide ; Cai, Xiao ; Caines, Helen Louise ; Calero Diaz, Liliet ; Caliva, Alberto ; Calvo Villar, Ernesto ; Camerini, Paolo ; Carena, Francesco ; Carena, Wisla ; Castillo Castellanos, Javier Ernesto ; Castro, Andrew John ; Casula, Ester Anna Rita ; Cavicchioli, Costanza ; Ceballos Sanchez, Cesar ; Čepila, Jan ; Cerello, Piergiorgio ; Chang, Beom-Su ; Chapeland, Sylvain ; Chartier, Marielle ; Charvet, Jean-Luc Fernand ; Chattopadhyay, Subhasis ; Chattopadhyay, Sukalyan ; Chelnokov, Volodymyr ; Cherney, Michael Gerard ; Cheshkov, Cvetan Valeriev ; Cheynis, Brigitte ; Chibante Barroso, Vasco Miguel ; Chinellato, David Dobrigkeit ; Chochula, Peter ; Choi, Kyungeon ; Chojnacki, Marek ; Choudhury, Subikash ; Christakoglou, Panagiotis ; Christensen, Christian Holm ; Christiansen, Peter L. ; Chujo, Tatsuya ; Chung, Suh-Urk ; Cicalò, Corrado ; Cifarelli, Luisa ; Cindolo, Federico ; Cleymans, Jean Willy Andre ; Colamaria, Fabio Filippo ; Colella, Domenico ; Collu, Alberto ; Colocci, Manuel ; Conesa Balbastre, Gustavo ; Conesa del Valle, Zaida ; Connors, Megan Elizabeth ; Contreras Nuno, Jesus Guillermo ; Cormier, Thomas Michael ; Corrales Morales, Yasser ; Cortés Maldonado, Ismael ; Cortese, Pietro ; Cosentino, Mauro Rogerio ; Costa, Filippo ; Crochet, Philippe ; Cruz Albino, Rigoberto ; Cuautle Flores, Eleazar ; Cunqueiro Mendez, Leticia ; Dahms, Torsten ; Dainese, Andrea ; Danu, Andrea ; Das, Debasish ; Das, Indranil ; Das, S. ; Dash, Ajay Kumar ; Dash, Sadhana ; De, Sudipan ; De Caro, Annalisa ; De Cataldo, Giacinto ; Cuveland, Jan de ; De Falco, Alessandro ; De Gruttola, Daniele ; De Marco, Nora ; De Pasquale, Salvatore ; Deisting, Alexander ; Deloff, Andrzej ; Dénes, Ervin Sandor ; D’Erasmo, Ginevra ; Di Bari, Domenico ; Di Mauro, Antonio ; Di Nezza, Pasquale ; Diaz Corchero, Miguel Angel ; Dietel, Thomas ; Dillenseger, Pascal ; Divià, Roberto ; Djuvsland, Øystein ; Dobrin, Alexandru Florin ; Dobrowolski, Tadeusz Antoni ; Domenicis Gimenez, Diogenes ; Dönigus, Benjamin ; Dordic, Olja ; Dubey, Anand Kumar ; Dubla, Andrea ; Ducroux, Laurent ; Dupieux, Pascal ; Ehlers, Raymond James ; Elia, Domenico ; Engel, Heiko ; Erazmus, Barbara Ewa ; Erhardt, Filip ; Eschweiler, Dominic ; Espagnon, Bruno ; Estienne, Magali Danielle ; Esumi, ShinIchi ; Evans, David ; Evdokimov, Sergey ; Eyyubova, Gyulnara ; Fabbietti, Laura ; Fabris, Daniela ; Faivre, Julien ; Fantoni, Alessandra ; Fasel, Markus ; Feldkamp, Linus ; Felea, Daniel ; Feliciello, Alessandro ; Feofilov, Grigori A. ; Ferencei, Jozef ; Fernández Téllez, Arturo ; Gonzalez Ferreiro, Elena ; Ferretti, Alessandro ; Festanti, Andrea ; Figiel, Jan ; Figueredo, Marcel Araujo Silva ; Filchagin, Sergey ; Finogeev, Dmitry ; Fionda, Fiorella Maria Celeste ; Fiore, Enrichetta Maria ; Fleck, Martin Gabriel ; Floris, Michele ; Foertsch, Siegfried Valentin ; Foka, Panagiota ; Fokin, Sergey ; Fragiacomo, Enrico ; Francescon, Andrea ; Frankenfeld, Ulrich ; Fuchs, Ulrich ; Furget, Christophe ; Furs, Artur ; Fusco Girard, Mario ; Gaardhøje, Jens Jørgen ; Gagliardi, Martino ; Gago Medina, Alberto Martín ; Gallio, Mauro ; Gangadharan, Dhevan Raja ; Ganoti, Paraskevi ; Gao, Chaosong ; Garabatos, Chilo ; Garcia-Solis, Edmundo Javier ; Gargiulo, Corrado ; Gasik, Piotr ; Germain, Marie ; Gheata, Andrei George ; Gheata, Mihaela ; Ghosh, Premomoy ; Ghosh, Sanjay Kumar ; Gianotti, Paola ; Giubellino, Paolo ; Giubilato, Piero ; Gładysz-Dziaduś, Ewa ; Glässel, Peter ; Gómez Coral, Diego Mauricio ; Gómez Ramírez, Andrés ; González Zamora, Pedro ; Gorbunov, Sergey ; Görlich, Lidia Maria ; Gotovac, Sven ; Grabski, Varlen ; Graczykowski, Łukasz Kamil ; Grelli, Alessandro ; Grigoras, Alina Gabriela ; Grigoraș, Costin ; Grigoriev, Vladislav A. ; Grigoryan, Ara ; Grigoryan, Smbat ; Grinyov, Boris V. ; Grion, Nevio ; Große-Oetringhaus, Jan Fiete ; Grossiord, Jean-Yves ; Grosso, Raffaele ; Grigoryan, Ara ; Grigoryan, Smbat ; Grinyov, Boris V. ; Grion, Nevio ; Große-Oetringhaus, Jan Fiete ; Grossiord, Jean-Yves ; Grosso, Raffaele ; Guber, Fedor ; Guernane, Rachid ; Guerzoni, Barbara ; Gulbrandsen, Kristjan Herlache ; Gulkanyan, Hrant ; Gunji, Taku ; Gupta, Anik ; Gupta, Ramni ; Haake, Rüdiger ; Haaland, Øystein Senneset ; Hadjidakis, Cynthia Marie ; Haiduc, Maria ; Hamagaki, Hideki ; Hamar, Gergö ; Hanratty, Luke David ; Hansen, Alexander ; Harris, John W. ; Hartmann, Helvi ; Harton, Austin Vincent ; Hatzifotiadou, Despina ; Hayashi, Shinichi ; Heckel, Stefan Thomas ; Heide, Markus ; Helstrup, Håvard ; Herghelegiu, Andrei Ionut ; Herrera Corral, Gerardo Antonio ; Hess, Benjamin Andreas ; Hetland, Kristin Fanebust ; Hilden, Timo Eero ; Hillemanns, Hartmut ; Hippolyte, Boris ; Hristov, Peter ; Huang, Meidana ; Humanic, Thomas J. ; Hussain, Nur ; Hussain, Tahir ; Hutter, Dirk ; Hwang, Dae Sung ; Ilkaev, Radiy ; Ilkiv, Iryna ; Inaba, Motoi ; Ionita, Costin ; Ippolitov, Mikhail ; Irfan, M. ; Ivanov, Marian ; Ivanov, Vladimir ; Izucheev, Vladimir ; Jacobs, Peter Martin ; Jahnke, Cristiane ; Jang, Haeng Jin ; Janik, Malgorzata Anna ; Jayarathna, Pahula Hewage Sandun Yasassri ; Jena, Chitrasen ; Jena, Satyajit ; Jiménez Bustamante, Raúl Tonatiuh ; Jones, Peter Graham ; Jung, H. ; Jusko, Anton ; Kalinak, Peter ; Kalweit, Alexander Philipp ; Kamin, Jason Adrian ; Kang, Ju Hwan ; Kaplin, Vladimir ; Kar, Somnath ; Karasu Uysal, Ayben ; Karavichev, Oleg V. ; Karavicheva, Tatiana L. ; Karpechev, Evgeny ; Kebschull, Udo ; Keidel, Ralf ; Keijdener, Darius Laurens D. ; Keil, Markus ; Khan, K. H. ; Khan, M. Mohisin ; Khan, P. ; Khan, Shuaib Ahmad ; Khanzadeev, Alexei ; Kharlov, Yury ; Kileng, Bjarte ; Kim, B. ; Kim, D. W. ; Kim, D. J. ; Kim, Hyeonjoong ; Kim, J. S. ; Kim, Mimae ; Kim, Minwoo ; Kim, S. ; Kim, T. ; Kirsch, Stefan ; Kisel, Ivan ; Kiselev, Sergej N. ; Kisiel, Adam Ryszard ; Kiss, Gabor ; Klay, Jennifer Lynn ; Klein, Carsten ; Klein, Jochen ; Klein-Bösing, Christian ; Kluge, Alexander ; Knichel, Michael Linus ; Knospe, Anders Garritt ; Kobayashi, Taiyo ; Kobdaj, Chinorat ; Varga-Kofarago, Monika ; Köhler, Markus Konrad ; Kollegger, Thorsten ; Kolojvari, Anatoly ; Kondratiev, Valery P. ; Kondratyeva, Natalia ; Kondratyuk, Evgeny ; Konevskikh, Artem ; Kour, Mandeep ; Kouzinopoulos, Charalampos ; Kovalenko, Vladimir ; Kowalski, Marek ; Kox, Serge ; Koyithatta Meethaleveedu, Greeshma ; Kral, Jiří ; Králik, Ivan ; Kravčáková, Adela ; Křelina, Michal ; Kretz, Matthias ; Krivda, Marian ; Krizek, Filip ; Kryshen, Evgeny ; Krzewicki, Mikolaj ; Kubera, Andrew Michael ; Kucera, Vít ; Kucheriaev, Yury ; Kugathasan, Thanushan ; Kuhn, Christian Claude ; Kuijer, Paulus Gerardus ; Kulakov, Igor ; Kumar, Ajay ; Kumar, Jitendra ; Kumar, Lokesh ; Kurashvili, Podist ; Kurepin, Alexander ; Kurepin, Alexey B. ; Kuryakin, Alexey ; Kushpil, Svetlana ; Kweon, Min Jung ; Kwon, Youngil ; La Pointe, Sarah Louise ; La Rocca, Paola ; Lagana Fernandes, Caio ; Lakomov, Igor ; Langoy, Rune ; Lara Martinez, Camilo Ernesto ; Lardeux, Antoine Xavier ; Lattuca, Alessandra ; Laudi, Elisa ; Lea, Ramona ; Leardini, Lucia ; Lee, Graham Richard ; Lee, Seongjoo ; Legrand, Iosif ; Lehnert, Jörg ; Lemmon, Roy Crawford ; Lenti, Vito ; Leogrande, Emilia ; Leon Monzon, Ildefonso ; Leoncino, Marco ; Lévai, Péter ; Li, Shuang ; Li, Xiaomei ; Lien, Jørgen André ; Lietava, Roman ; Lindal, Svein ; Lindenstruth, Volker ; Lippmann, Christian ; Lisa, Michael A. ; Ljunggren, Martin ; Lodato, Davide Francesco ; Lønne, Per-Ivar ; Loggins, Vera Renee ; Loginov, Vitaly ; Loizides, Constantinos ; Lopez, Xavier Bernard ; López Torres, Ernesto ; Lowe, Andrew John ; Lu, Xianguo ; Lüttig, Philipp ; Lunardon, Marcello ; Luparello, Grazia ; Maevskaya, Alla ; Mager, Magnus ; Mahajan, Sanjay ; Mahmood, Sohail Musa ; Maire, Antonin ; Majka, Richard Daniel ; Malaev, Mikhail ; Maldonado Cervantes, Ivonne Alicia ; Malinina, Liudmila ; Mal'Kevich, Dmitry ; Malzacher, Peter ; Mamonov, Alexander ; Manceau, Loic Henri Antoine ; Manko, Vladislav ; Manso, Franck ; Manzari, Vito ; Marchisone, Massimiliano ; Mareš, Jiří ; Margagliotti, Giacomo Vito ; Margotti, Anselmo ; Margutti, Jacopo ; Marin, Ana ; Markert, Christina ; Marquard, Marco ; Martashvili, Irakli ; Martin, Nicole Alice ; Martin Blanco, Javier ; Martinengo, Paolo ; Martínez Hernández, Mario Iván ; Martínez Garcia, Ginés ; Martinez Pedreira, Miguel ; Martynov, Yevgen ; Mas, Alexis Jean-Michel ; Masciocchi, Silvia ; Masera, Massimo ; Masoni, Alberto ; Massacrier, Laure Marie ; Mastroserio, Annalisa ; Matyja, Adam Tomasz ; Mayer, Christoph ; Mazer, Joel Anthony ; Mazzoni, Alessandra Maria ; Mcdonald, Daniel ; Meddi, Franco ; Menchaca-Rocha, Arturo Alejandro ; Meninno, Elisa ; Mercado Pérez, Jorge ; Meres, Michal ; Miake, Yasuo ; Mieskolainen, Matti Mikael ; 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Noferini, Francesco ; Nomokonov, Petr V. ; Nooren, Gerardus ; Norman, Jaime ; Nyanin, Alexander ; Nystrand, Joakim Ingemar ; Oeschler, Helmut ; Oh, Saehanseul ; Oh, Sun Kun ; Ohlson, Alice ; Okatan, Ali ; Okubo, Tsubasa ; Oláh, László ; Oleniacz, Janusz ; Silva, Antonio Carlos Oliveira da ; Oliver, Michael Henry ; Onderwaater, Jacobus ; Oppedisano, Chiara ; Ortiz Velasquez, Antonio ; Oskarsson, Anders ; Otwinowski, Jacek Tomasz ; Oyama, Ken ; Özdemir, Mahmut ; Pachmayer, Yvonne C. ; Pagano, Paola ; Paic, Guy ; Pajares Vales, Carlos ; Pal, Susanta Kumar ; Pan, Jinjin ; Pandey, Ashutosh Kumar ; Pant, Divyash ; Papikyan, Vardanush ; Pappalardo, Giuseppe Salvatore ; Pareek, Pooja ; Park, WooJin ; Parmar, Sonia ; Passfeld, Annika ; Paticchio, Vincenzo ; Paul, Biswarup ; Pawlak, Tomasz Jan ; Peitzmann, Thomas ; Pereira da Costa, Hugo Denis Antonio ; Filho, Elienos Pereira de Oliveira ; Peresunko, Dmitry Yurevich ; Pérez Lara, Carlos Eugenio ; Peskov, Vladimir ; Pestov, Yury N. ; Petráček, Vojtech ; Petrov, Viacheslav ; Petrovici, Mihai A. ; Petta, Catia ; Piano, Stefano ; Pikna, Miroslav ; Pillot, Philippe ; Pinazza, Ombretta ; Pinsky, Lawrence ; Piyarathna, Danthasinghe B. ; Płoskoń, Mateusz ; Planinic, Mirko ; Pluta, Jan Marian ; Pochybova, Sona ; Podesta Lerma, Pedro Luis Manuel ; Poghosyan, Martin G. ; Polichtchouk, Boris ; Poljak, Nikola ; Poonsawat, Wanchaloem ; Pop, Amalia ; Porteboeuf-Houssais, Sarah Julie ; Porter, Jeffrey Brent ; Pospisil, Jan ; Prasad, Sidharth Kumar ; Preghenella, Roberto ; Prino, Francesco ; Pruneau, Claude A. ; Pshenichnov, Igor A. ; Puccio, Maximiliano ; Puddu, Giovanna ; Pujahari, Prabhat Ranjan ; Punin, Valery ; Putschke, Jörn H. ; Qvigstad, Henrik ; Rachevski, Alexandre ; Raha, Sibaji ; Rajput, Sonia ; Rak, Jan ; Rakotozafindrabe, Andry Malala ; Ramello, Luciano ; Raniwala, Rashmi ; Raniwala, Sudhir ; Räsänen, Sami Sakari ; Rascanu, Bogdan Theodor ; Rathee, Deepika ; Razazi, Vahedeh ; Read, Kenneth Francis ; Real, Jean-Sébastien ; Redlich, Krzysztof ; 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The measurement of the mass differences for systems bound by the strong force has reached a very high precision with protons and anti-protons1,2. The extension of such measurement from (anti-)baryons to (anti-)nuclei allows one to probe any difference in the interactions between nucleons and anti-nucleons encoded in the (anti-)nuclei masses. This force is a remnant of the underlying strong interaction among quarks and gluons and can be described by effective theories3, but cannot yet be directly derived from quantum chromodynamics. Here we report a measurement of the difference between the ratios of the mass and charge of deuterons (d) and anti-deuterons (), and 3He and nuclei carried out with the ALICE (A Large Ion Collider Experiment)4 detector in Pb–Pb collisions at a centre-of-mass energy per nucleon pair of 2.76 TeV. Our direct measurement of the mass-over-charge differences confirms CPT invariance to an unprecedented precision in the sector of light nuclei5,6. This fundamental symmetry of nature, which exchanges particles with anti-particles, implies that all physics laws are the same under the simultaneous reversal of charge(s) (charge conjugation C), reflection of spatial coordinates (parity transformation P) and time inversion (T).