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  • Simon, Helene (2)
  • Burchardi, Nicole (1)
  • Eulenburg, Christine Helene zu (1)
  • Fehm, Tanja (1)
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Radiological patterns of brain metastases in breast cancer patients : a subproject of the german brain metastases in breast cancer (BMBC) registry (2016)
Laakmann, Elena ; Witzel, Isabell ; Scriba, Verena ; Grzyska, Ulrich ; Eulenburg, Christine Helene zu ; Burchardi, Nicole ; Hesse, Tobias ; Würschmidt, Florian ; Fehm, Tanja ; Möbus, Volker ; Minckwitz, Gunter von ; Loibl, Sibylle ; Park-Simon, Tjoung-Won ; Müller, Volkmar
Evidence about distribution patterns of brain metastases with regard to breast cancer subtypes and its influence on the prognosis of patients is insufficient. Clinical data, cranial computed tomography (CT) and magnetic resonance imaging (MRI) scans of 300 breast cancer patients with brain metastases (BMs) were collected retrospectively in four centers participating in the Brain Metastases in Breast Cancer Registry (BMBC) in Germany. Patients with positive estrogen (ER), progesterone (PR), or human epidermal growth factor receptor 2 (HER2) statuses, had a significantly lower number of BMs at diagnosis. Concerning the treatment mode, HER2-positive patients treated with trastuzumab before the diagnosis of BMs showed a lower number of intracranial metastases (p < 0.001). Patients with a HER2-positive tumor-subtype developed cerebellar metastases more often compared with HER2-negative patients (59.8% vs. 44.5%, p = 0.021), whereas patients with triple-negative primary tumors had leptomeningeal disease more often (31.4% vs. 18.3%, p = 0.038). The localization of Brain metastases (BMs) was associated with prognosis: patients with leptomeningeal disease had shorter survival compared with patients without signs of leptomeningeal disease (median survival 3 vs. 5 months, p = 0.025). A shorter survival could also be observed in the patients with metastases in the occipital lobe (median survival 3 vs. 5 months, p = 0.012). Our findings suggest a different tumor cell homing to different brain regions depending on subtype and treatment. View Full-Text
Aufgaben und Ziele der neuzeitlichen Wohlfahrtspflege (1922)
Simon, Helene
Der Anteil der Frau an der deutschen Industrie : nach den Ergebnissen der Berufszählung von 1907 ; Vortrag, gehalten auf der 2. Konferenz zur Förderung der Arbeiterinnen-Interessen (1910)
Simon, Helene
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