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Introduction: The German PID-NET registry was founded in 2009, serving as the first national registry of patients with primary immunodeficiencies (PID) in Germany. It is part of the European Society for Immunodeficiencies (ESID) registry. The primary purpose of the registry is to gather data on the epidemiology, diagnostic delay, diagnosis, and treatment of PIDs.
Methods: Clinical and laboratory data was collected from 2,453 patients from 36 German PID centres in an online registry. Data was analysed with the software Stata® and Excel.
Results: The minimum prevalence of PID in Germany is 2.72 per 100,000 inhabitants. Among patients aged 1–25, there was a clear predominance of males. The median age of living patients ranged between 7 and 40 years, depending on the respective PID. Predominantly antibody disorders were the most prevalent group with 57% of all 2,453 PID patients (including 728 CVID patients). A gene defect was identified in 36% of patients. Familial cases were observed in 21% of patients. The age of onset for presenting symptoms ranged from birth to late adulthood (range 0–88 years). Presenting symptoms comprised infections (74%) and immune dysregulation (22%). Ninety-three patients were diagnosed without prior clinical symptoms. Regarding the general and clinical diagnostic delay, no PID had undergone a slight decrease within the last decade. However, both, SCID and hyper IgE- syndrome showed a substantial improvement in shortening the time between onset of symptoms and genetic diagnosis. Regarding treatment, 49% of all patients received immunoglobulin G (IgG) substitution (70%—subcutaneous; 29%—intravenous; 1%—unknown). Three-hundred patients underwent at least one hematopoietic stem cell transplantation (HSCT). Five patients had gene therapy.
Conclusion: The German PID-NET registry is a precious tool for physicians, researchers, the pharmaceutical industry, politicians, and ultimately the patients, for whom the outcomes will eventually lead to a more timely diagnosis and better treatment.
Background: The integration of the non-cross-resistant chemotherapeutic agents capecitabine and vinorelbine into an intensified dose-dense sequential anthracycline- and taxane-containing regimen in high-risk early breast cancer (EBC) could improve efficacy, but this combination was not examined in this context so far. Methods: Patients with stage II/IIIA EBC (four or more positive lymph nodes) received post-operative intensified dose-dense sequential epirubicin (150mg/m2 every 2 weeks) and paclitaxel (225mg/m2 every 2 weeks) with filgrastim and darbepoetin alfa, followed by capecitabine alone (dose levels 1 and 3) or with vinorelbine (dose levels 2 and 4). Capecitabine was given on days 1-14 every 21 days at 1000 or 1250 mg/m2 twice daily (dose levels 1/2 and 3/4, respectively). Vinorelbine 25 mg/m2 was given on days 1 and 8 of each 21-day course (dose levels 2 and 4). Results: Fifty-one patients were treated. There was one dose-limiting toxicity (DLT) at dose level 1. At dose level 2 (capecitabine and vinorelbine), five of 10 patients experienced DLTs. Therefore evaluation of vinorelbine was abandoned and dose level 3 (capecitabine monotherapy) was expanded. Hand-foot syndrome and diarrhoea were dose limiting with capecitabine 1250 mg/m2 twice daily. At 35.2 months' median follow-up, the estimated 3-year relapse-free and overall survival rates were 82% and 91%, respectively. Administration of capecitabine monotherapy after sequential dose-dense epirubicin and paclitaxel is feasible in node-positive EBC, while the combination of capecitabine and vinorelbine as used here caused more DLTs. Trial registration: Current Controlled Trials ISRCTN38983527.
Early maternal care may counteract familial liability for psychopathology in the reward circuitry
(2018)
Reward processing is altered in various psychopathologies and has been shown to be susceptible to genetic and environmental influences. Here, we examined whether maternal care may buffer familial risk for psychiatric disorders in terms of reward processing. Functional magnetic resonance imaging during a monetary incentive delay task was acquired in participants of an epidemiological cohort study followed since birth (N = 172, 25 years). Early maternal stimulation was assessed during a standardized nursing/playing setting at the age of 3 months. Parental psychiatric disorders (familial risk) during childhood and the participants’ previous psychopathology were assessed by diagnostic interview. With high familial risk, higher maternal stimulation was related to increasing activation in the caudate head, the supplementary motor area, the cingulum and the middle frontal gyrus during reward anticipation, with the opposite pattern found in individuals with no familial risk. In contrast, higher maternal stimulation was associated with decreasing caudate head activity during reward delivery and reduced levels of attention deficit hyperactivity disorder (ADHD) in the high-risk group. Decreased caudate head activity during reward anticipation and increased activity during delivery were linked to ADHD. These findings provide evidence of a long-term association of early maternal stimulation on both adult neurobiological systems of reward underlying externalizing behavior and ADHD during development.
We present a higher-order call-by-need lambda calculus enriched with constructors, case-expressions, recursive letrec-expressions, a seq-operator for sequential evaluation and a non-deterministic operator amb that is locally bottom-avoiding. We use a small-step operational semantics in form of a single-step rewriting system that defines a (nondeterministic) normal order reduction. This strategy can be made fair by adding resources for bookkeeping. As equational theory we use contextual equivalence, i.e. terms are equal if plugged into any program context their termination behaviour is the same, where we use a combination of may- as well as must-convergence, which is appropriate for non-deterministic computations. We show that we can drop the fairness condition for equational reasoning, since the valid equations w.r.t. normal order reduction are the same as for fair normal order reduction. We evolve different proof tools for proving correctness of program transformations, in particular, a context lemma for may- as well as mustconvergence is proved, which restricts the number of contexts that need to be examined for proving contextual equivalence. In combination with so-called complete sets of commuting and forking diagrams we show that all the deterministic reduction rules and also some additional transformations preserve contextual equivalence.We also prove a standardisation theorem for fair normal order reduction. The structure of the ordering <=c a is also analysed: Ω is not a least element, and <=c already implies contextual equivalence w.r.t. may-convergence.
Motivated by the question of correctness of a specific implementation of concurrent buffers in the lambda calculus with futures underlying Alice ML, we prove that concurrent buffers and handled futures can correctly encode each other. Correctness means that our encodings preserve and reflect the observations of may- and must-convergence. This also shows correctness wrt. program semantics, since the encodings are adequate translations wrt. contextual semantics. While these translations encode blocking into queuing and waiting, we also provide an adequate encoding of buffers in a calculus without handles, which is more low-level and uses busy-waiting instead of blocking. Furthermore we demonstrate that our correctness concept applies to the whole compilation process from high-level to low-level concurrent languages, by translating the calculus with buffers, handled futures and data constructors into a small core language without those constructs.
The paper proposes a variation of simulation for checking and proving contextual equivalence in a non-deterministic call-by-need lambda-calculus with constructors, case, seq, and a letrec with cyclic dependencies. It also proposes a novel method to prove its correctness. The calculus’ semantics is based on a small-step rewrite semantics and on may-convergence. The cyclic nature of letrec bindings, as well as nondeterminism, makes known approaches to prove that simulation implies contextual equivalence, such as Howe’s proof technique, inapplicable in this setting. The basic technique for the simulation as well as the correctness proof is called pre-evaluation, which computes a set of answers for every closed expression. If simulation succeeds in finite computation depth, then it is guaranteed to show contextual preorder of expressions.
This paper proves several generic variants of context lemmas and thus contributes to improving the tools for observational semantics of deterministic and non-deterministic higher-order calculi that use a small-step reduction semantics. The generic (sharing) context lemmas are provided for may- as well as two variants of must-convergence, which hold in a broad class of extended process- and extended lambda calculi, if the calculi satisfy certain natural conditions. As a guide-line, the proofs of the context lemmas are valid in call-by-need calculi, in callby-value calculi if substitution is restricted to variable-by-variable and in process calculi like variants of the π-calculus. For calculi employing beta-reduction using a call-by-name or call-by-value strategy or similar reduction rules, some iu-variants of ciu-theorems are obtained from our context lemmas. Our results reestablish several context lemmas already proved in the literature, and also provide some new context lemmas as well as some new variants of the ciu-theorem. To make the results widely applicable, we use a higher-order abstract syntax that allows untyped calculi as well as certain simple typing schemes. The approach may lead to a unifying view of higher-order calculi, reduction, and observational equality.
We show on an abstract level that contextual equivalence in non-deterministic program calculi defined by may- and must-convergence is maximal in the following sense. Using also all the test predicates generated by the Boolean, forall- and existential closure of may- and must-convergence does not change the contextual equivalence. The situation is different if may- and total must-convergence is used, where an expression totally must-converges if all reductions are finite and terminate with a value: There is an infinite sequence of test-predicates generated by the Boolean, forall- and existential closure of may- and total must-convergence, which also leads to an infinite sequence of different contextual equalities.
Motivated by our experience in analyzing properties of translations between programming languages with observational semantics, this paper clarifies the notions, the relevant questions, and the methods, constructs a general framework, and provides several tools for proving various correctness properties of translations like adequacy and full abstractness. The presented framework can directly be applied to the observational equivalences derived from the operational semantics of programming calculi, and also to other situations, and thus has a wide range of applications.
Various concurrency primitives have been added to sequential programming languages, in order to turn them concurrent. Prominent examples are concurrent buffers for Haskell, channels in Concurrent ML, joins in JoCaml, and handled futures in Alice ML. Even though one might conjecture that all these primitives provide the same expressiveness, proving this equivalence is an open challenge in the area of program semantics. In this paper, we establish a first instance of this conjecture. We show that concurrent buffers can be encoded in the lambda calculus with futures underlying Alice ML. Our correctness proof results from a systematic method, based on observational semantics with respect to may and must convergence.
We investigate methods and tools for analyzing translations between programming languages with respect to observational semantics. The behavior of programs is observed in terms of may- and mustconvergence in arbitrary contexts, and adequacy of translations, i.e., the reflection of program equivalence, is taken to be the fundamental correctness condition. For compositional translations we propose a notion of convergence equivalence as a means for proving adequacy. This technique avoids explicit reasoning about contexts, and is able to deal with the subtle role of typing in implementations of language extensions.
We investigate methods and tools for analyzing translations between programming languages with respect to observational semantics. The behavior of programs is observed in terms of may- and mustconvergence in arbitrary contexts, and adequacy of translations, i.e., the reflection of program equivalence, is taken to be the fundamental correctness condition. For compositional translations we propose a notion of convergence equivalence as a means for proving adequacy. This technique avoids explicit reasoning about contexts, and is able to deal with the subtle role of typing in implementations of language extensions.
We investigate methods and tools for analysing translations between programming languages with respect to observational semantics. The behaviour of programs is observed in terms of may- and mustconvergence in arbitrary contexts, and adequacy of translations, i.e., the reflection of program equivalence, is taken to be the fundamental correctness condition. For compositional translations we propose a notion of convergence equivalence as a means for proving adequacy. This technique avoids explicit reasoning about contexts, and is able to deal with the subtle role of typing in implementations of language extensions.
We investigate methods and tools for analysing translations between programming languages with respect to observational semantics. The behaviour of programs is observed in terms of may- and mustconvergence in arbitrary contexts, and adequacy of translations, i.e., the reflection of program equivalence, is taken to be the fundamental correctness condition. For compositional translations we propose a notion of convergence equivalence as a means for proving adequacy. This technique avoids explicit reasoning about contexts, and is able to deal with the subtle role of typing in implementations of language extensions.
This paper shows equivalence of several versions of applicative similarity and contextual approximation, and hence also of applicative bisimilarity and contextual equivalence, in LR, the deterministic call-by-need lambda calculus with letrec extended by data constructors, case-expressions and Haskell's seq-operator. LR models an untyped version of the core language of Haskell. The use of bisimilarities simplifies equivalence proofs in calculi and opens a way for more convenient correctness proofs for program transformations. The proof is by a fully abstract and surjective transfer into a call-by-name calculus, which is an extension of Abramsky's lazy lambda calculus. In the latter calculus equivalence of our similarities and contextual approximation can be shown by Howe's method. Similarity is transferred back to LR on the basis of an inductively defined similarity. The translation from the call-by-need letrec calculus into the extended call-by-name lambda calculus is the composition of two translations. The first translation replaces the call-by-need strategy by a call-by-name strategy and its correctness is shown by exploiting infinite trees which emerge by unfolding the letrec expressions. The second translation encodes letrec-expressions by using multi-fixpoint combinators and its correctness is shown syntactically by comparing reductions of both calculi. A further result of this paper is an isomorphism between the mentioned calculi, which is also an identity on letrec-free expressions.
This paper shows equivalence of applicative similarity and contextual approximation, and hence also of bisimilarity and contextual equivalence, in LR, the deterministic call-by-need lambda calculus with letrec extended by data constructors, case-expressions and Haskell's seqoperator. LR models an untyped version of the core language of Haskell. Bisimilarity simplifies equivalence proofs in the calculus and opens a way for more convenient correctness proofs for program transformations.
The proof is by a fully abstract and surjective transfer of the contextual approximation into a call-by-name calculus, which is an extension of Abramsky's lazy lambda calculus. In the latter calculus equivalence of similarity and contextual approximation can be shown by Howe's method. Using an equivalent but inductive definition of behavioral preorder we then transfer similarity back to the calculus LR.
The translation from the call-by-need letrec calculus into the extended call-by-name lambda calculus is the composition of two translations. The first translation replaces the call-by-need strategy by a call-by-name strategy and its correctness is shown by exploiting infinite tress, which emerge by unfolding the letrec expressions. The second translation encodes letrec-expressions by using multi-fixpoint combinators and its correctness is shown syntactically by comparing reductions of both calculi. A further result of this paper is an isomorphism between the mentioned calculi, and also with a call-by-need letrec calculus with a less complex definition of reduction than LR.
Our motivation is the question whether the lazy lambda calculus, a pure lambda calculus with the leftmost outermost rewriting strategy, considered under observational semantics, or extensions thereof, are an adequate model for semantic equivalences in real-world purely functional programming languages, in particular for a pure core language of Haskell. We explore several extensions of the lazy lambda calculus: addition of a seq-operator, addition of data constructors and case-expressions, and their combination, focusing on conservativity of these extensions. In addition to untyped calculi, we study their monomorphically and polymorphically typed versions. For most of the extensions we obtain non-conservativity which we prove by providing counterexamples. However, we prove conservativity of the extension by data constructors and case in the monomorphically typed scenario.
Our motivation is the question whether the lazy lambda calculus, a pure lambda calculus with the leftmost outermost rewriting strategy, considered under observational semantics, or extensions thereof, are an adequate model for semantic equivalences in real-world purely functional programming languages, in particular for a pure core language of Haskell. We explore several extensions of the lazy lambda calculus: addition of a seq-operator, addition of data constructors and case-expressions, and their combination, focusing on conservativity of these extensions. In addition to untyped calculi, we study their monomorphically and polymorphically typed versions. For most of the extensions we obtain non-conservativity which we prove by providing counterexamples. However, we prove conservativity of the extension by data constructors and case in the monomorphically typed scenario.
This paper shows the equivalence of applicative similarity and contextual approximation, and hence also of bisimilarity and contextual equivalence, in the deterministic call-by-need lambda calculus with letrec. Bisimilarity simplifies equivalence proofs in the calculus and opens a way for more convenient correctness proofs for program transformations. Although this property may be a natural one to expect, to the best of our knowledge, this paper is the first one providing a proof. The proof technique is to transfer the contextual approximation into Abramsky's lazy lambda calculus by a fully abstract and surjective translation. This also shows that the natural embedding of Abramsky's lazy lambda calculus into the call-by-need lambda calculus with letrec is an isomorphism between the respective term-models.We show that the equivalence property proven in this paper transfers to a call-by-need letrec calculus developed by Ariola and Felleisen.
The goal of this report is to prove correctness of a considerable subset of transformations w.r.t. contextual equivalence in an extended lambda-calculus LS with case, constructors, seq, let, and choice, with a simple set of reduction rules; and to argue that an approximation calculus LA is equivalent to LS w.r.t. the contextual preorder, which enables the proof tool of simulation. Unfortunately, a direct proof appears to be impossible.
The correctness proof is by defining another calculus L comprising the complex variants of copy, case-reduction and seq-reductions that use variable-binding chains. This complex calculus has well-behaved diagrams and allows a proof of correctness of transformations, and that the simple calculus LS, the calculus L, and the calculus LA all have an equivalent contextual preorder.
We present a higher-order call-by-need lambda calculus enriched with constructors, case-expressions, recursive letrec-expressions, a seq-operator for sequential evaluation and a non-deterministic operator amb that is locally bottom-avoiding. We use a small-step operational semantics in form of a single-step rewriting system that defines a (nondeterministic) normal order reduction. This strategy can be made fair by adding resources for bookkeeping. As equational theory we use contextual equivalence, i.e. terms are equal if plugged into any program context their termination behaviour is the same, where we use a combination of may- as well as must-convergence, which is appropriate for non-deterministic computations. We show that we can drop the fairness condition for equational reasoning, since the valid equations w.r.t. normal order reduction are the same as for fair normal order reduction. We evolve different proof tools for proving correctness of program transformations, in particular, a context lemma for may- as well as mustconvergence is proved, which restricts the number of contexts that need to be examined for proving contextual equivalence. In combination with so-called complete sets of commuting and forking diagrams we show that all the deterministic reduction rules and also some additional transformations preserve contextual equivalence.We also prove a standardisation theorem for fair normal order reduction. The structure of the ordering <=c a is also analysed: Ω is not a least element, and <=c already implies contextual equivalence w.r.t. may-convergence.
The calculus CHF models Concurrent Haskell extended by concurrent, implicit futures. It is a process calculus with concurrent threads, monadic concurrent evaluation, and includes a pure functional lambda-calculus which comprises data constructors, case-expressions, letrec-expressions, and Haskell’s seq. Futures can be implemented in Concurrent Haskell using the primitive unsafeInterleaveIO, which is available in most implementations of Haskell. Our main result is conservativity of CHF, that is, all equivalences of pure functional expressions are also valid in CHF. This implies that compiler optimizations and transformations from pure Haskell remain valid in Concurrent Haskell even if it is extended by futures. We also show that this is no longer valid if Concurrent Haskell is extended by the arbitrary use of unsafeInterleaveIO.
Various static analyses of functional programming languages that permit infinite data structures make use of set constants like Top, Inf, and Bot, denoting all terms, all lists not eventually ending in Nil, and all non-terminating programs, respectively. We use a set language that permits union, constructors and recursive definition of set constants with a greatest fixpoint semantics in the set of all, also infinite, computable trees, where all term constructors are non-strict. This internal report proves decidability, in particular DEXPTIME-completeness, of inclusion of co-inductively defined sets by using algorithms and results from tree automata and set constraints, and contains detailed proofs. The test for set inclusion is required by certain strictness analysis algorithms in lazy functional programming languages and could also be the basis for further set-based analyses.
This paper shows the equivalence of applicative similarity and contextual approximation, and hence also of bisimilarity and contextual equivalence, in the deterministic call-by-need lambda calculus with letrec. Bisimilarity simplifies equivalence proofs in the calculus and opens a way for more convenient correctness proofs for program transformations. Although this property may be a natural one to expect, to the best of our knowledge, this paper is the first one providing a proof. The proof technique is to transfer the contextual approximation into Abramsky’s lazy lambda calculus by a fully abstract and surjective translation. This also shows that the natural embedding of Abramsky’s lazy lambda calculus into the call-by-need lambda calculus with letrec is an isomorphism between the respective term-models. We show that the equivalence property proven in this paper transfers to a call-by-need letrec calculus developed by Ariola and Felleisen. 1998 ACM Subject Classification: F.4.2, F.3.2, F.3.3, F.4.1. Key words and phrases: semantics, contextual equivalence, bisimulation, lambda calculus, call-by-need, letrec.
This note shows that in non-deterministic extended lambda calculi with letrec, the tool of applicative (bi)simulation is in general not usable for contextual equivalence, by giving a counterexample adapted from data flow analysis. It also shown that there is a flaw in a lemma and a theorem concerning finite simulation in a conference paper by the first two authors.
The calculus CHF models Concurrent Haskell extended by concurrent, implicit futures. It is a process calculus with concurrent threads, monadic concurrent evaluation, and includes a pure functional lambda-calculus which comprises data constructors, case-expressions, letrec-expressions, and Haskell’s seq. Futures can be implemented in Concurrent Haskell using the primitive unsafeInterleaveIO, which is available in most implementations of Haskell. Our main result is conservativity of CHF, that is, all equivalences of pure functional expressions are also valid in CHF. This implies that compiler optimizations and transformations from pure Haskell remain valid in Concurrent Haskell even if it is extended by futures. We also show that this is no longer valid if Concurrent Haskell is extended by the arbitrary use of unsafeInterleaveIO.
In this paper we present a non-deterministic call-by-need (untyped) lambda calculus lambda nd with a constant choice and a let-syntax that models sharing. Our main result is that lambda nd has the nice operational properties of the standard lambda calculus: confluence on sets of expressions, and normal order reduction is sufficient to reach head normal form. Using a strong contextual equivalence we show correctness of several program transformations. In particular of lambdalifting using deterministic maximal free expressions. These results show that lambda nd is a new and also natural combination of non-determinism and lambda-calculus, which has a lot of opportunities for parallel evaluation. An intended application of lambda nd is as a foundation for compiling lazy functional programming languages with I/O based on direct calls. The set of correct program transformations can be rigorously distinguished from non-correct ones. All program transformations are permitted with the slight exception that for transformations like common subexpression elimination and lambda-lifting with maximal free expressions the involved subexpressions have to be deterministic ones.
Sharing of substructures like subterms and subcontexts in terms is a common method for space-efficient representation of terms, which allows for example to represent exponentially large terms in polynomial space, or to represent terms with iterated substructures in a compact form. We present singleton tree grammars as a general formalism for the treatment of sharing in terms. Singleton tree grammars (STG) are recursion-free context-free tree grammars without alternatives for non-terminals and at most unary second-order nonterminals. STGs generalize Plandowski's singleton context free grammars to terms (trees). We show that the test, whether two different nonterminals in an STG generate the same term can be done in polynomial time, which implies that the equality test of terms with shared terms and contexts, where composition of contexts is permitted, can be done in polynomial time in the size of the representation. This will allow polynomial-time algorithms for terms exploiting sharing. We hope that this technique will lead to improved upper complexity bounds for variants of second order unification algorithms, in particular for variants of context unification and bounded second order unification.
Static analysis of different non-strict functional programming languages makes use of set constants like Top, Inf, and Bot denoting all expressions, all lists without a last Nil as tail, and all non-terminating programs, respectively. We use a set language that permits union, constructors and recursive definition of set constants with a greatest fixpoint semantics. This paper proves decidability, in particular EXPTIMEcompleteness, of subset relationship of co-inductively defined sets by using algorithms and results from tree automata. This shows decidability of the test for set inclusion, which is required by certain strictness analysis algorithms in lazy functional programming languages.
This paper proves correctness of Nöcker's method of strictness analysis, implemented in the Clean compiler, which is an effective way for strictness analysis in lazy functional languages based on their operational semantics. We improve upon the work of Clark, Hankin and Hunt did on the correctness of the abstract reduction rules. Our method fully considers the cycle detection rules, which are the main strength of Nöcker's strictness analysis. Our algorithm SAL is a reformulation of Nöcker's strictness analysis algorithm in a higher-order call-by-need lambda-calculus with case, constructors, letrec, and seq, extended by set constants like Top or Inf, denoting sets of expressions. It is also possible to define new set constants by recursive equations with a greatest fixpoint semantics. The operational semantics is a small-step semantics. Equality of expressions is defined by a contextual semantics that observes termination of expressions. Basically, SAL is a non-termination checker. The proof of its correctness and hence of Nöcker's strictness analysis is based mainly on an exact analysis of the lengths of normal order reduction sequences. The main measure being the number of 'essential' reductions in a normal order reduction sequence. Our tools and results provide new insights into call-by-need lambda-calculi, the role of sharing in functional programming languages, and into strictness analysis in general. The correctness result provides a foundation for Nöcker's strictness analysis in Clean, and also for its use in Haskell.
This paper proves correctness of Nocker s method of strictness analysis, implemented for Clean, which is an e ective way for strictness analysis in lazy functional languages based on their operational semantics. We improve upon the work of Clark, Hankin and Hunt, which addresses correctness of the abstract reduction rules. Our method also addresses the cycle detection rules, which are the main strength of Nocker s strictness analysis. We reformulate Nocker s strictness analysis algorithm in a higherorder lambda-calculus with case, constructors, letrec, and a nondeterministic choice operator used as a union operator. Furthermore, the calculus is expressive enough to represent abstract constants like Top or Inf. The operational semantics is a small-step semantics and equality of expressions is defined by a contextual semantics that observes termination of expressions. The correctness of several reductions is proved using a context lemma and complete sets of forking and commuting diagrams. The proof is based mainly on an exact analysis of the lengths of normal order reductions. However, there remains a small gap: Currently, the proof for correctness of strictness analysis requires the conjecture that our behavioral preorder is contained in the contextual preorder. The proof is valid without referring to the conjecture, if no abstract constants are used in the analysis.
This paper describes a method to treat contextual equivalence in polymorphically typed lambda-calculi, and also how to transfer equivalences from the untyped versions of lambda-calculi to their typed variant, where our specific calculus has letrec, recursive types and is nondeterministic. An addition of a type label to every subexpression is all that is needed, together with some natural constraints for the consistency of the type labels and well-scopedness of expressions. One result is that an elementary but typed notion of program transformation is obtained and that untyped contextual equivalences also hold in the typed calculus as long as the expressions are well-typed. In order to have a nice interaction between reduction and typing, some reduction rules have to be accompanied with a type modification by generalizing or instantiating types.
Context unification is a variant of second-order unification and also a generalization of string unification. Currently it is not known whether context uni cation is decidable. An expressive fragment of context unification is stratified context unification. Recently, it turned out that stratified context unification and one-step rewrite constraints are equivalent. This paper contains a description of a decision algorithm SCU for stratified context unification together with a proof of its correctness, which shows decidability of stratified context unification as well as of satisfiability of one-step rewrite constraints.
Context unification is a variant of second order unification. It can also be seen as a generalization of string unification to tree unification. Currently it is not known whether context unification is decidable. A specialization of context unification is stratified context unification, which is decidable. However, the previous algorithm has a very bad worst case complexity. Recently it turned out that stratified context unification is equivalent to satisfiability of one-step rewrite constraints. This paper contains an optimized algorithm for strati ed context unification exploiting sharing and power expressions. We prove that the complexity is determined mainly by the maximal depth of SO-cycles. Two observations are used: i. For every ambiguous SO-cycle, there is a context variable that can be instantiated with a ground context of main depth O(c*d), where c is the number of context variables and d is the depth of the SO-cycle. ii. the exponent of periodicity is O(2 pi ), which means it has an O(n)sized representation. From a practical point of view, these observations allow us to conclude that the unification algorithm is well-behaved, if the maximal depth of SO-cycles does not grow too large.
We introduce a new method for representing and solving a general class of non-preemptive resource-constrained project scheduling problems. The new approach is to represent scheduling problems as de- scriptions (activity terms) in a language called RSV, which allows nested expressions using pll, seq, and xor. The activity-terms of RSV are similar to concepts in a description logic. The language RSV generalizes previous approaches to scheduling with variants insofar as it permits xor's not only of atomic activities but also of arbitrary activity terms. A specific semantics that assigns their set of active schedules to activity terms shows correctness of a calculus normalizing activity terms RSV similar to propositional DNF-computation. Based on RSV, this paper describes a diagram-based algorithm for the RSV-problem which uses a scan-line principle. The scan-line principle is used for determining and resolving the occurring resource conflicts and leads to a nonredundant generation of all active schedules and thus to a computation of the optimal schedule.
This paper proves several generic variants of context lemmas and thus contributes to improving the tools to develop observational semantics that is based on a reduction semantics for a language. The context lemmas are provided for may- as well as two variants of mustconvergence and a wide class of extended lambda calculi, which satisfy certain abstract conditions. The calculi must have a form of node sharing, e.g. plain beta reduction is not permitted. There are two variants, weakly sharing calculi, where the beta-reduction is only permitted for arguments that are variables, and strongly sharing calculi, which roughly correspond to call-by-need calculi, where beta-reduction is completely replaced by a sharing variant. The calculi must obey three abstract assumptions, which are in general easily recognizable given the syntax and the reduction rules. The generic context lemmas have as instances several context lemmas already proved in the literature for specific lambda calculi with sharing. The scope of the generic context lemmas comprises not only call-by-need calculi, but also call-by-value calculi with a form of built-in sharing. Investigations in other, new variants of extended lambda-calculi with sharing, where the language or the reduction rules and/or strategy varies, will be simplified by our result, since specific context lemmas are immediately derivable from the generic context lemma, provided our abstract conditions are met.
Towards correctness of program transformations through unification and critical pair computation
(2011)
Correctness of program transformations in extended lambda calculi with a contextual semantics is usually based on reasoning about the operational semantics which is a rewrite semantics. A successful approach to proving correctness is the combination of a context lemma with the computation of overlaps between program transformations and the reduction rules, and then of so-called complete sets of diagrams. The method is similar to the computation of critical pairs for the completion of term rewriting systems.We explore cases where the computation of these overlaps can be done in a first order way by variants of critical pair computation that use unification algorithms. As a case study we apply the method to a lambda calculus with recursive let-expressions and describe an effective unification algorithm to determine all overlaps of a set of transformations with all reduction rules. The unification algorithm employs many-sorted terms, the equational theory of left-commutativity modelling multi-sets, context variables of different kinds and a mechanism for compactly representing binding chains in recursive let-expressions.
It is well known that first order uni cation is decidable, whereas second order and higher order unification is undecidable. Bounded second order unification (BSOU) is second order unification under the restriction that only a bounded number of holes in the instantiating terms for second order variables is permitted, however, the size of the instantiation is not restricted. In this paper, a decision algorithm for bounded second order unification is described. This is the fist non-trivial decidability result for second order unification, where the (finite) signature is not restricted and there are no restrictions on the occurrences of variables. We show that the monadic second order unification (MSOU), a specialization of BSOU is in sum p s. Since MSOU is related to word unification, this is compares favourably to the best known upper bound NEXPTIME (and also to the announced upper bound PSPACE) for word unification. This supports the claim that bounded second order unification is easier than context unification, whose decidability is currently an open question.
We develop a proof method to show that in a (deterministic) lambda calculus with letrec and equipped with contextual equivalence the call-by-name and the call-by-need evaluation are equivalent, and also that the unrestricted copy-operation is correct. Given a let-binding x = t, the copy-operation replaces an occurrence of the variable x by the expression t, regardless of the form of t. This gives an answer to unresolved problems in several papers, it adds a strong method to the tool set for reasoning about contextual equivalence in higher-order calculi with letrec, and it enables a class of transformations that can be used as optimizations. The method can be used in different kind of lambda calculi with cyclic sharing. Probably it can also be used in non-deterministic lambda calculi if the variable x is “deterministic”, i.e., has no interference with non-deterministic executions. The main technical idea is to use a restricted variant of the infinitary lambda-calculus, whose objects are the expressions that are unrolled w.r.t. let, to define the infinite developments as a reduction calculus on the infinite trees and showing a standardization theorem.
This paper describes context analysis, an extension to strictness analysis for lazy functional languages. In particular it extends Wadler's four point domain and permits in nitely many abstract values. A calculus is presented based on abstract reduction which given the abstract values for the result automatically finds the abstract values for the arguments. The results of the analysis are useful for veri fication purposes and can also be used in compilers which require strictness information.
The extraction of strictness information marks an indispensable element of an efficient compilation of lazy functional languages like Haskell. Based on the method of abstract reduction we have developed an e cient strictness analyser for a core language of Haskell. It is completely written in Haskell and compares favourably with known implementations. The implementation is based on the G#-machine, which is an extension of the G-machine that has been adapted to the needs of abstract reduction.
This paper shows equivalence of applicative similarity and contextual approximation, and hence also of bisimilarity and contextual equivalence, in LR, the deterministic call-by-need lambda calculus with letrec extended by data constructors, case-expressions and Haskell's seqoperator. LR models an untyped version of the core language of Haskell. Bisimilarity simplifies equivalence proofs in the calculus and opens a way for more convenient correctness proofs for program transformations.
The proof is by a fully abstract and surjective transfer of the contextual approximation into a call-by-name calculus, which is an extension of Abramsky's lazy lambda calculus. In the latter calculus equivalence of similarity and contextual approximation can be shown by Howe's method. Using an equivalent but inductive definition of behavioral preorder we then transfer similarity back to the calculus LR.
The translation from the call-by-need letrec calculus into the extended call-by-name lambda calculus is the composition of two translations. The first translation replaces the call-by-need strategy by a call-by-name strategy and its correctness is shown by exploiting infinite tress, which emerge by unfolding the letrec expressions. The second translation encodes letrec-expressions by using multi-fixpoint combinators and its correctness is shown syntactically by comparing reductions of both calculi. A further result of this paper is an isomorphism between the mentioned calculi, and also with a call-by-need letrec calculus with a less complex definition of reduction than LR.
This paper proposes a non-standard way to combine lazy functional languages with I/O. In order to demonstrate the usefulness of the approach, a tiny lazy functional core language FUNDIO , which is also a call-by-need lambda calculus, is investigated. The syntax of FUNDIO has case, letrec, constructors and an IO-interface: its operational semantics is described by small-step reductions. A contextual approximation and equivalence depending on the input-output behavior of normal order reduction sequences is defined and a context lemma is proved. This enables to study a semantics of FUNDIO and its semantic properties. The paper demonstrates that the technique of complete reduction diagrams enables to show a considerable set of program transformations to be correct. Several optimizations of evaluation are given, including strictness optimizations and an abstract machine, and shown to be correct w.r.t. contextual equivalence. Correctness of strictness optimizations also justifies correctness of parallel evaluation. Thus this calculus has a potential to integrate non-strict functional programming with a non-deterministic approach to input-output and also to provide a useful semantics for this combination. It is argued that monadic IO and unsafePerformIO can be combined in Haskell, and that the result is reliable, if all reductions and transformations are correct w.r.t. to the FUNDIO-semantics. Of course, we do not address the typing problems the are involved in the usage of Haskell s unsafePerformIO. The semantics can also be used as a novel semantics for strict functional languages with IO, where the sequence of IOs is not fixed.
Motivated by the question of correctness of a specific implementation of concurrent buffers in the lambda calculus with futures underlying Alice ML, we prove that concurrent buffers and handled futures can correctly encode each other. Correctness means that our encodings preserve and reflect the observations of may- and must-convergence, and as a consequence also yields soundness of the encodings with respect to a contextually defined notion of program equivalence. While these translations encode blocking into queuing and waiting, we also describe an adequate encoding of buffers in a calculus without handles, which is more low-level and uses busy-waiting instead of blocking. Furthermore we demonstrate that our correctness concept applies to the whole compilation process from high-level to low-level concurrent languages, by translating the calculus with buffers, handled futures and data constructors into a small core language without those constructs.
The goal of this report is to prove correctness of a considerable subset of transformations w.r.t. contextual equivalence in an extended lambda-calculus LS with case, constructors, seq, let, and choice, with a simple set of reduction rules; and to argue that an approximation calculus LA is equivalent to LS w.r.t. the contextual preorder, which enables the proof tool of simulation. Unfortunately, a direct proof appears to be impossible.
The correctness proof is by defining another calculus L comprising the complex variants of copy, case-reduction and seq-reductions that use variable-binding chains. This complex calculus has well-behaved diagrams and allows a proof of correctness of transformations, and that the simple calculus LS, the calculus L, and the calculus LA all have an equivalent contextual preorder.
The calculus LRP is a polymorphically typed call-by-need lambda calculus extended by data constructors, case-expressions, seq-expressions and type abstraction and type application. This report is devoted to the extension LRPw of LRP by scoped sharing decorations. The extension cannot be properly encoded into LRP if improvements are defined w.r.t. the number of lbeta, case, and seq-reductions, which makes it necessary to reconsider the claims and proofs of properties. We show correctness of improvement properties of reduction and transformation rules and also of computation rules for decorations in the extended calculus LRPw. We conjecture that conservativity of the embedding of LRP in LRPw holds.