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Düsseldorf is the capital of North Rhine-Westphalia, the state with the highest number of inhabitants in Germany. The city has a rich cultural history: The theatre history started in 1585 (the festivities in the context of a princely marriage at Düsseldorf). Theatre historiography marks three great periods for Düsseldorf (Immermann, 1834-1837; Dumont-Lindemann, 1905-1933; Gründgens, 1947-1955). In 2005 and 2006 we celebrate many anniversaries within the theatrical context: 100 years Schauspielhaus Dumont-Lindemann in 2005, 50 years theatre community Düsseldorf-Duisburg (Deutsche Oper am Rhein Düsseldorf-Duisburg), 50 years puppet theatre (Düsseldorfer Marionettentheater), 30 years children and youth theatre (Kinder- und Jugendtheater im Düsseldorfer Schauspielhaus), 10 years Capitol (musical theatre) beside other cultural events, for example the anniversaries of Heine and Schumann.
Background and Purpose of this Meeting With an opening reception sponsored by Thomson Scientific on the evening of Thursday, October 5, the University Library of Frankfurt and the German-North American Resources Partnership (GNARP) and will be hosting an important two-day conference this Autumn in Frankfurt, Germany: »The World According to GNARP: Prospects for Transatlantic Library Partnership in the Digital Age« Sessions at this meeting will explore the wealth of library resources - archival, print, and digital - available to students and researchers (in Germany and the United States) in five selected subject areas: North American Studies, German Studies, Judaica, Africana, and South Asia/India, highlighting both existing avenues (and obstacles) for transatlantic resource sharing along with future prospects. In addition, several other important topics will be highlighted through individual presentations and panel discussions: the future of German as a language of the sciences; existing and planned electronic journal archives in Germany and the U.S.; print and digital repositories; and a special panel on »comparative cataloging cultures« on both sides of the Atlantic. The »World According to GNARP« conference will be taking place simultaneously with the Frankfurt Book Fair, the largest book-related event in the world, attracting annually 285,000 visitors (2005), thus giving participants who arrive early the chance to combine attendance at both the Book Fair and Conference. A cultural event and dinner in Frankfurt are planned for Friday 6th October.
The University library in Frankfurt/Main owns the largest collection of literature on Judaism and Israel in Germany and one of the major collections in the world. Its task is to document the history of the Jewish people and to serve as a resource for study and research in Germany. The Jewish Division is therefore collecting all relevant national and international publications covering all aspects of post-biblical Judaism and Jewish culture in a most comprehensive manner, as well as all publications on the modern State of Israel. Two databases offer access to the large collections of the Judaica-Division. Yiddish Literature is the database that offers online access to the page images of the outstanding historical Yiddish collection, containing about 800 extremely rare and precious Yiddish and German-Jewish books printed in Hebrew letters from the 16th century onwards. Compact memory is a gateway to more than 100 Jewish periodicals in the German language area published in the 19th and 20th century, providing partly images, partly full-text-search and a bibliographic database of articles. The implementation of a third, new digital project, the »Virtual Judaica-collection« has just started - the digitization and online-presentation of the historical Judaica resources. Formed by his curator Prof. Aron Freimann, it was the largest and most significant Judaica collection on the European continent before the war. The goal is to offer free access to about 18.000 books with 2 Mill. pages over the web. In light of these developments, the presentation will evaluate the current possibilities of German-North-American cooperation in the area of digital projects.
Human communication takes place when one person does something that when seen or heard by another person is taken to be done with the intention to communicate, and the other person, having seen the communicator show his or her intention to communicate, then uses inference to determine what the communicator intends to communicate. This is possible because the addressee assumes that the communicator is a rational person, that is, acts with goals in mind (see Grice 1975), and so must be doing the act for a reason, and it is worth the addressee’s effort to try to determine what that reason is, that is, determine the relevance of the act.
The mission of the Harvard Judaica Collection is to comprehensively document Jewish history and civilization in all places and periods. To accomplish its mission, the Judaica Collection collects materials in all languages and in all formats—books, pamphlets, periodicals, newspapers, sound recordings, and videos, posters, broadsides, and photographs. A particular focus is the Library’s Documenting Israel program, which covers all aspects of Israeli life and culture in great depth; Harvard has the largest collection of Israeli publications and Israel-related materials outside the State of Israel. The Harvard Judaica Collection also attempts to have comprehensive coverage of the publications of Jewish communities throughout the globe, including a significant collection of publications from countries across Europe. Collecting these materials requires cooperation with a wide array of institutions and individuals around the world.
Temporal development of compensation strategies for perturbed palate shape in German /S/-production
(2006)
The palate shape of four speakers was changed by a prosthesis which either lowered the palate or retracted the alveoles. Subjects wore the prosthesis for two weeks and were recorded several times via EMA. Results of articulatory measurements show that speakers use different compensation methods at different stages of the adaptation. They lower the tongue immediately after the insertion of the prosthesis. Other compensation methods as for example lip protrusion are only acquired after longer practising periods. The results are interpreted as supporting the existence of different mappings between motor commands, vocal tract shape and auditory-acoustic target.
Objective: Establishment of an immunocompetent mouse model representing the typical progressive stages observed in malignant human gliomas for the in vivo evaluation of novel target-specific regimens.
Methods: Isolated clones from tumours that arose spontaneously in GFAP-v-src transgenic mice were used to develop a transplantable brain tumour model in syngeneic B6C3F1 mice. STAT3 protein was knocked down by infection of tumour cells with replication-defective lentivirus encoding STAT3-siRNA. Apoptosis is designed to be induced by soluble recombinant TRAIL + chemical Bcl-2/Bcl-xL inhibitors.
Results: Striatal implantation of 105 mouse tumour cells resulted in the robust development of microscopically (2 – 3 mm) infiltrating malignant gliomas. Immunohistochemically, the gliomas displayed the astroglial marker GFAP and the oncogenic form of STAT3 (Tyr-705-phosphorylated) which is found in many malignancies including gliomas. Phosphorylated STAT3 was particularly prominent in the nucleus but was also found at the plasma membrane of peripherally infiltrating glioma cells. To evaluate the role of STAT3 in tumour progression, we stably expressed siRNA against STAT3 in several murine glioma cell lines. The effect of STAT3 depletion on proliferation, invasion and survival will be first assessed in vitro and subsequently after transplantation in vivo. Upstream and downstream components of the STAT3 signalling pathway as well as possible non-specific side effects of STAT3-siRNA expression after lentiviral infection will be examined, too.
Conclusions: Its high rate of engraftment, its similarity to the malignant glioma of origin, and its rapid locally invasive growth should make this murine model useful in testing novel therapies for malignant gliomas.
Research on adverbials in sentence-medial position in the North- Ghanaian Gur language Buli suggests that the language offers two divergent slots for adverbials between subject and verb. Special attention is paid to the group of sentence-medial deictic temporal adverbials. While they have the potential to develop into tense markers, this process seems to depend on special information structural conditions.