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Harmonic decomposition of two particle angular correlations in Pb–Pb collisions at √sNN=2.76 TeV
(2012)
Angular correlations between unidentified charged trigger (t) and associated (a) particles are measured by the ALICE experiment in Pb–Pb collisions at √sNN=2.76 TeV for transverse momenta 0.25<pTt,a<15 GeV/c, where pTt>pTa. The shapes of the pair correlation distributions are studied in a variety of collision centrality classes between 0 and 50% of the total hadronic cross section for particles in the pseudorapidity interval |η|<1.0. Distributions in relative azimuth Δϕ≡ϕt−ϕa are analyzed for |Δη|≡|ηt−ηa|>0.8, and are referred to as “long-range correlations”. Fourier components VnΔ≡〈cos(nΔϕ)〉 are extracted from the long-range azimuthal correlation functions. If particle pairs are correlated to one another through their individual correlation to a common symmetry plane, then the pair anisotropy VnΔ(pTt,pTa) is fully described in terms of single-particle anisotropies vn(pT) as VnΔ(pTt,pTa)=vn(pTt)vn(pTa). This expectation is tested for 1⩽n⩽5 by applying a global fit of all VnΔ(pTt,pTa) to obtain the best values vn{GF}(pT). It is found that for 2⩽n⩽5, the fit agrees well with data up to pTa∼3–4 GeV/c, with a trend of increasing deviation as pTt and pTa are increased or as collisions become more peripheral. This suggests that no pair correlation harmonic can be described over the full 0.25<pT<15 GeV/c range using a single vn(pT) curve; such a description is however approximately possible for 2⩽n⩽5 when pTa<4 GeV/c. For the n=1 harmonic, however, a single v1(pT) curve is not obtained even within the reduced range pTa<4 GeV/c.
A Fallen Citadel and Other Poems is a powerful collection of over forty prose poems. The poems cover an array of issues ranging from the crisis that ensued after the 2007-2008 elections in Kenya to other social issues: loss of identity, poverty, hopelessness, and AIDs. These poems are powerful, vivid, full of imagery, and delightful. Some begin tragically, but end with hope; they begin with an everyday event, but end with a philosophical question about the meaning of life; and others are not only disturbing, but also thought provoking. Abala's poetic maneuvers in this collection are bound to delight and fascinate any reader.
The ALICE experiment has measured low-mass dimuon production in pp collisions at √s=7 TeV in the dimuon rapidity region 2.5<y<4. The observed dimuon mass spectrum is described as a superposition of resonance decays (η,ρ,ω,η′,ϕ) into muons and semi-leptonic decays of charmed mesons. The measured production cross sections for ω and ϕ are σω(1<pt<5 GeV/c,2.5<y<4)=5.28±0.54(stat)±0.49(syst) mb and σϕ(1<pt<5 GeV/c,2.5<y<4)=0.940±0.084(stat)±0.076(syst) mb. The differential cross sections d2σ/dydpt are extracted as a function of pt for ω and ϕ. The ratio between the ρ and ω cross section is obtained. Results for the ϕ are compared with other measurements at the same energy and with predictions by models.
he first measurements of the invariant differential cross sections of inclusive π0 and η meson production at mid-rapidity in proton–proton collisions at s=0.9 TeV and s=7 TeV are reported. The π0 measurement covers the ranges 0.4<pT<7 GeV/c and 0.3<pT<25 GeV/c for these two energies, respectively. The production of η mesons was measured at s=√7 TeV in the range 0.4<pT<15 GeV/c. Next-to-Leading Order perturbative QCD calculations, which are consistent with the π0 spectrum at s=0.9 TeV, overestimate those of π0 and η mesons at s=√7 TeV, but agree with the measured η/π0 ratio at s=√7 TeV.
The ALICE Collaboration has made the first measurement at the LHC of J/ψ photoproduction in ultra-peripheral Pb–Pb collisions at sNN=2.76 TeV. The J/ψ is identified via its dimuon decay in the forward rapidity region with the muon spectrometer for events where the hadronic activity is required to be minimal. The analysis is based on an event sample corresponding to an integrated luminosity of about 55 μb−1. The cross section for coherent J/ψ production in the rapidity interval −3.6<y<−2.6 is measured to be dσJ/ψcoh/dy=1.00±0.18(stat)−0.26+0.24(syst) mb. The result is compared to theoretical models for coherent J/ψ production and found to be in good agreement with those models which include nuclear gluon shadowing.
Identical neutral kaon pair correlations are measured in √s=7 TeV pp collisions in the ALICE experiment. One-dimensional Ks0Ks0 correlation functions in terms of the invariant momentum difference of kaon pairs are formed in two multiplicity and two transverse momentum ranges. The femtoscopic parameters for the radius and correlation strength of the kaon source are extracted. The fit includes quantum statistics and final-state interactions of the a0/f0 resonance. Ks0Ks0 correlations show an increase in radius for increasing multiplicity and a slight decrease in radius for increasing transverse mass, mT, as seen in ππ correlations in pp collisions and in heavy-ion collisions. Transverse mass scaling is observed between the Ks0Ks0 and ππ radii. Also, the first observation is made of the decay of the f2′(1525) meson into the Ks0Ks0 channel in pp collisions.
The ALICE Collaboration has measured inclusive J/ψ production in pp collisions at a center-of-mass energy √s=2.76 TeV at the LHC. The results presented in this Letter refer to the rapidity ranges |y|<0.9 and 2.5<y<4 and have been obtained by measuring the electron and muon pair decay channels, respectively. The integrated luminosities for the two channels are Linte=1.1 nb−1 and Lintμ=19.9 nb−1, and the corresponding signal statistics are NJ/ψe+e−=59±14 and NJ/ψμ+μ−=1364±53. We present dσJ/ψ/dy for the two rapidity regions under study and, for the forward-y range, d2σJ/ψ/dydpt in the transverse momentum domain 0<pt<8 GeV/c. The results are compared with previously published results at s=7 TeV and with theoretical calculations.
The ALICE Collaboration reports the measurement of the relative J/ψ yield as a function of charged particle pseudorapidity density dNch/dη in pp collisions at √s=7 TeV at the LHC. J/ψ particles are detected for pt>0, in the rapidity interval |y|<0.9 via decay into e+e−, and in the interval 2.5<y<4.0 via decay into μ+μ− pairs. An approximately linear increase of the J/ψ yields normalized to their event average (dNJ/ψ/dy)/〈dNJ/ψ/dy〉 with (dNch/dη)/〈dNch/dη〉 is observed in both rapidity ranges, where dNch/dη is measured within |η|<1 and pt>0. In the highest multiplicity interval with 〈dNch/dη(bin)〉=24.1, corresponding to four times the minimum bias multiplicity density, an enhancement relative to the minimum bias J/ψ yield by a factor of about 5 at 2.5<y<4 (8 at |y|<0.9) is observed.
The pT-differential inclusive production cross section of the prompt charm-strange meson Ds+ in the rapidity range |y|<0.5 was measured in proton–proton collisions at s=7 TeV at the LHC using the ALICE detector. The analysis was performed on a data sample of 2.98×108 events collected with a minimum-bias trigger. The corresponding integrated luminosity is Lint=4.8 nb−1. Reconstructing the decay Ds+→ϕπ+, with ϕ→K−K+, and its charge conjugate, about 480 Ds± mesons were counted, after selection cuts, in the transverse momentum range 2<pT<12 GeV/c. The results are compared with predictions from models based on perturbative QCD. The ratios of the cross sections of four D meson species (namely D0, D+, D⁎+ and Ds+) were determined both as a function of pT and integrated over pT after extrapolating to full pT range, together with the strangeness suppression factor in charm fragmentation. The obtained values are found to be compatible within uncertainties with those measured by other experiments in e+e−, ep and pp interactions at various centre-of-mass energies.
A measurement of the multi-strange Ξ− and Ω− baryons and their antiparticles by the ALICE experiment at the CERN Large Hadron Collider (LHC) is presented for inelastic proton–proton collisions at a centre-of-mass energy of 7 TeV. The transverse momentum (pT) distributions were studied at mid-rapidity (|y|<0.5) in the range of 0.6<pT<8.5 GeV/c for Ξ− and Ξ¯+ baryons, and in the range of 0.8<pT<5 GeV/c for Ω− and Ω¯+. Baryons and antibaryons were measured as separate particles and we find that the baryon to antibaryon ratio of both particle species is consistent with unity over the entire range of the measurement. The statistical precision of the current data has allowed us to measure a difference between the mean pT of Ξ− (Ξ¯+) and Ω− (Ω¯+). Particle yields, mean pT, and the spectra in the intermediate pT range are not well described by the PYTHIA Perugia 2011 tune Monte Carlo event generator, which has been tuned to reproduce the early LHC data. The discrepancy is largest for Ω− (Ω¯+). This PYTHIA tune approaches the pT spectra of Ξ− and Ξ¯+ baryons below pT<0.85 GeV/c and describes the Ξ− and Ξ¯+ spectra above pT>6.0 GeV/c. We also illustrate the difference between the experimental data and model by comparing the corresponding ratios of (Ω−+Ω¯+)/(Ξ−+Ξ¯+) as a function of transverse mass.
Heavy flavour decay muon production at forward rapidity in proton–proton collisions at √s=7 TeV
(2012)
The production of muons from heavy flavour decays is measured at forward rapidity in proton–proton collisions at √s=7 TeV collected with the ALICE experiment at the LHC. The analysis is carried out on a data sample corresponding to an integrated luminosity Lint=16.5 nb−1. The transverse momentum and rapidity differential production cross sections of muons from heavy flavour decays are measured in the rapidity range 2.5<y<4, over the transverse momentum range 2<pt<12 GeV/c. The results are compared to predictions based on perturbative QCD calculations.
Inhibitor of Apoptosis (IAP) proteins are expressed at high levels in many cancers and contribute to apoptosis resistance. Therefore, they represent promising anticancer drug targets. Here, we report that small molecule IAP inhibitors at subtoxic concentrations cooperate with monoclonal antibodies against TRAIL receptor 1 (Mapatumumab) or TRAIL receptor 2 (Lexatumumab) to induce apoptosis in neuroblastoma cells in a highly synergistic manner (combination index <0.1). Importantly, we identify RIP1 as a critical regulator of this synergism. RIP1 is required for the formation of a RIP1/FADD/caspase-8 complex that drives caspase-8 activation, cleavage of Bid into tBid, mitochondrial outer membrane permeabilization, full activation of caspase-3 and caspase-dependent apoptosis. Indeed, knockdown of RIP1 abolishes formation of the RIP1/FADD/caspase-8 complex, subsequent caspase activation and apoptosis upon treatment with IAP inhibitor and TRAIL receptor antibodies. Similarly, inhibition of RIP1 kinase activity by Necrostatin-1 inhibits IAP inhibitor- and TRAIL receptor-triggered apoptosis. By comparison, over-expression of the dominant-negative superrepressor IκBα-SR or addition of the TNFα-blocking antibody Enbrel does not inhibit IAP inhibitor- and Lexatumumab-induced apoptosis, pointing to a NF-κB- and TNFα-independent mechanism. Of note, IAP inhibitor also significantly reduces TRAIL receptor-mediated loss of cell viability of primary cultured neuroblastoma cells, underscoring the clinical relevance. By demonstrating that RIP1 plays a key role in the IAP inhibitor-mediated sensitization for Mapatumumab- or Lexatumumab-induced apoptosis, our findings provide strong rationale to develop the combination of IAP inhibitors and TRAIL receptor agonists as a new therapeutic strategy for the treatment of human cancer.
It is proposed to install an experimental setup in the fixed-target hall of the Nuclotron with the final goal to perform a research program focused on the production of strange matter in heavyion collisions at beam energies between 2 and 6 A GeV. The basic setup will comprise a large acceptance dipole magnet with inner tracking detector modules based on double-sided Silicon micro-strip sensors and GEMs. The outer tracking will be based on the drift chambers and straw tube detector. Particle identification will be based on the time-of-flight measurements. This setup will be sufficient perform a comprehensive study of strangeness production in heavy-ion collisions, including multi-strange hyperons, multi-strange hypernuclei, and exotic multi-strange heavy objects. These pioneering measurements would provide the first data on the production of these particles in heavy-ion collisions at Nuclotron beam energies, and would open an avenue to explore the third (strangeness) axis of the nuclear chart. The extension of the experimental program is related with the study of in-medium effects for vector mesons decaying in hadronic modes. The studies of the NN and NA reactions for the reference is assumed.
En mi artículo analizaré la lectura que hace Axel Honneth de uno de los textos más importantes del período de Jena de Hegel: el Sistema de la Eticidad. En términos generales, quisiera determinar qué importancia y qué limitaciones presenta este texto, en relación con otros trabajos del mismo período, para la formulación de la teoría del reconocimiento de Honneth. Para lograr este propósito considero necesario centrarme, particularmente, en la exégesis que hace de la cuestión del delito y del carácter ambivalente que presenta en el libro mencionado. Por un lado, constituye un acto destructivo que desgarra los procesos consolidados de reconocimiento; es decir, lesiona a la persona como sujeto de derechos y a la “persona como un todo” originando así una conflicto y una lucha entre ellas. Por otro lado, el delito conserva un “papel constructivo" en la medida en que exhorta a tomar conciencia de la dependencia respecto a la comunidad y de la necesidad de ser reconocido en su seno. Otro factor que resulta teóricamente productivo del modelo hegeliano es que provee las coordenadas, si bien de forma elusiva e implícita, para comprender la génesis y los motivos del delito haciendo alusión a una falta de reconocimiento inicial que se perpetúa en el derecho abstracto. En definitiva, lo que busco demostrar es que la interpretación que realiza Honneth respecto a la cuestión del delito en el Sistema de la Eticidad permite comprender elementos centrales de su propuesta de “sociologización del modelo de pensamiento hegeliano”.
Es gibt zahlreiche Publikationen, die dokumentieren, dass Wirbeltiere in das Beutespektrum von Spinnen gehören können, wobei offensichtlich insbesondere Amphibien und Reptilien erbeutet werden (z.B. De Armas 2001, Menin et al. 2005, Toledo 2005, Maffei et al. 2010). Solche Berichte stützen sich fast immer auf Beobachtungen aus den Tropen.
In this paper, we develop a state-dependent sensitivity value-at-risk (SDSVaR) approach that enables us to quantify the direction, size, and duration of risk spillovers among financial institutions as a function of the state of financial markets (tranquil, normal, and volatile). Within a system of quantile regressions for four sets of major financial institutions (commercial banks, investment banks, hedge funds, and insurance companies) we show that while small during normal times, equivalent shocks lead to considerable spillover effects in volatile market periods. Commercial banks and, especially, hedge funds appear to play a major role in the transmission of shocks to other financial institutions. Using daily data, we can trace out the spillover effects over time in a set of impulse response functions and find that they reach their peak after 10 to 15 days.
It is the aim of this book while clarifying doubts and misconceptions, to provide a thorough reappraisal of the intellectual and rich cultural heritage of Islam with regards to the principles and practice of medicine and its representation to the world in the language of today. In nine chapters a range of topics are discussed including: The Promotion of Medical Education and Health Services; Personal and Environmental Hygiene; Circumcision; Manners of Eating; Social and Mental Heath; Curative Medicine; The Provision of Adequate and Potable Water; Magic, Witchcraft, Enchantments and Charms; Euthanasia; Suicide; The Rehabilitation of the Sick and the Needy; The Source of Human Creation; Sex Differentiation and Determination; Healing through Miracles; Magic and Soothsaying; HIV Infection and AIDS; Abortion; Females in Medical Practice; and The Challenges of Modem Medicine to Muslims.
Introduction: aims and points of departure. 1. The problem of the knowledge of law: whether previous general rules may support a casuistic decision. 2. The problem of legal ethics: whether there are autonomous rights, which do not depend on positive law. 3. The ways of modern dogmatics to deal with these problems. 4. The question remains the same.
We introduce tree-width for first order formulae φ, fotw(φ). We show that computing fotw is fixed-parameter tractable with parameter fotw. Moreover, we show that on classes of formulae of bounded fotw, model checking is fixed parameter tractable, with parameter the length of the formula. This is done by translating a formula φ with fotw(φ)<k into a formula of the k-variable fragment Lk of first order logic. For fixed k, the question whether a given first order formula is equivalent to an Lk formula is undecidable. In contrast, the classes of first order formulae with bounded fotw are fragments of first order logic for which the equivalence is decidable. Our notion of tree-width generalises tree-width of conjunctive queries to arbitrary formulae of first order logic by taking into account the quantifier interaction in a formula. Moreover, it is more powerful than the notion of elimination-width of quantified constraint formulae, defined by Chen and Dalmau (CSL 2005): for quantified constraint formulae, both bounded elimination-width and bounded fotw allow for model checking in polynomial time. We prove that fotw of a quantified constraint formula φ is bounded by the elimination-width of φ, and we exhibit a class of quantified constraint formulae with bounded fotw, that has unbounded elimination-width. A similar comparison holds for strict tree-width of non-recursive stratified datalog as defined by Flum, Frick, and Grohe (JACM 49, 2002). Finally, we show that fotw has a characterization in terms of a cops and robbers game without monotonicity cost.
We present measurements of exclusive ensuremathπ+,0 and η production in pp reactions at 1.25GeV and 2.2GeV beam kinetic energy in hadron and dielectron channels. In the case of π+ and π0 , high-statistics invariant-mass and angular distributions are obtained within the HADES acceptance as well as acceptance-corrected distributions, which are compared to a resonance model. The sensitivity of the data to the yield and production angular distribution of Δ (1232) and higher-lying baryon resonances is shown, and an improved parameterization is proposed. The extracted cross-sections are of special interest in the case of pp → pp η , since controversial data exist at 2.0GeV; we find \ensuremathσ=0.142±0.022 mb. Using the dielectron channels, the π0 and η Dalitz decay signals are reconstructed with yields fully consistent with the hadronic channels. The electron invariant masses and acceptance-corrected helicity angle distributions are found in good agreement with model predictions.
Background: During early stages of brain development, secreted molecules, components of intracellular signaling pathways and transcriptional regulators act in positive and negative feed-back or feed-forward loops at the mid-hindbrain boundary. These genetic interactions are of central importance for the specification and subsequent development of the adjacent mid- and hindbrain. Much less, however, is known about the regulatory relationship and functional interaction of molecules that are expressed in the tectal anlage after tectal fate specification has taken place and tectal development has commenced.
Results: Here, we provide experimental evidence for reciprocal regulation and subsequent cooperation of the paired-type transcription factors Pax3, Pax7 and the TALE-homeodomain protein Meis2 in the tectal anlage. Using in ovo electroporation of the mesencephalic vesicle of chick embryos we show that (i) Pax3 and Pax7 mutually regulate each other's expression in the mesencephalic vesicle, (ii) Meis2 acts downstream of Pax3/7 and requires balanced expression levels of both proteins, and (iii) Meis2 physically interacts with Pax3 and Pax7. These results extend our previous observation that Meis2 cooperates with Otx2 in tectal development to include Pax3 and Pax7 as Meis2 interacting proteins in the tectal anlage.
Conclusion: The results described here suggest a model in which interdependent regulatory loops involving Pax3 and Pax7 in the dorsal mesencephalic vesicle modulate Meis2 expression. Physical interaction with Meis2 may then confer tectal specificity to a wide range of otherwise broadly expressed transcriptional regulators, including Otx2, Pax3 and Pax7.
Ischemia/reperfusion (I/R) is at the basis of renal transplantation and acute kidney injury. Molecular mechanisms underlying proximal tubule response to I/R will allow the identification of new therapeutic targets for both clinical settings. microRNAs have emerged as crucial and tight regulators of the cellular response to insults including hypoxia. Here, we have identified several miRNAs involved in the response of the proximal tubule cell to I/R. Microarrays and RT-PCR analysis of proximal tubule cells submitted to I/R mimicking conditions in vitro demonstrated that miR-127 is induced during ischemia and also during reperfusion. miR-127 is also modulated in a rat model of renal I/R. Interference approaches demonstrated that ischemic induction of miR-127 is mediated by Hypoxia Inducible Factor-1alpha (HIF-1α) stabilization. Moreover, miR-127 is involved in cell-matrix and cell-cell adhesion maintenance, since overexpression of miR-127 maintains focal adhesion complex assembly and the integrity of tight junctions. miR-127 also regulates intracellular trafficking since miR-127 interference promotes dextran-FITC uptake. In fact, we have identified the Kinesin Family Member 3B (KIF3B), involved in cell trafficking, as a target of miR-127 in rat proximal tubule cells. In summary, we have described a novel role of miR-127 in cell adhesion and its regulation by HIF-1α. We also identified for the first time KIF3B as a miR-127 target. Both, miR-127 and KIF3B appear as key mediators of proximal epithelial tubule cell response to I/R with potential al application in renal ischemic damage management.
In this paper, an analysis of Robert Frost’s poem Mending Wall is presented as a hermeneutical key to investigate and criticize two examples of the oblivion of the reasonable distinction and the reasonable relationship between ethics and law proposed by a new Brazilian private law movement called Escola do Direito Civil-Constitucional (The Private-Constitutional School of Thought). Those examples of unreasonable relationship between ethics and law are: 1) the right to be loved and 2) the right to get a private education without paying for it.
In his works, Hans Kelsen elaborates several objections to the so-called “doctrine of natural law”, especially in his essay The Natural-Law Doctrine Before the Tribunal of Science. Kelsen argues that natural law theorists, searching for an absolute criterion for justice, try to deduce from nature the rules of human behavior. Robert P. George, in the essay Kelsen and Aquinas on the ‘Natural Law Doctrine’ examines his criticism and concludes that what Kelsen understands as the Natural-law doctrine does not include the natural law theory elaborated by Thomas Aquinas. In this paper, we will try to corroborate George’s theses and try to show how Aquinas’ natural law theory can be vindicated against Kelsens criticisms.
This article considers the Brazilian Legal System and the requirements of an act performed by public administration. To do so, it presents six main chapters. The first one considers Brazilian Constitution as it regards State form, legal and judicial systems. The second chapter presents the public administration stated in the Constitution. The requirements of a public administration act are presented in the third chapter. The improbity law, which determines how public administration acts should be performed, is presented on the fourth chapter. How one of the main judicial courts of Brazil has understood this law is the topic of the fifth chapter. The sixth chapter presents a proposal of how could be Phronesis used to solve misunderstandings about improbity in the Brazilian Legal System.
Die Rassenmischung bekam in der Entwicklung der Sozialwissenschaften in Brasilien immer wieder neue Bedeutungen, um sich an jeden politischen Zusammenhang anzupassen. Sie wurde von den Männern des Wissens als Problem und später als Lösung angesehen – nämlich durch die Aufhellung – gemäß der evolutionären Rassentheorien Ende des 19. Jahrhunderts. Aber vor allem in den 1930er Jahren betrachteten einige Intellektuelle Brasiliens, wie Gilberto Freyre, die Mischung der drei Rassen, die das Volk Brasiliens bilden, als Bestandteil der Nation. Eine solche Vorstellung brachte juristische und politische, manchmal unmerkliche Folgen für den Platz des Mischlings innerhalb der brasilianischen Gesellschaft. Dieser wird als Notausstieg Mulatte nach Carl Degler oder als epistemologisches Hindernis nach Eduardo de Oliveira e Oliveira verstanden. Der Zweck dieser Arbeit besteht darin, aufzuzeigen, inwiefern jene Tradition eine tiefe Auseinandersetzung verbirgt und wie sie juristische Auswirkungen in der Gegenwart hervorruft, z.B. in Bezug auf die Debatte über Rassenquoten an öffentlichen Universitäten.
1 Purpose of the Study:
The purpose of this retrospective study was to assess the volumetric changes of our institutional pediatric neuroblastoma in response to various therapeutic protocols.
2 Materials and Methods:
A retrospective study was conducted on children with neuroblastoma from different anatomical locations including suprarenal, paraspinal, pelvic, mediastinal and cervical neuroblastoma primaries. These children underwent tumor-stage based therapeutic protocols in Johann Wolfgang Goethe University Hospital, Frankfurt am Main, Germany, between January 1996 and July 2008. The study included 72 patients (44 males and 28 females). Patient demographics (age and gender), disease-related symptoms, laboratory results (tumor biomarkers including ferritin, neuron specific enolase, and urine catecholamine) and histopathological reports were collected from the electronic medical archiving system and subsequently analyzed.
Patients were classified into following groups according the anatomical origin of the primary neuroblastoma into:
1) Suprarenal neuroblastoma Group: This group included patients with neuroblastoma arising from the suprarenal gland. This group composed of 54 patients with male to female ratio (32:22).
2) Paravertebral neuroblastoma Group: This group composed of 6 male patients.
3) Mediastinal neuroblastoma Group: This group included patients with mediastinal neuroblastoma and composed of 3 patients (1 male and 2 females).
4) Pelvic neuroblastoma Group: This group included patients with pelvic neuroblastoma and composed of 6 patients (3 males and 3 females).
5) Cervical neuroblastoma Group: This group included patients with cervical neuroblastoma and composed of 2 male patients.
3 Results:
The mean volume of all suprarenal neuroblastoma group involved in the study before therapy was 176.62 cm3 (SD: 234.15) range: 239.4-968.9cm3. The mean initial volume of all suprarenal neuroblastoma group who underwent observation protocol was 86.0378 cm3 (SD: 114.44) range: 5.2-347.94cm3. Volumetric evaluation of suprarenal neuroblastoma following observation (Wait and See) protocol revealed continuous reduction of the tumor volumes in a statistically significant manner during the follow up periods up to 12 months with p value of less than 0.05. The volumetric changes afterwards were statistically insignificant.
The mean initial volume of all suprarenal neuroblastoma group who underwent primary surgery protocol was 42.4 cm3 (SD: 28.5) range: 7.5-90cm3. Complete surgical resection of the tumor was not feasible in all lesions due to local tumor extension and / or infiltration with the associated risk of injury of nearby organs or structures. However statistical analysis of the volumetric changes in the successive follow up periods did not reveal statistical significance.
Volumetric estimation of the tumor in the subsequent follow up periods revealed significant changes within the period first (3-9 month periods). The changes afterwards were statistically non significant. On the other hand, the mean initial volume of all suprarenal neuroblastoma group who underwent combined chemotherapy and Stem cell transplantation protocol only without surgical interference was 99.98cm3 (SD:46.2) range: 48.48-160.48 cm3. In this group the volumetric changes were variable and difference in volumes in follow up was statistically non significant during the follow up period.
The mean initial volume of all abdominal paravertebral neuroblastoma group was 249.197cm3 (SD: 249.63) range: 9.6-934cm3. The mean initial volume of all pelvic neuroblastoma group was 118.88cm3 (SD: 50.61) range: 73.4-173.4cm3. The mean initial volume of all mediastinal neuroblastoma group was 189.7cm3 (SD: 139.057) range: 10.7-415 cm3. The mean initial volume of all cervical neuroblastoma group was 189.7cm3 (SD: 139.057) range: 10.7-415 cm3. The volumetric measurements in the corresponding follow up periods according to the therapeutic protocol of abdominal paravertebral neuroblastoma, pelvic neuroblastoma, mediastinal and cervical neuroblastoma revealed significant change in the tumor volume within the early 3-6 months from the initial therapy while subsequently the tumor volumetric changes were statistically non significant.
4 Conclusion:
In conclusion, the role of MRI volumetry in the evaluation of tumor response is dependent on the risk adapted concept of neuroblastoma with the combination of different imaging modalities as well the therapeutic protocol. MRI Volumetry in addition to new protocols such as Whole-body imaging and 3D visualization techniques are gaining more importance and acceptance.
A relação pai-filho é uma das pedras angulares da pesquisa psicanalítica. Este artigo examina tal relação, assim como se apresenta no romance "Zipper und sein Vater" (1928, "Zipper e seu pai"), de Joseph Roth, em um contexto histórico e psicossocial relevante. Traçando um paralelo entre a figural paternal do Imperador Austro-Húngaro, Franz Joseph, e o pai de Arnold Zipper, e valendo-se da experiência pessoal do narrador (e do próprio Roth), o artigo apresenta uma análise da importância da figura e as consequências devastadoras de sua ausência.
Since the existence of Nilgiri hills, bryophyte- the miniatures of plant kingdom play an important and crucial role in the stabilization of Blue Mountains ecology. Unlike Himalayas, the landslides were rare in the area, but with the time and changing global environment it had become a common sight. Significantly ever increasing population and vehicular traffic is the prime reason for them, to cater the need, roads are periodically broadened by cutting road sides destroying the habitat as also the inhabiting species. Bryophytes, are efficient soil binders that regulate the soil moisture and provide substrate for future plant succession. The habitat loss and nudeness of substratum gives impetus to rapid soil erosion that further enhances the problem of their very survival. The present communication provides significance of these avascular cryptogams in environmental assessment, ecological balance and their role in decreasing the pore pressure to check land slides.
In succession of terrestrial ecosystem, bryophytes, algae and lichens constitute the primary components. Not only phylogenetically but also physically they are related to each other, as they are also found in close association and intermixed with each other on same substratum. A chlorophycean alga Ulothrix zonata (Weber & Mohr) Kützing has been found growing as an epiphyte on moss Macromitrium sulcatum (Hook.) Brid.. The association is peculiar as the algal filaments form a close net over the surface of moss leaves and axis.
Bryoflora of Munsyari and Dharchula Tehsil of Pithoragarh, Uttarakhand, Western Himalayas, India
(2012)
Uttarakhand state of India comprises unique topographical conditions and hence is rich in bryophytes. In present work two Tehsils-Munsyari and Dharchula of Pithoragarh have been explored extensively to assess the bryophytic wealth of this district. A preliminary checklist has been prepared which revealed the occurrence of 51 taxa of bryophytes from this district.
Parson’s valley is an area explored for the first time in Indian Bryology; it is situated in Nilgiri hills (Western Ghats). The region is very conducive for the growth of liverworts and it is evident by the present study of recent collections from this area in which 27 taxa (under 12 genera and 5 families) of liverworts have been recorded, of which few are new to Nilgiri hills as well as south India.
Hoffmann unterschätzt und disqualifiziert hier - natürlich auch im Interesse der Aufwertung eigener künstlerisch-kritischer Produktion - die Beliebtheit des spät- und popularaufklärerischen Genres der Blindenheilung, das die handfest-praktische Gegenseite des hochambitionierten und spätestens seit Diderot auch philosophisch prominenten Phänomens darstellt. Als „hochbesetzte Technik des 17./18. Jahrhunderts“ oder gar als „Urszene der Aufklärung“ verbindet das Starstechen den Gewinn des Augenlichts mit dem potentiellen Verlust anderer, ersatzweise erworbener, oft aber auch stärker als normal ausdifferenzierter Fähigkeiten. So folgt zumindest auf die literarisierte Blindenheilung regelmäßig der Wunsch nach erneuter Blindheit m – oder der Abbruch der Narration, „als bedeute das Tageslicht das Ende der Fiktion“. Peter Utz belegte diesen Konnex bereits 1990 mit Beispielen von Jean Paul über Goethe bis zu Bonaventuras Nachtwachen, machte aber auch auf den Rat von dessen Erzählerinstanz aufmerksam, die mögliche Fortsetzung der Geschichte „als Material für trivialromantische Verwertung“ zu nutzen. Hoffmann hingegen entwertet – wahrscheinlich wider besseres Wissen – das philosophische wie narratologische Problempotential der Blindenheilung, indem er probehalber eine Reihe anderer Varianten durchspielt, vom Arterienverschluss (,Aneurisma') über den Wundbrand bis hin zur geglückten Amputation.
The small bowel is essential to sustain alimentation and small bowel Crohn's disease (CD) may severely limit its function. Small bowel imaging is a crucial element in diagnosing small
bowel CD, and treatment control with imaging is increasingly used to optimize the patients outcome. Thereby, capsule endoscopy, Balloon-assisted enteroscopy, and Magnetic resonance imaging have become key players to manage CD patients. In this review, role of small bowel imaging is detailed discussed for use in diagnosing and managing Crohn's disease patients.
This inaugural Democracy Index for Botswana is intended to set a benchmark for democracy to be measured against. The tool, developed and honed by Idasa over many years, assesses the depth of democracy in a country through five focus areas: participation, elections, accountability, political rights, and human dignity. The research relies on expert analysis to answer a set of questions that interrogate how closely, in practice, democracy meets the broad ideal of self-representative government. More specifically, to what extent can citizens control elected officials and government appointees who make decisions about public affairs? And how equal are citizens to one another in this accountability process? The purpose of the scores is to assist citizens in making their own judgements, based on the information made available, to stimulate national debate and to provide democracy promoters with a tool for identifying issues and needs that can be addressed by education, advocacy, training, institution building and policy revision. Idasa's Democracy Index - initially developed for South Africa - is being expanded into Southern Africa in an effort to broaden the capacity of individuals and organisations monitoring and supporting democratic governance efforts in the region.
In this study, it is demonstrated that moving sounds have an effect on the direction in which one sees visual stimuli move. During the main experiment sounds were presented consecutively at four speaker locations inducing left or rightward auditory apparent motion. On the path of auditory apparent motion, visual apparent motion stimuli were presented with a high degree of directional ambiguity. The main outcome of this experiment is that our participants perceived visual apparent motion stimuli that were ambiguous (equally likely to be perceived as moving left or rightward) more often as moving in the same direction than in the opposite direction of auditory apparent motion. During the control experiment we replicated this finding and found no effect of sound motion direction on eye movements. This indicates that auditory motion can capture our visual motion percept when visual motion direction is insufficiently determinate without affecting eye movements.
In this paper we develop empirical measures for the strength of spillover effects. Modifying and extending the framework by Diebold and Yilmaz (2011), we quantify spillovers between sovereign credit markets and banks in the euro area. Spillovers are estimated recursively from a vector autoregressive model of daily CDS spread changes, with exogenous common factors. We account for interdependencies between sovereign and bank CDS spreads and we derive generalised impulse response functions. Specifically, we assess the systemic effect of an unexpected shock to the creditworthiness of a particular sovereign or country-specific bank index to other sovereign or bank CDSs between October 2009 and July 2012. Channels of transmission from or to sovereigns and banks are aggregated as a Contagion index (CI). This index is disentangled into four components, the average potential spillover: i) amongst sovereigns, ii) amongst banks, iii) from sovereigns to banks, and iv) vice-versa. We highlight the impact of policy-related events along the different components of the contagion index. The systemic contribution of each sovereign or banking group is quantified as the net spillover weight in the total net-spillover measure. Finally, the captured time-varying interdependence between banks and sovereigns emphasises the evolution of their strong nexus.
Alzheimeŕs disease (AD) represents the most prevalent neurodegenerative disorder that causes cognitive decline in old age. In its early stages, AD is associated with microstructural abnormalities in white matter (WM). In the current study, multiple indices of diffusion tensor imaging (DTI) and brain volumetric measurements were employed to comprehensively investigate the landscape of AD pathology. The sample comprised 58 individuals including cognitively normal subjects (controls), amnestic mild cognitive impairment (MCI) and AD patients. Relative to controls, both MCI and AD subjects showed widespread changes of anisotropic fraction (FA) in the corpus callosum, cingulate and uncinate fasciculus. Mean diffusivity and radial changes were also observed in AD patients in comparison with controls. After controlling for the gray matter atrophy the number of regions of significantly lower FA in AD patients relative to controls was decreased; nonetheless, unique areas of microstructural damage remained, e.g., the corpus callosum and uncinate fasciculus. Despite sample size limitations, the current results suggest that a combination of secondary and primary degeneration occurrs in MCI and AD, although the secondary degeneration appears to have a more critical role during the stages of disease involving dementia.
Making a Difference
(2012)
'Failure is not in my vocabulary' says Libertina Inaaviposa Amathila - medical doctor, leading member of Namibia's liberation movement SWAPO, and Cabinet Minister for 20 years. Insightful, candid and amusing, this book traces Libertina Amathila's journey from a village in western Namibia travelling alone to Dar es Salaam, Tanzania in 1962; medical training in Poland, Sweden and London; and the health and education centres in Zambia and Angola that she helped develop and run for Namibians in exile; to a victorious return home in 1989; service in the Cabinet of independent Namibia; and a leading role in the World Health Organisation. Courageous, committed, cutting through difficulties that deterred others, Libertina Amathila has assisted and empowered Namibian communities, particularly women, in exile and at home. As Minister of Regional and Local Government and Housing, Minister of Health and Social Services, and Deputy Prime Minister, she focused on those in need, such as squatters, street children, and those affected by HIV/AIDS, and undertook immediate practical measures to improve their lives. Packing her tent and supplies, she drove to remote areas and camped out until houses and clinics were built for marginalized communities, assisting in the design and construction process herself. An indomitable spirit drives this remarkable woman. This is her story.
This paper traces the development of National Socialist cultural and legal policy towards the arts. It examines the role of censure in this development starting with Hitler's first attempts at power in the Weimar republic. It then looks more closely into aspects of the development of new policies in and after 1933 and their implementation in institutions of the totalitarian state. As the paper shows, policies were carried out within a legal framework that included parliament and constitutional law but they were often also accompanied by aggressive political actions. Racial and nationalistic ideologies were at the heart of the National Socialist discourse about culture. This discourse quickly established modernity as its principal enemy and saw modernist culture (in the broad sense of the word), and especially art criticism, as being under Jewish domination. True German Kultur was set against this; Hitler himself promoted German art both through exhibitions and through policies which included the removal of un-German art and the exclusion of writers and artists who did not conform the cultural ideal. As Jewish artists and intellectuals in modernist culture posed the greatest threat to the establishment of a new German culture, Nazi policies towards the arts embarked on a process of censure, exclusion and annihilation. The purpose of these policies was nothing less than the elimination of all modernist (Jewish and ‘degenerate’) culture and any memory of it.
Orthotopic liver transplantation in human-immunodeficiency-virus-positive patients in Germany
(2012)
Objectives: This summary evaluates the outcomes of orthotopic liver transplantation (OLT) of HIV-positive patients in Germany.
Methods: Retrospective chart analysis of HIV-positive patients, who had been liver-transplanted in Germany between July 1997 and July 2011.
Results: 38 transplantations were performed in 32 patients at 9 German transplant centres. The reasons for OLT were end-stage liver disease (ESLD) and/or liver failure due to hepatitis C (HCV) (n = 19), hepatitis B (HBV) (n = 10), multiple viral infections of the liver (n = 2) and Budd-Chiari-Syndrome. In July 2011 19/32 (60%) of the transplanted patients were still alive with a median survival of 61 months (IQR (interquartile range): 41-86 months). 6 patients had died in the early post-transplantation period from septicaemia (n = 4), primary graft dysfunction (n = 1), and intrathoracal hemorrhage (n = 1). Later on 7 patients had died from septicaemia (n = 2), delayed graft failure (n = 2), recurrent HCC (n = 2), and renal failure (n = 1). Recurrent HBV infection was efficiently prevented in 11/12 patients; HCV reinfection occurred in all patients and contributed considerably to the overall mortality.
Conclusions: Overall OLT is a feasible approach in HIV-infected patients with acceptable survival rates in Germany. Reinfection with HCV still remains a major clinical challenge in HIV/HCV coinfection after OLT.
On 13 July 2010, in a woodland near the village of Verin Khotanan, Armenia, five males of Cordulegaster vanbrinkae were captured. These specimens are documented, compared with the holotype from Iran and discussed in detail. The current protection situation of this species in Armenia is briefly commented. In addition, the locus typicus information of the holotype from Iran is corrected and detailed.
The revolution will be tweeted : how the internet can stimulate the public exercise of freedoms
(2012)
This article discusses how new technologies of communication, especially the Internet and, more specifically, social network services, can interfere in social interactions and in political relations. The main objective is to problematize the concept of public liberty and verify how the new technologies can promote the reoccupation of public spaces and the recovery of public life, in opposition to the tendency to valorize the private sphere, observed in the second half of the twentieth century. The theoretical benchmark adopted for the investigation is Hannah Arendt's theory about the exercise of fundamental political capacities in order to establish a public space of freedom, as presented in “On Revolution”. The “Praia da Estação” (“Station Beach”) case is chosen to test the hypothesis. In 2010 in the Brazilian city of Belo Horizonte, different individuals articulated a movement through blogs, Twitter and facebook, in order to protest against the Mayor’s act that banned the assembling of cultural events in one of the main public places of the city, the “Praça da Estação” (Station Square). By applying Arendt's concepts to the selected case, it is possible to demonstrate that the Internet can assume an important role against governmental arbitrariness and abuse of power, as it can stimulate the public exercise of fundamental freedoms, such as freedom of assembly and manifestation.
Die vorliegende Arbeit stellt die Phonologie, Morphologie und Syntax des Nyam, einer westtschadischen Minoritätensprache Nordostnigerias, dar. Es handelt sich um eine Erstbeschreibung, die im Zuge eines von der DFG finanzierten Projekts mit dem Titel „Das Nyam – Dokumentation einer westtschadischen Minoritätensprache“ durchgeführt werden konnte.
Ziel dieser Arbeit ist es, eine grammatische Beschreibung des Nyam – eine bis dato unbekannte Sprache – vorzulegen. Mit nur ca. 5000 Sprechern ist sie schon im Hinblick auf die geringe Zahl, vor allem aber durch die regionale Dominanz der mit ihr genetisch verwandten Verkehrssprache Hausa, akut in ihrer Existenz bedroht. Zudem befindet sich diese Sprache in einer geographisch exponierten Lage, d.h. sie ist weitgehend von Benue-Kongo-Sprachen umgeben. Vor diesem Hintergrund kann die Dokumentation des Nyam einerseits den Nyam-Sprechern selbst zur Erhaltung ihrer kulturellen Identität und der damit verbundenen Traditionen dienen. Andererseits ist dieser wissenschaftliche Beitrag als Ergänzung zu den noch fehlenden Grammatiken innerhalb der tschadischen Sprachfamilie und im Besonderen der Bole-Tangale-Sprachgruppe zu sehen und kann als Grundstein zukünftiger Forschungen für vergleichende Arbeiten mit den benachbarten Benue-Kongo-Sprachen betrachtet werden.
We introduce a top-down stylized model to analyse the impact of a transition to a European power system based only on wind and solar power. Wind and solar power generation is calculated from high-resolution weather data and based on the country specific electricity demand alone, we introduce a model of the conventional power system that facilitates simple spatio-temporal modelling of its macroscopic behavior without direct reference to the underlying technological, economical, and political development in the system. Using this model, we find that wind and solar power generation can replace conventional power generation and power capacity to a large degree if power transmission across the continent is made possible.
We present, in the framework of the interacting hadron resonance gas, an evaluation of thermodynamical quantities. The interaction is modelled via a correction for the finite size of the hadrons. We investigate the sensitivity of the model calculations on the radius of the hadrons, which is a parameter of the model. Our calculations for thermodynamical quantities as energy and entropy densities and pressure are confronted with predictions using the lattice Quantum Chromodynamics (QCD) formalism.
A simple and fast method of lipid analysis of isolated intact mitochondria by means of MALDI-TOF mass spectrometry is described. Mitochondria isolated from bovine heart and yeast have been employed to set up and validate the new method of lipid analysis. The mitochondrial suspension is directly applied over the target and, after drying, covered by a thin layer of the 9-aminoacridine matrix solution. The lipid profiles acquired with this procedure contain all peaks previously obtained by analyzing the lipid extracts of isolated mitochondria by TLC and/or mass spectrometry. The novel procedure allows the quick, simple, precise, and accurate analysis of membrane lipids, utilizing only a tiny amount of isolated organelle; it has also been tested with intact membranes of the bacterium Paracoccus denitrificans for its evolutionary link to present-day mitochondria. The method is of general validity for the lipid analysis of other cell fractions and isolated organelles.
Buchbesprechungen
(2012)
Rezension zu: Wolfgang Bunzel (Hrsg.) unter Mitarbeit von Anke Harms und Anja Leinweber : Hänsel und Gretel im Bilderwald. Illustrationen romantischer Märchen aus 200 Jahren Frankfurt am Main 2012, Frankfurter Goethe-Haus/Freies Deutsches Hochstift 2012, ISBN 978-3-9814599-1-3, 165 Seiten, 19,90 Euro.
While it is apparent that rare variation can play an important role in the genetic architecture of autism spectrum disorders (ASDs), the contribution of common variation to the risk of developing ASD is less clear. To produce a more comprehensive picture, we report Stage 2 of the Autism Genome Project genome-wide association study, adding 1301 ASD families and bringing the total to 2705 families analysed (Stages 1 and 2). In addition to evaluating the association of individual single nucleotide polymorphisms (SNPs), we also sought evidence that common variants, en masse, might affect the risk. Despite genotyping over a million SNPs covering the genome, no single SNP shows significant association with ASD or selected phenotypes at a genome-wide level. The SNP that achieves the smallest P-value from secondary analyses is rs1718101. It falls in CNTNAP2, a gene previously implicated in susceptibility for ASD. This SNP also shows modest association with age of word/phrase acquisition in ASD subjects, of interest because features of language development are also associated with other variation in CNTNAP2. In contrast, allele scores derived from the transmission of common alleles to Stage 1 cases significantly predict case status in the independent Stage 2 sample. Despite being significant, the variance explained by these allele scores was small (Vm< 1%). Based on results from individual SNPs and their en masse effect on risk, as inferred from the allele score results, it is reasonable to conclude that common variants affect the risk for ASD but their individual effects are modest.
The subject of revolutionary overthrow of constitutional orders in Africa is at the intersection of three disciplines: jurisprudence and legal philosophy, constitutional law and power politics, and civil-military relations, that is, military security policy which is one aspect of national security policy. The subject is of interest in at least four ways. It problematizes the inescapable question of governance in the African continent. It challenges the democratization agenda in Africa - how does one democratize not only political governance but also the instruments of violence in the state? It also challenges African constitutional lawyers and policy makers to seek a constitutional model that addresses the enduring menace of the power of the gun in African affairs and the changing role of the military in African politics. Finally, it underscores concerns about sovereignty and national security. This book contributes to a fuller understanding of the coup syndrome in African. To this end, it vigorously interrogates the place of coups in the governance of Africa, and explores the relevance of Kelsen's theory of revolutionary legality in the context of coup d'états in Africa. It is a major contribution by a leading thinker in the field.
Das Gedicht 'Verse, auf eine Banknote geschrieben' unterscheidet sich in der Formensprache derart von der frühen Lyrik Hofmannsthals, dass sich beinahe der Eindruck eines absichtsvoll Schlechten herstellt. Es handelt sich um Gedankenlyrik, die kaum etwas von der subtilen Widerständigkeit und traumhaften Hermetik aufweist, die an der Lyrik des jungen Hofmannsthal bewundert worden ist. Andererseits ist der Gedankengang so scharfsinnig und verdichtet durchgeführt, dass der Text trotz der konventionellen Form den meisten Zeitgenossen vermutlich unzugänglich gewesen wäre. Das Raffinierte des Texts besteht in einer merkwürdigen Dialektik von Mimesis an den besprochenen Gegenstand und Selbstverleugnung in einer Poetik der Nichtidentität.
This article discusses one of many possible strategies that translators use in rendering an idiom from a L1 to a L2, i.e. the verbatim or the literal translation. The points of view according to this strategy differ very much among the researchers: some treat them as semantic false friends. Based on the replies to a questionnaire that was handed out to 10 Romanian native speakers, one could state that the context in which the literal translation of a source-idiom is situated plays an important role for the understanding of the text. Beyond that, the translation of an idiom cannot be judged only by virtue of the denotative meaning – the pragmatic function of the translation as a whole is just as important. The questionnaire was compiled of literal translations of Swedish idioms into Romanian (from different translations of different novels). The article further discusses some of the text examples from this questionnaire and describes some of the phenomena related to idioms which hinder the so-called idiom-understanding and which probably led to misinterpretation and a failed literal translation.
Cyber-Mobbing im Web 2.0
(2012)
In this article I advance an account of human rights as individual claims that can be justified within the conceptual framework of social contract theories. The contractarian approach at issue here aims, initially, at a justification of morality at large, and then at the specific domain of morality which contains human rights concepts. The contractarian approach to human rights has to deal with the problem of universality, i.e. how can human rights be ‘universal’? I deal with this problem by examining the relationship between moral dispositions and what I call ‘diffuse legal structure’.
This book, with contributions in both English and French, is a product of collaborative research between the Institut de recherche pour le développement (IRD, France), the University of Ghana, Legon and CODESRIA. It examines various economic, social and environmental challenges of urbanization that critically affect the capital of Ghana, which has experienced high demographic growth and territorial expansion. The study analyses the Greater Accra city dwellers residential practices, and focuses on two main factors influencing land and rental markets. On the one hand, it interrogates the constraints and dynamics of urban families, their needs and gender characteristics in terms of accommodation. On the other hand, it explores the opportunities and interests in investment on the part of land owners and real estate developers. At these two levels of describing the social and spatial discriminations, the book attempts to explain the difficult choices that this fragmented city faces. It emphasizes the role of mobility in structuring the metropolitan area, and the negative impact of lack of mobility which results in some households and communities suffering more than others. Light is thrown on diagnostics and prospects in the matter of urban planning.
Two new species of the genus Pahamunaya Schmid (Trichoptera: Polycentropodidae), P. talon sp. n. and P. spinifera sp. n., from Vietnam are described and illustrated. Examination of the holotype male of P. khoii Oláh and Johanson, in combination with an additional specimen of the same species, revealed new characters. New illustrations for this species are provided.
Macrophages are highly plastic leukocytes that differentiate from monocytes following their entry into extravascular tissues. Macrophages can enter various tissues under inflammatory or non-inflammatory conditions and assume different functions and phenotypes according to the cues they receive from the environment. The notion that inflammation in general and macrophage responses in particular affect physiological phenomena that were previously considered to be not immune-related has enhanced and broadened our understanding of macrophage function during inflammation and its resolution....
Two new species of Goera, G. zwicki and G. nozakii (Trichoptera, Goeridae), from the Philippines and one new species, G. meyi, from Vietnam are described and illustrated herein. In addition, type specimens of G. disparilis Banks, G. octospina Banks, G. tagalica Banks, and G. uniformis Banks are illustrated. All species of Goera known from both the Philippines and Vietnam are listed.
[Jahresbericht 2012] Katholische Theologie der Johann Wolfgang Goethe-Universität Frankfurt am Main
(2012)
Die Fortschritte der Neurowissenschaften in den letzten hundert Jahren ließen auch andere Wissensbereiche nicht unberührt und haben dazu geführt, dass traditionelle Vorstellungen von Identität mehreren Revisionen unterzogen werden mussten. Die Rede vom Gehirn als Grundlage der Individualität hat eine tiefgreifende Blickwinkelverschiebung zur Folge, die sich sodann auch in der philosophischen und literarischen Auseinandersetzung mit der Frage der neurobiologischen Grundlage von Individualität niederschlägt. Mit Blick auf den übergeordneten Titel der Veranstaltung Grenzen überschreiten in der Germanistik liegt hier gar eine zweifache Grenzübertretung vor: zunächst wird die Grenze zwischen zwei verschiedenen Disziplinen, der Literatur und der Neurobiologie, die ganz unterschiedliche Diskurse und damit Sprech- und Arbeitsweisen einschließen, überschritten. Zum zweiten erfolgt eine Grenzüberschreitung von traditionellen Identitätskonzepten, wenn in der Äußerung Ich bin mein Gehirn reduktionistisch konstatiert wird, Identität sei nicht mehr als die Summe einer Verschaltung von Neuronen und ihrer Aktivitäten im menschlichen Gehirn.
Seed disperser preferences may mediate the impact of invasive, non-native plant species on their new ecological communities. Significant seed disperser preference for invasives over native species could facilitate the spread of the invasives while impeding native plant dispersal. Such competition for dispersers could negatively impact the fitness of some native plants. Here, we review published literature to identify circumstances under which preference for non-native fruits occurs. The importance of fruit attraction is underscored by several studies demonstrating that invasive, fleshy-fruited plant species are particularly attractive to regional frugivores. A small set of studies directly compare frugivore preference for native vs. invasive species, and we find that different designs and goals within such studies frequently yield contrasting results. When similar native and non-native plant species have been compared, frugivores have tended to show preference for the non-natives. This preference appears to stem from enhanced feeding efficiency or accessibility associated with the non-native fruits. On the other hand, studies examining preference within existing suites of co-occurring species, with no attempt to maximize fruit similarity, show mixed results, with frugivores in most cases acting opportunistically or preferring native species. A simple, exploratory meta-analysis finds significant preference for native species when these studies are examined as a group. We illustrate the contrasting findings typical of these two approaches with results from two smallscale aviary experiments we conducted to determine preference by frugivorous bird species in northern California. In these case studies, native birds preferred the native fruit species as long as it was dissimilar from non-native fruits, while non-native European starlings preferred non-native fruit. However, native birds showed slight, non-significant preference for non-native fruit species when such fruits were selected for their physical resemblance to the native fruit species. Based on our review and case studies, we propose that fruit characteristics of native plant communities could dictate how well a non-native, fleshy-fruited plant species competes for dispersers with natives. Native bird preferences may be largely influenced by regional native fruits, such that birds are attracted to the colors, morphology, and infructescence structures characteristic of preferred native fruits. Non-native fruits exhibiting similar traits are likely to encounter bird communities predisposed to consume them. If those non-natives offer greater fruit abundance, energy content, or accessibility, they may outcompete native plants for dispersers.
From its very inception, detective fiction has enjoyed a great popularity among the young and the old, the learned and the not so learned. By some unfortunate stroke of irony, its respect has not kept pace with its enormous popularity. For over half a century now, it has remained the bane of creative writing. In strict intellectual circles, it is very rare to find people talk defensively and interestingly about the genre. Yet Asong has chosen to do just that. He has stoutly defended the weak by putting up a good case for its continued existence. He has also shown how irresistible key elements of the genre are to even the best respected novelists. Finally he has demonstrated for the first time, how the genre has been domesticated by African writers of very great repute such as Ngugi, Sembene and Lessing. That he has been able to prove that these writers have used techniques of detective fiction is a significant broadening of the horizons for appreciating creative writing in Africa.
Das Internet ist nicht nur ein Medium, das neue Kommunikationsformen ermöglicht, es ist selbst auch das Produkt eines verstärkten Bedarfs, Wunsches und Drangs nach Kommunikation. Beim Internet handelt es sich um ein hybrides Konstrukt, das auf drei Säulen aufruht: 1. eine neue Ordnung von Daten/ Informationen (Stichwort: Hypertext; Beispiel: Suchmaschinen wie Google), 2. die Entwicklung neuer Formen von Interaktion (Stichwort: neue Kommunikationsplattformen, Beispiele: MySpace, Facebook), 3. die globale Ausweitung der Zugangsformen (Stichwort: erschwingliche Computer und handheld devices, Vervielfältigung der Server, Knoten, Terminals). Diese drei Aspekte des Internets sind das Ergebnis zunächst eigenständiger technologischer Erfindungen und Entwicklungen, die dann miteinander fusioniert wurden. "Es ist an der Zeit, die digitale Revolution, die mehr ist als das Web 2.0, in ihrer ganzen Wucht zu erkennen", schrieb Frank Schirrmacher in der FAZ. Ich werde mich in diese grundsätzliche Debatte über das Internet und die anthropologischen und politischen Konsequenzen der neuen Datenordnung hier jedoch nicht einschalten, die derzeit von Meinungsmachern wie Frank Schirrmacher, Stephen Baker und Sascha Lobo geführt wird, sondern mich nur auf die zweite Säule, die Neugestaltung der Kommunikation durch das Web 2.0 konzentrieren.
Im Folgenden soll am Beispiel der deutschen Erinnerungsgeschichte nach 1945 der lange, aber doch eindeutige und wohl auch irreversible Weg vom Vergessen zum Erinnern nachgezeichnet werden. Im Mittelpunkt dieser Entwicklungslinie steht das Thema Auschwitz, das Meier ja als Ausnahme seiner Regel aus seiner Darstellung herausgenommen hatte. [In] Abweichung von dieser These soll hier gezeigt werden, dass die Erinnerung an Auschwitz auch auf andere historische Ereignisse abgefärbt hat und deshalb nicht als ein abgesonderter Ausnahmefall anzusehen ist, sondern als Anstoß einer erinnerungskulturellen Wende. Diese Folgeerscheinungen, die zu einem Erinnerungsanspruch auch für andere historische Verbrechen gegen die Menschlichkeit wie die Sklaverei oder die Ausrottung indigener Urbevölkerungen geführt hat, sind inzwischen gut dokumentiert.
Das Kanonproblem gehört zu den Themen, die seit den letzten dreißig Jahren unvermindert aktuell waren, wenn sich auch die Perspektiven von Jahrzehnt zu Jahrzehnt grundlegend geändert haben. Es lassen sich mindestens drei Schwerpunkte des Interesses an diesem Thema ausmachen, die, auch wenn sie sich nicht gänzlich ausschließen, eine deutliche Verlagerung des Problembewußtseins markieren. In den 70er Jahren stand der Bildungs-Kanon auf dem Prüfstand, der an Schulen und Hochschulen die Geltung traditioneller Texte und Werte unverändert fortschrieb. Gegen diesen mehr oder weniger emphatischen Traditionalismus richtete sich ein ikonoklastischer Impuls, der seine Energien aus einem veränderten Geschichts- und Gesellschaftsbewußtsein bezog. Einerseits führte die Anerkennung der faschistischen deutschen Vergangenheit Ende der 60er Jahre durch die Nachkriegsgeneration zu grundsätzlichen Fragen an eine kontaminierte Tradition; andererseits führte die expansive Bildungspolitik der 60er und 70er Jahre zu einer Umstürzung der Bildungspläne. Auf die ikonoklastische Phase folgte in den 5Oer Jahren die klassizistische Phase.
An der Goethe Universität in Frankfurt wird ein Konzept für ein magnetostatischen Hochstromspeicherring für Protonen- und Ionenstrahlen entwickelt und untersucht. Zur Zeit stehen dem Experiment zwei Toroidsegmente und eine Volumenionenquelle zur Verfügung. An diesem Aufbau werden Experimente mit dem Ziel die Strahldynamik zu untersuchen und die Strahldiagnose in toroidalen Magnetfeldern zu entwickeln, durchgeführt [Joshi] Für Experimente ist eine Strahldiagnose entlang der starken toroidalen Magnetfelder bis maximal 0, 6T nötig. Dabei sind die zur Verfügung stehenden Strahldiagnoseverfahren zum Einen ein Faraday-Cup und zum Anderen ein entlang des kompletten Aufbaus beweglicher Szintillatordetektor. Der Szintillatordetektor, besteht aus einem Phosphorschirm und einer Kamera, die hinter dem Schirm angebracht ist. [Nonn] Aufgrund der geschlossenen Ringgeometrie und dem Anspruch auf eine hohe Flexibilität des Detektors ist die Konstruktion eines neuen von starken Magnetfeldern unbeeinflussbaren und sehr kompakten Detektors notwendig. Ziel dieser Arbeit ist es, ein allgemeines Strahldiagnoseverfahren zu entwickeln.
The prognostic impact of epidermal growth factor receptor in patients with metastatic gastric cancer
(2012)
Background: The epidermal growth factor receptor (EGFR) is a potential target of anticancer therapy in gastric cancer. However, its prognostic role in metastatic gastric or gastroesophageal junction (GE) cancer has not been established yet.
Methods: EGFR status was analyzed by immunohistochemistry (IHC) in paraffin-embedded samples from 357 patients who received chemotherapy in 4 first-line trials. Automated RNA extraction from paraffin and RT-quantitative PCR were additionally used to evaluate EGFR mRNA expression in 130 patients.
Results: EGFR protein expression (any grade) and overexpression (3+) were observed in 43% and 11% of patients, respectively. EGFR positivity correlated with intestinal type histology (p = 0.05), but not with other clinicopathologic characteristics. Median follow-up was 18.2 months. Median overall survival (OS) was similar in patients with EGFR positive vs. those with EGFR negative tumors, regardless whether positivity was defined as ≥1+ (10.6 vs. 10.9 months, p = 0.463) or as 3+ (8.6 vs. 10.8 months, p = 0.377). The multivariate analysis indicated that EGFR status is not an independent prognostic factor (hazard ratio 0.85, 0.56 to 1.12, p = 0.247). There were also no significant differences in overall survival when patients were categorized according to median (p = 0.116) or quartile (p = 0.767) distribution of EGFR mRNA gene expression. Similar distributions of progression-free survival according to EGFR status were observed.
Conclusions: Unlike different cancer types where EGFR-positive disease is associated with an adverse prognostic value, EGFR positivity is not prognostic of patient outcome in metastatic gastric or GE cancer.
Parkinson's disease is the second most frequent neurodegenerative disorder. While most cases occur sporadic mutations in a growing number of genes including Parkin (PARK2) and PINK1 (PARK6) have been associated with the disease. Different animal models and cell models like patient skin fibroblasts and recombinant cell lines can be used as model systems for Parkinson's disease. Skin fibroblasts present a system with defined mutations and the cumulative cellular damage of the patients. PINK1 and Parkin genes show relevant expression levels in human fibroblasts and since both genes participate in stress response pathways, we believe fibroblasts advantageous in order to assess, e.g. the effect of stressors. Furthermore, since a bioenergetic deficit underlies early stage Parkinson's disease, while atrophy underlies later stages, the use of primary cells seems preferable over the use of tumor cell lines. The new option to use fibroblast-derived induced pluripotent stem cells redifferentiated into dopaminergic neurons is an additional benefit. However, the use of fibroblast has also some drawbacks. We have investigated PARK6 fibroblasts and they mirror closely the respiratory alterations, the expression profiles, the mitochondrial dynamics pathology and the vulnerability to proteasomal stress that has been documented in other model systems. Fibroblasts from patients with PARK2, PARK6, idiopathic Parkinson's disease, Alzheimer's disease, and spinocerebellar ataxia type 2 demonstrated a distinct and unique mRNA expression pattern of key genes in neurodegeneration. Thus, primary skin fibroblasts are a useful Parkinson's disease model, able to serve as a complement to animal mutants, transformed cell lines and patient tissues.
Wissenschaftliches "Niedermachen" : Science Slam im Seminar – ein studentischer Erfahrungsbericht
(2012)
Background. Leukotriene B4 (LTB4), a proinflammatory lipid mediator correlates well with the acute phase of Acute Respiratory Distress Syndrome (ARDS). Therefore, LTB4-levels were investigated to determine whether they might be a useful clinical marker in predicting pulmonary complications (PC) in multiply traumatized patients. Methods: Plasma levels of LTB4 were determined in 100 patients on admission (ED) and for five consecutive days (daily). Twenty healthy volunteers served as control. LTB4-levels were measured by ELISA. Thirty patients developed PC (pneumonia, respiratory failure, acute lung injury (ALI), ARDS, pulmonary embolism) and 70 had no PC (ØPC). Results. LTB4-levels in the PC-group [127.8 pg/mL, IQR: 104–200pg/ml] were significantly higher compared to the ØPC-group on admission [95.6 pg/mL, IQR: 55–143 pg/mL] or control-group [58.4 pg/mL, IQR: 36–108 pg/mL]. LTB4 continuously declined to basal levels from day 1 to 5 without differences between the groups. The cutoff to predict PC was calculated at 109.6 pg/mL (72% specificity, 67% sensitivity). LTB4 was not influenced by overall or chest injury severity, age, gender or massive transfusion. Patients with PC received mechanical ventilation for a significantly longer period of time, and had prolonged intensive care unit and overall hospital stay. Conclusion. High LTB4-levels indicate risk for PC development in multiply traumatized patients
This book is the fascinating study of Christian enclaves in the Southern Cameroons of the colonial era. The Christian enclaves came into being with absolute spontaneity as a modus vivendi. Oblivious of the danger in store both colonial governments and traditional authorities provided the conditions in which these Christian villages took root and flourished. However what had taken root in the territory as a self-protection mechanism, soon unleashed its lethal, enticing tentacles luring both the wives of royals and commoners into their bosom. This disruptive influence of Christian villages threatened the survival of ethnic groups, arousing the rancour of traditional authorities and civil administrators. In many ways the Christian enclaves inhibited the potential of colonial governments to administer the territory. These states within a state propagated by the missionary in the most insidious and perfidious of all manners sowed within their own bosom the seed of self-destruction. The whole issue of runaway wives of royals and commoners alike who took refuge in the Christian villages troubled both the colonial and traditional authorities. By offering a safe haven to these runaway wives and welcoming women who were outside the traditional male authority in a tribal setup, the missionaries began sowing within the Christian communities the seeds of their own self destruction. Records of wives of Fons and commoners escaping into these enclaves, eloping with a man and returning pregnant remained the regular subject of several colonial intelligence reports. Highhanded methods by missionaries in these villages brought both the missionaries and their work into disrepute. In less than a quarter of a century these enclaves had lost the war of attrition waged by colonial and traditional authorities. Worn out by endless strife and dissension within and without and forced by contingency, what had been conceived to be ideal Christian communities with snowballing effects, saw its premature demise.
Este trabalho examina os "Escritos sobre a Música e os Músicos", do compositor alemão Robert Schumann, em especial as resenhas escritas entre 1834 e 1836, com vistas a identificar ecos das principais ideias sobre linguagem e tradução desenvolvidas na Alemanha entre o final do séc. XVIII e o início do séc. XIX. Os eixos escolhidos para construir essa ideia são os eixos do sujeito e do tempo perpassados pela noção de movimento. Do primeiro, destacase a ancoragem vertical, personalíssima, operada no interior do sujeito que transita de um sistema sígnico para outro, que traduz seus pensamentos, ou ainda que empreende a passage de uma língua para outra. Do segundo, tem-se em conta a configuração desse mergulho num produto que desmantela as barreiras do tempo e, de um só golpe, contemporiza o passado e inclui o futuro.
The Cowrie Necklace is a graphic account of the struggle for meaning in life. The poems are a carefully woven sizzling and cracking attempt to mirror society. The poet runs a long and wide gamut of poetic themes which include the intricacies of joy and sadness, God and the devil, nature and nurture, good and evil, love, deceit and treachery. The narrative style is reminiscent of Wole Soyinka, Francesco Nditsouna and D.H. Lawrence. The Cowrie Necklace is a "must read".
In meiner Arbeit zeige ich, dass es sich bei der klitischen Dopplung im Spanischen und Katalanischen um dasselbe Phänomen handelt, nämlich um ein synchrones Stadium einer sprachlichen Entwicklung der romanischen Sprachen: der Umwandlung der Objektmarkierung vom morphologischem Kasus hin zu anderen Strategien. Die existierenden Unterschiede zwischen den Sprachen und innerhalb ihrer Varietäten lässt sich so erklären, dass die Entwicklung der sprachlichen Systeme nicht gleichförmig verläuft - während das Spanische des Rio de la Plata-Raums bereits weit fortgeschritten ist, zeigt sich das Katalanische noch recht konservativ.
Background: The transcription factor T-bet is pivotal for initiation of Th1-related immunoactivation. Identification of novel genes directly regulated by T-bet is crucial.
Results: Genome-wide analysis and subsequent experiments revealed that T-bet up-regulates IL-36γ/IL-1F9 in myeloid cells.
Conclusion: IL-1-related IL-36γ is a direct T-bet target in myeloid cells.
Significance: Observations suggest that IL-36γ , besides IFNγ, contributes to T-bet functions in immunopathology
By concerted action in dendritic (DC) and T cells, T-box expressed in T cells (T-bet, Tbx21) is pivotal for initiation and perpetuation of Th1 immunity. Identification of novel T-bet-regulated genes is crucial for further understanding the biology of this transcription factor. By combining siRNA technology with genome-wide mRNA expression analysis, we sought to identify new T-bet-regulated genes in predendritic KG1 cells activated by IL-18. One gene robustly dependent on T-bet was IL-36γ, a recently described novel IL-1 family member. Promoter analysis revealed a T-bet binding site that, along with a κB site, enables efficient IL-36γ induction. Using knock-out animals, IL-36γ reliance on T-bet was extended to murine DC. IL-36γ expression by human myeloid cells was confirmed using monocyte-derived DC and M1 macrophages. The latter model was employed to substantiate dependence of IL-36γ on endogenous T-bet in human primary cells. Ectopic expression of T-bet likewise mediated IL-36γ production in HaCaT keratinocytes that otherwise lack this transcription factor. Additional experiments furthermore revealed that mature IL-36γ has the capability to establish an inflammatory gene expression profile in human primary keratinocytes that displays enhanced mRNA levels for TNFα, CCL20, S100A7, inducible NOS, and IL-36γ itself. Data presented herein shed further light on involvement of T-bet in innate immunity and suggest that IL-36γ, besides IFNγ, may contribute to functions of this transcription factor in immunopathology.
'[C]ulture as text' initially proved to be a pivotal bridging metaphor between cultural anthropology and literary studies. Following an admittedly ambivalent career path, the concept of 'culture as text' has nevertheless continued to rise and has become an over-determined general principle, an emphatic key metaphor, even an overall "programmatic motto for the study of culture" […]. At first, this concept was still closely connected to ethnographic research and to the semiotic framework of interpretive cultural anthropology. However, since the end of the 1990s it has been utilised to encompass a much broader interdisciplinary horizon for the study of culture. 'Culture as text' advanced from being a conceptual metaphor for the condensation of cultural meanings to a rather free-floating formula frequently referred to in analyses within disciplines involved in the study of culture. Surprisingly, 'culture as text' has remained a consistent key phrase throughout the discourses concerned with the study of culture—even after the culture debate had long since turned away from the holistic understanding of culture implied by the formula.
Investigations of current and historical human rights discourses gain new perspectives when viewed as a problem of translation: by examining non-European transformations/displacements/revisions of the universal principles of the UN Declaration (1948), critical implementations of these principles in local practices and – almost more importantly – re-translations of these local transformations into new declarations of human rights principles. The article discusses the complex conditions under which the universal claim of a western human rights discourse could be challenged by considering translational activities which attempt to identify new, but common reference points for a transcultural human rights discourse.
It is no longer possible to ignore how crucial processes of cultural translation and their analysis have become, whether for cultural contact or interreligious relations and conflicts, for integration strategies in multicultural societies or for the exploration of productive interfaces between the humanities and the natural sciences. The globalisation of world society, in particular, demands increased attention to mediation processes and problems of transfer, in terms of both the circulation of global representations and 'travelling concepts' and of the interactions that make up cultural encounters. Here, translation becomes, on the one hand, a condition for global relations of exchange ('global translatability') and, on the other, a medium especially liable to reveal cultural differences, power imbalances and the scope for action. An explicit focus on translation processes— something increasingly prevalent across the humanities—may thus enable us to scrutinise more closely current and historical situations of cultural encounter as complex processes of cultural translation. Translation is opened up to a transnational cultural practice that in no way remains restricted to binary relationships between national languages, national literatures or national cultures.
Preface
(2012)
Mit der vorliegenden Quellenanthologie präsentieren Tim Geelhaar und John Thomas ein Ergebnis aus dem transkulturellen und internationalen Forschungsprojekt "Stiftungstod. Säkularisation von Kirchengut und andere Gefährdungen für die Stiftungszwecke durch staatliche Gewalt in der lateinischen und griechisch-orthodoxen Christenheit des Mittelalters", das von der Fritz Thyssen Stiftung finanziert und von Michael Borgolte geleitet wurde. Den enthaltenen Quellen voran geht eine ausführliche und detaillierte Einleitung, deren allgemeiner Teil (S. 3–17) nicht nur die Entwicklung und Grenzen der eigenen Fragestellung benennt, sondern darüber hinaus die theoretischen und methodischen Prämissen des Vorhabens transparent darlegt und in der gebotenen Kürze die einhergehenden Schwierigkeiten und Konsequenzen präzise formuliert. Hieran schließt sich eine ebenso konzise Übersicht über die ausgewählten lateinischen (S. 19–35) und byzantinischen (S. 37–46) Quellen sowie deren vergleichende Perspektive (S. 47–56) an. Abgeschlossen wird der einleitende Teil durch einen kurzen Exkurs zu einer der ideengebenden Auseinandersetzung mit dem Thema staatlicher Einflussnahme in Stiftungsbesitz im byzantinischen Reich ("The Charanis Thesis Revisited", S. 57–68), der es dem Leser ermöglicht, anhand eines anschaulichen Beispiels nachzuvollziehen, welche Fragen, Lösungsversuche und grundsätzlichen Motivationen als treibende Kräfte in der Produktion der Anthologie gewirkt haben. Als Kernstück des Bandes folgt dann die Quellenauswahl aus dem 5. bis 15. Jahrhundert (lateinische, S. 94–303; byzantinische, S. 306–421), deren chronologische Anordnung und stets mitgelieferte Übersetzung (im Fall der byzantinischen Quellen oftmals erstmalig) es dem – auch nicht ausschließlich fachkundigen – Leser ermöglicht, Entwicklungslinien in der "staatlichen" Gefährdung von Stiftungsbesitz zu verfolgen und im byzantinisch/abendländischen Vergleich zu betrachten. Für eine eingehendere Auseinandersetzung mit der besagten Thematik haben die Herausgeber zusätzlich noch ein ausführliches Quellen- und Literaturverzeichnis (S. 71–91) bereitgestellt. ...
Nach dem für das Instrument zur Verfügung stehenden Gesamtvolumen sollte die Zahl der ausgestellten Qualifizierungsschecks monatlich etwa 133 (165 unter Berücksichtigung der verkürzten Laufzeit) betragen. Diese Anzahl wurde 2011 durchgängig übertroffen. Die im Zeitablauf bereits seit 2010 beobachtete deutlich positive Entwicklung hat sich auch 2011 fortgesetzt bzw. verstärkt. 2011 wurden bis zum 10.12.2011 fast 3.900 Qualifizierungsschecks ausgestellt, das sind über 1.500 mehr als 2010. Immer noch wird eine nicht unerhebliche Anzahl an Qualifizierungsschecks zwar ausge-
stellt, aber von den Teilnehmer/innen nicht fristgereicht eingelöst. Der Anteil an verfallenen Qualifizierungsschecks an allen ausgestellten Schecks liegt inzwischen bei ca. 20%.
Die Ursachen hierfür konnten bislang noch nicht eruiert werden. Die in den ersten Jahren beobachteten starken regionalen Unterschiede bei den quantitativen Teilnehmerzahlen sind zwar noch vorhanden, haben sich aber deutlich reduziert.
Wird die unterschiedliche Größe der Landkreise bzw. kreisfreien Städte berücksichtigt, dann wird das Instrument nach wie vor in den nördlichen Kreisen um die Stadt Kassel
sowie in einigen südhessischen Landkreisen besonders gut angenommen. Unterdurchschnittlich ist – gemessen an den Teilnehmerpotenzialen – die Teilnahme in vielen kreis-
freien Städten, insbesondere in Frankfurt, Wiesbaden und Offenbach. Die Öffnung des Instruments für Teilzeitbeschäftigte mit weniger als 30 Stunden/pro
Woche wurde sehr gut angenommen. Über 40% der 2011 ausgestellten Schecks gingen an Teilzeitbeschäftigte.
Bezüglich der Teilnehmerstruktur ist festzuhalten, dass sich Frauen weiterhin überdurchschnittlich häufig an dem Instrument beteiligen. Ihr Anteil lag 2011 bei ca. 60%. Der Anteil an Beschäftigten mit Migrationshintergrund, die das Instrument nutzen, ist wieder angestiegen nachdem zwischen 2008 und 2010 eine rückläufige Tendenz beobachtbar war. Die Gruppe der Älteren wird nach wie vor in ausreichendem Maße über das Instrument angesprochen. Für Beschäftigte ohne Berufsabschluss trifft dies nicht zu. Die Anteile an Beschäftigten ohne Abschluss oder nur mit einem Schulabschluss sind weiterhin gering. Zudem verfügten 2011 etwa 43% der Teilnehmer über einen anerkannten Abschluss in der ausgeübten Tätigkeit, 2008 lag der Anteil noch bei 25%. Zugangswege und Informationskanäle zum Instrument verlaufen am häufigsten über die Arbeitgeber. Die Bildungsträger, die im Vorjahr noch die wichtigste Informationsquelle waren, haben hingegen an Bedeutung eingebüßt, spielen aber nach wie vor eine bedeu-
tende Rolle. Die Bedeutung der Arbeitgeber als Informationsquelle hat zwar bei nahezu allen Beschäftigtengruppen zugenommen, die Betriebe gehen dabei aber immer noch selektiv vor: Sie informieren überdurchschnittlich häufig Männer und jüngere Beschäftigte. Große Bedeutung haben weiterhin informelle Informationswege über Freunde und Ver-
wandte. Die gilt insbesondere für Frauen und Beschäftigte mit Migrationshintergrund. Rund 46% der Teilnehmer/innen trug 2011 die Kosten für den nicht förderungsfähigen Anteil der Weiterbildungsmaßnahme selbst. Dies ist ein geringerer Wert als 2010 (54%). Die betriebliche Unterstützung hat deutlich zugenommen, bei jedem zweiten Scheck beteiligen sich die Betriebe inzwischen an der Ko-Finanzierung. Die Bereiche der Weiterbildungsmaßnahmen haben sich gegenüber den Vorjahren verändert. Deutlich zugenommen haben Maßnahmen aus den Bereichen soft skills bzw. soziale Qualifikationen. Abgenommen haben dafür Verwaltungs- und rechungswesenschulungen. Die Teilnehmer/innen bewerten das Instrument bezüglich Information, Beratungsqualität, Berücksichtigung der individuellen Situation und auch des organisatorischen Ablaufs
und Aufwands weiter ausgesprochen gut. Zwar sind hier je nach Strukturmerkmal (Geschlecht, Alter, Qualifikation) Unterschiede in der Bewertung feststellbar, jedoch gibt es
keine Beschäftigtengruppe, die zu einer negativen Bewertung kommt. Im Vergleich zum Vorjahr hat sich insbesondere die Bewertung durch ältere Teilnehmer/innen verbessert. Auch die von Teilnehmer/innen mit Migrationshintergrund ist
überdurchschnittlich gut. Die Wirkungsanalyse mittels der telefonischen Nachbefragung zeigt weiterhin sehr posi-
tive Effekte. Die Qualität der Weiterbildungsmaßnahme wird in der Regel als sehr gut oder gut beschrieben. Über 90% der Teilnehmer/innen gab an, dass sich ihre berufliche
Situation (subjektiv oder objektiv) seit der Teilnahme an dem Instrument verbessert habe. Die sehr guten Bewertungen des Instruments und die positiven Wirkungen auf die Er-
werbssituation sind sicherlich sehr erfreuliche Ergebnisse. Dennoch bleibt auch 2011 festzuhalten, dass es eine nicht unerhebliche Anzahl an Mitnahmeeffekten gibt. Viele
Teilnehmer/innen gaben an auch ohne den Scheck an einer Qualifizierungsmaßnahme teilgenommen zu haben. Diese Mitnahmeeffekte sind zwar rückläufig, aber immer noch
von Bedeutung.
Pasolini was simultaneously a revolutionary Marxist and a man forever influenced by his religious childhood. So his question was: do the revolutionary becoming of history and political negativity represent a destruction of the tragic beauty of the Greek myths and of the peaceful promise of Christianity? Or do we have to speak of a subtraction where an affirmative reconciliation of beauty and peace becomes possible in a new egalitarian world?
Adipose tissue as a stem cell source is ubiquitously available and has several advantages compared to other sources. It is easily accessible in large quantities with minimal invasive harvesting procedure, and isolation of adipose-derived mesenchymal stromal/stem cells (ASCs) yields a high amount of stem cells, which is essential for stem-cell-based therapies and tissue engineering. Several studies have provided evidence that ASCs in situ reside in a perivascular niche, whereas the exact localization of ASCs in native adipose tissue is still under debate. ASCs are isolated by their capacity to adhere to plastic. Nevertheless, recent isolation and culture techniques lack standardization. Cultured cells are characterized by their expression of characteristic markers and their capacity to differentiate into cells from meso-, ecto-, and entodermal lineages. ASCs possess a high plasticity and differentiate into various cell types, including adipocytes, osteoblasts, chondrocytes, myocytes, hepatocytes, neural cells, and endothelial and epithelial cells. Nevertheless, recent studies suggest that ASCs are a heterogeneous mixture of cells containing subpopulations of stem and more committed progenitor cells. This paper summarizes and discusses the current knowledge of the tissue localization of ASCs in situ, their characterization and heterogeneity in vitro, and the lack of standardization in isolation and culture methods.
The aim of this article is to systematize selected existing definitions of texts and, from the perspective of research into text comprehension, to compare and contextualize the most frequent concepts applied in the field. These concepts are used in the description of the basic phases and aspects of the text comprehension process; they may be divided into three groups depending on whether they denote the comprehension process itself, the results of this process, or the properties of text. This division should not be viewed as an immutable set of concepts, but rather as a starting point for research into issues of text comprehension and comprehensibility.
Thema der Dissertation ist der signifikante pathognomische Ausdruck, also die Mimik von Figuren, die in den Jahren um 1600 ein großes Thema in der bildenden Kunst, den kunsttheoretischen Traktaten und der Kirche im Zuge der Gegenreformation war. In der künstlerischen Darstellung dieser Jahre lag ein besonderes Gewicht auf einer an rhetorischen Modellen angelehnten Ausdrucks- und Gebärdensprache der Figuren.
Mit der Mimik, deren Darstellung eine enorme Bandbreite entwickelt, wurde zunehmend gespielt und gezielt manipuliert. Und zwar von Seiten der Kunst wie auch der Kirche. Die Arbeit untersucht sowohl die äußeren Umstände unter denen sich eine zunehmende Schematisierung der Gesichtsausdrücke der Figuren entwickelte und die als Formelhaftigkeit zu beschreiben ist, als auch, wie diese von Seiten der Künstler gehandhabt wurde. Erstaunlich war die Feststellung, dass diese „mimischen Formeln“, die man - besonders durch ihr häufiges Auftreten- mit einem bestimmten Kontext verband, nun immer wieder in ganz anderen Zusammenhängen auftauchten und somit einer Figur oder Geschichte einen neuen Sinn gaben. Oft übertrafen sie gar den gesamten übrigen ikonografischen Apparat an Aussagekraft.
Akrasia, or weak-will, is a term denoting a phenomenon when one acts freely and intentionally contrary to his or her better judgment. Discussion of akrasia originates in the Plato's Protagoras where he states that “No one who either knows or believes that there is another possible course of action, better than the one he is following, will ever continue on his present course”. However, in his influential article from 1970, Donald Davidson argued that akrasia is theoretically possible yet irrational. Some other critics of Plato's stance point out that phenomenon of akrasia is common in our everyday experience, therefore it must be possible.
These two arguments in favor of akrasia existence – theoretical and empirical – will be discussed from both – philosophical and psychological points of view. Especially, George Ainslie's argument that akrasia results from hyperbolic discounting will be taken into consideration to show how it affects traditional thinking about weak-willed actions.
Finally, the paper will discuss how the contemporary notion of akrasia may affect the idea of responsibility and free will. Implications for the philosophy of law will be shown, i.a. whether it is possible to claim that a given example of a weak-willed action was indeed free and intentional and one should be held responsible for its results.
Bollywood ist ein Massenphänomen. Schätzungsweise 12 bis 14 Millionen Menschen drängen sich täglich in indische Kinos, um ihre Stars auf der Leinwand zu bewundern. In den riesigen Sälen herrscht große Empathie zwischen den Zuschauern und ihren Filmidolen. Helden werden bejubelt und beklatscht, Bösewichte lauthals ausgebuht und mit Pfiffen geschmäht. Selbst kleine Opfergaben in Form von Früchten oder Münzen werden den Schauspielern dargeboten. Auch außerhalb des Kinos inspiriert Bollywood die indische Bevölkerung: in ihrer Art zu reden, ihrer Kleidung, ihrem Musikgeschmack aber auch ihrer politischen Gesinnung. Doch ist die Meinungsmacht der indischen Traumfabrik nur auf den Subkontinent beschränkt?
Mithilfe einer qualitativen Studie geht die vorliegende Arbeit dieser Frage nach und zeigt auf, welche Relevanz Bollywood bei der Identitätsbildung der 2. Generation der indischen Migranten in Deutschland besitzt. Anhand der Aussagen von 13 Probanden indischer Abstammung im Alter von 15 bis 38 Jahren wurde dabei eine Typologie verschiedener Identitätstypen entwickelt, die sich in unterschiedlichem Masse durch Bollywood beeinflussen lassen. So dient der Hindifilm Menschen, die in ihrem Selbstbild stark zu Indien tendieren, als Ressource um kulturelles Wissen über Indien zu sammeln, als Brücke in eine oft entfremdete Heimat sowie als Substitut für eine fehlende Sozia-lisation in Indien. Vertreter einer hybriden Identität, die sich zu gleichen Teilen als Inder und Deutsche verstehen, freuen sich über das wachsende Interesse der deutschen Mehrheitsbevölkerung an der indischen Kultur, was maßgeblich durch den Bollywoodhype Mitte der 2000er Jahre initiiert wurde. Das steigende Verständnis für indische Werte, aber auch die Adaption der indischen Kultur durch die Mehrheitsgesellschaft erleichtert es den ethnischen Hybriden für ihre Multikulturelle Identität akzeptiert zu werden. Dieselbe Entwicklung ist für Personen indischer Herkunft, die eine deutsche Identität etablieren wollen, oftmals ein zweifelhafter Segen. So werden sie von ihren Freunden und Bekannten mit Fragen zu oder auch Kritiken an Bollywood konfrontiert, was zu Ge-fühlen der Entfremdung bei den Befragten führen kann, zeigt es doch, dass ihr Gegenüber sie nicht als vollkommen deutsch wahrnimmt. Bollywood scheint also auch im 6759 Kilometer entfernten Deutschland noch eine gewisse Wirkung zu entfalten, ob diese von den Menschen gewollt ist oder nicht.
The increase in the volume of litigation verified since the 1990’s, having the Brazilian society as context, made the judiciary open itself to new technologies which facilitate the access to justice, as well as to a faster resolution of the demands. However, the intense insertion of technical rationalization in the process and decision operations by the judiciary, during the last years, led to a legalization supported by presuppositions of technical-instrumental regulation. According to the goal policy established by the CNJ, the annoyance of the instrumental rationality is present “with respect to purposes”, which demands, more and more, a mere fulfillment of previously instituted goals from the law operators. The matter is to know if the implementation of new technologies to solve the growing litigation coming from the complexity of societies is enough to adjust the Law to a post-conventional platform. If the social complexity implies resources coming from new technologies, it’s not certain that such technologies, on their own, satisfactorily answer a judicial model which, seen under the eyes of the post- conventional legitimacy and regulation, is adequate to complex societies. This illustrates that a judicial model, able to deal with the social plurality, must take into account not only the rules of instrumental rationality, but also the fundamental issues of communicative rationality. This current work intends to evaluate if the applicability of the instrumental rationality in the judiciary equally allows the law to extent the useful conditions of the communicative rationality to the consensual formation of will and opinion in the Democratic State of Law.
Donose se neke nove spoznaje o Lajpciškom lekcionaru, ćiriličnom rukopisu najvjerojatnije iz šestog ili sedmog desetljeća XVI. stoljeća. Ponajprije je riječ o rezultatima analize vodenih znakova, što je osobito važno jer je datacija rukopisa u literaturi bila prijeporna, a zatim i o novim podacima o knjižnici i signaturi rukopisa. Također se, u bliskoj vezi s analizom folijacije rukopisa, izlaže jedna važna tekstološka spoznaja koja pouzdano pokazuje da je predložak bio cjelovit, što indirektno osnažuje tezu da rukopisu na početku nedostaje devet listova, a ne, kako je tvrdio Joseph Schütz, samo jedan.
A preliminary study has been made for Borail Wild Life Sanctuary, Assam, India. A total of 25 species of liverwort (Marchantiophyta) and one species of hornwort (Anthocerotophyta) have been enumerated. Of these, Frullania berthoumieuii is new to India, Caudalejeunea reniloba new to North East India, 13 species new to Assam and 11 species are reported for the first time from Borail WLS. Folioceros paliformis is rediscovered after its type.
Es wird eine Verbindung zwischen dem von Antiphon entwickelten infinitesimalen Berechnungsverfahren, der Theorie Verteilungsgerechtigkeit von Aristoteles, des Hebelgesetzes, der eben radialen Figuren und der Verteilung hergestellt.
Die Problemstellung stellt sich wie folgt dar: dem Kennenlernen der Gründe, die Antiphon mutmaßen ließ, die Exhaustionsmethode als ein Mittel der Bildung des Quadratur des Kreises anzusehen, Beziehungen von grundsätzlicher und historischer Art zwischen der Verteilungsgerechtigkeit und den Hebelgesetz herzustellen, ein Model der Verteilungsgerechtigkeit, basierend auf der modernen Mathematik der Verteilung, von multipler Partizipierung zu konstruieren.
Die Zielsetzungen sind:
Die These zu erstellen, dass die Exhaustionsmethode aus der Gerichtspraxis stammt; dass das Hebelgesetz und die Theorie der Proportionen von Eudoxos Modelle der Verteilungsgerechtigkeit von Aristoteles sind; weiter soll gezeigt werden, dass die ebene Verteilung der materiellen Partikel auch ein Modell der Verteilungsgerechtigkeit ist.
Das Modell der Mehrteiligkeit der Verteilung, das vorgestellt wurde, enthält zwei Arten von Freiheitsgraden, einen für den Wert der zu verteilenden Güter an jeweils einen der Beteiligten und einen zweiter Freiheitsgrad für die verschieden Ebene zwischen den Beteiligten im Falle der Ungleichheit.
Keywords: Exhaustionsmethode, Hebelgesetz, Verteilungsgerechtigkeit, Verteilung.
This paper is aimed to re-elaborate questions and discuss them rather than presenting answers. It starts with the dialog concerning specific contributions of philosophy of language to Law, followed by the re-elaboration of some yet unanswered problems, as well as the discussion of possible paths for this issue.
"O crime do professor de Matemática", de Clarice Lispector, aborda a necessidade inconsciente de punição advinda do sentimento de culpa, que constitui elemento inexorável da psique humana. O espelhamento do homem em seu animal o conduz à aproximação de uma possível consciência deste transtorno, fato que culmina no irremissível abandono do cão. Com base nos ensaios "O estranho" e "O mal–estar na civilização", de Sigmund Freud, almeja–se entender a origem da dolente identificação entre estes dois personagens narrada no conto, bem como o corolário da cultura, responsável pela tristeza humana com a qual o professor irremediavelmente se coaduna.
Quando se acompanha o discurso filosófico acerca da sensibilidade artística, salta aos olhos que nele impera uma dupla tendência no que se refere aos recursos expressivos. Por um lado, nota-se que os meios de expressão acabam resistindo uns em relação aos outros; por outro, percebe-se que tal resistência também se revela bastante fraca, descerrando novas fronteiras e ocasionando ulteriores transições. Tendo isso em vista, o propósito geral do presente artigo consiste em pôr à prova a hipótese de que é no âmbito da música que a moderna ponderação estética descobre o sentido e o alcance do vínculo entre as artes, forjado, em geral, nos termos da auto-compreensão das vanguardas artísticas. Trata-se, em suma, de refazer os passos por meio dos quais a música terminou por se converter, no século XIX, num dos mais importantes veículos de ideias para, a partir do ponto de inflexão representado pela filosofia nietzschiana da maturidade, trazer à plena luz a concepção de "emaranhamento" [Verfransung] das artes, a qual ganha relevo, em especial, na derradeira etapa do itinerário intelectual de Th. W. Adorno.