Refine
Year of publication
Document Type
- Article (31483)
- Part of Periodical (11568)
- Book (8325)
- Doctoral Thesis (5736)
- Part of a Book (3969)
- Working Paper (3387)
- Review (2940)
- Contribution to a Periodical (2368)
- Preprint (2232)
- Report (1560)
Language
- German (42872)
- English (29725)
- French (1060)
- Portuguese (840)
- Spanish (309)
- Croatian (302)
- Multiple languages (263)
- Italian (198)
- mis (174)
- Turkish (168)
Has Fulltext
- yes (76235) (remove)
Keywords
- Deutsch (1076)
- Literatur (868)
- taxonomy (768)
- Deutschland (553)
- Rezension (511)
- new species (453)
- Rezeption (354)
- Frankfurt <Main> / Universität (341)
- Übersetzung (329)
- Geschichte (300)
Institute
- Medizin (7777)
- Präsidium (5215)
- Physik (4591)
- Extern (2738)
- Wirtschaftswissenschaften (2698)
- Gesellschaftswissenschaften (2374)
- Biowissenschaften (2198)
- Biochemie und Chemie (1978)
- Frankfurt Institute for Advanced Studies (FIAS) (1774)
- Center for Financial Studies (CFS) (1630)
Con la finalidad de responder positivamente a la pregunta planteada en el título de este trabajo, el autor presenta y cuestiona, en primer Jugar, el supuesto filosófico tradicional, por el que se hace depender al lenguaje unilateralmente de la intenciones moralmente relevantes de los individuos. Expone luego las estaciones del fracaso de los intentos de fundamentación moral sobre la base del solipsismo metódico de la filosofía moderna antes del giro pragmático-lingüístico. Y defiende finalmente la posición de la fundamentación pragmático-trascendental última frente a las interpretaciones relativistas del mencionado giro de la filosofía contemporánea.
En el relato periodístico retrospectivo de un partido de futbol –el de Chile contra México por la Copa América, el 30 de junio de 1999- se puede observar el uso de diversos elementos narratológicos que lo vuelven interesante. Los reportajes de distintos diarios chilenos contienen crónicas, historias y esquemas narrativos construidos a partir del antagonismo entre adversarios, el protagonismo de ciertos personajes y los puntos culminantes que ellos viven. Además, hay en los relatos una identificación con el punto de vista del equipo chileno. El resultado son construcciones variadas de una misma realidad, cuya elaboración explica, al menos en parte, el interés del público por acceder a ellas. Incluso cuando esos lectores han asistido al estadio o han conocido el encuentro por radio o televisión, buscan historias para entender mejor y mas completamente lo ocurrido.
¿Hacia dónde va Venezuela?
(2008)
Recién un amigo investigador, italiano radicado en Barcelona me visitó en Caracas. Después de unos diez días me comentó entusiasmado que nunca había visto en algún país del mundo tanta gente participar, discutir, manifestar, opinar e intentando aprender más que en Venezuela. Eso sin diferencia de clase, género o pertenencia étnica. "Nunca he visto la democracia tan viva como aquí", me dijo cuando se despidió. ...
Se estudia el rol que una Constitución Europea puede desempeñar en la integración de Europa. Luego de considerar las razones que motivaron la integración, el artículo sugiere que el interese económicos, que ha sido motivación poderosa, no será suficiente para asegurar un proyecto de verdadera unión política. Las emociones, más que los intereses, habrán de movilizar a los europeos; ellas unen a las personas para defender su modo de vida contra el tipo de sociedad que tienden a imponer los modelos económicos dominantes. Tres elementos son importantes para la integración: un Parlamento de Estrasburgo fuerte y público, una esfera pública europea, y una cultura política común.
Alzheimer’s Disease (AD) is the most common neurodegenerative disorder marked by progressive loss of memory and cognitive ability. The pathology of AD is characterised by the presence of amyloid plaques, intracellular neurofibrillary tangles and pronounced cell death. The aim of this thesis was to investigate pathways involved in the Aß cascade of neurodegeneration. Since novel findings indicate that already this Aß species exerts neurotoxic effects long before hyperphosphorylated tau, neurofibrillary tangles and extracellular Aß plaques appear, the investigations were accomplished with specific regard to the effects of intracellular Aß. The Swedish double mutation in the APP gene results in six- to eightfold increased Aß production of both Aß1-40 and Aß1-42 compared to human wildtype APP cells (APPwt). Data obtained from PC12 cells indicate that it is possible to specifically increase the Aß load without enhancing APP expression levels. On the basis of these findings, it seemed possible to investigate dose-dependent effects of Aß in multiple experimental designs. These assay designs were created in order to mimick different in-vivo situations that are discussed to occur in AD patients: APPsw PC12 cells exhibit low physiological concentrations of Aß within picomolar range in contrast to APPsw HEK cells, expressing Aß levels within the nanomolar range. Of note, the APPsw HEK cells showed a specific and highly significant increase in the intracellular accumulation of insoluble Aß1-42. Moreover, an intracellular accumulation of Aß and APP was found in the mitochondria of the HEK APPsw cells suggesting a direct impact on mitochondrial function on these cells. This effect might finally lead to disturbances in the energy metabolism of the cell or to increased cell death. Furthermore, baseline g- and ß-secretase activity was assessed since these enzymes represent promising therapeutic targets to slow or halt the disease process. As expected, ß-secretase activity was significantly elevated in all APPsw cell lines. This might be due to the proximity of the Swedish double mutation next to the N-terminus of the Aß sequence. Interestingly, g-secretase activity was similarly increased in PC12 APPsw cells. In addition, the toxicity of different Aß species was investigated in SY5Y and PC12 cells with regard to their effect on cellular viability mirrored by mitochondrial activity using MTT assay. Here, it turned out that not monomers, but already dimers are neurotoxic correlates. Fibrillar Aß species showed the highest toxicity. In the next step, SY5Y cells forming endogenous, dimeric APP and Aß were investigated. In accordance with previous findings, these cells showed a decreased MTT reduction potential in comparison to APPwt and control SY5Y cells reflecting a decrease of cellular viability. The impaired energy metabolism of the cells was even more drastically mirrored by reduced baseline ATP levels. In the second part of this thesis, the expression and intracellular distribution of Bcl-2 family proteins and pro-apoptotic mitochondrial factors under baseline conditions and during oxidative stress were analyzed in the APPwt and APPsw bearing cells. The most prominent finding was the reduction of expression levels of the anti-apoptotic factor Bcl-xL in the cytosolic fractions of APPwt and APPsw PC12 cells. This might indicate that a lack of anti-apoptotic factors or their altered intracellular distribution, rather than an increase in caspase-dependent pro-apoptotic factors, could be responsible for the increased vulnerability of APPwt- and APPsw-transfected PC12 cells against oxidative stress. Since total Bcl-xL expression was unaffected in PC12 cells, in contrast to APPwt and APPsw-expressing SY5Y and HEK cells revealing significantly decreased Bcl-xL expression levels. Thus, alterations in Bcl-xL distribution seem to be an early event in the disease process. Increasing Bcl-xL expression might potentially be one promising strategy for AD modification. PC12 and HEK cells bearing APPsw or APPwt were treated with the potent g-secretase inhibitor DAPT. Of note, DAPT did not only efficiently block Aß production, but additionally led to an elevation of the MTT reduction potential, reflecting an increase in cellular viability. As another disease-modifying strategy, several efforts are undertaken to ameliorate AD-relevant symptoms by the treatment with nerve growth factor (NGF). Generally, it is known that substituted pyrimidines have modest growth-promoting effects. Here, KP544, a novel substituted pyrimidine, was characterised. This drug increased MTT reduction potential in terminally differentiated and undifferentiated PC12 cells. Furthermore, treatment with KP544 led to a reduction in Aß1-40 secretion. Thus, one may conclude that the target of KP544, GSK-3ß, represents a connecting link between the two main pathological hallmarks of AD and might thus be a very promising therapeutic target for AD.
ß-Hydroxybutyrate (BHB) is a ketone body formed in high amounts during lipolysis and fasting. Ketone bodies and the ketogenic diet were suggested as neuroprotective agents in neurodegenerative disease. In the present work, we induced transient ischemia in mouse brain by unilaterally occluding the middle cerebral artery for 90 min. BHB (30 mg/kg), given immediately after reperfusion, significantly improved the neurological score determined after 24 h. In isolated mitochondria from mouse brain, oxygen consumption by the complexes I, II and IV was reduced immediately after ischemia but recovered slowly over 1 week. The single acute BHB administration after reperfusion improved complex I and II activity after 24 h while no significant effects were seen at later time points. After 24 h, plasma and brain BHB concentrations were strongly increased while mitochondrial intermediates (citrate, succinate) were unchanged in brain tissue. Our data suggest that a single administration of BHB may improve mitochondrial respiration for 1–2 days but not for later time points. Endogenous BHB formation seems to complement the effects of exogenous BHB administration.
The poem "Zurich, zum Storchen" by Paul Celan is often read as a document on the tension between Celan and Nelly Sachs, which resulted particularly from their different attitudes to the Shoah. However if the poem is read in connection with the cycle "Die Niemandsrose" and with Celan’s poetological thinking at this time, Celan’s opposite standpoint means much more than a theological discussion: it serves for the affirmation of human presence.
Este artigo procura resumir e ilustrar argumentações centrais de estudos teóricos e ensaios sobre a literatura austríaca (Menasse; Schmidt-Dengler; Sebald, Weiss, Zeyringer) que se referem, especificamente, à questão da existência de diferenças entre essa literatura e outras em língua alemã. Para elucidar os debates mais recentes, os contrastamos com argumentações representativas acerca da literatura austríaca das primeiras décadas do pósguerra. Ao comparar as diferentes abordagens, podemos perceber que a germanística austríaca atual deixou de se esforçar na construção de um "mito austríaco" e na procura do que seria a "essência" da literatura desse país. Passou da construção à análise do mito austríaco e do contexto sócio-histórico no qual se insere a produção literária da Áustria. Há diferenças argumentativas substanciais entre abordagens tradicionais com viés essencialista e as dos referidos teóricos. Ao mesmo tempo, é significativa a insistência por parte de germanistas e pensadores contemporâneos em se aceitar a existência (muitas vezes ignorada) de uma literature austríaca cuja especificidade – resultante, sobretudo, de peculiaridades dos contextos históricopolíticos nos quais se inserem os escritores austríacos – não deve ser ignorada em pesquisas da área.
Il existe sans doute peu d’histoire des relations entre deux aires culturelles qui suscite autant d’attention à l’heure actuelle que celle des relations entre « l’Occident » et le « monde musulman ». Elle montre particulièrement bien combien la période que nous qualifions communément de « Moyen Âge » influence les débats actuels. Certains phénomènes de cette histoire sont aujourd’hui si fortement enracinés dans l’imaginaire collectif qu’ils continuent à façonner de manière significative la représentation même de ces relations. C’est le cas en particulier de l’expansion arabo-musulmane, des croisades et de ce que l’on appelle la « Reconquista » : ces phénomènes n’évoquent pas seulement des images de fanatiques religieux, mais ils sont – les croisades notamment – ancrés si profondément dans notre pensée conceptuelle qu’ils sont considérés comme l’expression d’un antagonisme quasi épique entre deux civilisations, au fondement desquelles se trouvent une variante de monothéisme (chrétienté / islam) et une langue sur laquelle repose la vie intellectuelle (latin / arabe). ...
Les données de l’effet d’affaiblissement de l’obviation (ou encore référence disjointe du subjonctif) dans la littérature linguistique sont soit fondées sur l’intuition des auteurs soit issues de publications d’autres chercheurs, bien que cet effet soit connu depuis longtemps et bien qu’il fasse partie de plusieurs modélisations théoriques. En conséquence, aucune réponse de nature empirique/expérimentale a été offerte à la question « A quel point les affirmations portant sur l'effet d'affaiblissement de l'obviation sont-elles solides ? ». Cet article se fixe en conséquence un double objectif : (i) mettre en oeuvre un jugement de grammaticalité afin de répondre expérimentalement à la question précédente, et (ii) proposer une analyse syntaxique provisoire des résultats obtenus. Ici, nous étudions six facteurs qui – selon Ruwet (1984/1991) – déclenchent l’affaiblissement. Les résultats montrent que seul un facteur (la coordination) déclenche l’affaiblissement. En conséquence, l’appareil théorique permettant de modéliser l’affaiblissement peut être réduit radicalement, et nous proposons des pistes de modélisation syntaxique n’intégrant que le facteur de coordination
Cette communication s’est voulu un essai d’analyse toponymique pas forcément destinée à des linguistes. Elle indique tout de même la nécessité de recourir à la linguistique dans le cas où plusieurs versions étiologiques sont soumises à propos d’un toponyme donné. Que le résultat de l’analyse linguistique aboutisse au caractère plausible ou non plausible de l’étiologie, ce volet est complété par le recours à d’autres domaines de connaissances. C’est cette association qui permet de parler d’analyse toponymique. Même si les résultats obtenus ne sont pas forcément définitifs, ils permettent au moins d’éviter des choix arbitraires. Dans le cas de sia par example, la voie est ouverte vers une autre direction où il faudra refaire une autre analyse complète.
Àgbéyèwò Bíbelì Ìròyìn Ayò
(2007)
History of the bible in Yoruba
Na prática do ensino de Alemão como Língua Estrangeira (ALE), os conteúdos de 'Landeskunde' são abordados cada vez mais sob a perspectiva de que culturas heterogêneas permeiam os diferentes países de idioma alemão. Questionando-nos acerca da representatividade, em materiais didáticos, de países cujo idioma oficial é alemão, dedicamo-nos ao levantamento e à análise de dados sobre os aspectos culturais da Áustria presentes no livro didático "DaF Kompakt neu" (2016), material utilizado em boa parte dos cursos de graduação para formação de professores de alemão no Brasil. Os dados coletados foram categorizados e, então, analisados, de forma que pudéssemos averiguar a inclusão de informações implícitas e explícitas sobre a Áustria e seu potencial para incentivar discusses em sala de aula. Destacamos na exposição dos resultados que o material selecionado apresenta menções profícuas e, mais ainda, que a quantidade e complexidade dessas aumentariam conforme o avanço dos níveis de línguas ensinados. Concluímos ressaltando que, apesar da representatividade do material didático, outros elementos como preparo e disposição do professor, além de materiais suplementares, seriam indispensáveis para a presentificação do 'DACH-Prinzip' no ensino de ALE.
The article argues that within the genre of the Arthurian romance the tales about King Arthur’s vow to fast, show a possibility to conceptualize the status of ‘text’, a possibility which has historically become unfamiliar. Under these circumstances the act of telling and the content of what is told differ, if at all, slightly and this seems to be an explanation for the fact that the medieval language provided only one word for the tale and its plot: âventiure.
Die Knochenansammlung im grauen vulkanischen Tuff der Südserengeti gibt als ökologisch unmögliches
Gemisch ein gutes Abbild des Gesamtbestandes und des Lebensraumes der altquartärcn ost- und innerafrikanischen Fauna. Diese lebte formenreich in Urwald, Savanne und offener Steppe. Das Fehlen wasserlebender Tiere ist hier auf örtliche Umstände zurückzuführen: die vulkanischen Aschen gingen auf Steppenboden nieder, Die benachbarten, ungefähr gleichalten Knochenlager enthalten solche Tiere. Neu ist an der Serengetifauna der bereits beträchtliche Anteil von Kleinsäugern (Nager; Insektivoren fehlen noch). Diese wird weitere Forschung vermehren. Die klimatische Entsprechung der Fauna wird in tropischen, feuchtwarmen Bedingungen erblickt. Obwohl viele tertiäre Formen enthaltend, wird die Fauna nicht als jungtertiär angesehen, sondern wegen des Auftretens moderner· Formen als eine Tiergesellschaft, welche das Quartär eröffnet. Als Leitfossil für dessen Beginn wird der Gattung Archidiskodon, aus welcher die echten Elefanten, darunter auch der afrikanische (Loxodonta africana ) entstanden sind, vor den Equiden der Vorzug gegeben.
Ostafrika, das ja als Tierparadies schlechthin gilt, lebte bis vor kurzem noch im Quartär. Das Schrifttum über seine Tierwelt scheint zwar fast unermeßlich groß, aufs Ganze gesehen ist das Wissen weder tief noch auch nur oberflächlich vollständig. Die Hauptleistung des "weißen Mannes" bestand in der Störung und Vernichtung der Fauna. Aber die Natur ist groß; sie hält noch einen Schatz im Inneren ihrer Gebirge bereit, damit der Mensch seine Stellung zu ihr und den Sinn seines Lebens ergründe, einen von vielen: dle quartäre Lebewelt selbst. Möge die hohe Aufgabe, ihn zu heben, uns Deutschen vergönnt sein! Eine Probe hat Dr. KOHL-LARSEN gesichert.