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Die Berichterstattung über den Nahostkonflikt gehört seit Jahrzehnten zum Standardrepertoire der Nachrichten. Hierzulande hat fast jeder eine Meinung zum israelisch-arabischen Konflikt, doch wenige verstehen, um was es den Konfliktparteien eigentlich geht, was in bisherigen Verhandlungen erreicht worden ist und wo genau die Hürden für eine Konfliktregelung liegen. Dieses Buch liefert eine kompakte und zugleich anschauliche und detaillierte Analyse des Konflikts zwischen Israel und seinen arabischen Nachbarn. Dabei stehen die lokalen und regionalen Akteure im Mittelpunkt. Um die Konfliktdynamiken zu erklären, geht das Buch vor allem auf die konkurrierenden Interessen und Narrative der Konfliktparteien sowie ihre Wechselwirkungen ein.
Background: Histone lysine demethylases (KDMs) are of interest as drug targets due to their regulatory roles in chromatin organization and their tight associations with diseases including cancer and mental disorders. The first KDM inhibitors for KDM1 have entered clinical trials, and efforts are ongoing to develop potent, selective and cell-active ‘probe’ molecules for this target class. Robust cellular assays to assess the specific engagement of KDM inhibitors in cells as well as their cellular selectivity are a prerequisite for the development of high-quality inhibitors. Here we describe the use of a high-content cellular immunofluorescence assay as a method for demonstrating target engagement in cells.
Results: A panel of assays for the Jumonji C subfamily of KDMs was developed to encompass all major branches of the JmjC phylogenetic tree. These assays compare compound activity against wild-type KDM proteins to a catalytically inactive version of the KDM, in which residues involved in the active-site iron coordination are mutated to inactivate the enzyme activity. These mutants are critical for assessing the specific effect of KDM inhibitors and for revealing indirect effects on histone methylation status. The reported assays make use of ectopically expressed demethylases, and we demonstrate their use to profile several recently identified classes of KDM inhibitors and their structurally matched inactive controls. The generated data correlate well with assay results assessing endogenous KDM inhibition and confirm the selectivity observed in biochemical assays with isolated enzymes. We find that both cellular permeability and competition with 2-oxoglutarate affect the translation of biochemical activity to cellular inhibition.
Conclusions: High-content-based immunofluorescence assays have been established for eight KDM members of the 2-oxoglutarate-dependent oxygenases covering all major branches of the JmjC-KDM phylogenetic tree. The usage of both full-length, wild-type and catalytically inactive mutant ectopically expressed protein, as well as structure-matched inactive control compounds, allowed for detection of nonspecific effects causing changes in histone methylation as a result of compound toxicity. The developed assays offer a histone lysine demethylase family-wide tool for assessing KDM inhibitors for cell activity and on-target efficacy. In addition, the presented data may inform further studies to assess the cell-based activity of histone lysine methylation inhibitors.
The amyloid precursor protein (APP) was discovered in the 1980s as the precursor protein of the amyloid A4 peptide. The amyloid A4 peptide, also known as A-beta (Aβ), is the main constituent of senile plaques implicated in Alzheimer’s disease (AD). In association with the amyloid deposits, increasing impairments in learning and memory as well as the degeneration of neurons especially in the hippocampus formation are hallmarks of the pathogenesis of AD. Within the last decades much effort has been expended into understanding the pathogenesis of AD. However, little is known about the physiological role of APP within the central nervous system (CNS). Allocating APP to the proteome of the highly dynamic presynaptic active zone (PAZ) identified APP as a novel player within this neuronal communication and signaling network. The analysis of the hippocampal PAZ proteome derived from APP-mutant mice demonstrates that APP is tightly embedded in the underlying protein network. Strikingly, APP deletion accounts for major dysregulation within the PAZ proteome network. Ca2+-homeostasis, neurotransmitter release and mitochondrial function are affected and resemble the outcome during the pathogenesis of AD. The observed changes in protein abundance that occur in the absence of APP as well as in AD suggest that APP is a structural and functional regulator within the hippocampal PAZ proteome. Within this review article, we intend to introduce APP as an important player within the hippocampal PAZ proteome and to outline the impact of APP deletion on individual PAZ proteome subcommunities.
We compare the cost effectiveness of two pronatalist policies:
(a) child allowances; and
(b) daycare subsidies.
We pay special attention to estimating how intended fertility (fertility before children are born) responds to these policies. We use two evaluation tools:
(i) a dynamic model on fertility, labor supply, outsourced childcare time, parental time, asset accumulation and consumption; and
(ii) randomized vignette-survey policy experiments.
We implement both tools in the United States and Germany, finding consistent evidence that daycare subsidies are more cost effective. Nevertheless, the required public expenditure to increase fertility to the replacement level might be viewed as prohibitively high.
We extend the classical ”martingale-plus-noise” model for high-frequency prices by an error correction mechanism originating from prevailing mispricing. The speed of price reversal is a natural measure for informational efficiency. The strength of the price reversal relative to the signal-to-noise ratio determines the signs of the return serial correlation and the bias in standard realized variance estimates. We derive the model’s properties and locally estimate it based on mid-quote returns of the NASDAQ 100 constituents. There is evidence of mildly persistent local regimes of positive and negative serial correlation, arising from lagged feedback effects and sluggish price adjustments. The model performance is decidedly superior to existing stylized microstructure models. Finally, we document intraday periodicities in the speed of price reversion and noise-to-signal ratios.
Fit to play : posture and seating position analysis with professional musicians - a study protocol
(2017)
Background: Musical performance-associated musculoskeletal disorders (MSD) are a common health problem among professional musicians. Considering the manifold consequences arising for the musicians, they can be seen as a threat for their professional activity. String players are the most affected group of musicians in this matter. Faults in upper body posture while playing the instrument, causing un-ergonomic static strain on the back and unergonomic limp-movements, are a main reason for musculoskeletal disorders and pain syndromes.
Methods: A total of 66 professional musicians, divided into three groups, are measured.
The division is performed by average duration of performance, intensity of daily exercise and professional experience. Video raster stereography, a three-dimensional analysis of the body posture, is used to analyse the instrument-specific posture. Furthermore the pressure distribution during seating is analysed. Measurements are performed because the musician is sitting on varying music chairs differing in structure and/or construction of the seating surface. The measurements take place in habitual seating position as well as during playing the instrument.
Results: To analyse the influence of different chairs, ANOVA for repeated measurements or Friedman-test is used, depending on normality assumptions. Comparison of posture between amateur musicians, students, and professional orchestral musicians is carried out the non-parametric Jonckheere-Terpstra-test.
Conclusions: Our method attempts to give the musicians indications for the right music chair choice by analyzing the chair concepts, so that thereby preemptively MSD can be reduced or prevented.
The critical debates of liberal peace are grounded in a "paradox of liberalism" (Sabaratnam 2013): Western liberalism is criticized as oppressive, colonial and bellicose, but also implicitly relied on as the source of emancipation. This has not rejected in a rejection of liberal interventionism, but rather in demands for more cultural sensitivity, more local participation or an efficient control to save the idea of liberal peace...
Die Wahlen über den Verbleib Großbritanniens in der EU haben die europäische Ordnung erschüttert. Der Vortrag/Die Präsentation soll nicht nur die Hintergründe beleuchten, sondern auch zeigen, welche Chancen die neue Situation eröffnet, Chancen, die es vorher so nicht gegeben hat...
Three basic elements should be part of researching in contexts where power asymmetries and colonial connotations are relevant (which applies to many, if not the majority of research contexts in conflict studies): a thorough reflexivity of the researcher’s own role and social conditioning, the construction of research as a political act as it intervenes in scientific and political discourse, and the fact that (especially empirical) research is a product of many (Kaltmeier 2012, Abu Lughod 1991)...
In my paper I claim that methodology inspired by postcolonial theory not only unearths how Western international institutions perpetuate hegemonic truth claims, but that at the same time engaging in a “learning to learn from below” might sense irritations within these truth claims which can open up spaces to think beyond truth in a sense of a justice to come. (Derrida 2002) Since the (mis)understanding of knowledge production as truth finding is constitutive of both, the scientific and the legal discourse, the engagement in such research accordingly has the potential to unfold a twofold deconstructive force...
"European" interventions
(2017)
While conflicts can be managed and resolved to the extent of peace keeping, evolving to state of peace and peace society is a far larger and challenging experience. The armed forces by definition and global practice are nurtured and trained to violence. However, it takes a lot more time and enough maturity and strength for a non-violent struggle...
Far-right parties gained considerable support in many European countries in recent years. Austria comes within a whisker of becoming the first country in the history of the European Union to elect a far-right president, Horbert Hofer, the candidate from the Freedom Party. Similarly, in France, Marie Le Pen is expected to be Front National’s (FN) candidate in the 2017 presidential election and probably to make it to the second round of voting...
Security, arms control, disarmament and confidence building measures in the Baltic sea region
(2017)
Taking into consideration the stalemete of all disarmament negotiations as well as the worsening situation in the Baltic Sea region, I would like to present another paper as well, discussing the security trends in the Baltic Sea region and the potential of confidence building measures in this region as well as to discuss in this context the prospects of arms control and disarmament in general as well as specifically in Europeparticularly in the Baltic Sea region...
Conflict and insecurity have largely been the major driving factors behind the current wave of population influx in Europe. It is desirable that to understand the current migrant crisis in Europe, it is essential to understand the nature of the on-going conflict and existing insecurities in the home states from where the migrants are coming...
When Donald Trump arrived to power, many experts were concerned regarding his ideas on U.S. nuclear weapons. Particular attention was paid to his tweet about strengthening the U.S. nuclear arsenal after 25 years of the consistent WMD-disarmament under "The Cooperative Threat Reduction Program" (aka "Nunn-Lugar Program" an array of START treaties). In that preiod, U.S. and Russia removed more than 8,000 warheads and elements of the nuclear triad – submarines, ICBMs and long-range bombers. Now, experts worry that Trump’s aspirations will bury the U.S.-Russian nuclear cooperation aimed at global security...
Rethinking concepts of peace
(2017)
Motivated by a structural blind spot of Peace Studies regarding the (manifoldness of) definitions of its central concept "peace", I argue that this blind spot is especially manifested in the Eurocentric view on peace. My claim: Non-"Western" concepts of peace should be considered more in Peace Studies...
The overall aim of my work is to contribute to a future theory of epistemic violence – thereby enabling us to gain a better understanding of the various forms of direct, physical violence which are usually analysed within peace studies, IR, political theory and related fields. My perspective starts from transdisciplinary peace studies, is concerned with the sociology of knowledge, and informed by post- and de-colonial theory as well as by feminist critique and political theory...
For feminists, reflexivity has always meant more than a methodological tool...
AFK-EUPRA – 13 : feminist interventionism, postcolonial critique and non-western feminist approaches
(2017)
The study I would like to present concerns ethnically mixed borderland communities caught in a trap of competing national narratives spread from the surrounding states. I conduct an ethnographic research on a rare contemporary case of peaceful co-living of Armenian and Azerbaijani communities, which takes place in rural areas of Georgia’s southern borderland...
The concept of the "comprehensive approach" has become a paradigm for international state engagement in the field of fostering sustainable peace in crisis-ridden countries. This approach stipulates joint actions of different governmental institutions. The ministry of defence, providing interventionist armed forces; the ministry of interior, providing police personal; the ministry of foreign affairs, providing crisis aid and the ministry of economic cooperation and development define the core actors on the highest level, whilst the implementation of this approach is left to the various, highly heterogeneous employees of the ministries and their sub-contractors...
Armed resistance by interest groups against governments, their policies and symbols has a long history all across the world. During the currency of resistance movement, given the checkered stake holder ship in the conflict, weapon supply to funding of the myriad resistance groups has been a regular modus operandi to generate resistance movement funding...
Women’s protection has been largely discussed in conflict and gender scholarship and promoted as a key priority for governments, NGOs and international community. However, when critically analysed, the meaning of protection in conflict settings and the understanding of who should provide protection in emergencies, conflict and complex humanitarian crisis remain ambiguous. In long-term conflict settings for example, it is unclear whose role it is to protect civilians...
The paper introduces the socio-anthropological concept of international representations to examine the relationship between a civilizational rhetoric, the West European and the international politics of otherization and containment of Southeast Europe, and an essentialist and timeless bias in international relations theory, including both radical and constructivist trends...
Much of today’s conflicts and challenges, globally and locally, can be in part attributed to or are influenced by the hegemony of Western over non-Western cultures and politics. Long-standing and still reproduced Western dominance and power are directed at the protection of own interests, thereby re-creating power imbalances, inequalities and practices of exclusion...
Consensus modality : accommodating parties and containing overt violence in Nepal’s peace process
(2017)
Throughout this decade, most of the literatures in social sciences on Nepal contain Maoist Armed Conflict (1996-2006) in its introduction part. The country is in constant political turmoil even after the Comprehensive Peace Accord of 2006 between Government of Nepal and then rebel force. Since the peace agreement, Nepalese society has observed diverse socio-political tensions in different forms and become fragile society. Nepal is exerting a growing concern on international politics because of the complication in the peace process of ensuring sustainable peace, stability and economic progress. The implications for peace, stability and economic development in fragile countries present a challenge to the international community (In Grävingholt et al, 2013). Political culture and social structure are empirically related to political stability (Lijphart, 1969: 208). So we cannot separate our social and cultural context with the idea of stability...
Regional actors like the European Union (EU) and the African Union (AU) are increasingly seeking to conceptualize their transitional justice engagements through policy frameworks and carve out spaces for themselves in transitional justice processes. While the EU adopted its Policy Framework on Support to Transitional Justice in November 2015, the AU is still in the process of developing its African Transitional Justice Framework. It is the starting assumption of this paper that the policy discourses inevitably have an effect on the understanding, scope and institutionalization of transitional justice that these two regional bodies will support – the EU mostly as a development strategy outside and the AU within its borders...
International mediation has traditionally been understood as an instrument aimed at getting political representatives to agree on a negotiated settlement. However, in cases where referendums were required for ratification, peace agreements have been rejected bythe people. This paper uncovers how mediators can help political leaders reach agreementsthat are supported by the people they represent by comparing the Annan Plan and Good Friday Agreement (GFA) mediations and referendums in Cyprus and Northern Ireland, respectively...
Who is Ângkar? The nature of authority and responsibility under the Khmer Rouge Forme cadres of the Khmer Rouge today still speak of Ângkar, the organisation of the Khmer Rouge, with the utmost respect and subservience. Unlike in other genocidal regimes in which state actors played an important role, such as the NSDAP and SS in the Holocaust or Ittihad in the Ottoman genocide of the Armenians, Ângkar cannot be reduced merely to the name of the party organisation of the Khmer Rouge. Although Ângkar is a concept known to all in Cambodia and remains synonymous with absolute authority and the necessity for unwavering obedience, there is a broad variety of perspectives when trying to state who or what Ângkar actually is...
When is a crisis a crisis?
(2017)
The refugee and migration crisis has contributed to promote and consolidate new practices. The NGOs’ SAR Operations represent a new aspect of the humanitarian new normal phenomenon which is here analysed to deepen the existing knowledge about the response of the state, the citizens and the organised civil society to the crisis. The paper, which is based on an expert survey research conducted by researchers of the University of Catania, contends that Europeans overwhelmingly perceive irregular migrants as a threat...
In the past years a variety of papers have been presented by the European Commission and by the EU High Representative, outlining strategies of the EU in foreign-, security- and refugee policies. Many of these strategic documents reflect the ambivalence of the EU Policy. On the one hand the complementarity and coherence of approaches is emphasized; on the other hand, core elements of the foreign-, security- and refugee policy undermine aims in other policy fields...
Threat perceptions is a popular topic among scholars of international relations, yet the focus is oftentimes how two states perceive and misperceive threats (Robert Jervis, David Singer among others). Threats are generally understood as potential harm directed against the territorial integrity or the political regime of the states in question or both. Wandering on the borders of the mainstream realist theory and the rational choice theory – popular since when behavioralism entered into IR literature in the 1960s – and the constructivism of the reflectivist era (Wendt), the topic has been made a subject of study through such several different conceptual lenses but mostly on an international/state level of analysis a la Waltz...
The paper will outline a research project – its goals and methods – that focuses on what 1) makes humans flee from their home, land and country, at the risk of losing their lives, 2) seek refuge in another place, 3) what individual assessments they made before, during and after flight, and 4) how they assess the question of return to their countries/places of origin when the original causes of their flight – e.g. civil unrest, civil strife or civil war – are not any more directly present in the country or place from which they fled...
Exodus Eritrea
(2017)
The post-liberal debate on peacebuilding and reconciliation seems to have advanced. We observe efforts “bringing the local back in” (Debiel/Rink 2016) by enhancing local ownership, relational sensitivity, contextualization, culturalization, hybridity and last but not least resilience. Concepts furthermore try to integrate transnational dynamics, international power shifts and trends of regionalization. However, many questions remain: for scholars, for practitioners and last but not least for the local population...
How do coalition governments affect the risk of civil war onset in ethnically divided societies? Existing research argues that power-sharing coalitions decrease the risk of civil war because they redress grievances. Building on a formal model of coalition formation, we predict that ethnic elites are most likely to form oversized rather than minimum-winning coalitions in anticipation of future challenges to the regime. Put differently, we expect most power-sharing to occur where the risk of regime-threatening civil war is highest...
This year’s conference of the AFK (German Association for Peace and Conflict Studies) and the European Peace Research Association (EuPRA) is on "Peace and Conflict Studies from the Margins to the Centre; Rethinking Europe in an Unequal World" (16 – 18 March 2017 in Schwerte (nearby Dortmund), Germany).
The virtual realm of the internet is often seen as an egalitarian world where differences such as those between young and established researchers do not seem so significant. While we do not fully agree with this thesis, we want to use this blog to make a model attempt at providing a platform in which those participating in the conference and others can enter discussion with young students, established researchers, and peace activists.
To make this possible, we started a project in cooperation with the Bretterblog – a young team of researchers who established this blog some years ago. Here we will discuss the topics of the conference and will inform a broader audience about the newest results in peace and conflict research from different countries.
Eosinophilic cholangitis is a potentially underdiagnosed etiology in indeterminate biliary stricture
(2017)
AIM: To investigate presence and extent of eosinophilic cholangitis (EC) as well as IgG4-related disease in patients with indeterminate biliary stricture (IBS).
METHODS: All patients with diagnosis of sclerosing cholangitis (SC) and histopathological samples such as biopsies or surgical specimens at University Hospital Frankfurt from 2005-2015 were included. Histopathological diagnoses as well as further clinical course were reviewed. Tissue samples of patients without definite diagnosis after complete diagnostic work-up were reviewed regarding presence of eosinophilic infiltration and IgG4 positive plasma cells. Eosinophilic infiltration was as well assessed in a control group of liver transplant donors and patients with primary sclerosing cholangitis.
RESULTS: one hundred and thirty-five patients with SC were included. In 10/135 (13.5%) patients, no potential cause of IBS could be identified after complete diagnostic work-up and further clinical course. After histopathological review, a post-hoc diagnosis of EC was established in three patients resulting in a prevalence of 2.2% (3/135) of all patients with SC as well as 30% (3/10) of patients, where no cause of IBS was identified. 2/3 patients with post-hoc diagnosis of EC underwent surgical resection with suspicion for malignancy. Diagnosis of IgG4-related cholangitis was observed in 7/135 patients (5.1%), whereas 3 cases were discovered in post-hoc analysis. 6/7 cases with IgG4-related cholangitis (85.7%) presented with eosinophilic infiltration in addition to IgG4 positive plasma cells. There was no patient with eosinophilic infiltration in the control group of liver transplant donors (n = 27) and patients with primary sclerosing cholangitis (n = 14).
CONCLUSION: EC is an underdiagnosed benign etiology of SC and IBS, which has to be considered in differential diagnosis of IBS.
Very few people doubt that it is a fundamental demand of justice that members of legal-political normative orders ought to have legal rights that define their basic standing as subjects of such an order. But when it comes to the concrete understanding of such rights, debates abound. What is the nature of these rights – are they an expression of the sovereign will of individuals, or are they based on important human interests? How should these rights be justified – do they have a particular moral ground, and if so, only one or many?