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Numbers and space are two semantic primitives that interact with each other. Both recruit brain regions along the dorsal pathway, notably parietal cortex. This makes parietal cortex a candidate for the origin of numerical–spatial interaction. The underlying cognitive architecture of the interaction is still under scrutiny. Two classes of explanations can be distinguished. The early interaction approach assumes that numerical and spatial information are integrated into a single representation at a semantic level. A second approach postulates independent semantic representations. Only at the stage of response selection and preparation these two streams interact. In this study we used a numerical landmark task to identify the locus of the interaction between numbers and space. While lying in an MR scanner participants decided on the smaller of two numerical intervals in a visually presented number triplet. The spatial position of the middle number was varied; hence spatial intervals were congruent or incongruent with the numerical intervals. Responses in incongruent trials were slower and less accurate than in congruent trials. By combining across-vertex correlations (micro pattern) with a cluster analysis (macro pattern) we identified large-scale networks that were devoted to number processing, eye movements, and sensory–motor functions. Using support vector classification in different regions of interest along the intraparietal sulcus, the frontal eye fields, and supplementary motor area we were able to distinguish between congruent and incongruent trials in each of the networks. We suggest that the identified networks participate in the integration of numerical and spatial information and that the exclusive assumption of either an early or a late interaction between numerical and spatial information does not do justice to the complex interaction between both dimensions.
Sphingosine kinases (SK) catalyze the phosphorylation of proapoptotic sphingosine to the prosurvival factor sphingosine 1-phosphate (S1P), thereby promoting oncogenic processes. Breast (MDA-MB-231), lung (NCI-H358), and colon (HCT 116) carcinoma cells were transduced with shRNA to downregulate SK-1 expression or treated with a pharmacologic SK-1 inhibitor. The effects of SK-1 targeting were investigated by measuring the level of intracellular sphingosine, the activity of protein kinase C (PKC) and cell cycle regulators, and the mitotic index. Functional assays included measurement of cell proliferation, colony formation, apoptosis, and cell cycle analysis. Downregulation of SK-1 or its pharmacologic inhibition increased intracellular sphingosine and decreased PKC activity as shown by reduced phosphorylation of PKC substrates. In MDA-MB-231 cells this effect was most pronounced and reduced cell proliferation and colony formation, which could be mimicked using exogenous sphingosine or the PKC inhibitor RO 31-8220. SK-1 downregulation in MDA-MB-231 cells increased the number of cells with 4N and 8N DNA content, and similar effects were observed upon treatment with sphingosine or inhibitors of SK-1 or PKC. Examination of cell cycle regulators unveiled decreased cdc2 activity and expression of Chk1, which may compromise spindle checkpoint function and cytokinesis. Indeed, SK-1 kd cells entered mitosis but failed to divide, and in the presence of taxol also failed to sustain mitotic arrest, resulting in further increased endoreduplication and apoptosis. Our findings delineate an intriguing link between SK-1, PKC and components of the cell cycle machinery, which underlines the significance of SK-1 as a target for cancer therapy.
The experiments presented in my thesis were performed to resolve the following major questions: i. Initial experiments are based on the systematic characterization of the C-terminal domains of all 21 HSFs of Arabidopsis with respect to their transactivation potential as well as intracellular localization. This led to the identification of a signature motif for class A HSFs, that consists of an AHA motif (essential for activator potential), and a C-treminal NES (nuclear export signal). With this signature motif, we could identify homologues sequences of more than 90 HSFs in various plant species. ii. Analysis of developmental expression profiles of HSFs using AtGenExpress microarray data led to the identification of the unique expression of HsfA9 during late seed developmental stages. This was the starting point for the investigation of the regulation of HsfA9 as well as its function during seed development. iii. The seed specific transcription factor ABI3 was identified to be responsible for the regulation of HsfA9 by using knock out mutant lines and ectopically expressing transgenic lines for ABI3 gene. Furthermore, the importance of a RY/Sph motif, as binding site for ABI3 on HsfA9 promoter has been analyzed with transient GUS reporter assays. In addition, contribution of component(s) of ABA (abscisic acid) signaling cascade as a functional interacting partner of ABI3 on HsfA9 promoter has been shown and discussed. iv. The essential role of HsfA9 as master regulator for the expression of seed specific members of of HSP encoding genes and GolS1 was shown by analyzing transgenic plants ectopically expressing HsfA9 as well as, by carrying out transient GUS reporter assays. Correlating with this, transgenic plants with ectopic expression of HsfA9 showed a thermotolerent phenotype. Furthermore, a model where HsfA9 plays a key function for the regulation of seed expressed genes which might involved in providing dessication tolerance during seed maturation has been proposed.
The recently published experimental dependence of the J/psi suppression pattern in Pb+Pb collisions at the CERN SPS on the energy of zero degree calorimeter EZDC are analyzed. It is found that the data obtained within the minimum bias analysis (using theoretical Drell-Yan ) are at variance with the previously published experimental dependence of the same quantity on the transversal energy of neutral hadrons ET . The discrepancy is related to the moderate centrality region: 100 << Np << 200 (Np is the number of nucleon participants). This could result from systematic experimental errors in the minimum bias sample. A possible source of the errors may be contamination of the minimum bias sample by o -target interactions. The data obtained within the standard analysis (using measured Drell-Yan multiplicity) are found to be much less sensitive to the contamination.
The study of hidden charm production is an important part of the heavy ion program. The standard approach to this problem [1] assumes that c¯c bound states are created only at the initial stage of the reaction and then partially destroyed at later stages due to interactions with the medium [2, 3, 4].
Production of J/ψ mesons in heavy ion collisions is considered within the statistical coalescence model. The model is in agreement with the experimental data of the NA50 Collaboration for Pb+Pb collisions at 158 AGeV in a wide centrality range, including the so-called “anomalous” suppression domain. The model description of the J/ψ data requires, however, strong enhancement of the open charm production in central Pb+Pb collisions. This model prediction may be checked in the future SPS runs.
The quantum mechanical formula for Mayer s second cluster integral for the gas of relativistic particles with hard-core interaction is derived. The proper pion volume calculated with quantum mechanical formula is found to be an order of magnitude larger than its classical evaluation. The second cluster integral for the pion gas is calculated in quantum mechanical approach with account for both attractive and hard-core repulsive interactions. It is shown that, in the second cluster approximation, the repulsive -interactions as well as the finite width of resonances give important but almost canceling contributions. In contrast, an appreciable deviation from the ideal gas of pions and pion resonances is observed beyond the second clus- ter approximation in the framework of the Van der Waals excluded-volume model.
The equation of state for the pion gas is analyzed within the third virial approximation. The second virial coeffcient is found from the pi pi -scattering data, while the third one is considered as a free parameter. The proposed model leads to a first-order phase transition from the pion gas to a more dense phase at the temperature Tpt < 136 MeV. Due to relatively low temperature this phase transition cannot be related to the deconfinement. This suggests that a new phase of hadron matter hot pion liquid may exist.
The high E(T) drop of J / psi to Drell-Yan ratio from the statistical c anti-c coalescence model
(2002)
The dependence of the J/psi yield on the transverse energy ET in heavy ion collisions is considered within the statistical c¯c coalescence model. The model fits the NA50 data for Pb+Pb collisions at the CERN SPS even in the high-ET region (ET >< 100 GeV). Here ET -fluctuations and ET -losses in the dimuon event sample naturally create the celebrated drop in the J/psi to Drell-Yan ratio.
Statistical coalescence model analysis of J / psi production in Pb + Pb collisions at 158 A GeV
(2001)
Production of J/psi mesons in heavy ion collisions is considered within the statistical coalescence model. The model is in agreement with the experi- mental data of the NA50 Collaboration for Pb+Pb collisions at 158 A·GeV in a wide centrality range, including the so called anomalous suppression domain. The model description of the J/ psi data requires, however, strong enhancement of the open charm production in central Pb+Pb collisions. This model prediction may be checked in the future SPS runs.
The J/psi yield at midrapidity at the top RHIC (relativistic heavy ion collider) energy is calculated within the statistical coalescence model, which assumes charmonium formation at the late stage of the reaction from the charm quarks and antiquarks created earlier in hard parton collisions. The results are compared to the new PHENIX data and to predictions of the standard models, which assume formation of charmonia exclusively at the initial stage of the reaction and their subsequent suppression. Two versions of the suppression scenario are considered. One of them assumes gradual charmonium suppression by comovers, while the other one supposes that the suppression sets in abruptly due to quark-gluon plasma formation. Surprisingly, both versions give very similar results. In contrast, the statistical coalescence model predicts a few times larger J/psi yield in the most central collisions.
Objective: Most patients suffering with rheumatic diseases who undergo surgical treatment are receiving immune-modulating therapy. To determine whether these medications affect their outcomes a national registry was established in Germany by the German Society of Surgery (DGORh). Data from the first 1000 patients were used in a pilot study to identify relevant corisk factors and to determine whether such a registry is suitable for developing accurate and relevant recommendations.
Design and participants: Data were collected from patients undergoing surgical treatments with their written consent. A second consent form was used, if complications occurred. During this pilot study, in order to obtain a quicker overview, risk factors were considered only in patients with complications. Only descriptive statistical analysis was employed in this pilot study due to limited number of observed complications and inhomogeneous data regarding the surgery and the medications the patients received. Analytical statistics will be performed to confirm the results in a future outcome study.
Results: Complications occurred in 26 patients and were distributed equally among the different types of surgeries. Twenty one of these patients were receiving immune-modulating therapy at the time, while five were not. Infections were observed in 2.3% of patients receiving and in 5.1% not receiving immunosuppression.
Conclusions: Due to the low number of cases, inhomogeneity in the diseases and the treatments received by the patients in this pilot study, it is not possible to develop standardised best-practice recommendations to optimise their care. Based on this observation we conclude that in order to be suitable to develop accurate and relevant recommendations a national registry must include the most important and relevant variables that impact the care and outcomes of these patients.
Caspase-8 is an aspartate-specific cysteine protease, which is best known for its apoptotic functions. Caspase-8 is placed at central nodes of multiple signal pathways, regulating not only the cell cycle but also the invasive and metastatic cell behavior, the immune cell homeostasis and cytokine production, which are the two major components of the tumor microenvironment (TME). Ovarian cancer often has dysregulated caspase-8 expression, leading to imbalance between its apoptotic and non-apoptotic functions within the tumor and the surrounding milieu. The downregulation of caspase-8 in ovarian cancer seems to be linked to high aggressiveness with chronic inflammation, immunoediting, and immune resistance. Caspase-8 plays therefore an essential role not only in the primary tumor cells but also in the TME by regulating the immune response, B and T lymphocyte activation, and macrophage differentiation and polarization. The switch between M1 and M2 macrophages is possibly associated with changes in the caspase-8 expression. In this review, we are discussing the non-apoptotic functions of caspase-8, highlighting this protein as a modulator of the immune response and the cytokine composition in the TME. Considering the low survival rate among ovarian cancer patients, it is urgently necessary to develop new therapeutic strategies to optimize the response to the standard treatment. The TME is highly heterogenous and provides a variety of opportunities for new drug targets. Given the variety of roles of caspase-8 in the TME, we should focus on this protein in the development of new therapeutic strategies against the TME of ovarian cancer.
We relate time-varying aggregate ambiguity (V-VSTOXX) to individual investor trading. We use the trading records of more than 100,000 individual investors from a large German online brokerage from March 2010 to December 2015. We find that an increase in ambiguity is associated with increased investor activity. It also leads to a reduction in risk-taking which does not reverse over the following days. When ambiguity is high, the effect of sentiment looms larger. Survey evidence reveals that ambiguity averse investors are more prone to ambiguity shocks. Our results are robust to alternative survey-, newspaper- or market-based ambiguity measures.
Sympetrum fonscolombii is for the first time reported for Tuva (Tyva Republic, Russia), as found in the UbsuNur Depression. New data are provided on Odonata of the Turan or TuranUyuk Depression of Tuva, including the first record of Somatochlora exuberata in Tuva beyond the Todzha Depression and Coenagrion armatum, C. ecornutum, Aeshna juncea, A. grandis, Somatochlora graeseri and Libellula quadrimaculata for the first time reported for the Turan Depression. New distributional data and comments on Ophiogomphus spinicornis Selys, 1878 are added. Somatochlora alpestris found at Lake Oyskoe is for the first time reported for the southern Krasnoyarskiy Kray.
The Tyva Republic, within the Russian Federation, has acquired its present name in 1991. It was formerly known as the Tuvinian Autonomous Region within the USSR. Its common names in the past centuries were Uryankhaiskii Krai or Soyotskii Krai. In modern Russian, it is known under the name Tuva (not Tyva), which will be used further in the text. This country, for example, embraces the sources of the great Siberian river Yenisei and its capital, the town of Kyzyl, represents the geographical centre of Asia. To date, this vast and clear cut territory was hitherto almost unexplored in odonatological respect. In particular, it was not visited by the outstanding Siberian odonatologist B. F. Belyshev. Scarce materials from the recent Tuvinian territory were mentioned by Valle (1942), who considered it to be Mongolian. In the only paper concerning the dragonflies of Tuva in particular (two localities in its very south) 14 species were reported (Zaika & Kosterin 1990). The "transitional form between Ophiogomphus serpentinus and O. reductus” considered in that work, however, turned out to be the Chinese-Mongolian species Ophiogomphus spinicornis (Kosterin, 1999). Finally, one of us published two works on the general lentic fauna of the Ubsu-Nur Hollow in general (Zaika, 1996) and Lake Tere-Khol' in particular (Zaika, 1999), where 26 and 9 species were listed, respectively. The latter work was based on larval identification. Because this is difficult, this information should be taken with caution. The presence of species such as Ischnura pumilio and Cordulia aenea was not confirmed by records of adults and may be erroneous.
Part 1, Oleg E. Kosterin and Vladimir I. Solovyev, page 1-43:
Odonata found in mid-summer 2015 and 2016 at the north-westernmost Black Sea Coast of the Caucasus, with the first record of Cordulegaster picta Selys, 1854 in Russian Federation
Abstract: Results are presented of brief odonatological examination of the Black Sea coastal northwesternmost spurs of the Caucasus between Anapa and Gelendzhik (mostly at Kabardinka village), Russia, in late July/early August 2015 and early-mid July 2016. In total, 28 Odonata species were found, including Cordulegaster picta for the first time in Russia. For C. picta and Caliaeschna microstigma, the world’s northernmost records were made. New localities of species rare in this area are reported: one for Coenagrion scitulum and three for Selysiothemis nigra, including their breeding habitat. Numerous migrant individuals of Pantala flavescens were observed in many localities in 2015 but none in 2016. Observations on trophic activity of Aeshna affinis and A. mixta are reported, the former showing predominantly matutinal and vespertinal activity and the latter diurnal activity. Occurrence of the Chalcolestes spp. in the Caucasus is discussed.
Part 2, Oleg E. Kosterin, page 45 - 57:
Calopteryx virgo feminalis subsp. nov., a long known under the same name but hitherto formally nameless subspecies from the Caucasian Black Sea Coast
Abstract: The populations of Calopteryx virgo of the Black Sea Coast of the Caucasus have females with the distal hindwing part darkened and males with the underside of S10 and appendages whitish, They are known for more than a century and deserve a subspecific status but since the name feminalis Bartenev, 1910 proposed to them is unavailable, a new subspecies is formally erected under the same name, Calopteryx virgo feminalis Kosterin subsp. nov., with the following type locality: Russia, Krasnodarskiy Kray, Gelendzhik Municipality, Kabardinka village, the Doob River lowermost reaches, 44°38'26-53'', 37°55'55''-57'58'' E.