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Abdulhamid, Muhammad Ibrahim ; Aboona, Bassam ; Adam, Jaroslav ; Adams, Joseph ; Agakishiev, Geydar ; Aggarwal, Ishu ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Aitbaev, Alisher ; Alekseev, Igor ; Anderson, Derek ; Aparin, Alexey ; Aslam, Sameer ; Atchison, Joseph ; Averichev, Georgy ; Bairathi, Vipul ; Baker, William ; Ball Cap, Jonathan Gonzalo ; Barish, Kenneth ; Bhagat, Pratibha ; Bhasin, Anju ; Bhatta, Somadutta ; Bordyuzhin, Igor G. ; Brandenburg, James ; Brandin, Andrei ; Cai, Xiang-Zhou ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Cebra, Daniel ; Češka, Jakub ; Chakaberia, Irakli ; Chan, Brian ; Chang, Zilong ; Chatterjee, Arghya ; Chen, Ding ; Chen, J. ; Chen, J.H. ; Chen, Zhenyu ; Cheng, Jianping ; Cheng, Yunshan ; Choudhury, Subikash ; Christie, Bill ; Christie, William ; Chu, Xiaoxuan ; Crawford, Henry J. ; Dale-Gau, Gabriel ; Das, Ayanabha ; Daugherity, Michael ; Dedovich, Tatiana ; Deppner, Ingo Martin ; Derevschikov, Anatoly ; Dhamija, Arushi ; Di Carlo, Launa ; Dixit, Prabhupada ; Dong, Xin ; Drachenberg, James ; Duckworth, Emilie ; Dunlop, James ; Engelage, Jack ; Eppley, Geary Wareham ; Esumi, ShinIchi ; Evdokimov, Olga ; Ewigleben, Annika ; Eyser, Kjeld Oleg ; Fatemi, Renee ; Fazio, Salvatore ; Feng, Chan-Jui ; Feng, Yicheng ; Finch, Evan ; Fisyak, Yuri V. ; Flor, Fernando Antonio ; Fu, Chuan ; Gao, Taoya ; Geurts, Frank ; Ghimire, Navagyan ; Gibson, Adam ; Gopal, Krishan ; Gou, Xingrui ; Grosnick, David P. ; Gupta, Anik ; Hamed, Ahmed ; Han, Yiding ; Harasty, Matthew D. ; Harris, John W. ; Harrison-Smith, Hannah ; He, Wanbing ; He, Xionghong ; He, Yang ; Hu, Chenlu ; Hu, Qiang ; Hu, Y. ; Huang, H. ; Huang, Huan Zhong ; Huang, Shengli ; Huang, Te-Chuan ; Huang, Xinjie ; Huang, Y. ; Huang, Y. ; Humanic, Thomas J. ; Isenhower, Donald ; Isshiki, Moe ; Jacobs, William ; Jalotra, Ashish ; Jena, Chitrasen ; Ji, Yuanjing ; Jia, Jiangyong ; Jin, Chenliang ; Ju, Xin-Yue ; Judd, Eleanor ; Kabana, Sonia ; Kabir, Md Latiful ; Kalinkin, Dmitry ; Kang, Kejun ; Kapukchyan, David ; Kauder, Kolja ; Keane, Declan ; Kechechyan, Armen ; Kelsey, Matthew ; Kimelman, Benjamin ; Kiselev, Alexander ; Knospe, Anders ; Ko, Ho San ; Kochenda, Leonid ; Korobitsin, Artem ; Kravtsov, Petr ; Kumar, Lokesh ; Kumar, Shyam ; Kunnawalkam Elayavalli, Raghav ; Lacey, Roy Alphanso ; Landgraf, Jeffery ; Lebedev, Alexei ; Lednicky, Richard ; Lee, Jeong-Hun ; Leung, Yue Hang ; Lewis, Nicole ; Li, Changfeng ; Li, Wei ; Li, Xiujun ; Li, Y. ; Li, Y. ; Li, Ziyang ; Liang, Xilin ; Liang, Yue ; Lin, Ting ; Liu, Chengyang ; Liu, Feng ; Liu, Guoming ; Liu, H. ; Liu, H. ; Liu, Li-ke ; Liu, Tong ; Liu, Xiaoyu ; Liu, Yanfang ; Liu, Zuowen ; Ljubicic, Tonko ; Llope, William Joseph ; Lomicky, Ondrej ; Longacre, Ronald S. ; Loyd, E.M. ; Lu, Tan ; Lukow, Nicholas ; Luo, Xiaofeng ; Luong, V.B. ; Ma, Long ; Ma, Rongrong ; Ma, Yu-Gang ; Magdy Abdelwahab Abdelrahman, Niseem ; Mallick, Dukhishyam ; Margetis, Spiros ; Matis, Howard ; Mazer, Joel Anthony ; McNamara, Grant ; Mi, K. ; Minaev, Nikolai ; Mohanty, Bedanga ; Mouli, Mriganka Mouli ; Mooney, Isaac A. ; Morozov, Dmitry ; Mudrokh, Aleksandr ; Nagy, Marton ; Nain, Ankita ; Nam, J.D. ; Nasim, M. ; Neff, Dylan ; Nelson, John M. ; Nemes, Daniel ; Nie, Maowu ; Nigmatkulov, Grigory ; Niida, Takafumi ; Nishitani, Risa ; Nogach, Larisa ; Nonaka, Toshihiro ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Oh, Saehanseul ; Okorokov, Vitaly A. ; Okubo, Kosuke ; Page, Brian ; Pak, Robert ; Pan, Jinjin ; Pandav, Ashish ; Pandey, Ashutosh ; Panebratsev, Yuri ; Pani, Tanmay ; Parfenov, Petr ; Paul, Ananya ; Perkins, Chris ; Pokhrel, B.R. ; Posik, Matthew ; Protzman, Tristan ; Pruthi, Navneet Kumar ; Putschke, Jörn H. ; Qin, Zhi ; Qiu, Hao ; Quintero, Amilkar ; Racz, Cameron ; Radhakrishnan, Sooraj Krishnan ; Raha, Nandita ; Ray, Lanny ; Ritter, Hans Georg ; Robertson, Charles ; Rogachevskiy, Oleg ; Rosales Aguilar, Manuel ; Roy, Diptanil ; Ruan, Lijuan ; Sahoo, Aswini ; Sahoo, Nihar Ranjan ; Sako, Hiroyuki ; Salur, Sevil ; Samigullin, Edward ; Sato, Susumu ; Schmidke, William B. ; Schmitz, Norbert ; Seger, Janet ; Seto, Richard ; Seyboth, Peter ; Shah, Neha ; Shahaliev, Ehtiram ; Shanmuganathan, Prashanth V. ; Shao, Tianhao ; Sharma, Mahima ; Sharma, Natasha ; Sharma, Rishabh ; Sharma, Sharang Rav ; Sheikh, Ashik Ikbal ; Shen, D. ; Shen, D.Y. ; Shen, Kaifeng ; Shi, Shusu ; Shi, Yingying ; Shou, Qiye ; Si, Fan ; Singh, Jagbir ; Singha, Subhash ; Sinha, Priyanshi ; Skoby, Michael J. ; Soehngen, Yannick ; Song, Youqi ; Srivastava, Brijesh ; Stanislaus, Shirvel ; Stewart, David ; Strikhanov, Mikhail ; Stringfellow, Blair ; Su, Yuan ; Sun, Chuan ; Sun, X. ; Sun, Y. ; Sun, Y. ; Surrow, Bernd ; Svirida, Dmitry ; Sweger, Zachary W. ; Tamis, Andrew ; Tang, Aihong ; Tang, Zebo ; Taranenko, Arkadiy ; Tarnowsky, Terry ; Thomas, James H. ; Tlusty, David ; Todoroki, Takahito ; Tokarev, Michael ; Tomkiel, Catherine ; Trentalange, Steven ; Tribble, Robert ; Tribedy, Prithwish ; Tsai, Oleg D. ; Tsang, Chun Yuen ; Tu, Zhoudunming ; Tyler, Jace ; Ullrich, Thomas ; Underwood, David G. ; Upsal, Isaac ; Van Buren, Gene ; Vasiliev, Alexander ; Verkest, Veronica ; Videbæk, Flemming ; Vokal, Stanislav ; Voloshin, Sergei ; Wang, Fuqiang ; Wang, Gang ; Wang, J.S. ; Wang, J. ; Wang, Xiaofeng ; Wang, Y. ; Wang, Y. ; Wang, Y. ; Wang, Zhen ; Webb, Jason ; Weidenkaff, Philipp ; Westfall, Gary D. ; Wieman, Howard ; Wilks, Gavin ; Wissink, Scott ; Wu, J. ; Wu, J. ; Wu, Xiao ; Wu, Xiao ; Wu, Yang ; Xi, Baoshan ; Xiao, Zhigang ; Xie, Guannan ; Xie, Wei ; Xu, Haojie ; Xu, N. ; Xu, Qinghua ; Xu, Y. ; Xu, Y. ; Xu, Z. ; Xu, Z. ; Yan, Gaoguo ; Yan, Zhengxi ; Yang, Chi ; Yang, Qian ; Yang, Shuai ; Yang, Y. ; Ye, Z. ; Ye, Z. ; Yi, L. ; Yip, Kin ; Yu, Y. ; Zha, Wangmei ; Zhang, ChunJian ; Zhang, Dingwei ; Zhang, Jinlong ; Zhang, Shenghui ; Zhang, Wei ; Zhang, Xin ; Zhang, Y. ; Zhang, Y. ; Zhang, Y. ; Zhang, Y. ; Zhang, Z.J. ; Zhang, Z. ; Zhang, Z. ; Zhao, Fengyi ; Zhao, Jie ; Zhao, Minghui ; Zhou, Chensheng ; Zhou, Jian ; Zhou, Shuai ; Zhou, Yingjie ; Zhu, Xianglei ; Żurek, Maria Katarzyna ; Zyzak, Maksym
The polarization of Λ and Λ¯ hyperons along the beam direction has been measured relative to the second and third harmonic event planes in isobar Ru+Ru and Zr+Zr collisions at √sNN = 200 GeV. This is the first experimental evidence of the hyperon polarization by the triangular flow originating from the initial density fluctuations. The amplitudes of the sine modulation for the second and third harmonic results are comparable in magnitude, increase from central to peripheral collisions, and show a mild pT dependence. The azimuthal angle dependence of the polarization follows the vorticity pattern expected due to elliptic and triangular anisotropic flow, and qualitatively disagree with most hydrodynamic model calculations based on thermal vorticity and shear induced contributions. The model results based on one of existing implementations of the shear contribution lead to a correct azimuthal angle dependence, but predict centrality and pT dependence that still disagree with experimental measurements. Thus, our results provide stringent constraints on the thermal vorticity and shear-induced contributions to hyperon polarization. Comparison to previous measurements at RHIC and the LHC for the second-order harmonic results shows little dependence on the collision system size and collision energy.
Endothelial to mesenchymal transition in cardiovascular disease : JACC state-of-the-art review
(2019)
Kovacic, Jason C. ; Dimmeler, Stefanie ; Harvey, Richard P. ; Finkel, Toren ; Aikawa, Elena ; Krenning, Guido ; Baker, Andrew H.
Endothelial to mesenchymal transition (EndMT) is a process whereby an endothelial cell undergoes a series of molecular events that lead to a change in phenotype toward a mesenchymal cell (e.g., myofibroblast, smooth muscle cell). EndMT plays a fundamental role during development, and mounting evidence indicates that EndMT is involved in adult cardiovascular diseases (CVDs), including atherosclerosis, pulmonary hypertension, valvular disease, and fibroelastosis. Therefore, the targeting of EndMT may hold therapeutic promise for treating CVD. However, the field faces a number of challenges, including the lack of a precise functional and molecular definition, a lack of understanding of the causative pathological role of EndMT in CVDs (versus being a “bystander-phenomenon”), and a lack of robust human data corroborating the extent and causality of EndMT in adult CVDs. Here, we review this emerging but exciting field, and propose a framework for its systematic advancement at the molecular and translational levels.
Boos, Frederike ; Oo, James A. ; Warwick, Timothy ; Günther, Stefan ; Ponce, Judit Izquierdo ; Buchmann, Giulia Karolin ; Li, Tianfu ; Seredinski, Sandra ; Haydar, Shaza ; Kashefiolasl, Sepide ; Baker, Andrew H. ; Boon, Reinier ; Schulz, Marcel Holger ; Miller, Francis J. ; Brandes, Ralf ; Leisegang, Matthias
Long non-coding RNAs (lncRNAs) can act as regulatory RNAs which, by altering the expression of target genes, impact on the cellular phenotype and cardiovascular disease development. Endothelial lncRNAs and their vascular functions are largely undefined. Deep RNA-Seq and FANTOM5 CAGE analysis revealed the lncRNA LINC00607 to be highly enriched in human endothelial cells. LINC00607 was induced in response to hypoxia, arteriosclerosis regression in non-human primates and also in response to propranolol used to induce regression of human arteriovenous malformations. siRNA knockdown or CRISPR/Cas9 knockout of LINC00607 attenuated VEGF-A-induced angiogenic sprouting. LINC00607 knockout in endothelial cells also integrated less into newly formed vascular networks in an in vivo assay in SCID mice. Overexpression of LINC00607 in CRISPR knockout cells restored normal endothelial function. RNA- and ATAC-Seq after LINC00607 knockout revealed changes in the transcription of endothelial gene sets linked to the endothelial phenotype and in chromatin accessibility around ERG-binding sites. Mechanistically, LINC00607 interacted with the SWI/SNF chromatin remodeling protein BRG1. CRISPR/Cas9-mediated knockout of BRG1 in HUVEC followed by CUT&RUN revealed that BRG1 is required to secure a stable chromatin state, mainly on ERG-binding sites. In conclusion, LINC00607 is an endothelial-enriched lncRNA that maintains ERG target gene transcription by interacting with the chromatin remodeler BRG1.
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