Refine
Year of publication
Document Type
- Article (97)
Language
- English (97)
Has Fulltext
- yes (97)
Is part of the Bibliography
- no (97)
Keywords
- inflammation (16)
- macrophage (14)
- cancer (7)
- breast cancer (6)
- macrophages (6)
- apoptosis (5)
- macrophage polarization (5)
- sphingosine-1-phosphate (5)
- hypoxia (4)
- lipocalin-2 (4)
- microRNA (4)
- mitochondria (4)
- reactive oxygen species (4)
- tumor microenvironment (4)
- Hypoxia (3)
- Macrophages (3)
- RNA therapeutics (3)
- iron (3)
- lipoxygenase (3)
- psoriasis (3)
- tumor-associated macrophages (3)
- ATP-citrate lyase (2)
- Breast cancer (2)
- Breast tumors (2)
- Cancer (2)
- Chronic inflammation (2)
- HIF (2)
- IL-1β (2)
- Immunology (2)
- Inflammation (2)
- Iron (2)
- Messenger RNA (2)
- Mitochondria (2)
- Mitochondrial ROS (2)
- Nrf2 (2)
- ROS (2)
- acetyl-CoA (2)
- angiogenesis (2)
- atherosclerosis (2)
- chemotherapy (2)
- cholesterol (2)
- endoplasmic reticulum (2)
- gene expression (2)
- histone acetylation (2)
- immunity (2)
- interleukin-4 (2)
- metabolism (2)
- monocytes (2)
- pain (2)
- phagocytosis (2)
- proliferation (2)
- prostaglandins (2)
- renal cell carcinoma (2)
- resolution (2)
- sepsis (2)
- tumor progression (2)
- 5' UTR (1)
- AMP-activated kinase (AMPK) (1)
- ASCT (1)
- AU-rich element (1)
- Acute inflammation (1)
- BIAM-switch (1)
- CD36 (1)
- CD40 (1)
- CHIP (1)
- CYP1A1 (1)
- Cell binding (1)
- Cell death (1)
- Cell death and immune response (1)
- Cell signalling (1)
- Cell staining (1)
- Cellular stress responses (1)
- Complex II (1)
- Cytoskeleton (1)
- DNA damage (1)
- ER stress (1)
- Erythrophagocytosis (1)
- Extracellular vesicles (1)
- FTMT (1)
- Ferritinophagy (1)
- Ferroptosis (1)
- Flow cytometry (1)
- G2A (1)
- GEMs (1)
- GPCR (1)
- GRAND-SLAM (1)
- Gene expression (1)
- Gene prediction (1)
- Gene/Regulation (1)
- Genome annotation (1)
- Glycolysis (1)
- HAI‐1 (1)
- HCC marker (1)
- HDAC (1)
- HGF (1)
- HIF-1α (1)
- HIF-2 (1)
- HIF-2α (1)
- Hepatocellular carcinoma (1)
- Hypoxia inducible factor (1)
- IFN-β (1)
- IL-27 cytokine (1)
- ISR (1)
- Immune cells (1)
- JNK (1)
- Kinases (1)
- Kupffer cells (1)
- LDHB (1)
- LDL (1)
- Lipid peroxidation (1)
- Lipid signalling (1)
- MMP9 (1)
- Macrophage (1)
- Mild hypoxia (1)
- Monocytes and macrophages (1)
- Mouse models (1)
- Mφs (1)
- NADPH oxidase (1)
- NASH (1)
- NCOA4 (1)
- NLRP3 inflammasomes (1)
- Oxidative phosphorylation (1)
- PD-L1 (1)
- PDPK1 (1)
- PPTC7 (1)
- PTEN inducible kinase 1 (1)
- Parkinson's disease (1)
- Peritoneal macrophages (1)
- Physiology (1)
- Protein translation (1)
- RNA extraction (1)
- RNA isolation (1)
- RNA sequencing (1)
- RNA stability (1)
- RNA therapy (1)
- RNA-binding protein (1)
- RNA/MicroRNA (1)
- Receptors/Nuclear (1)
- Respiratory chain (1)
- Ribosomes (1)
- S1PR1 (1)
- S1PR4 (1)
- SDH (1)
- SLAM-seq (1)
- SLC7A11 (1)
- SPM (1)
- STAT1 (1)
- Sterols (1)
- T cells (1)
- TMEM126B (1)
- Transcription (1)
- Translation initiation (1)
- UPR (1)
- Zymosan-induced peritonitis (1)
- acute inflammation (1)
- adipose-derived stem cells (ASCs) (1)
- alcoholic hepatitis (1)
- alpha-synuclein (1)
- antioxidants (1)
- arachidonate 12/15-lipoxygenase (Alox12/15) (1)
- arachidonate 15-lipoxygenase (1)
- arachidonic acid (AA) (1)
- asparaginyl endopepdidase (AEP) (1)
- astrocytes (1)
- autologous stem cell transplantation (1)
- breast tumor (1)
- cancer cell metabolism (1)
- cancer metastases (1)
- cancer-associated fibroblasts (1)
- carcinoma (1)
- chelation therapy (1)
- chemokine (1)
- chronic hypoxia (1)
- chronic myeloid leukemia (1)
- clonal dominance (1)
- clonal hematopoiesis (1)
- complex I (1)
- costimulation (1)
- cytokine (1)
- cytokine, angiogenesis (1)
- cytotoxic T cells (1)
- cytotoxic lymphocytes (1)
- cytotoxicity (1)
- de novo transcription (1)
- diabetic nephropathy (1)
- differentiation (1)
- drug discovery (1)
- efferocytosis (1)
- electron transport chain (1)
- electrophiles (1)
- endothelial cell (1)
- epigenetic (1)
- erastin (1)
- exosome (1)
- exosomes (1)
- extracellular signal-regulated kinase (1)
- fatty acid (1)
- fatty acids (1)
- ferroportin (1)
- ferroptosis (1)
- fibrosarcoma (1)
- flow cytometry (1)
- gene signature (1)
- glucosylceramides (1)
- glutamine (1)
- glycolysis (1)
- hematopoietic stem cells (1)
- hematopoietic stress (1)
- hierarchical clustering (1)
- immune checkpoint (1)
- immunotherapy (1)
- infection (1)
- innate immunity (1)
- inflammation (1)
- iron chelator (1)
- iron chelators (1)
- iron homeostasis (1)
- iron metabolism (1)
- iron-trafficking (1)
- legumain (1)
- leukemia (1)
- lipid mediator (1)
- lipid metabolism (1)
- lipids (1)
- lipoproteins (1)
- lipoxin A4 (1)
- liver (1)
- liver X receptor (1)
- lung cancer (1)
- lung tumor heterogeneity (1)
- lymphangiogenesis (1)
- mRNA stability (1)
- mTOR (1)
- mammary cancer (1)
- mammary carcinoma (1)
- mast cells (1)
- metabolic reprogramming (1)
- miR (1)
- miR-375 (1)
- miR-6862-5p (1)
- miRNA let-7e (1)
- microenvironment (1)
- migration (1)
- mitochondrial dynamics (1)
- mitochondrial respiration (1)
- multiple myeloma (1)
- multispectral flow cytometry (1)
- natural killer T cells (1)
- nuclear factor 2 (erythroid-derived 2-like factor) (NFE2L2) (Nrf2) (1)
- oxidative stress (1)
- oxidized low density lipoprotein (1)
- p-eIF2α (1)
- p53 (1)
- peritoneal macrophages (1)
- peroxisome proliferator-activated receptor (1)
- polarization (1)
- polyunsaturated fatty acid (1)
- post-transcriptional regulation (1)
- prostacyclin (1)
- prostaglandin (1)
- protein-protein interaction (1)
- proteomics (1)
- resolution of inflammation (1)
- resolution of inflammation (1)
- resveratrol (1)
- sensory loss (1)
- signal transduction (1)
- somatic mutations (1)
- specialized pro-resolving lipid mediators (SPMs) (1)
- specialized pro-resolving mediator (1)
- sphingolipids (1)
- sterol regulatory element binding protein-2 (1)
- thromboxane (1)
- toll-like receptor (1)
- transcription (1)
- transcription factor (1)
- transcriptional profiling (1)
- transcriptome (1)
- tumor stroma (1)
- tumor-associated macrophages (TAM) (1)
- tumor‐associated macrophages (1)
- type B (1)
- tyrosine kinase inhibitors. (1)
- xenobiotics (1)
- zymosan (1)
Institute
- Medizin (95)
- Sonderforschungsbereiche / Forschungskollegs (36)
- Biochemie und Chemie (13)
- Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit (ZAFES) (6)
- Biochemie, Chemie und Pharmazie (3)
- Exzellenzcluster Makromolekulare Komplexe (2)
- Pharmazie (2)
- Biowissenschaften (1)
- Buchmann Institut für Molekulare Lebenswissenschaften (BMLS) (1)
- Institut für Ökologie, Evolution und Diversität (1)
Lipoxygenases (LOXs) catalyze the stereo-specific peroxidation of polyunsaturated fatty acids (PUFAs) to their corresponding hydroperoxy derivatives. Human macrophages express two arachidonic acid (AA) 15-lipoxygenating enzymes classified as ALOX15 and ALOX15B. ALOX15, which was first described in 1975, has been extensively characterized and its biological functions have been investigated in a number of cellular systems and animal models. In macrophages, ALOX15 functions to generate specific phospholipid (PL) oxidation products crucial for orchestrating the nonimmunogenic removal of apoptotic cells (ACs) as well as synthesizing precursor lipids required for production of specialized pro-resolving mediators (SPMs) that facilitate inflammation resolution. The discovery of ALOX15B in 1997 was followed by comprehensive analyses of its structural properties and reaction specificities with PUFA substrates. Although its enzymatic properties are well described, the biological functions of ALOX15B are not fully understood. In contrast to ALOX15 whose expression in human monocyte-derived macrophages is strictly dependent on Th2 cytokines IL-4 and IL-13, ALOX15B is constitutively expressed. This review aims to summarize the current knowledge on the regulation and functions of ALOX15 and ALOX15B in human macrophages.