Proverbes et énigmes wolof cités dans le dictionnaire volof-français de Mgr Kobès et du R.P. Abiven
(2000)
La documentation démographique concernant les populations rurales de l’Ouest-Africain ne s’est vraiment développée qu’à une époque très récente. On remarque une disparité entre les données relatives aux villes et escales, et celles qui ont trait à la situation rurale. La population urbaine a pu faire l’objet de véritables études démographiques, dès avant les indépendances, alors qu’en milieu rural, on s’est contenté des dénombrements effectués à des fins administratives et fiscales.
Background: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer's cases and 48,466 controls.
Principal findings: In addition to earlier reported genes, we detected genome-wide significant loci on chromosomes 8 (TP53INP1, p = 1.4×10−6) and 14 (IGHV1-67 p = 7.9×10−8) which indexed novel susceptibility loci.
Significance: The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimer's disease.
