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Mobilität ist eine wesentliche Voraussetzung, um an außerhäuslichen Aktivitäten teilzunehmen und somit am gesellschaftlichen Leben teilhaben zu können. Da das Nutzen von Verkehrsmitteln mit Kosten verbunden ist, kann dies insbesondere für Personen mit geringen Einkünften eine Mobilitätsbarriere darstellen und das Risiko erhöhen, von mobilitätsbezogener sozialer Exklusion betroffen zu sein.
Eine besondere und tragende Rolle fällt dem öffentlichen Personennahverkehr zu (ÖPNV), auf den wir mit diesem methodischen Beitrag eingehen möchten: Zunächst tragen wir zusammen, wie finanzielle ÖPNV-Erschwinglichkeit quantifiziert werden kann, wobei wir auf Grundlage internationaler Fachliteratur zwei Ansätze (beobachtete und potenzielle Erschwinglichkeit) unterscheiden. Anschließend diskutieren wir mögliche Indikatoren für die ÖPNV-Erschwinglichkeit, die auf dem Einkommen privater Haushalte basieren. Darüber hinaus skizzieren wir einen GIS-basierten Indikator für den Nutzen des Deutschlandtickets, das seit Mai 2023 bundesweit im ÖPNV gilt.
Objectives: We explore the importance of SARS-CoV-2 sentinel surveillance testing in primary care during a regional COVID-19 outbreak in Austria.
Design: Prospective cohort study.
Setting: A single sentinel practice serving 22 829 people in the ski-resort of Schladming-Dachstein.
Participants: All 73 patients presenting with mild-to-moderate flu-like symptoms between 24 February and 03 April, 2020.
Intervention: Nasopharyngeal sampling to detect SARS-CoV-2 using real-time reverse transcriptase-quantitative PCR (RT-qPCR).
Outcome measures: We compared RT-qPCR at presentation with confirmed antibody status. We split the outbreak in two parts, by halving the period from the first to the last case, to characterise three cohorts of patients with confirmed infection: early acute (RT-qPCR reactive) in the first half; and late acute (reactive) and late convalescent (non-reactive) in the second half. For each cohort, we report the number of cases detected, the accuracy of RT-qPCR, the duration and variety of symptoms, and the number of viral clades present.
Results: Twenty-two patients were diagnosed with COVID-19 (eight early acute, seven late acute and seven late convalescent), 44 patients tested SARS-CoV-2 negative and 7 were excluded. The sensitivity of RT-qPCR was 100% among all acute cases, dropping to 68.1% when including convalescent. Test specificity was 100%. Mean duration of symptoms for each group were 2 days (range 1–4) among early acute, 4.4 days (1–7) among late acute and 8 days (2–12) among late convalescent. Confirmed infection was associated with loss of taste. Acute infection was associated with loss of taste, nausea/vomiting, breathlessness, sore throat and myalgia; but not anosmia, fever or cough. Transmission clusters of three viral clades (G, GR and L) were identified.
Conclusions: RT-qPCR testing in primary care can rapidly and accurately detect SARS-CoV-2 among people with flu-like illness in a heterogeneous viral outbreak. Targeted testing in primary care can support national sentinel surveillance of COVID-19.
An important experimental program on Nuclear Astrophysics is being carried out at the n_TOF since several years, in order to address the still open issues in stellar and primordial nucleosynthesis. Several neutron capture reactions relevant to s-process nucleosynthesis have been measured so far, some of which on important branching point radioisotopes. Furthermore, the construction of a second experimental area has recently opened the way to challenging measurements of (n, charged particle) reactions on isotopes of short half-life. The Nuclear Astrophysics program of the n_TOF Collaboration is here described, with emphasis on recent results relevant for stellar nucleosynthesis, stellar neutron sources and primordial nucleosynthesis.