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Odyniec, Grazyna Janina ; Afanasiev, Sergey V. ; Alber, Thomas ; Appelshäuser, Harald ; Bächler, Joachim ; Bailey, Stephen John ; Barnby, Lee Stuart ; Bartke, Jerzy ; Białkowska, Helena ; Blyth, Charles O. ; Bock, Rudolf ; Bormann, Christian ; Brady, Franklin Paul ; Brockmann, Robert ; Buncic, Nenad ; Bunčić, Predrag ; Caines, Helen Louise ; Cebra, Daniel A. ; Chan, P. ; Cooper, Glenn E. ; Cramer, John G. ; Cramer, Pauline B. ; Csató, Péter ; Dietz, Oliver ; Dunn, Jason ; Eckardt, Volker ; Eckhardt, Frank ; Ferguson, M. I. ; Fischer, Hans Gerhard ; Flierl, Dominik Bernhard ; Fodor, Zoltán ; Foka, Panagiota ; Freund, Peter ; Friese, Volker ; Fuchs, M. ; Gabler, Frank ; Gál, József ; Gaździcki, Marek ; Gładysz-Dziaduś, Ewa ; Grebieszkow, Jaroslaw ; Günther, Jörg ; Harris, John W. ; Hegyi, Sándor ; Henkel, Torsten ; Hill, L. A. ; Huang, Isaac ; Howe, Mark A. ; Hümmler, Holm Gero ; Igo, George J. ; Irmscher, Detlef ; Jacobs, Peter Martin ; Jones, Peter Graham ; Kadija, Krešo ; Kolesnikov, Vadim I. ; Konashenok, Anton ; Kowalski, Marek ; Lasiuk, Brian ; Lévai, Péter ; Malakhov, Aleksandr I. ; Margetis, Spyridon ; Markert, Christina ; Melkumov, Georgy L. ; Mock, Andreas ; Molnár, József ; Nelson, John M. ; Pálla, Gabriella ; Panagiotou, Apostolos D. ; Petridis, Athanasios ; Piper, Andreas ; Porter, R. Jefferson ; Poskanzer, Arthur M. ; Poziombka, Stefan ; Prindle, Duncan J. ; Pühlhofer, Falk ; Rauch, Wolfgang Hans ; Reid, Jeffrey G. ; Renfordt, Rainer Arno Ernst ; Retyk, Waldemar ; Ritter, Hans Georg ; Röhrich, Dieter ; Roland, Christof ; Roland, Gunther ; Rudolph, Heinrich ; Rybicki, Andrzej ; Sakrejda, Iwona ; Sandoval, Andres ; Sann, Hans ; Semenov, Alexei Yu. ; Schäfer, Erich ; Schmischke, Dirk ; Schmitz, Norbert ; Schönfelder, Stefan ; Seyboth, Peter ; Seyerlein, Jürgen ; Siklér, Ferenc ; Skrzypczak, Ewa ; Squier, Gordon Thomas Anderson ; Stock, Reinhard ; Ströbele, Herbert ; Szentpétery, Imre ; Sziklai, János ; Toy, Milton Y. ; Trainor, Thomas A. ; Trentalange, Stephen ; Ullrich, Thomas ; Vassiliou, Maria ; Vesztergombi, György ; Vranić, Danilo ; Wang, Feipeng ; Weerasundara, Dhammika D. ; Wenig, Siegfried ; Whitten, Charles A. ; Wienold, Thomas ; Wood, Lindsay ; Yates, Tim A. ; Zimányi, József ; Zhu, Xue-Zhou ; Zybert, Ryszard
Using the NA49 main TPC, the central production of hyperons has been measured in CERN SPS Pb - Pb collisions at 158 GeV c-1. The preliminary ratio, studied at 2.0 < y < 2.6 and 1 < pT < 3 GeV c-1, equals ~ (13 ± 4)% (systematic error only). It is compatible, within errors, with the previously obtained ratios for central S + S [1], S + W [2], and S + Au [3] collisions. The fit to the transverse momentum distribution resulted in an inverse slope parameter T of 297 MeV. At this level of statistics we do not see any noticeable enhancement of hyperon production with the increased volume (and, possibly, degree of equilibration) of the system from S + S to Pb + Pb. This result is unexpected and counterintuitive, and should be further investigated. If confirmed, it will have a significant impact on our understanding of mechanisms leading to the enhanced strangeness production in heavy-ion collisions.
Röhlen, Natascha ; Döring, Claudia ; Hansmann, Martin-Leo ; Grünwald, Frank ; Vorländer, Christian ; Bechstein, Wolf Otto ; Holzer, Katharina ; Badenhoop, Klaus ; Penna Martinez, Marissa
Background: Protective effects of vitamin D have been reported in autoimmune and malignant thyroid diseases, though little is known about the underlying mechanism. Sirtuin 1 histon deacethylase (SIRT1) links the vitamin D pathway with regulation of transcription factor FOXO3a, a key player in cell cycle regulation and apoptosis. Aim of the present study was to investigate common single nucleotide polymorphisms (SNP's) in FOXO3a gene in respect to thyroid diseases, as well as to evaluate the hypothesis of Sirtuin1-FOXO3a interaction being a mediator of anti-proliferative vitamin D effects.
Methods: The SNP's FOXO3a rs4946936/rs4945816/rs9400239 were genotyped in 257 patients with differentiated thyroid carcinoma (DTC), 139 patients with Hashimoto thyroiditis (HT) and 463 healthy controls (HC). Moreover, T-helper cells of HC and papillary thyroid cancer cell line BCPAP were incubated with 1,25(OH)2D3 and/or SIRT1 inhibitor Ex-527 in order to elucidate SIRT1- dependent vitamin D effects on cell proliferation and FOXO3a gene expression in vitro.
Results: Patients with DTC tended to carry more often allele C in FOXO3a rs4946936 in comparison to HC (pcorrected = pc = 0.08). FOXO3a rs9400239T and rs4945816C was more frequent in HT in comparison to HC (pc = 0.02 and pc = 0.01, respectively). In both DTC and HT, we could not find a correlation of FOXO3a SNP's with vitamin D status. However, on in vitro level, 1,25(OH)2D3 showed an anti-proliferative effect in both T-helper cells and BCPAP, that was blocked by SIRT1 inhibition (T-helper cells: p = 0.0059, BCPAP: p = 0.04) and accompanied by elevated FOXO3a gene expression in T-helper cells (p = 0.05).
Conclusions: FOXO3a rs9400239T and rs4945816C may constitute risk factors for HT, independent of the vitamin D status.This indicates the implication of FOXO3a in pathogenesis of autoimmune thyroid diseases. The dependency of anti-proliferative vitamin D effects on SIRT1 activity further suggests a key role of vitamin D-SIRT1-FOXO3a axis for protective vitamin D effects.
Trebicka, Jonel ; Gu, Wenyi ; De Ledinghen, Victor ; Aubé, Christophe ; Krag, Aleksander ; Praktiknjo, Michael ; Castera, Laurent ; Dumortier, Jerome ; Bauer, David Josef Maria ; Friedrich-Rust, Mireen ; Pol, Stanislas ; Grgurevic, Ivica ; Zheng, Rongqin ; Francque, Sven ; Gottfriedovà, Halima ; Mustapic, Sanda ; Sporea, Ioan ; Berzigotti, Annalisa ; Uschner, Frank Erhard ; Simbrunner, Benedikt Michael ; Ronot, Maxime ; Cassinotto, Christophe ; Kjaergaard, Maria ; Andrade, Filipe ; Schulz, Martin ; Semmler, Georg ; Tjesic Drinkovic, Ida ; Chang, Johannes ; Brol, Maximilian ; Rautou, Pierre Emmanuel ; Vanwolleghem, Thomas ; Straßburg, Christian P. ; Boursier, Jerome ; Ferstl, Philip ; Rasmussen, Ditlev Nytoft ; Reiberger, Thomas ; Vilgrain, Valerie ; Guibal, Aymeric ; Guillaud, Olivier ; Zeuzem, Stefan ; Vassord, Camille ; Lu, Xue ; Vonghia, Luisa ; Senkerikova, Renata ; Popescu, Alina ; Margini, Cristina ; Wang, Wenping ; Thiele, Maja ; Jansen, Chrisitan
Objective: Liver stiffness measurement (LSM) is a tool used to screen for significant fibrosis and portal hypertension. The aim of this retrospective multicentre study was to develop an easy tool using LSM for clinical outcomes in advanced chronic liver disease (ACLD) patients.
Design: This international multicentre cohort study included a derivation ACLD patient cohort with valid two-dimensional shear wave elastography (2D-SWE) results. Clinical and laboratory parameters at baseline and during follow-up were recorded. LSM by transient elastography (TE) was also recorded if available. The primary outcome was overall mortality. The secondary outcome was the development of first/further decompensation.
Results: After screening 2148 patients (16 centres), 1827 patients (55 years, 62.4% men) were included in the 2D-SWE cohort, with median liver SWE (L-SWE) 11.8 kPa and a model for end stage liver disease (MELD) score of 8. Combination of MELD score and L-SWE predict independently of mortality (AUC 0.8). L-SWE cut-off at ≥20 kPa combined with MELD ≥10 could stratify the risk of mortality and first/further decompensation in ACLD patients. The 2-year mortality and decompensation rates were 36.9% and 61.8%, respectively, in the 305 (18.3%) high-risk patients (with L-SWE ≥20 kPa and MELD ≥10), while in the 944 (56.6%) low-risk patients, these were 1.1% and 3.5%, respectively. Importantly, this M10LS20 algorithm was validated by TE-based LSM and in an additional cohort of 119 patients with valid point shear SWE-LSM.
Conclusion: The M10LS20 algorithm allows risk stratification of patients with ACLD. Patients with L-SWE ≥20 kPa and MELD ≥10 should be followed closely and receive intensified care, while patients with low risk may be managed at longer intervals.
Gu, Wenyi ; Hortlik, Hannah ; Erasmus, Hans-Peter ; Schaaf, Louisa ; Zeleke, Yasmin ; Uschner, Frank Erhard ; Ferstl, Philip ; Schulz, Martin ; Peiffer, Kai-Henrik ; Queck, Alexander David Roger ; Sauerbruch, Tilman ; Brol, Maximilian ; Rohde, Gernot Gerhard Ulrich ; Sanchez, Cristina ; Moreau, Richard ; Arroyo, Vicente ; Zeuzem, Stefan ; Welsch, Christoph ; Trebicka, Jonel
Background: Cirrhosis is known to have a high prevalence and mortality worldwide. However, in Europe, the epidemiology of cirrhosis is possibly undergoing demographic changes, and etiologies may have changed due to improvements in standard of care. The aim of this population-based study was to analyze the trends and the course of liver cirrhosis and its complications in recent years in Germany.
Methods: We analyzed the data of all hospital admissions in Germany within diagnosis-related groups from 2005 to 2018. The diagnostic records of cirrhosis and other categories of diseases were based on ICD-10-GM codes. The primary outcome measurement was in-hospital mortality. Trends were analyzed through Poisson regression of annual number of admissions. The impact of cirrhosis on overall in-hospital mortality were assessed through the multivariate multilevel logistic regression model adjusted for age, sex, and comorbidities.
Findings: Of the 248,085,936 admissions recorded between 2005 and 2018, a total of 2,302,171(0•94%) were admitted with the diagnosis of cirrhosis, mainly as a comorbidity. Compared with other chronic diseases, patients admitted with cirrhosis were younger, mainly male and had the highest in-hospital mortality rate. Diagnosis of cirrhosis was an independent risk factor of in-hospital mortality with the highest odds ratio (OR:6•2[95%CI:6.1-6•3]) among all diagnoses. The prevalence of non-alcoholic fatty liver disease has increased four times from 2005 to 2018, while alcoholic cirrhosis is 20 times than other etiologies. Bleeding was found to be decreasing over time, but ascites remained the most common complication and was increasing.
Interpretation: This nationwide study demonstrates that cirrhosis represents a considerable healthcare burden, as shown by the increasing in-hospital mortality, also in combination with other chronic diseases. Alcohol-related cirrhosis and complications are on the rise. More resources and better management strategies are warranted.
Adams, J. ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Amonett, John ; Anderson, Bryon D. ; Arkhipkin, Dmitry A. ; Averichev, Georgy S. ; Badyal, S. K. ; Bai, Yu ; Balewski, Jan ; Barannikova, Olga ; Barnby, Lee Stuart ; Baudot, Jérome ; Bekele, Selemon ; Belaga, Victoria Vladimirovna ; Bellwied, Rene ; Berger, Jens ; Bezverkhny, B. I. ; Bharadwaj, Somnath ; Bhasin, Anju ; Bhati, Ashok Kumar ; Bhatia, V. S. ; Bichsel, Hans ; Billmeier, Anja ; Bland, Leslie C. ; Blyth, Charles O. ; Bonner, Billy E. ; Botje, Michiel ; Boucham, Abdelkrim ; Brandin, Andrei V. ; Bravar, Alessandro ; Bystersky, M. ; Cadman, R. V. ; Cai, Xiang-Zhou ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Castillo Castellanos, Javier Ernesto ; Cebra, Daniel A. ; Chajecki, Zbigniew ; Chaloupka, Petr ; Chattopdhyay, S. ; Chen, H. F. ; Chen, Y. ; Cheng, J. ; Cherney, Michael Gerard ; Chikanian, Alexei ; Christie, William ; Coffin, Jean Pierre ; Cormier, Thomas Michael ; Cramer, John G. ; Crawford, Henry J. ; Das, Debasish ; Das, Supriya ; Moura, M. M. de ; Derevschikov, Anatoly A. ; Didenko, Lidia ; Dietel, Thomas ; Dogra, Sunil Manohar ; Dong, W. J. ; Dong, X. ; Draper, James E. ; Du, F. ; Dubey, Anand Kumar ; Dunin, V. B. ; Dunlop, James C. ; Dutta Mazumdar, M. R. ; Eckardt, Volker ; Edwards, W. R. ; Efimov, Leonid G. ; Emelianov, V. ; Engelage, Jon M. ; Eppley, Geary Wareham ; Erazmus, Barbara Ewa ; Estienne, Magali Danielle ; Fachini, Patricia ; Faivre, Julien ; Fatemi, Renee H. ; Fedorišin, Jan ; Filimonov, Kirill ; Filip, Peter ; Finch, Evan ; Fine, Valeri ; Fisyak, Yuri V. ; Fomenko, K. ; Fu, J. ; Gagliardi, Carl A. ; Gans, J. ; Ganti, Murthy S. ; Gaudichet, L. ; Geurts, Frank ; Ghazikhanian, Vahe ; Ghosh, Premomoy ; Gonzalez, Johan Enmanuel ; Grachov, Oleg A. ; Grebenyuk, Oleksandr ; Grosnick, David P. ; Guertin, Steven M. ; Guo, Y. ; Gupta, Anik ; Gutierrez, Thomas Dominic ; Hallman, Timothy J. ; Hamed, Ahmed M. ; Hardtke, David H. ; Harris, John W. ; Heinz, Mark Thomas ; Henry, Thomas W. ; Hepplemann, S. ; Hippolyte, Boris ; Hirsch, Andrew S. ; Hjort, Eric ; Hoffmann, Gerald W. ; Huang, Huan Zhong ; Huang, Shengli ; Hughes, Emlyn Willard ; Humanic, Thomas J. ; Igo, George J. ; Ishihara, A. ; Jacobs, Peter Martin ; Jacobs, William W. ; Janik, Michał ; Jiang, H. ; Jones, Peter Graham ; Judd, Eleanor G. ; Kabana, Sonia ; Kang, K. ; Kaplan, Morton ; Keane, Declan ; Khodyrev, V. Yu. ; Kiryluk, Joanna ; Kisiel, Adam Ryszard ; Kislov, E. M. ; Klay, Jennifer Lynn ; Klein, Spencer Robert ; Klyachko, A. ; Koetke, Donald D. ; Kollegger, Thorsten ; Kopytine, M. ; Kotchenda, L. ; Kramer, M. ; Kravtsov, Peter ; Kravtsov, Vladimir I. ; Krueger, Keith William ; Kuhn, Christian Claude ; Kulikov, Anatoly I. ; Kumar, Ajay ; Kutuev, R. Kh. ; Kuznetsov, A. A. ; Lamont, Matthew A. C. ; Landgraf, Jeffery M. ; Lange, S. ; Laue, Frank ; Lauret, Jerome ; Lebedev, Alexei ; Lednicky, Richard ; Lehocka, S. ; LeVine, Micheal J. ; Li, C. ; Li, Q. ; Li, Y. ; Lin, G. ; Lindenbaum, Sam J. ; Lisa, Michael A. ; Liu, F. ; Liu, L. ; Liu, Q. J. ; Liu, Z. ; Ljubicic, Tonko A. ; Llope, William Joseph ; Long, H. ; Longacre, Ronald S. ; Lopez-Noriega, M. ; Love, William A. ; Lu, Y. ; Ludlam, Thomas ; Lynn, David ; Ma, G. L. ; Ma, Jing-guo ; Ma, Yu-Gang ; Magestro, Daniel ; Mahajan, Sanjay ; Mahapatra, D. P. ; Majka, Richard Daniel ; Mangotra, Lalit K. ; Manweiler, Robert W. ; Margetis, Spyridon ; Markert, Christina ; Martin, L. ; Marx, Jay N. ; Matis, Howard S. ; Matulenko, Yuri A. ; McClain, C. J. ; McShane, Tom S. ; Meissner, F. ; Melnick, Yu. ; Meščanin, Aleksei P. ; Miller, M. L. ; Minaev, Nikolai G. ; Mironov, Camelia ; Mischke, André ; Mishra, D. K. ; Mitchell, J. ; Mohanty, Bedangadas ; Molnar, Levente ; Moore, C. F. ; Morozov, Dmitry A. ; Munhoz, Marcelo Gameiro ; Nandi, Basanta Kumar ; Nayak, S. K. ; Nayak, Tapan Kumar ; Nelson, John M. ; Netrakanti, Pawan Kumar ; Nikitin, Vladimir A. ; Nogach, Larisa V. ; Nurušev, Sandibek B. ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Okorokov, Vitaly A. ; Oldenburg, Markus D. ; Olson, Douglas L. ; Pal, Susanta Kumar ; Panebratsev, Yuri ; Panitkin, Sergei Yurievich ; Pavlinov, A. I. ; Pawlak, Tomasz Jan ; Peitzmann, Thomas ; Perevoztchikov, V. ; Perkins, Chris ; Peryt, Wiktor Stanislaw ; Petrov, V. A. ; Phatak, S. C. ; Picha, R. ; Planinic, Mirko ; Pluta, Jan Marian ; Porile, Norbert T. ; Porter, Jeffrey Brent ; Poskanzer, Arthur M. ; Potekhin, Maxim ; Potrebenikova, E. ; Potukuchi, B. V. K. S. ; Prindle, Duncan J. ; Pruneau, Claude A. ; Putschke, Jörn H. ; Rakness, Gregory L. ; Raniwala, Rashmi ; Raniwala, Sudhir ; Ravel, Olivier ; Ray, Robert L. ; Razin, Sergej V. ; Reichhold, Dennis Michael ; Reid, Jeffrey G. ; Renault, G. ; Retiere, Fabrice ; Ridiger, Alexey ; Ritter, Hans Georg ; Roberts, Jabus B. ; Rogačevskij, Oleg V. ; Romero, Juan L. ; Rose, A. ; Roy, Christelle Sophie ; Ruan, Lijuan ; Sahoo, Raghunath ; Sakrejda, Iwona ; Salur, Sevil ; Sandweiss, Jack H. ; Savin, Igor A. ; Sazhin, P. S. ; Schambach, Joachim ; Scharenberg, Rolf Paul ; Schmitz, Norbert ; Schweda, Kai ; Seger, Janet Elizabeth ; Seyboth, Peter ; Shahaliev, Ehtiram ; Shao, M. ; Shao, W. ; Sharma, M. ; Shen, W. Q. ; Shestermanov, Konstantin E. ; Shimanskiy, S. S. ; Sichtermann, Ernst P. ; Simon, F. ; Singaraju, Rama Narayana ; Skoro, Goran P. ; Smirnov, Nikolai ; Snellings, Raimond ; Sood, Gopika ; Sorensen, Paul Richard ; Sowinski, James ; Speltz, Jeff ; Spinka, Harold. M. ; Srivastava, Brijesh Kumar ; Stadnik, A. ; Stanislaus, T. D. Shirvel ; Stock, Reinhard ; Stolpovsky, Alexander ; Strichanov, Michail Nikolaevič ; Stringfellow, Blair ; Suaide, Alexandre Alarcon do Passo ; Sugarbaker, Evan R. ; Suire, Christophe Pierre ; Šumbera, Michal ; Surrow, Bernd ; Symons, Timothy James MacNeil ; Toledo, Alejandro Szanto de ; Szarwas, Piotr ; Tai, An ; Takahashi, Jun ; Tang, Aihong ; Tarnowsky, Terence J. ; Thein, Dylan ; Thomas, James H. ; Timoshenko, Sergei ; Tokarev, Mikhail V. ; Trainor, Thomas A. ; Trentalange, Stephen ; Tribble, Robert E. ; Tsai, Oleg D. ; Ulery, Jason Glyndwr ; Ullrich, Thomas ; Underwood, David G. ; Urkinbaev, Anarbay ; Van Buren, Gene ; Leeuwen, Marco van ; Molen, A. M. Vander ; Varma, Raghava ; Vasilevski, I. M. ; Vasiliev, Alexander Nikolaevich ; Vernet, Renaud ; Vigdor, Steven E. ; Viyogi, Yogendra P. ; Vokal, Stanislav ; Voloshin, Sergei ; Vznuzdaev, Marat ; Waggoner, William T. ; Wang, F. ; Wang, G. ; Wang, G. ; Wang, X. L. ; Wang, Y. ; Wang, Y. ; Wang, Z. M. ; Ward, H. ; Watson, J. W. ; Webb, Jason C. ; Wells, R. ; Westfall, Gary D. ; Wetzler, Alexander Albert ; Jr., C. Whitten ; Wieman, Howard ; Wissink, Scott W. ; Witt, Richard ; Wood, J. ; Wu, J. ; Xu, N. ; Xu, Z. ; Xu, Z. Z. ; Yamamoto, E. ; Yepes, Pablo P. ; Yurevich, Vladimir Yurevich ; Zanevsky, Yuri V. ; Zhang, Haitao ; Zhang, W. M. ; Zhang, Z. P. ; Zolnierczuk, Piotr Adam ; Zoulkarneev, R. ; Zoulkarneeva, Youlia ; Zubarev, A. N.
Correlations in the hadron distributions produced in relativistic Au+Au collisions are studied in the discrete wavelet expansion method. The analysis is performed in the space of pseudorapidity (| eta | <= 1) and azimuth(full 2 pi ) in bins of transverse momentum (pt) from 0.14 <= pt <= 2.1GeV/c. In peripheral Au+Au collisions a correlation structure ascribed to minijet fragmentation is observed. It evolves with collision centrality and pt in a way not seen before, which suggests strong dissipation of minijet fragmentation in the longitudinally expanding medium.
Adams, J. ; Adler, Clemens ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Berger, Jens ; Amonett, John ; Dietel, Thomas ; Anderson, Bryon D. ; Anderson, Mike ; Flierl, Dominik Bernhard ; Arkhipkin, Dmitry A. ; Kollegger, Thorsten ; Averichev, Georgy S. ; Lange, Jens Sören ; Badyal, S. K. ; Balewski, Jan ; Struck, Christof ; Barannikova, Olga ; Barnby, Lee Stuart ; Baudot, Jérome ; Bekele, Selemon ; Belaga, Victoria Vladimirovna ; Bellwied, Rene ; Berger, Jens ; Bezverkhny, B. I. ; Bhardwaj, S. ; Bhaskar, P. ; Bhati, Ashok Kumar ; Bichsel, Hans ; Billmeier, Anja ; Bland, Leslie C. ; Blyth, Charles O. ; Bonner, Billy E. ; Botje, Michiel ; Boucham, Abdelkrim ; Brandin, Andrei V. ; Bravar, Alessandro ; Cadman, R. V. ; Cai, Xiang-Zhou ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Carroll, J. ; Castillo Castellanos, Javier Ernesto ; Castro, M. ; Cebra, Daniel A. ; Chaloupka, Petr ; Chattopadhyay, S. ; Chen, H. F. ; Chen, Y. ; Chernenko, S. P. ; Cherney, Michael Gerard ; Chikanian, Alexei ; Choi, B. ; Christie, William ; Coffin, Jean Pierre ; Cormier, Thomas Michael ; Cramer, John G. ; Crawford, Henry J. ; Das, Debasish ; Das, Supriya ; Derevschikov, Anatoly A. ; Didenko, Lidia ; Dietel, Thomas ; Dong, X. ; Draper, James E. ; Drees, K. A. ; Du, F. ; Dubey, Anand Kumar ; Dunin, V. B. ; Dunlop, James C. ; Majumdar, M. R. Dutta ; Eckardt, Volker ; Efimov, Leonid G. ; Emelianov, V. ; Engelage, Jon M. ; Eppley, Geary Wareham ; Erazmus, Barbara Ewa ; Fachini, Patricia ; Faine, V. ; Faivre, Julien ; Fatemi, Renee H. ; Filimonov, Kirill ; Filip, Peter ; Finch, Evan ; Fisyak, Yuri V. ; Flierl, Dominik Bernhard ; Foley, K. J. ; Fu, J. ; Gagliardi, Carl A. ; Ganti, Murthy S. ; Gagunashvili, N. ; Gans, J. ; Gaudichet, L. ; Germain, Marie ; Geurts, Frank ; Ghazikhanian, Vahe ; Ghosh, Premomoy ; Gonzalez, Johan Enmanuel ; Grachov, Oleg A. ; Grigoriev, Vladislav A. ; Gronstal, S. ; Grosnick, David P. ; Guedon, M. ; Guertin, Steven M. ; Gupta, Anik ; Gushin, E. ; Gutierrez, Thomas Dominic ; Hallman, Timothy J. ; Hardtke, David H. ; Harris, John W. ; Heinz, Mark Thomas ; Henry, Thomas W. ; Heppelmann, Steven Francis ; Herston, T. ; Hippolyte, Boris ; Hirsch, Andrew S. ; Hjort, Eric ; Hoffmann, Gerald W. ; Horsley, M. ; Huang, Huan Zhong ; Huang, Shengli ; Humanic, Thomas J. ; Igo, George J. ; Ishihara, A. ; Jacobs, Peter Martin ; Jacobs, William W. ; Janik, Michał ; Johnson, I. ; Jones, Peter Graham ; Judd, Eleanor G. ; Kabana, Sonia ; Kaneta, Kaneta ; Kaplan, Morton ; Keane, Declan ; Kiryluk, Joanna ; Kisiel, Adam Ryszard ; Klay, Jennifer Lynn ; Klein, Spencer Robert ; Klyachko, A. ; Kollegger, Thorsten ; Konstantinov, A. S. ; Kopytine, M. ; Kotchenda, L. ; Kovalenko, A. D. ; Kramer, M. ; Kravtsov, Peter ; Krueger, Keith William ; Kuhn, Christian Claude ; Kulikov, Anatoly I. ; Kumar, Ajay ; Kunde, Gerd J. ; Kunz, Christopher Lee ; Kutuev, R. Kh. ; Kuznetsov, A. A. ; Lamont, Matthew A. C. ; Landgraf, Jeffery M. ; Lange, S. ; Lansdell, Curtis Patrick Leon ; Lasiuk, Brian ; Laue, Frank ; Lauret, Jerome ; Lebedev, Alexei ; Lednický, Richard ; Leontiev, V. M. ; LeVine, Micheal J. ; Li, C. ; Li, Q. ; Lindenbaum, Sam J. ; Lisa, Michael A. ; Liu, F. ; Liu, L. ; Liu, Z. ; Liu, Q. J. ; Ljubicic, Tonko A. ; Llope, William Joseph ; Long, H. ; Longacre, Ronald S. ; Lopez-Noriega, M. ; Love, William A. ; Ludlam, Thomas ; Lynn, David ; Ma, Jing-guo ; Ma, Yu-Gang ; Magestro, Daniel ; Mahajan, Sanjay ; Mangotra, Lalit K. ; Mahapatra, D. P. ; Majka, Richard Daniel ; Manweiler, Robert W. ; Margetis, Spyridon ; Markert, Christina ; Martin, L. ; Marx, Jay N. ; Matis, Howard S. ; Matulenko, Yuri A. ; McShane, Tom S. ; Meissner, F. ; Melnick, Yu. ; Meščanin, Aleksei P. ; Messer, Matthias ; Miller, M. L. ; Milosevich, Z. ; Minaev, Nikolai G. ; Mironov, Camelia ; Mishra, Debadeepti ; Mitchell, J. ; Mohanty, Bedangadas ; Molnar, Levente ; Moore, C. F. ; Mora-Corral, M. J. ; Morozov, V. ; de Moura, M. M. ; Munhoz, Marcelo Gameiro ; Nandi, Basanta Kumar ; Nayak, S. K. ; Nayak, Tapan Kumar ; Nelson, John M. ; Nevski, P. ; Nikitin, Vladimir A. ; Nogach, Larisa V. ; Norman, B. ; Nurušev, Sandibek B. ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Okorokov, Vitaly A. ; Oldenburg, Markus D. ; Olson, Douglas L. ; Paic, Guy ; Pandey, S. U. ; Pal, Susanta Kumar ; Panebratsev, Yuri ; Panitkin, Sergei Yurievich ; Pavlinov, A. I. ; Pawlak, Tomasz Jan ; Perevoztchikov, V. ; Peryt, Wiktor Stanislaw ; Petrov, V. A. ; Phatak, S. C. ; Picha, R. ; Planinic, Mirko ; Pluta, Jan Marian ; Porile, Norbert T. ; Porter, Jeffrey Brent ; Poskanzer, Arthur M. ; Potekhin, Maxim ; Potrebenikova, E. ; Potukuchi, B. V. K. S. ; Prindle, Duncan J. ; Pruneau, Claude A. ; Putschke, Jörn H. ; Rai, Gulshan ; Rakness, Gregory L. ; Raniwala, Rashmi ; Raniwala, Sudhir ; Ravel, Olivier ; Ray, Robert L. ; Razin, Sergej V. ; Reichhold, Dennis Michael ; Reid, Jeffrey G. ; Renault, G. ; Retiere, Fabrice ; Ridiger, Alexey ; Ritter, Hans Georg ; Roberts, Jabus B. ; Rogachevski, O. V. ; Romero, Juan L. ; Rose, A. ; Roy, Christelle Sophie ; Ruan, Lijuan ; Rykov, Vladimir L. ; Sahoo, Raghunath ; Sakrejda, Iwona ; Salur, Sevil ; Sandweiss, Jack H. ; Savin, Igor A. ; Schambach, Joachim ; Scharenberg, Rolf Paul ; Schmitz, Norbert ; Schroeder, Lee S. ; Schweda, Kai ; Seger, Janet Elizabeth ; Seliverstov, D. ; Seyboth, Peter ; Shahaliev, Ehtiram ; Shao, M. ; Sharma, M. ; Shestermanov, Konstantin E. ; Shimanskii, S. S. ; Singaraju, Rama Narayana ; Simon, F. ; Skoro, Goran P. ; Smirnov, Nikolai ; Snellings, Raimond ; Sood, Gopika ; Sorensen, Paul Richard ; Sowinski, James ; Spinka, Harold. M. ; Srivastava, Brijesh Kumar ; Stanislaus, S. ; Stock, Reinhard ; Stolpovsky, Alexander ; Strichanov, Michail Nikolaevič ; Stringfellow, Blair ; Struck, Christof ; Suaide, Alexandre Alarcon do Passo ; Sugarbaker, Evan R. ; Suire, Christophe Pierre ; Šumbera, Michal ; Surrow, Bernd ; Symons, Timothy James MacNeil ; Toledo, Alejandro Szanto de ; Szarwas, Piotr ; Tai, An ; Takahashi, Jun ; Tang, Aihong ; Thein, Dylan ; Thomas, James H. ; Tikhomirov, V. ; Tokarev, Mikhail V. ; Tonjes, Marguerite Belt ; Trainor, Thomas A. ; Trentalange, Stephen ; Tribble, Robert E. ; Trivedi, M. D. ; Trofimov, V. ; Tsai, Oleg D. ; Ullrich, Thomas ; Underwood, David G. ; Van Buren, Gene ; VanderMolen, A. M. ; Vasiliev, Alexander Nikolaevich ; Vasiliev, M. ; Vigdor, Steven E. ; Viyogi, Yogendra P. ; Voloshin, Sergei ; Waggoner, William T. ; Wang, F. ; Wang, G. ; Wang, X. L. ; Wang, Z. M. ; Ward, H. ; Watson, J. W. ; Wells, R. ; Westfall, Gary D. ; Whitten, Charles A. ; Wieman, Howard ; Willson, Robert ; Wissink, Scott W. ; Witt, Richard ; Wood, J. ; Wu, J. ; Xu, N. ; Xu, Z. ; Xu, Z. Z. ; Yakutin, A. E. ; Yamamoto, E. ; Yang, J. ; Yepes, Pablo P. ; Yurevich, Vladimir Yurevich ; Zanevski, Y. V. ; Zborovský, I. ; Zhang, Haitao ; Zhang, H. Y. ; Zhang, W. M. ; Zhang, Z. P. ; Żołnierczuk, Piotr Adam ; Zoulkarneev, R. ; Zoulkarneeva, J. ; Zubarev, A. N.
We report high statistics measurements of inclusive charged hadron production in Au+Au and p+p collisions at sqrt[sNN]=200 GeV. A large, approximately constant hadron suppression is observed in central Au+Au collisions for 5<pT<12 GeV/c. The collision energy dependence of the yields and the centrality and pT dependence of the suppression provide stringent constraints on theoretical models of suppression. Models incorporating initial-state gluon saturation or partonic energy loss in dense matter are largely consistent with observations. We observe no evidence of pT-dependent suppression, which may be expected from models incorporating jet attenuation in cold nuclear matter or scattering of fragmentation hadrons.
Adamczyk, Leszek ; Adams, Joseph R. ; Adkins, J. Kevin ; Agakishiev, Geydar ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Ajitanand, N.N. ; Alekseev, Igor G. ; Anderson, Derek M. ; Aoyama, Ryo ; Aparin, Alexey ; Arkhipkin, Dmitry A. ; Aschenauer, Elke Caroline ; Ashraf, Muhammad Usman ; Attri, Anjali ; Averichev, Georgy S. ; Bairathi, Vipul ; Barish, Kenneth ; Behera, Arabinda ; Bellwied, Rene ; Bhasin, Anju ; Bhati, Ashok Kumar ; Bhattarai, P. ; Bielčík, Jaroslav ; Bielčíková, Jana ; Bland, Leslie C. ; Bordyuzhin, Igor G. ; Bouchet, Jonathan ; Brandenburg, James D. ; Brandin, Andrei V. ; Brown, D. ; Bryslawskyj, Jason ; Bunzarov, Ivan ; Butterworth, Joseph ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Campbell, J.M. ; Cebra, Daniel A. ; Chakaberia, Irakli ; Chaloupka, Petr ; Chang, Z. ; Chankova-Bunzarova, N. ; Chatterjee, A. ; Chattopadhyay, S. ; Chen, J.H. ; Chen, X. ; Chen, X. ; Cheng, J. ; Cherney, Michael Gerard ; Christie, William ; Contin, Giacomo ; Crawford, Henry J. ; Dedovič, Tatiana G. ; Deng, J. ; Deppner, Ingo Martin ; Derevschikov, Anatoly A. ; Didenko, Lidia ; Dilks, Christopher ; Dong, X. ; Drachenberg, James Lucus ; Draper, James E. ; Dunlop, James C. ; Efimov, Leonid G. ; Elsey, Nicholas ; Engelage, Jon M. ; Eppley, Geary Wareham ; Esha, Roli ; Esumi, ShinIchi ; Evdokimov, Olga Y. ; Ewigleben, Justin ; Eyser, Kjeld Oleg ; Fatemi, Renee H. ; Fazio, Salvatore ; Federič, Pavol ; Federicova, P. ; Fedorišin, Jan ; Feng, Z. ; Filip, Peter ; Finch, Evan ; Fisyak, Yuri V. ; Flores, C.E. ; Fujita, J. ; Fulek, Łukasz ; Gagliardi, Carl A. ; Geurts, Frank ; Gibson, Adam ; Girard, M. ; Grosnick, David P. ; Gunarathne, D.S. ; Guo, Y. ; Gupta, Anik ; Guryn, Włodzimierz ; Hamad, Ayman ; Hamed, Ahmed M. ; Harlenderova, Alena ; Harris, John W. ; He, L. ; Heppelmann, Samuel ; Heppelmann, Steven Francis ; Herrmann, Norbert ; Hirsch, Andrew S. ; Horvat, S. ; Huang, X. ; Huang, Huan Zhong ; Huang, T. ; Huang, Bingchu ; Humanic, Thomas J. ; Huo, P. ; Igo, George J. ; Jacobs, William W. ; Jentsch, Alexander ; Jia, Jiangyong ; Jiang, K. ; Jowzaee, S. ; Judd, Eleanor G. ; Kabana, Sonia ; Kalinkin, Dmitry ; Kang, K. ; Kapukchyan, David ; Kauder, Kolja ; Ke, Hongwei ; Keane, Declan ; Kechechyan, Armen ; Khan, Z. ; Kikoła, Daniel P. ; Kim, C. ; Kisel, Ivan ; Kisiel, Adam Ryszard ; Kočenda, L. M. ; Kocmanek, M. ; Kollegger, Thorsten ; Kosarzewski, Leszek Krzysztof ; Kraishan, A.F. ; Krauth, L. ; Kravtsov, Peter ; Krueger, Keith William ; Kulathunga, Nalinda ; Kumar, Lokesh ; Kvapil, Jakub ; Kwasizur, Joseph H. ; Lacey, Roy Alphanso ; Landgraf, Jeffery M. ; Landry, K.D. ; Lauret, Jerome ; Lebedev, Alexei ; Lednicky, Richard ; Lee, J.H. ; Li, W. ; Li, C. ; Li, Xiaomei ; Li, Y. ; Lidrych, J. ; Lin, T. ; Lisa, Michael A. ; Liu, Y. ; Liu, H. ; Liu, F. ; Liu, P. ; Ljubicic, Tonko A. ; Llope, William Joseph ; Lomnitz, Michael ; Longacre, Ronald S. ; Luo, X. ; Luo, S. ; Ma, L. ; Ma, Yu-Gang ; Ma, G.L. ; Ma, R. ; Magdy Abdelwahab Abdelrahman, Niseem ; Majka, Richard Daniel ; Mallick, Dukhishyam ; Margetis, Spyridon ; Markert, Christina ; Matis, Howard S. ; Mayes, D. ; Meehan, Kathryn ; Mei, Jincheng ; Miller, Z.W. ; Minaev, Nikolai G. ; Mioduszewski, Saskia ; Mishra, Debadeepti ; Mizuno, S. ; Mohanty, Bedangadas ; Mouli, Mriganka Mouli ; Morozov, Dmitry A. ; Mustafa, M.K. ; Nasim, Md. ; Nayak, Tapan Kumar ; Nelson, John M. ; Nemes, Daniel B. ; Nie, Maowu ; Nigmatkulov, Grigory A. ; Niida, Takafumi ; Nogach, Larisa V. ; Nonaka, Toshihiro ; Nurušev, Sandibek B. ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Oh, Kunsu ; Okorokov, Vitaly A. ; Olvitt, D. ; Page, Brian S. ; Pak, Robert ; Pandit, Y. ; Panebratsev, Yuri ; Pawlik, Bogdan ; Pei, Hua ; Perkins, Chris ; Pluta, Jan Marian ; Poniatowska, K. ; Porter, Jeffrey Brent ; Posik, Matthew ; Pruthi, Navneet Kumar ; Przybycien, Mariusz ; Putschke, Jörn H. ; Quintero, Amilkar ; Ramachandran, Suvarna ; Ray, Robert L. ; Reed, Rosi Jan ; Rehbein, M.J. ; Ritter, Hans Georg ; Roberts, Jabus B. ; Rogačevskij, Oleg V. ; Romero, Juan L. ; Roth, J.D. ; Ruan, Lijuan ; Rusnak, Jan ; Rusnakova, Olga ; Sahoo, Nihar Ranjan ; Sahu, Pradip Kumar ; Salur, Sevil ; Sandweiss, Jack H. ; Saur, M. ; Schambach, Joachim ; Schmah, Alexander ; Schmidke, William B. ; Schmitz, Norbert ; Schweid, Benjamin R. ; Seger, Janet Elizabeth ; Sergeeva, Maria ; Seto, Richard ; Seyboth, Peter ; Shah, N. ; Shahaliev, Ehtiram ; Shanmuganathan, Prashanth V. ; Shao, M. ; Shen, W.Q. ; Shi, Shusu ; Shi, Z. ; Shou, Q.Y. ; Sichtermann, Ernst P. ; Sikora, Rafał ; Šimko, Miroslav ; Singha, Subhash ; Skoby, Michael J. ; Smirnov, Nikolai ; Smirnov, Dmitri V. ; Solyst, William ; Sorensen, Paul Richard ; Spinka, Harold. M. ; Srivastava, Brijesh Kumar ; Stanislaus, T. D. Shirvel ; Stewart, David J. ; Strichanov, Michail Nikolaevič ; Stringfellow, Blair ; Suaide, Alexandre Alarcon do Passo ; Sugiura, Tetsuro ; Šumbera, Michal ; Summa, Branden ; Sun, X. ; Sun, X.M. ; Sun, Y. ; Surrow, Bernd ; Svirida, Dmitry N. ; Tang, Zebo ; Tang, Aihong ; Taranenko, Arkadiy ; Tarnowsky, Terence J. ; Tawfik, Abdel Nasser ; Thäder, Jochen ; Thomas, James H. ; Timmins, Anthony Robert ; Tlusty, David ; Todoroki, Takahito ; Tokarev, Mikhail V. ; Trentalange, Stephen ; Tribble, Robert E. ; Tribedy, Prithwish ; Tripathy, Srikanta Kumar ; Trzeciak, Barbara Antonina ; Tsai, Oleg D. ; Tu, B. ; Ullrich, Thomas ; Underwood, David G. ; Upsal, Isaac ; Van Buren, Gene ; Nieuwenhuizen, Gerrit J. van ; Vasiliev, Alexander Nikolaevich ; Videbæk, Flemming ; Vokal, Stanislav ; Voloshin, Sergei ; Vossen, A. ; Wang, G. ; Wang, Y. ; Wang, Y. ; Wang, F. ; Webb, Grant ; Webb, Jason C. ; Wen, L. ; Westfall, Gary D. ; Wieman, Howard ; Wissink, Scott W. ; Witt, Richard ; Wu, Y. ; Xiao, Z.G. ; Xie, Guannan ; Xie, W. ; Xu, N. ; Xu, Y.F. ; Xu, Qinghua ; Xu, Z. ; Yang, Y. ; Yang, C. ; Yang, S. ; Yang, Q. ; Ye, Z. ; Ye, Z. ; Yi, L. ; Yip, K. ; Yoo, In-Kwon ; Zbroszczyk, Hanna Paulina ; Zha, Wangmei ; Zhang, J.B. ; Zhang, J. ; Zhang, S. ; Zhang, J. ; Zhang, S. ; Zhang, Zuman ; Zhang, Y. ; Zhang, L. ; Zhang, X.P. ; Zhao, J. ; Zhong, C. ; Zhou, C. ; Zhou, L. ; Zhu, X. ; Zhu, Z. ; Zyzak, Maksym
The transversity distribution, which describes transversely polarized quarks in transversely polarized nucleons, is a fundamental component of the spin structure of the nucleon, and is only loosely constrained by global fits to existing semi-inclusive deep inelastic scattering (SIDIS) data. In transversely polarized p↑+p collisions it can be accessed using transverse polarization dependent fragmentation functions which give rise to azimuthal correlations between the polarization of the struck parton and the final state scalar mesons.This letter reports on spin dependent di-hadron correlations measured by the STAR experiment. The new dataset corresponds to 25 pb−1 integrated luminosity of p↑+p collisions at s=500 GeV, an increase of more than a factor of ten compared to our previous measurement at s=200 GeV. Non-zero asymmetries sensitive to transversity are observed at a Q2 of several hundred GeV and are found to be consistent with the former measurement and a model calculation. We expect that these data will enable an extraction of transversity with comparable precision to current SIDIS datasets but at much higher momentum transfers where subleading effects are suppressed.
Transverse spin transfer to Λ and ¯Λ hyperons in polarized proton-proton collisions at √𝑠=200 GeV
(2018)
Adam, Jaroslav ; Adamczyk, Leszek ; Adams, Joseph R. ; Adkins, J. Kevin ; Agakishiev, Geydar ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Alekseev, Igor G. ; Anderson, Derek M. ; Aoyama, Ryo ; Aparin, Alexey ; Arkhipkin, Dmitry A. ; Aschenauer, Elke Caroline ; Ashraf, Muhammad Usman ; Atetalla, Fareha ; Attri, Anjali ; Averichev, Georgy S. ; Bai, X. ; Bairathi, Vipul ; Barish, Kenneth ; Bassill, Aaron J. ; Behera, Arabinda ; Bellwied, Rene ; Bhasin, Anju ; Bhati, Ashok Kumar ; Bielčík, Jaroslav ; Bielčíková, Jana ; Bland, Leslie C. ; Bordyuzhin, Igor G. ; Brandenburg, James D. ; Brandin, Andrei V. ; Brown, D. ; Bryslawskyj, Jason ; Bunzarov, Ivan ; Butterworth, Joseph ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Cebra, Daniel A. ; Chakaberia, Irakli ; Chaloupka, Petr ; Chan, B. K. ; Chang, F-H. ; Chang, Z. ; Chankova-Bunzarova, N. ; Chatterjee, A. ; Chattopadhyay, S. ; Chen, J. H. ; Chen, X. ; Chen, X. ; Cheng, J. ; Cherney, Michael Gerard ; Christie, William ; Contin, Giacomo ; Crawford, Henry J. ; Csanád, Máté ; Das, Supriya ; Dedovich, T. G. ; Deppner, Ingo Martin ; Derevschikov, Anatoly A. ; Didenko, Lidia ; Dilks, Christopher ; Dong, X. ; Drachenberg, James Lucus ; Dunlop, James C. ; Efimov, Leonid G. ; Elsey, Nicholas ; Engelage, Jon M. ; Eppley, Geary Wareham ; Esha, Roli ; Esumi, ShinIchi ; Evdokimov, Olga Y. ; Ewigleben, J. ; Eyser, Kjeld Oleg ; Fatemi, Renee H. ; Fazio, Salvatore ; Federič, Pavol ; Federicova, P. ; Fedorišin, Jan ; Filip, Peter ; Finch, Evan ; Fisyak, Yuri V. ; Flores, C. E. ; Fulek, Łukasz ; Gagliardi, Carl A. ; Galatyuk, Tetyana ; Geurts, Frank ; Gibson, Adam ; Grosnick, David P. ; Gunarathne, D. S. ; Guo, Y. ; Gupta, Anik ; Guryn, Włodzimierz ; Hamad, A. I. ; Hamed, Ahmed M. ; Harlenderova, Alena ; Harris, John W. ; He, L. ; Heppelmann, S. ; Heppelmann, S. ; Herrmann, Norbert ; Hirsch, Andrew S. ; Holub, Lukáš ; Hong, Y. ; Horvat, S. ; Huang, Bingchu ; Huang, Huan Zhong ; Huang, Shengli ; Huang, T. ; Huang, X. ; Humanic, Thomas J. ; Huo, P. ; Igo, George J. ; Jacobs, William W. ; Jentsch, Alexander ; Jia, Jiangyong ; Jiang, K. ; Jowzaee, S. ; Ju, Xin-Yue ; Judd, Eleanor G. ; Kabana, Sonia ; Kagamaster, Skipper ; Kalinkin, Dmitry ; Kang, K. ; Kapukchyan, David ; Kauder, Kolja ; Ke, Hongwei ; Keane, Declan ; Kechechyan, Armen ; Kikoła, Daniel P. ; Kim, C. ; Kinghorn, Todd Adler ; Kisel, Ivan ; Kisiel, Adam Ryszard ; Kočenda, L. M. ; Kosarzewski, Leszek Krzysztof ; Kraishan, A. F. ; Kramarik, L. ; Krauth, L. ; Kravtsov, Peter ; Krueger, Keith William ; Kulathunga, Nalinda ; Kumar, Lokesh ; Kunnawalkam Elayavalli, Raghav ; Kvapil, Jakub ; Kwasizur, Joseph H. ; Lacey, Roy Alphanso ; Landgraf, Jeffery M. ; Lauret, Jerome ; Lebedev, Alexei ; Lednicky, Richard ; Lee, J. H. ; Li, C. ; Li, W. ; Li, X. ; Li, Y. ; Liang, Y. ; Lidrych, J. ; Lin, T. ; Lipiec, Andrzej ; Lisa, Michael A. ; Liu, F. ; Liu, H. ; Liu, P. ; Liu, P. ; Liu, Y. ; Liu, Z. ; Ljubicic, Tonko A. ; Llope, William Joseph ; Lomnitz, M. ; Longacre, Ronald S. ; Luo, S. ; Luo, X. ; Ma, G. L. ; Ma, L. ; Ma, R. ; Ma, Yu-Gang ; Magdy Abdelwahab Abdelrahman, Niseem ; Majka, Richard Daniel ; Mallick, Dukhishyam ; Margetis, Spyridon ; Markert, Christina ; Matis, Howard S. ; Matonoha, Oliver ; Mazer, Joel Anthony ; Meehan, K. ; Mei, J. C. ; Minaev, Nikolai G. ; Mioduszewski, Saskia ; Mishra, Debadeepti ; Mohanty, Bedangadas ; Mouli, Mriganka Mouli ; Mooney, Isaac A. ; Morozov, Dmitry A. ; Nasim, Md. ; Negrete, J. D. ; Nelson, John M. ; Nemes, Daniel B. ; Nie, M. ; Nigmatkulov, Grigory A. ; Niida, Takafumi ; Nogach, Larisa V. ; Nonaka, Toshihiro ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Oh, K. ; Oh, Saehanseul ; Okorokov, Vitaly A. ; Olvitt, D. ; Page, Brian S. ; Pak, Robert ; Panebratsev, Yuri ; Pawlik, Bogdan ; Pei, Hua ; Perkins, Chris ; Pinter, Roland Laszlo ; Pluta, Jan Marian ; Porter, Jeffrey Brent ; Posik, Matthew ; Pruthi, Navneet Kumar ; Przybycien, Mariusz ; Putschke, Jörn H. ; Quintero, Amilkar ; Radhakrishnan, Sooraj Krishnan ; Ramachandran, Suvarna ; Ray, Robert L. ; Reed, Rosi Jan ; Ritter, Hans Georg ; Roberts, Jabus B. ; Rogačevskij, Oleg V. ; Romero, Juan L. ; Ruan, L. ; Rusnak, Jan ; Rusnakova, O. ; Sahoo, Nihar Ranjan ; Sahu, Pradip Kumar ; Salur, Sevil ; Sandweiss, Jack H. ; Schambach, Joachim ; Schmah, A. M. ; Schmidke, William B. ; Schmitz, Norbert ; Schweid, Benjamin R. ; Seck, Florian ; Seger, Janet Elizabeth ; Sergeeva, Maria ; Seto, Richard ; Seyboth, Peter ; Shah, N. ; Shahaliev, Ehtiram ; Shanmuganathan, Prashanth V. ; Shao, M. ; Shen, F. ; Shen, W. Q. ; Shi, Shusu ; Shou, Q. Y. ; Sichtermann, Ernst P. ; Siejka, Sebastian ; Sikora, Rafał ; Šimko, Miroslav ; Singh, J. ; Singha, Subhash ; Smirnov, Dmitri V. ; Smirnov, Nikolai ; Solyst, William ; Sorensen, Paul Richard ; Spinka, Harold. M. ; Srivastava, B. ; Stanislaus, T. D. Shirvel ; Stewart, David J. ; Strichanov, Michail Nikolaevič ; Stringfellow, Blair ; Suaide, Alexandre Alarcon do Passo ; Sugiura, Tetsuro ; Šumbera, Michal ; Summa, Branden ; Sun, X. M. ; Sun, X. ; Sun, Y. ; Surrow, Bernd ; Svirida, Dmitry N. ; Szymański, Paweł ; Tang, Aihong ; Tang, Zebo ; Taranenko, Arkadiy ; Tarnowsky, Terence J. ; Thomas, James H. ; Timmins, Anthony Robert ; Tlusty, David ; Todoroki, Takahito ; Tokarev, Mikhail V. ; Tomkiel, C. A. ; Trentalange, Stephen ; Tribble, Robert E. ; Tribedy, Prithwish ; Tripathy, Srikanta Kumar ; Tsai, Oleg D. ; Tu, B. ; Ullrich, Thomas ; Underwood, David G. ; Upsal, Isaac ; Van Buren, Gene ; Vanek, Jan ; Vasiliev, Alexander Nikolaevich ; Vassiliev, Iouri ; Videbæk, Flemming ; Vokal, Stanislav ; Voloshin, Sergei ; Vossen, A. ; Wang, F. ; Wang, G. ; Wang, P. ; Wang, Y. ; Wang, Y. ; Webb, Jason C. ; Wen, L. ; Westfall, Gary D. ; Wieman, Howard ; Wissink, Scott W. ; Witt, Richard ; Wu, Y. ; Xiao, Z. G. ; Xie, Guannan ; Xie, W. ; Xu, J. ; Xu, N. ; Xu, Qinghua ; Xu, Y. F. ; Xu, Z. ; Yang, C. ; Yang, Q. ; Yang, S. ; Yang, Y. ; Ye, Z. ; Ye, Z. ; Yi, L. ; Yip, K. ; Yoo, In-Kwon ; Yu, N. ; Zbroszczyk, Hanna Paulina ; Zha, Wangmei ; Zhang, J. ; Zhang, J. ; Zhang, L. ; Zhang, S. ; Zhang, S. ; Zhang, X. P. ; Zhang, Y. ; Zhang, Z. ; Zhao, J. ; Zhong, C. ; Zhou, C. ; Zhu, X. ; Zhu, Z. ; Zyzak, Maksym
The transverse spin transfer from polarized protons to Λ and Λ¯ hyperons is expected to provide sensitivity to the transversity distribution of the nucleon and to the transversely polarized fragmentation functions. We report the first measurement of the transverse spin transfer to Λ and Λ¯ along the polarization direction of the fragmenting quark, DTT, in transversely polarized proton-proton collisions at s√=200GeV with the STAR detector at RHIC. The data correspond to an integrated luminosity of 18pb−1 and cover the pseudorapidity range |η|<1.2 and transverse momenta pT up to 8GeV/c. The dependence on pT and η are presented. The DTT results are found to be comparable with a model prediction, and are also consistent with zero within uncertainties.
Alber, Thomas ; Appelshäuser, Harald ; Bächler, Joachim ; Bartke, Jerzy ; Białkowska, Helena ; Bieser, Fred ; Bloomer, Matthew A. ; Blyth, Charles O. ; Bock, Rudolf ; Bormann, Christian ; Brady, Franklin Paul ; Brockmann, Robert ; Bunčić, Predrag ; Caines, Helen Louise ; Cebra, Daniel A. ; Chan, Phaikying ; Cooper, Glenn E. ; Cramer, John G. ; Cramer, Pauline B. ; Csató, Péter ; Derado, Ivan ; Dunn, Jason ; Eckardt, Volker ; Eckhardt, Frank ; Euler, Sebastian ; Ferguson, M. I. ; Fischer, Hans Gerhard ; Fodor, Zoltán ; Foka, Panagiota ; Freund, Peter ; Fuchs, Matthias ; Gál, József ; Gaździcki, Marek ; Gładysz-Dziaduś, Ewa ; Grebieszkow, Jaroslaw ; Günther, Jörg ; Harris, John W. ; Heck, W. ; Hegyi, Sándor ; Hill, L. A. ; Huang, Isaac ; Howe, Mark A. ; Igo, George J. ; Irmscher, Detlef ; Jacobs, Peter Martin ; Jones, Peter Graham ; Kadija, Krešo ; Kecskemeti, J. ; Kowalski, Marek ; Kühmichel, Andreas ; Lasiuk, Brian ; Margetis, Spyridon ; Mitchell, J. W. ; Mock, Andreas ; Nelson, John M. ; Odyniec, Grazyna Janina ; Pálinkás, József ; Pálla, Gabriella ; Panagiotou, Apostolos D. ; Petridis, Athanasios ; Piper, Andreas ; Poskanzer, Arthur M. ; Prindle, Duncan J. ; Pühlhofer, Falk ; Rauch, Wolfgang Hans ; Renfordt, Rainer Arno Ernst ; Retyk, Waldemar ; Ritter, Hans Georg ; Röhrich, Dieter ; Rudolph, Heinrich ; Runge, Kay ; Sandoval, Andres ; Sann, Hans ; Schäfer, Erich ; Schmitz, Norbert ; Schönfelder, Stefan ; Seyboth, Peter ; Seyerlein, Jürgen ; Sikler, Ferenc ; Skrzypczak, Ewa ; Stock, Reinhard ; Ströbele, Herbert ; Szentpetery, Imre ; Sziklai, János ; Toy, Milton Y. ; Trainor, Thomas A. ; Trentalange, Stephen ; Vassiliou, Maria ; Vesztergombi, György ; Vranić, Danilo ; Wenig, Siegfried ; Whitten, Charles A. ; Wienold, Thomas ; Wood, Lindsay ; Zimanyi, József ; Zhu, X. -Z. ; Zybert, Ryszard
Praktiknjo, Michael ; Simón-Talero, Macarena ; Römer, Julia ; Roccarina, Davide ; Martínez, Javier ; Lampichler, Katharina ; Baiges, Anna ; Low, Gavin ; Llop, Elba ; Maurer, Martin H. ; Zipprich, Alexander ; Triolo, Michela ; Maleux, Geert ; Fialla, Annette Dam ; Dam, Claus ; Vidal-González, Judit ; Majumdar, Avik ; Picón, Carmen ; Toth, Daniel ; Darnell, Anna ; Abraldes, Juan G. ; López, Marta ; Jansen, Christian ; Chang, Johannes ; Schierwagen, Robert ; Uschner, Frank Erhard ; Kukuk, Guido ; Meyer, Carsten ; Thomas, Daniel ; Wolter, Karsten ; Straßburg, Christian P. ; Laleman, Wim ; La Mura, Vincenzo ; Ripoll, Cristina ; Berzigotti, Annalisa ; Calleja, José Luis ; Tandon, Puneeta ; Hernández-Gea, Virginia ; Reiberger, Thomas ; Albillos, Agustin ; Tsochatzis, Emmanuel A. ; Krag, Aleksander ; Genescà, Joan ; Trebicka, Jonel
Background & Aims: Spontaneous portosystemic shunts (SPSS) frequently develop in liver cirrhosis. Recent data suggested that the presence of a single large SPSS is associated with complications, especially overt hepatic encephalopathy (oHE). However, the presence of >1 SPSS is common. This study evaluates the impact of total cross-sectional SPSS area (TSA) on outcomes in patients with liver cirrhosis.
Methods: In this retrospective international multicentric study, CT scans of 908 cirrhotic patients with SPSS were evaluated for TSA. Clinical and laboratory data were recorded. Each detected SPSS radius was measured and TSA calculated. One-year survival was the primary endpoint and acute decompensation (oHE, variceal bleeding, ascites) was the secondary endpoint.
Results: A total of 301 patients (169 male) were included in the training cohort. Thirty percent of all patients presented with >1 SPSS. A TSA cut-off of 83 mm2 was used to classify patients with small or large TSA (S-/L-TSA). Patients with L-TSA presented with higher model for end-stage liver disease score (11 vs. 14) and more commonly had a history of oHE (12% vs. 21%, p <0.05). During follow-up, patients with L-TSA experienced more oHE episodes (33% vs. 47%, p <0.05) and had lower 1-year survival than those with S-TSA (84% vs. 69%, p <0.001). Multivariate analysis identified L-TSA (hazard ratio 1.66; 95% CI 1.02–2.70, p <0.05) as an independent predictor of mortality. An independent multicentric validation cohort of 607 patients confirmed that patients with L-TSA had lower 1-year survival (77% vs. 64%, p <0.001) and more oHE development (35% vs. 49%, p <0.001) than those with S-TSA.
Conclusion: This study suggests that TSA >83 mm2 increases the risk for oHE and mortality in patients with cirrhosis. Our results support the clinical use of TSA/SPSS for risk stratification and decision-making in the management of patients with cirrhosis.
Lay summary: The prevalence of spontaneous portosystemic shunts (SPSS) is higher in patients with more advanced chronic liver disease. The presence of more than 1 SPSS is common in advanced chronic liver disease and is associated with the development of hepatic encephalopathy. This study shows that total cross-sectional SPSS area (rather than diameter of the single largest SPSS) predicts survival in patients with advanced chronic liver disease. Our results support the clinical use of total cross-sectional SPSS area for risk stratification and decision-making in the management of SPSS.
Abdallah, Mohamed Samy ; Aboona, Bassam ; Adam, Jaroslav ; Adamczyk, Leszek ; Adams, Joseph R. ; Adkins, J. Kevin ; Agakishiev, G. ; Aggarwal, Ishu ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Aitbaev, A. ; Alekseev, I. ; Anderson, D. M. ; Aparin, A. ; Aschenauer, Elke Caroline ; Ashraf, M. U. ; Atetalla, F. G. ; Averichev, G. S. ; Bairathi, Vipul ; Baker, W. ; Ball Cap, Jonathan Gonzalo ; Barish, Kenneth ; Behera, A. ; Bellwied, Rene ; Bhagat, Pratibha ; Bhasin, Anju ; Bielčík, Jaroslav ; Bielčíková, Jana ; Bordyuzhin, I. G. ; Brandenburg, James D. ; Brandin, A. V. ; Cai, Xiang-Zhou ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Cebra, Daniel A. ; Chakaberia, Irakli ; Chaloupka, Petr ; Chan, B. K. ; Chang, F-H. ; Chang, Z. ; Chatterjee, A. ; Chattopadhyay, S. ; Chen, D. ; Chen, J. ; Chen, J. H. ; Chen, X. ; Chen, Z. ; Cheng, J. ; Choudhury, Subikash ; Christie, William ; Chu, Xiaoxuan ; Crawford, Henry J. ; Csanád, Máté ; Daugherity, M. ; Dedovich, T. G. ; Deppner, Ingo Martin ; Derevschikov, Anatoly A. ; Dhamija, A. ; Di Carlo, L. ; Didenko, Lidia ; Dixit, Prabhupada ; Dong, X. ; Drachenberg, James Lucus ; Duckworth, Emilie ; Dunlop, James C. ; Engelage, Jon M. ; Eppley, Geary Wareham ; Esumi, ShinIchi ; Evdokimov, Olga Y. ; Ewigleben, A. ; Eyser, Kjeld Oleg ; Fatemi, Renee H. ; Fawzi, F. M. ; Fazio, Salvatore ; Feng, C. J. ; Feng, Yicheng ; Finch, Evan ; Fisyak, Yuri V. ; Francisco, A. ; Fu, C. ; Gagliardi, Carl A. ; Galatyuk, T. ; Geurts, Frank ; Ghimire, Navagyan ; Gibson, Adam ; Gopal, Krishan ; Gou, X. ; Grosnick, David P. ; Gupta, Anik ; Guryn, Włodzimierz ; Hamed, Ahmed M. ; Han, Yiding ; Harabasz, Szymon ; Harasty, Matthew D. ; Harris, John W. ; Harrison, Hannah ; He, S. ; He, W. ; He, Xionghong ; He, Y. ; Heppelmann, S. ; Herrmann, Norbert ; Hoffman, E. ; Holub, Lukáš ; Hu, C. ; Hu, Q. ; Hu, Y. ; Huang, H. ; Huang, Huan Zhong ; Huang, Shengli ; Huang, T. ; Huang, X. ; Huang, Y. ; Humanic, Thomas J. ; Isenhower, D. ; Isshiki, M. ; Jacobs, William W. ; Jena, Chitrasen ; Jentsch, Alexander ; Ji, Yuanjing ; Jia, Jiangyong ; Jiang, K. ; Ju, Xin-Yue ; Judd, Eleanor G. ; Kabana, Sonia ; Kabir, M. L. ; Kagamaster, S. ; Kalinkin, Dmitry ; Kang, K. ; Kapukchyan, David ; Kauder, Kolja ; Ke, H. W. ; Keane, Declan ; Kechechyan, A. ; Kelsey, M. ; Kikoła, Daniel P. ; Kimelman, B. ; Kincses, D. ; Kisel, Ivan ; Kiselev, A. ; Klein, S. R. ; Knospe, Anders Garritt ; Ko, H. S. ; Kochenda, L. ; Korobitsin, A. ; Kosarzewski, Leszek Krzysztof ; Kramarik, L. ; Kravtsov, P. ; Kumar, Lokesh ; Kumar, S. ; Kunnawalkam Elayavalli, Raghav ; Kwasizur, J. H. ; Lacey, Roy Alphanso ; Lan, Shaowei ; Landgraf, Jeffery M. ; Lauret, Jerome ; Lebedev, A. ; Lednicky, R. ; Lee, J. H. ; Leung, Yue Hang ; Lewis, N. ; Li, C. ; Li, C. ; Li, W. ; Li, X. ; Li, Y. ; Li, Y. ; Liang, X. ; Liang, Y. ; Licenik, Robert ; Lin, T. ; Lin, Y. ; Lisa, Michael A. ; Liu, F. ; Liu, H. ; Liu, H. ; Liu, P. ; Liu, T. ; Liu, X. ; Liu, Y. ; Liu, Z. ; Ljubicic, Tonko A. ; Llope, W. J. ; Longacre, Ronald S. ; Loyd, E. ; Lu, T. ; Lukow, N. S. ; Luo, X. F. ; Ma, L. ; Ma, R. ; Ma, Y. G. ; Magdy Abdelwahab Abdelrahman, Niseem ; Mallick, D. ; Manukhov, S. L. ; Margetis, Spyridon ; Markert, Christina ; Matis, Howard S. ; Mazer, J. A. ; Minaev, N. G. ; Mioduszewski, Saskia ; Mohanty, Bedangadas ; Mouli, Mriganka Mouli ; Mooney, Isaac A. ; Morozov, D. A. ; Mukherjee, A. ; Nagy, M. ; Nam, J. D. ; Nasim, Md. ; Nayak, K. ; Neff, D. ; Nelson, John M. ; Nemes, Daniel B. ; Nie, M. ; Nigmatkulov, Grigory A. ; Niida, Takafumi ; Nishitani, R. ; Nogach, L. V. ; Nonaka, Toshihiro ; Nunes, A. S. ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Oh, Saehanseul ; Okorokov, Vitaly A. ; Okubo, K. ; Page, Brian S. ; Pak, Robert ; Pan, J. ; Pandav, Ashish ; Pandey, A. K. ; Panebratsev, Yuri ; Parfenov, P. ; Paul, A. ; Pawlik, Bogdan ; Pawłowska, Diana ; Perkins, Chris ; Pluta, Jan Marian ; Pokhrel, B. R. ; Porter, J. ; Posik, Matthew ; Prozorova, V. ; Pruthi, Navneet Kumar ; Przybycien, Mariusz ; Putschke, Jörn H. ; Qiu, H. ; Quintero, Amilkar ; Racz, Cameron ; Radhakrishnan, Sooraj Krishnan ; Raha, N. ; Ray, Robert L. ; Reed, Rosi Jan ; Ritter, Hans Georg ; Robotkova, Monika ; Romero, J. L. ; Roy, D. ; Ruan, L. ; Sahoo, Aswini Kumar ; Sahoo, Nihar Ranjan ; Sako, H. ; Salur, Sevil ; Samigullin, E. ; Sandweiss, J. ; Sato, Susumu ; Schmidke, William B. ; Schmitz, Norbert ; Schweid, B. R. ; Seck, F. ; Seger, Janet Elizabeth ; Seto, Richard ; Seyboth, Peter ; Shah, N. ; Shahaliev, E. ; Shanmuganathan, Prashanth V. ; Shao, M. ; Shao, Tianhao ; Sharma, R. ; Sheikh, Ashik Ikbal ; Shen, D. Y. ; Shi, Shusu ; Shi, Y. ; Shou, Q. Y. ; Sichtermann, E. P. ; Sikora, R. ; Singh, J. ; Singha, Subhash ; Sinha, P. ; Skoby, Michael J. ; Smirnov, N. ; Söhngen, Yannick ; Solyst, W. ; Song, Y. ; Spinka, Harold. M. ; Srivastava, B. ; Stanislaus, T. D. S. ; Stefaniak, Maria ; Stewart, David J. ; Strikhanov, M. ; Stringfellow, Blair ; Suaide, Alexandre Alarcon do Passo ; Šumbera, Michal ; Sun, X. M. ; Sun, X. ; Sun, Y. ; Sun, Y. ; Surrow, Bernd ; Svirida, D. N. ; Sweger, Zachary W. ; Szymanski, P. ; Tang, Aihong ; Tang, Zebo ; Taranenko, A. ; Tarnowsky, Terence J. ; Thomas, James H. ; Timmins, Anthony Robert ; Tlusty, David ; Todoroki, Takahito ; Tokarev, Mikhail V. ; Tomkiel, C. A. ; Trentalange, Stephen ; Tribble, Robert E. ; Tribedy, Prithwish ; Tripathy, Srikanta Kumar ; Truhlar, Tomas ; Trzeciak, Barbara Antonina ; Tsai, Oleg D. ; Tu, Zhoudunming ; Ullrich, Thomas ; Underwood, David G. ; Upsal, Isaac ; Van Buren, Gene ; Vanek, Jan ; Vasiliev, A. N. ; Vassiliev, Iouri ; Verkest, Veronica ; Videbæk, Flemming ; Vokal, S. ; Voloshin, Sergei ; Wang, F. ; Wang, G. ; Wang, J. S. ; Wang, P. ; Wang, X. ; Wang, Y. ; Wang, Y. ; Wang, Z. ; Webb, Jason C. ; Weidenkaff, Philipp ; Westfall, Gary D. ; Wieman, Howard ; Wissink, Scott W. ; Witt, Richard ; Wu, J. ; Wu, J. ; Wu, Y. ; Xi, B. ; Xiao, Z. G. ; Xie, Guannan ; Xie, W. ; Xu, H. ; Xu, N. ; Xu, Qinghua ; Xu, Y. ; Xu, Z. ; Xu, Z. ; Yan, G. ; Yang, C. ; Yang, Q. ; Yang, S. ; Yang, Y. ; Ye, Z. ; Ye, Z. ; Yi, L. ; Yip, K. ; Yu, Y. ; Zbroszczyk, Hanna Paulina ; Zha, Wangmei ; Zhang, C. ; Zhang, Dingwei ; Zhang, J. ; Zhang, S. ; Zhang, S. ; Zhang, Y. ; Zhang, Y. ; Zhang, Y. ; Zhang, Z. J. ; Zhang, Z. ; Zhang, Z. ; Zhao, F. ; Zhao, J. ; Zhao, M. ; Zhou, C. ; Zhou, Y. ; Zhu, X. ; Żurek, Maria Katarzyna ; Zyzak, Maksym
A linearly polarized photon can be quantized from the Lorentz-boosted electromagnetic field of a nucleus traveling at ultrarelativistic speed. When two relativistic heavy nuclei pass one another at a distance of a few nuclear radii, the photon from one nucleus may interact through a virtual quark-antiquark pair with gluons from the other nucleus, forming a short-lived vector meson (e.g., ρ0). In this experiment, the polarization was used in diffractive photoproduction to observe a unique spin interference pattern in the angular distribution of ρ0 → π+π− decays. The observed interference is a result of an overlap of two wave functions at a distance an order of magnitude larger than the ρ0 travel distance within its lifetime. The strong-interaction nuclear radii were extracted from these diffractive interactions and found to be 6.53 ± 0.06 fm (197Au) and 7.29 ± 0.08 fm (238U), larger than the nuclear charge radii. The observable is demonstrated to be sensitive to the nuclear geometry and quantum interference of nonidentical particles. Polarized photon-gluon fusion reveals quantum wave interference of non-identical particles and shape of high-energy nuclei.
Augustin, Albert J. ; Bopp, Silvia ; Fechner, Martin ; Holz, Frank ; Sandner, Dirk ; Winkgen, Andrea ; Khoramnia, Ramin ; Neuhann, Thomas ; Warscher, Marcus ; Spitzer, Martin ; Sekundo, Walter ; Seitz, Berthold ; Duncker, Tobias ; Ksinsik, Christian ; Höh, Helmuth ; Gentsch, Daniela
Introduction: The Retro-IDEAL (ILUVIEN Implant for chronic DiabEtic MAcuLar edema) study is a retrospective study designed to assess real-world outcomes achieved with the ILUVIEN® (0.19 mg fluocinolone acetonide (FAc)) in patients with chronic diabetic macular edema (DME) in clinical practices in Germany.
Methods: This study was conducted across 16 sites in Germany and involved 81 eyes (63 patients) with persistent or recurrent DME and a prior suboptimal response to a first-line intravitreal therapy (primarily anti-VEGF intravitreal therapies).
Results: Patients were followed-up for 30.8 ± 11.3 months (mean ± standard deviation) and had a mean age of 68.0 ± 10.4 years. Best-recorded visual acuity (BRVA) improved by +5.5 letters at month 9 (P ⩽ 0.005, n=56; from a baseline of 49 letters) and this was maintained through to month 30 (P ⩽ 0.05, n = 42). There was a concurrent improvement in central macular thickness with a reduction from 502 µm at baseline to 338 µm at year 1 (P ⩽ 0.0001, n = 43). This effect was sustained to year 3 (i.e. 318 µm; P ⩽ 0.0001, n = 29). Mean intraocular pressure (IOP) remained constant between baseline and year 3 with a peak change of 1.9 mm Hg occurring at year 1. Elevated IOP was observed in a similar percentage of patients prior to (22.2% of cases) and following (27.2%) treatment with the FAc implant. In the majority of cases, these elevations were managed effectively with IOP medications.
Conclusions: Despite substantial amounts of prior intravitreal treatments – primarily with anti–vascular endothelial growth factor (VEGF) drugs – this real-world study showed that sustained structural and functional improvements can last for up to 3 years with a single FAc implant.
Adams, John ; Adler, Clemens ; Ahammed, Zubayer ; Allgower, Chris ; Amonett, John ; Anderson, Bryon D. ; Anderson, Mike ; Arkhipkin, Dmitry A. ; Averichev, Georgy S. ; Balewski, Jan ; Barannikova, Olga ; Barnby, Lee Stuart ; Baudot, Jérome ; Bekele, Selemon ; Belaga, Victoria Vladimirovna ; Bellwied, Rene ; Berger, Jens ; Bichsel, Hans ; Billmeier, Anja ; Bland, Leslie C. ; Blyth, Charles O. ; Bonner, Billy E. ; Botje, Michiel ; Boucham, Abdelkrim ; Brandin, Andrei V. ; Bravar, Alessandro ; Cadman, R. V. ; Cai, Xiang-Zhou ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Cardenas, Alex ; Carroll, J. ; Castillo Castellanos, Javier Ernesto ; Castro, M. ; Cebra, Daniel A. ; Chaloupka, Petr ; Chattopadhyay, S. ; Chen, Yu ; Chernenko, S. P. ; Cherney, Michael Gerard ; Chikanian, Alexei ; Choi, Bum ; Christie, William ; Coffin, Jean Pierre ; Cormier, Thomas Michael ; Corral, M. Mora ; Cramer, John G. ; Crawford, Henry J. ; Derevschikov, Anatoly A. ; Didenko, Lidia ; Dietel, Thomas ; Draper, James E. ; Dunin, V. B. ; Dunlop, James C. ; Eckardt, Volker ; Efimov, Leonid G. ; Emelianov, V. ; Engelage, Jon M. ; Eppley, Geary Wareham ; Erazmus, Barbara Ewa ; Fachini, Patricia ; Faine, V. ; Faivre, Julien ; Fatemi, Renee H. ; Filimonov, Kirill ; Finch, Evan ; Fisyak, Yuri V. ; Flierl, Dominik Bernhard ; Foley, K. J. ; Fu, Jinghua ; Gagliardi, Carl A. ; Gagunashvili, N. ; Gans, Jon ; Gaudichet, Ludovic ; Germain, Marie ; Geurts, Frank ; Ghazikhanian, Vahe ; Grachov, Oleg A. ; Guedon, M. ; Guertin, Steven M. ; Gushin, E. ; Gutierrez, Thomas Dominic ; Hallman, Timothy J. ; Hardtke, David H. ; Harris, John W. ; Heinz, Mark ; Henry, Thomas W. ; Heppelmann, Steven Francis ; Herston, Timothy ; Hippolyte, Boris ; Hirsch, Andrew S. ; Hjort, Eric ; Hoffmann, Gerald W. ; Horsley, Matthew ; Huang, Huan Zhong ; Humanic, Thomas J. ; Igo, George J. ; Ishihara, Aya ; Jacobs, Peter Martin ; Jacobs, William W. ; Janik, Michał ; Johnson, Ian ; Jones, Peter Graham ; Judd, Eleanor G. ; Kabana, Sonia ; Kaneta, Kaneta ; Kaplan, Morton ; Keane, Declan ; Kiryluk, Joanna ; Kisiel, Adam Ryszard ; Klay, Jennifer Lynn ; Klein, Spencer Robert ; Klyachko, A. ; Kollegger, Thorsten ; Konstantinov, A. S. ; Kopytine, M. ; Kotchenda, L. ; Kovalenko, A. D. ; Kramer, M. ; Kravtsov, Peter ; Krueger, Keith William ; Kuhn, Christian Claude ; Kulikov, Anatoly I. ; Kunde, Gerd J. ; Kunz, Christopher Lee ; Kutuev, R. Kh. ; Kuznetsov, A. A. ; Lamont, Matthew A. C. ; Landgraf, Jeffery M. ; Lange, S. ; Lansdell, Curtis Patrick Leon ; Lasiuk, Brian ; Laue, Frank ; Lauret, Jerome ; Lebedev, Alexei ; Lednický, Richard ; Leontiev, V. M. ; LeVine, Micheal J. ; Li, Q. ; Lindenbaum, Sam J. ; Lisa, Michael A. ; Liu, Feng ; Liu, L. ; Liu, Zhixu ; Liu, Q. J. ; Ljubicic, Tonko A. ; Llope, William Joseph ; Long, Hui ; Longacre, Ronald S. ; Lopez-Noriega, Mercedes ; Love, William A. ; Ludlam, Thomas ; Lynn, David ; Ma, Jingguo ; Ma, Yu-Gang ; Magestro, Daniel ; Majka, Richard Daniel ; Margetis, Spyridon ; Markert, Christina ; Martin, L. ; Marx, Jay N. ; Matis, Howard S. ; Matulenko, Yuri A. ; McShane, Tom S. ; Meissner, F. ; Melnick, Yu. ; Meščanin, Aleksei P. ; Messer, Matthias ; Miller, Michael L. ; Milosevich, Z. ; Minaev, Nikolai G. ; Mitchell, J. ; Molnar, Levente ; Moore, C. F. ; Morozov, Vladimir ; de Moura, M. M. ; Munhoz, Marcelo Gameiro ; Nelson, John M. ; Nevski, P. ; Nikitin, Vladimir A. ; Nogach, Larisa V. ; Norman, Ben ; Nurušev, Sandibek B. ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Okorokov, Vitaly A. ; Oldenburg, Markus D. ; Olson, Douglas L. ; Paic, Guy ; Pandey, S. U. ; Panebratsev, Yuri ; Panitkin, Sergei Yurievich ; Pavlinov, A. I. ; Pawlak, Tomasz Jan ; Perevoztchikov, V. ; Peryt, Wiktor Stanislaw ; Petrov, V. A ; Picha, R. ; Planinic, Mirko ; Pluta, Jan Marian ; Porile, Norbert T. ; Porter, Jeffrey Brent ; Poskanzer, Arthur M. ; Potrebenikova, E. ; Prindle, Duncan J. ; Pruneau, Claude A. ; Putschke, Jörn H. ; Rai, Gulshan ; Rakness, Gregory L. ; Ravel, Olivier ; Ray, Robert L. ; Razin, Sergej V. ; Reichhold, Dennis Michael ; Reid, Jeffrey G. ; Renault, Gael ; Retiere, Fabrice ; Ridiger, Alexey ; Ritter, Hans Georg ; Roberts, Jabus B. ; Rogachevski, O. V. ; Romero, Juan L. ; Rose, A. ; Roy, Christelle Sophie ; Rykov, Vladimir L. ; Sakrejda, Iwona ; Salur, Sevil ; Sandweiss, Jack H. ; Savin, Igor A. ; Schambach, Joachim ; Scharenberg, Rolf Paul ; Schmitz, Norbert ; Schroeder, Lee S. ; Schweda, Kai ; Seger, Janet Elizabeth ; Seyboth, Peter ; Shahaliev, Ehtiram ; Shestermanov, Konstantin E. ; Shimanskii, S. S. ; Simon, Frank ; Skoro, Goran P. ; Smirnov, Nikolai ; Snellings, Raimond ; Sorensen, Paul ; Sowinski, James ; Spinka, Harold. M. ; Srivastava, Brijesh Kumar ; Stephenson, Edward J. ; Stock, Reinhard ; Stolpovsky, Alexander ; Strichanov, Michail Nikolaevič ; Stringfellow, Blair ; Struck, Christof ; Suaide, Alexandre Alarcon do Passo ; Sugarbaker, Evan R. ; Suire, Christophe Pierre ; Šumbera, Michal ; Surrow, Bernd ; Symons, Timothy James MacNeil ; Toledo, Alejandro Szanto de ; Szarwas, Piotr ; Tai, An ; Takahashi, Jun ; Tang, Aihong ; Thein, Dylan ; Thomas, James H. ; Thompson, M. ; Timoshenko, Sergei ; Tokarev, Mikhail V. ; Tonjes, Marguerite B. ; Trainor, Thomas A. ; Trentalange, Stephen ; Tribble, Robert E. ; Trofimov, V. ; Tsai, Oleg D. ; Ullrich, Thomas ; Underwood, David G. ; Van Buren, Gene ; Vander Molen, A. M. ; Vasiliev, Alexander Nikolaevich ; Vigdor, Steven E. ; Voloshin, Sergei ; Vznuzdaev, Marat ; Wang, F. ; Wang, Yiqun ; Ward, H. ; Watson, J. W. ; Wells, Randy ; Westfall, Gary D. ; Whitten, Charles A. ; Wieman, Howard ; Willson, Robert ; Wissink, Scott W. ; Witt, Richard ; Wood, Jeff ; Xu, N. ; Xu, Zhangbu ; Yakutin, A. E. ; Yamamoto, Eugene ; Yang, J. ; Yepes, Pablo P. ; Yurevich, Vladimir Yurevich ; Zanevski, Y. V. ; Zborovský, I. ; Zhang, Haitao ; Zhang, W. M. ; Zoulkarneev, R. ; Zoulkarneeva, J. ; Zubarev, A. N.
Data from the first physics run at the Relativistic Heavy-Ion Collider at Brookhaven National Laboratory, Au+Au collisions at sqrt[sNN]=130 GeV, have been analyzed by the STAR Collaboration using three-pion correlations with charged pions to study whether pions are emitted independently at freeze-out. We have made a high-statistics measurement of the three-pion correlation function and calculated the normalized three-particle correlator to obtain a quantitative measurement of the degree of chaoticity of the pion source. It is found that the degree of chaoticity seems to increase with increasing particle multiplicity.
Elke, Gunnar ; Bloos, Frank ; Wilson, Darius Cameron ; Brunkhorst, Frank Martin ; Briegel, Josef ; Reinhart, Konrad ; Löffler, Markus ; Kluge, Stefan ; Nierhaus, Axel ; Jaschinski, Ulrich ; Mörer, Onnen ; Weyland, Andreas ; Meybohm, Patrick
Background: This study assessed the ability of mid-regional proadrenomedullin (MR-proADM) in comparison to conventional biomarkers (procalcitonin (PCT), lactate, C-reactive protein) and clinical scores to identify disease severity in patients with sepsis.
Methods: This is a secondary analysis of a randomised controlled trial in patients with severe sepsis or septic shock across 33 German intensive care units. The association between biomarkers and clinical scores with mortality was assessed by Cox regression analysis, area under the receiver operating characteristic and Kaplan-Meier curves. Patients were stratified into three severity groups (low, intermediate, high) for all biomarkers and scores based on cutoffs with either a 90% sensitivity or specificity.
Results: 1089 patients with a 28-day mortality rate of 26.9% were analysed. According to the Sepsis-3 definition, 41.2% and 58.8% fulfilled the criteria for sepsis and septic shock, with respective mortality rates of 20.0% and 32.1%. MR-proADM had the strongest association with mortality across all Sepsis-1 and Sepsis-3 subgroups and could facilitate a more accurate classification of low (e.g. MR-proADM vs. SOFA: N = 265 vs. 232; 9.8% vs. 13.8% mortality) and high (e.g. MR-proADM vs. SOFA: N = 161 vs. 155; 55.9% vs. 41.3% mortality) disease severity. Patients with decreasing PCT concentrations of either ≥ 20% (baseline to day 1) or ≥ 50% (baseline to day 4) but continuously high MR-proADM concentrations had a significantly increased mortality risk (HR (95% CI): 19.1 (8.0–45.9) and 43.1 (10.1–184.0)).
Conclusions: MR-proADM identifies disease severity and treatment response more accurately than established biomarkers and scores, adding additional information to facilitate rapid clinical decision-making and improve personalised sepsis treatment.
Adam, Jaroslav ; Adamczyk, Leszek ; Adams, Joseph R. ; Adkins, J. Kevin ; Agakishiev, Geydar ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Ajitanand, N.N. ; Alekseev, Igor G. ; Anderson, Derek M. ; Aoyama, Ryo ; Aparin, Alexey ; Arkhipkin, Dmitry A. ; Aschenauer, Elke Caroline ; Ashraf, Muhammad Usman ; Atetalla, Fareha ; Attri, Anjali ; Averichev, Georgy S. ; Bai, Xiaozhi ; Bairathi, Vipul ; Barish, Kenneth ; Bassill, Aaron J. ; Behera, Arabinda ; Bellwied, Rene ; Bhasin, Anju ; Bhati, Ashok Kumar ; Bielčík, Jaroslav ; Bielčíková, Jana ; Bland, Leslie C. ; Bordyuzhin, Igor G. ; Brandenburg, James D. ; Brandin, Andrei V. ; Brown, D. ; Bryslawskyj, Jason ; Bunzarov, Ivan ; Butterworth, Joseph ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Campbell, J.M. ; Cebra, Daniel A. ; Chakaberia, Irakli ; Chaloupka, Petr ; Chang, Z. ; Chang, F.-H. ; Chankova-Bunzarova, N. ; Chatterjee, A. ; Chattopadhyay, Subhasis ; Chen, J.H. ; Chen, X. ; Chen, X. ; Cheng, J. ; Cherney, Michael Gerard ; Christie, William ; Contin, Giacomo ; Crawford, Henry J. ; Das, Supriya ; Dedovič, Tatiana G. ; Deppner, Ingo Martin ; Derevschikov, Anatoly A. ; Didenko, Lidia ; Dilks, Christopher ; Dong, X. ; Drachenberg, James Lucus ; Dunlop, James C. ; Efimov, Leonid G. ; Elsey, Nicholas ; Engelage, Jon M. ; Eppley, Geary Wareham ; Esha, Roli ; Esumi, ShinIchi ; Evdokimov, Olga Y. ; Ewigleben, Justin ; Eyser, Kjeld Oleg ; Fatemi, Renee H. ; Fazio, Salvatore ; Federič, Pavol ; Federicova, P. ; Fedorišin, Jan ; Filip, Peter ; Finch, Evan ; Fisyak, Yuri V. ; Flores, C.E. ; Fulek, Łukasz ; Gagliardi, Carl A. ; Galatyuk, Tetyana ; Geurts, Frank ; Gibson, Adam ; Grosnick, David P. ; Gunarathne, D.S. ; Guo, Y. ; Gupta, Anik ; Guryn, Włodzimierz ; Hamad, Ayman ; Hamed, Ahmed M. ; Harlenderova, Alena ; Harris, John W. ; He, L. ; Heppelmann, Samuel ; Heppelmann, Steven Francis ; Herrmann, Norbert ; Hirsch, Andrew S. ; Holub, Lukáš ; Horvat, S. ; Huang, Bingchu ; Huang, X. ; Huang, Shengli ; Huang, T. ; Huang, Huan Zhong ; Humanic, Thomas J. ; Huo, P. ; Igo, George J. ; Jacobs, William W. ; Jentsch, Alexander ; Jia, Jiangyong ; Jiang, K. ; Jowzaee, S. ; Judd, Eleanor G. ; Kabana, Sonia ; Kalinkin, Dmitry ; Kang, K. ; Kapukchyan, David ; Kauder, Kolja ; Ke, Hongwei ; Keane, Declan ; Kechechyan, Armen ; Kikoła, Daniel P. ; Kim, C. ; Kinghorn, Todd Adler ; Kisel, Ivan ; Kisiel, Adam Ryszard ; Kočenda, L. M. ; Kosarzewski, Leszek Krzysztof ; Kraishan, A.F. ; Kramárik, Lukáš ; Krauth, L. ; Kravtsov, Peter ; Krueger, Keith William ; Kulathunga, Nalinda ; Kumar, Shyam ; Kumar, Lokesh ; Kunnawalkam Elayavalli, Raghav ; Kvapil, Jakub ; Kwasizur, Joseph H. ; Lacey, Roy Alphanso ; Landgraf, Jeffery M. ; Lauret, Jerome ; Lebedev, Alexei ; Lednicky, Richard ; Lee, J.H. ; Li, Y. ; Li, W. ; Li, C. ; Li, Xiaomei ; Liang, Y. ; Lidrych, J. ; Lin, T. ; Lipiec, Andrzej ; Lisa, Michael A. ; Liu, H. ; Liu, P. ; Liu, F. ; Liu, Y. ; Ljubicic, Tonko A. ; Llope, William Joseph ; Lomnitz, Michael ; Longacre, Ronald S. ; Luo, S. ; Luo, X. ; Ma, L. ; Ma, G.L. ; Ma, R. ; Ma, Yu-Gang ; Magdy Abdelwahab Abdelrahman, Niseem ; Majka, Richard Daniel ; Mallick, Dukhishyam ; Margetis, Spyridon ; Markert, Christina ; Matis, Howard S. ; Matonoha, Oliver ; Mayes, D. ; Mazer, Joel Anthony ; Meehan, Kathryn ; Mei, Jincheng ; Minaev, Nikolai G. ; Mioduszewski, Saskia ; Mishra, Debadeepti ; Mohanty, Bedangadas ; Mouli, Mriganka Mouli ; Mooney, Isaac A. ; Morozov, Dmitry A. ; Nasim, Md. ; Negrete, J.D. ; Nelson, John M. ; Nemes, Daniel B. ; Nie, Maowu ; Nigmatkulov, Grigory A. ; Niida, Takafumi ; Nogach, Larisa V. ; Nonaka, Toshihiro ; Nurušev, Sandibek B. ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Oh, Saehanseul ; Oh, Kunsu ; Okorokov, Vitaly A. ; Olvitt, D. ; Page, Brian S. ; Pak, Robert ; Panebratsev, Yuri ; Pawlik, Bogdan ; Pei, Hua ; Perkins, Chris ; Pluta, Jan Marian ; Porter, Jeffrey Brent ; Posik, Matthew ; Pruthi, Navneet Kumar ; Przybycien, Mariusz ; Putschke, Jörn H. ; Quintero, Amilkar ; Radhakrishnan, Sooraj Krishnan ; Ramachandran, Suvarna ; Ray, Robert L. ; Reed, Rosi Jan ; Ritter, Hans Georg ; Roberts, Jabus B. ; Rogačevskij, Oleg V. ; Romero, Juan L. ; Ruan, Lijuan ; Rusnak, Jan ; Rusnakova, Olga ; Sahoo, Nihar Ranjan ; Sahu, Pradip Kumar ; Salur, Sevil ; Sandweiss, Jack H. ; Schambach, Joachim ; Schmah, Alexander ; Schmidke, William B. ; Schmitz, Norbert ; Schweid, Benjamin R. ; Seck, Florian ; Seger, Janet Elizabeth ; Sergeeva, Maria ; Seto, Richard ; Seyboth, Peter ; Shah, N. ; Shahaliev, Ehtiram ; Shanmuganathan, Prashanth V. ; Shao, M. ; Shen, W.Q. ; Shen, F. ; Shi, Shusu ; Shou, Q.Y. ; Sichtermann, Ernst P. ; Siejka, Sebastian ; Sikora, Rafał ; Šimko, Miroslav ; Singha, Subhash ; Smirnov, Dmitri V. ; Smirnov, Nikolai ; Solyst, William ; Sorensen, Paul Richard ; Spinka, Harold. M. ; Srivastava, Brijesh Kumar ; Stanislaus, T. D. Shirvel ; Stewart, David J. ; Strichanov, Michail Nikolaevič ; Stringfellow, Blair ; Suaide, Alexandre Alarcon do Passo ; Sugiura, Tetsuro ; Šumbera, Michal ; Summa, Branden ; Sun, X. ; Sun, Y. ; Sun, X.M. ; Surrow, Bernd ; Svirida, Dmitry N. ; Szymański, Paweł ; Tang, Zebo ; Tang, Aihong ; Taranenko, Arkadiy ; Tarnowsky, Terence J. ; Thomas, James H. ; Timmins, Anthony Robert ; Tlusty, David ; Todoroki, Takahito ; Tokarev, Mikhail V. ; Tomkiel, Catherine A. ; Trentalange, Stephen ; Tribble, Robert E. ; Tribedy, Prithwish ; Tripathy, Srikanta Kumar ; Tsai, Oleg D. ; Tu, B. ; Ullrich, Thomas ; Underwood, David G. ; Upsal, Isaac ; Van Buren, Gene ; Vanek, Jan ; Vasiliev, Alexander Nikolaevich ; Vassiliev, Iouri ; Videbæk, Flemming ; Vokal, Stanislav ; Voloshin, Sergei ; Vossen, A. ; Wang, F. ; Wang, G. ; Wang, Y. ; Wang, Y. ; Webb, Jason C. ; Wen, L. ; Westfall, Gary D. ; Wieman, Howard ; Wissink, Scott W. ; Witt, Richard ; Wu, Y. ; Xiao, Z.G. ; Xie, W. ; Xie, Guannan ; Xu, Z. ; Xu, J. ; Xu, Y.F. ; Xu, N. ; Xu, Qinghua ; Yang, Y. ; Yang, C. ; Yang, S. ; Yang, Q. ; Ye, Z. ; Ye, Z. ; Yi, L. ; Yip, K. ; Yoo, In-Kwon ; Yu, N. ; Zbroszczyk, Hanna Paulina ; Zha, Wangmei ; Zhang, Zuman ; Zhang, J. ; Zhang, L. ; Zhang, J. ; Zhang, Y. ; Zhang, X.P. ; Zhang, S. ; Zhang, S. ; Zhao, J. ; Zhong, C. ; Zhou, C. ; Zhou, L. ; Zhu, Z. ; Zhu, X. ; Zyzak, Maksym
We present the first measurement of the proton–Ω correlation function in heavy-ion collisions for the central (0–40%) and peripheral (40–80%) Au + Au collisions at √sNN = 200 GeV by the STAR experiment at the Relativistic Heavy-Ion Collider (RHIC). Predictions for the ratio of peripheral collisions to central collisions for the proton–Ω correlation function are sensitive to the presence of a nucleon– bound state. These predictions are based on the proton– interaction extracted from (2 + 1)-flavor lattice QCD calculations at the physical point. The measured ratio of the proton–Ω correlation function between the peripheral (small system) and central (large system) collisions is less than unity for relative momentum smaller than 40 MeV/c. Comparison of our measured correlation ratio with theoretical calculation slightly favors a proton– bound system with a binding energy of ∼ 27 MeV.
Hudson, Lawrence N. ; Newbold, Tim ; Contu, Sara ; Hill, Samantha L. L. ; Lysenko, Igor ; Palma, Adriana de ; Phillips, Helen R. P. ; Senior, Rebecca A. ; Bennett, Dominic J. ; Booth, Hollie ; Choimes, Argyrios ; Correia, David L. P. ; Day, Julie ; Echeverria-Londono, Susy ; Garon, Morgan ; Harrison, Michelle L. K. ; Ingram, Daniel J. ; Jung, Martin ; Kemp, Victoria ; Kirkpatrick, Lucinda ; Martin, Callum D. ; Pan, Yuan ; White, Hannah J. ; Aben, Job ; Abrahamczyk, Stefan ; Adum, Gilbert B. ; Aguilar-Barquero, Virginia ; Aizen, Marcelo ; Ancrenaz, Marc ; Arbelaez-Cortes, Enrique ; Armbrecht, Inge ; Azhar, Badrul ; Azpiroz, Adrián B. ; Baeten, Lander ; Báldi, András ; Banks, John E. ; Barlow, Jos ; Batáry, Péter ; Bates, Adam J. ; Bayne, Erin M. ; Beja, Pedro ; Berg, Åke ; Berry, Nicholas J. ; Bicknell, Jake E. ; Bihn, Jochen H. ; Böhning-Gaese, Katrin ; Boekhout, Teun ; Boutin, Celine ; Bouyer, Jeremy ; Brearley, Francis Q. ; Brito, Isabel ; Brunet, Jörg ; Buczkowski, Grzegorz ; Buscardo, Erika ; Cabra-Garcia, Jimmy ; Calvino-Cancela, Maria ; Cameron, Sydney A. ; Cancello, Eliana M. ; Carrijo, Tiago F. ; Carvalho, Anelena L. ; Castro, Helena ; Castro-Luna, Alejandro Antonio ; Cerda, Rolando ; Cerezo, Alexis ; Chauvat, Matthieu ; Clarke, Frank M. ; Cleary, Daniel F. R. ; Connop, Stuart P. ; D'Aniello, Biagio ; Silva, Pedro Giovani da ; Darvill, Ben ; Dauber, Jens ; Dejean, Alain ; Diekötter, Tim ; Dominguez-Haydar, Yamileth ; Dormann, Carsten F. ; Dumont, Bertrand ; Dures, Simon G. ; Dynesius, Mats ; Edenius, Lars ; Elek, Zoltan ; Entling, Martin H. ; Farwig, Nina ; Fayle, Tom M. ; Felicioli, Antonio ; Felton, Annika M. ; Ficetola, Gentile Francesco ; Filgueiras, Bruno K. C. ; Fonte, Steve J. ; Fraser, Lauchlan H. ; Fukuda, Daisuke ; Furlani, Dario ; Ganzhorn, Jörg U. ; Garden, Jenni G. ; Gheler-Costa, Carla ; Giordani, Paolo ; Giordano, Simonetta ; Gottschalk, Marco S. ; Goulson, Dave ; Gove, Aaron D. ; Grogan, James ; Hanley, Mick E. ; Hanson, Thor ; Hashim, Nor R. ; Hawes, Joseph E. ; Hébert, Christian ; Helden, Alvin J. ; Henden, John-André ; Hernández, Lionel ; Herzog, Felix ; Higuera-Diaz, Diego ; Hilje, Branko ; Horgan, Finbarr G. ; Horvath, Roland ; Hylander, Kristoffer ; Horvath, Roland ; Isaacs-Cubides, Paola ; Ishitani, Mashiro ; Jacobs, Carmen T. ; Jaramillo, Victor J. ; Jauker, Birgit ; Jonsell, Matts ; Jung, Thomas S. ; Kapoor, Vena ; Kati, Vassiliki ; Katovai, Eric ; Kessler, Michael ; Knop, Eva ; Kolb, Annette ; Körösi, Àdám ; Lachat, Thibault ; Lantschner, Victoria ; Le Féon, Violette ; LeBuhn, Gretchen ; Légaré, Jean-Philippe ; Letcher, Susan G. ; Littlewood, Nick A. ; López-Quintero, Carlos A. ; Louhaichi, Mounir ; Lövei, Gabor L. ; Lucas-Borja, Manuel Esteban ; Luja, Victor H. ; Maeto, Kaoru ; Magura, Tibor ; Mallari, Neil Aldrin D. ; Marin-Spiotta, Erika ; Marshall, Edward Jon P. ; Martínez, Eliana ; Mayfield, Margaret M. ; Mikusinski, Gregorz ; Milder, Jeffery C. ; Miller, James R. ; Morales, Carolina L. ; Muriithi-Muchane, Mary Nyawira ; Muchane, Muchai ; Naidoo, Robin ; Nakamura, Akihiro ; Naoe, Shoji ; Nates-Parra, Guiomar ; Navarerete Gutierrez, Dario A. ; Neuschulz, Eike Lena ; Noreika, Norbertas ; Norfolk, Olivia ; Noriega, Jorge Ari ; Nöske, Nicole M. ; O'Dea, Niall ; Oduro, William ; Ofori-Boateng, Caleb ; Oke, Chris O. ; Osgathorpe, Lynne M. ; Paritsis, Juan ; Parrah, Alejandro ; Pelegrin, Nicolás ; Peres, Carlos A. ; Persson, Anna S. ; Petanidou, Theodora ; Phalan, Ben ; Philips, T. Keith ; Poveda, Katja ; Power, Eileen F. ; Presley, Steven J. ; Proença, Vânia ; Quaranta, Marino ; Quintero, Carolina ; Redpath-Downing, Nicola A. ; Reid, J. Leighton ; Reis, Yana T. ; Ribeiro, Danilo B. ; Richardson, Barbara A. ; Richardson, Michael J. ; Robles, Carolina A. ; Römbke, Jörg ; Romero-Duque, Luz Piedad ; Rosselli, Loreta ; Rossiter, Stephen J. ; Roulston, T'ai H. ; Rousseau, Laurent ; Sadler, Jonathan P. ; Sáfián, Szbolcs ; Saldaña-Vásquez, Romeo A. ; Samnegård, Ulrika ; Schüepp, Christof ; Schweiger, Oliver ; Sedlock, Jodi L. ; Shahabuddin, Ghazala ; Sheil, Douglas ; Silva, Fernando A. B. ; Slade, Eleanor ; Smith-Pardo, Allan H. ; Sodhi, Navjot S. ; Somarriba, Eduardo J. ; Sosa, Ramón A. ; Stout, Jane C. ; Struebig, Matthew J. ; Sung, Yik-Hei ; Threlfall, Caragh G. ; Tonietto, Rebecca ; Tóthmérész, Béla ; Tscharntke, Teja ; Turner, Edgar C. ; Tylianakis, Jason M. ; Vanbergen, Adam J. ; Vassilev, Kiril ; Verboven, Hans A. F. ; Vergara, Carlos H. ; Vergara, Pablo M. ; Verhulst, Jort ; Walker, Tony R. ; Wang, Yanping ; Watling, James I. ; Wells, Konstans ; Williams, Christopher D. ; Willig, Michael R. ; Woinarski, John Casimir Zichy ; Wolf, Jan H. D. ; Woodcock, Ben A. ; Yu, Douglas W. ; Zailsev, Andreys ; Collen, Ben ; Ewers, Rob M. ; Mace, Georgina M. ; Purves, Drew W. ; Scharlemann, Jörn P. W. ; Pervis, Andy
Biodiversity continues to decline in the face of increasing anthropogenic pressures such as habitat destruction, exploitation, pollution and introduction of alien species. Existing global databases of species’ threat status or population time series are dominated by charismatic species. The collation of datasets with broad taxonomic and biogeographic extents, and that support computation of a range of biodiversity indicators, is necessary to enable better understanding of historical declines and to project – and avert – future declines. We describe and assess a new database of more than 1.6 million samples from 78 countries representing over 28,000 species, collated from existing spatial comparisons of local-scale biodiversity exposed to different intensities and types of anthropogenic pressures, from terrestrial sites around the world. The database contains measurements taken in 208 (of 814) ecoregions, 13 (of 14) biomes, 25 (of 35) biodiversity hotspots and 16 (of 17) megadiverse countries. The database contains more than 1% of the total number of all species described, and more than 1% of the described species within many taxonomic groups – including flowering plants, gymnosperms, birds, mammals, reptiles, amphibians, beetles, lepidopterans and hymenopterans. The dataset, which is still being added to, is therefore already considerably larger and more representative than those used by previous quantitative models of biodiversity trends and responses. The database is being assembled as part of the PREDICTS project (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems – www.predicts.org.uk). We make site-level summary data available alongside this article. The full database will be publicly available in 2015.
Wiesmann, Frank ; Vachta, Jan ; Ehret, Robert ; Walter, Hauke ; Kaiser, Rolf ; Stürmer, Martin ; Tappe, André ; Däumer, Martin ; Berg, Thomas ; Naeth, Gudrun ; Braun, Patrick ; Knechten, Heribert
Background: Although being considered as a rarely observed HIV-1 protease mutation in clinical isolates, the L76V-prevalence increased 1998-2008 in some European countries most likely due to the approval of Lopinavir, Amprenavir and Darunavir which can select L76V. Beside an enhancement of resistance, L76V is also discussed to confer hypersusceptibility to the drugs Atazanavir and Saquinavir which might enable new treatment strategies by trying to take advantage of particular mutations. Results: Based on a cohort of 47 L76V-positive patients, we examined if there might exist a clinical advantage for L76V-positive patients concerning long-term success of PI-containing regimens in patients with limited therapy options. Genotypic- and phenotypic HIV-resistance tests from 47 mostly multi-resistant, L76V-positive patients throughout Germany were accomplished retrospectively 1999-2009. Five genotype-based drug-susceptibility predictions received from online interpretation-tools for Atazanavir, Saquinavir, Amprenavir and Lopinavir, were compared to phenotype-based predictions that were determined by using a recombinant virus assay along with a Virtual Phenotype™(Virco). The clinical outcome of the L76V-adapted follow-up therapy was determined by monitoring viral load for 96 weeks. Conclusions: In this analysis, the mostly used interpretation systems overestimated the L76V-mutation concerning Atazanavir- and SQV resistance. In fact, a clear benefit in drug susceptibility for these drugs was observed in phenotype analysis after establishment of L76V. More importantly, long-term therapy success was significantly higher in patients receiving Atazanavir and/or Saquinavir plus one L76V-selecting drug compared to patients without L76V-selecting agents (p = 0.002). In case of L76V-occurrence ATV and/or SQV may represent encouraging options for patients in deep salvage situations.
Casper, Markus ; Mengel, Martin ; Fuhrmann, Christine ; Herrmann, Eva ; Appenrodt, Beate ; Schiedermaier, Peter ; Reichert, Matthias ; Bruns, Tony ; Engelmann, Cornelius ; Grünhage, Frank ; Lammert, Frank
Background: Patients with liver cirrhosis have a highly elevated risk of developing bacterial infections that significantly decrease survival rates. One of the most relevant infections is spontaneous bacterial peritonitis (SBP). Recently, NOD2 germline variants were found to be potential predictors of the development of infectious complications and mortality in patients with cirrhosis. The aim of the INCA (Impact of NOD2 genotype-guided antibiotic prevention on survival in patients with liver Cirrhosis and Ascites) trial is to investigate whether survival of this genetically defined high-risk group of patients with cirrhosis defined by the presence of NOD2 variants is improved by primary antibiotic prophylaxis of SBP.
Methods/Design: The INCA trial is a double-blind, placebo-controlled clinical trial with two parallel treatment arms (arm 1: norfloxacin 400 mg once daily; arm 2: placebo once daily; 12-month treatment and observational period). Balanced randomization of 186 eligible patients with stratification for the protein content of the ascites (<15 versus ≥15 g/L) and the study site is planned. In this multicenter national study, patients are recruited in at least 13 centers throughout Germany. The key inclusion criterion is the presence of a NOD2 risk variant in patients with decompensated liver cirrhosis. The most important exclusion criteria are current SBP or previous history of SBP and any long-term antibiotic prophylaxis. The primary endpoint is overall survival after 12 months of treatment. Secondary objectives are to evaluate whether the frequencies of SBP and other clinically relevant infections necessitating antibiotic treatment, as well as the total duration of unplanned hospitalization due to cirrhosis, differ in both study arms. Recruitment started in February 2014.
Discussion: Preventive strategies are required to avoid life-threatening infections in patients with liver cirrhosis, but unselected use of antibiotics can trigger resistant bacteria and worsen outcome. Thus, individualized approaches that direct intervention only to patients with the highest risk are urgently needed. This trial meets this need by suggesting stratified prevention based on genetic risk assessment. To our knowledge, the INCA trial is first in the field of hepatology aimed at rapidly transferring and validating information on individual genetic risk into clinical decision algorithms.
Trial registrations: German Clinical Trials Register DRKS00005616. Registered 22 January 2014. EU Clinical Trials Register EudraCT 2013-001626-26. Registered 26 January 2015.
Walaszczyk, Ireneusz ; Čech, Stanislav ; Crampton, James S. ; Dubicka, Zofia ; Ifrim, Christina ; Jarvis, Ian ; Kennedy, William James ; Lees, Jackie A. ; Lodowski, Damian ; Pearce, Martin ; Peryt, Danuta ; Sageman, Bradley B. ; Schiøler, Poul ; Todes, Jordan ; Uličný, David ; Voigt, Silke ; Wiese, Frank ; Linnert, Christian ; Püttmann, Tobias ; Toshimitsu, Seiichi
Following votes in the Coniacian Working Group, the Cretaceous Subcommission and the International Commission on Stratigraphy, on May 1st, 2021, the International Union of Geological Sciences voted unanimously to ratify the Global Stratotype Section and Point (GSSP) proposal for the base of the Coniacian Stage of the Upper Cretaceous Series and Cretaceous System. The lower boundary of the Coniacian Stage is placed at the base of Bed 46 of the Salzgitter-Salder section in northern Germany. The boundary is defined by the first appearance of the inoceramid bivalve species Cremnoceramus deformis erectus (Meek) and complemented by the Navigation carbon isotope event. Additional data include the bivalve genus Didymotis, foraminifera, ammonite, nannofossil and organic-walled dinoflagellate cyst events. Three auxiliary sections (Słupia Nadbrzeżna, central Poland; Střeleč, Czech Republic; El Rosario, NE Mexico) supplement the details of the boundary record in various facies, and in differing geographic and biogeographic contexts.
Michaelis, Martin ; Voges, Yvonne ; Rothweiler, Florian ; Weipert, Fabian ; Zia-Ahmad, Amara ; Cinatl, Jaroslav ; Deimling, Andreas von ; Westermann, Frank ; Rödel, Franz ; Wass, Mark N. ; Cinatl, Jindrich
The survivin suppressant YM155 is a drug candidate for neuroblastoma. Here, we tested YM155 in 101 neuroblastoma cell lines (19 parental cell lines, 82 drug-adapted sublines). Seventy seven (77) cell lines displayed YM155 IC50s in the range of clinical YM155 concentrations. ABCB1 was an important determinant of YM155 resistance. The activity of the ABCB1 inhibitor zosuquidar ranged from being similar to that of the structurally different ABCB1 inhibitor verapamil to being 65-fold higher. ABCB1 sequence variations may be responsible for this, suggesting that the design of variant-specific ABCB1 inhibitors may be possible. Further, we showed that ABCC1 confers YM155 resistance. Previously, p53 depletion had resulted in decreased YM155 sensitivity. However, TP53-mutant cells were not generally less sensitive to YM155 than TP53 wild-type cells in this study. Finally, YM155 cross-resistance profiles differed between cells adapted to drugs as similar as cisplatin and carboplatin. In conclusion, the large cell line panel was necessary to reveal an unanticipated complexity of the YM155 response in neuroblastoma cell lines with acquired drug resistance. Novel findings include that ABCC1 mediates YM155 resistance and that YM155 cross-resistance profiles differ between cell lines adapted to drugs as similar as cisplatin and carboplatin.
Löschmann, Nadine ; Michaelis, Martin ; Rothweiler, Florian ; Zehner, Richard ; Cinatl, Jaroslav ; Voges, Yvonne ; Sharifi, Mohsen ; Riecken, Kristoffer ; Meyer, Jochen ; Deimling, Andreas von ; Fichtner, Iduna ; Ghafourian, Taravat ; Westermann, Frank ; Cinatl, Jindrich
Novel treatment options are needed for the successful therapy of patients with high-risk neuroblastoma. Here, we investigated the cyclin-dependent kinase (CDK) inhibitor SNS-032 in a panel of 109 neuroblastoma cell lines consisting of 19 parental cell lines and 90 sublines with acquired resistance to 14 different anticancer drugs. Seventy-three percent of the investigated neuroblastoma cell lines and all four investigated primary tumor samples displayed concentrations that reduce cell viability by 50% in the range of the therapeutic plasma levels reported for SNS-032 (<754 nM). Sixty-two percent of the cell lines and two of the primary samples displayed concentrations that reduce cell viability by 90% in this concentration range. SNS-032 also impaired the growth of the multidrug-resistant cisplatin-adapted UKF-NB-3 subline UKF-NB-3rCDDP1000 in mice. ABCB1 expression (but not ABCG2 expression) conferred resistance to SNS-032. The antineuroblastoma effects of SNS-032 did not depend on functional p53. The antineuroblastoma mechanism of SNS-032 included CDK7 and CDK9 inhibition-mediated suppression of RNA synthesis and subsequent depletion of antiapoptotic proteins with a fast turnover rate including X-linked inhibitor of apoptosis (XIAP), myeloid cell leukemia sequence 1 (Mcl-1), baculoviral IAP repeat containing 2 (BIRC2; cIAP-1), and survivin. In conclusion, CDK7 and CDK9 represent promising drug targets and SNS-032 represents a potential treatment option for neuroblastoma including therapy-refractory cases.
Babac, Ana ; Frank, Martin ; Pauer, Frédéric ; Litzkendorf, Svenja ; Rosenfeldt, Daniel ; Lührs, Verena ; Biehl, Lisa ; Hartz, Tobias ; Storf, Holger ; Schauer, Franziska ; Wagner, Thomas O. F. ; Schulenburg, Johann-Matthias von der
Background: Rare diseases are, by definition, very serious and chronic diseases with a high negative impact on quality of life. Approximately 350 million people worldwide live with rare diseases. The resulting high disease burden triggers health information search, but helpful, high-quality, and up-to-date information is often hard to find. Therefore, the improvement of health information provision has been integrated in many national plans for rare diseases, discussing the telephone as one access option. In this context, this study examines the need for a telephone service offering information for people affected by rare diseases, their relatives, and physicians.
Methods: In total, 107 individuals participated in a qualitative interview study conducted in Germany. Sixty-eight individuals suffering from a rare disease or related to somebody with rare diseases and 39 health care professionals took part. Individual interviews were conducted using a standardized semi-structured questionnaire. Interviews were analysed using the qualitative content analysis, triangulating patients, relatives, and health care professionals. The fulfilment of qualitative data processing standards has been controlled for.
Results: Out of 68 patients and relatives and 39 physicians, 52 and 18, respectively, advocated for the establishment of a rare diseases telephone service. Interviewees expected a helpline to include expert staffing, personal contact, good availability, low technical barriers, medical and psychosocial topics of counselling, guidance in reducing information chaos, and referrals. Health care professionals highlighted the importance of medical topics of counselling—in particular, differential diagnostics—and referrals.
Conclusions: Therefore, the need for a national rare diseases helpline was confirmed in this study. Due to limited financial resources, existing offers should be adapted in a stepwise procedure in accordance with the identified attributes.
Waidmann, Oliver ; Pleli, Thomas ; Weigert, Andreas ; Imelmann, Esther ; Kakoschky, Bianca ; Schmithals, Jens Christian Johannes ; Döring, Claudia ; Frank, Matthias ; Longerich, Thomas ; Köberle, Verena ; Hansmann, Martin-Leo ; Brüne, Bernhard ; Zeuzem, Stefan ; Piiper, Albrecht ; Đikić, Ivan
The nuclear factor kappa beta (NFκB) signaling pathway plays an important role in liver homeostasis and cancer development. Tax1-binding protein 1 (Tax1BP1) is a regulator of the NFκB signaling pathway, but its role in the liver and hepatocellular carcinoma (HCC) is presently unknown. Here we investigated the role of Tax1BP1 in liver cells and murine models of HCC and liver fibrosis. We applied the diethylnitrosamine (DEN) model of experimental hepatocarcinogenesis in Tax1BP1+/+ and Tax1BP1−/− mice. The amount and subsets of non-parenchymal liver cells in in Tax1BP1+/+ and Tax1BP1−/− mice were determined and activation of NFκB and stress induced signaling pathways were assessed. Differential expression of mRNA and miRNA was determined. Tax1BP1−/− mice showed increased numbers of inflammatory cells in the liver. Furthermore, a sustained activation of the NFκB signaling pathway was found in hepatocytes as well as increased transcription of proinflammatory cytokines in isolated Kupffer cells from Tax1BP1−/− mice. Several differentially expressed mRNAs and miRNAs in livers of Tax1BP1−/− mice were found, which are regulators of inflammation or are involved in cancer development or progression. Furthermore, Tax1BP1−/− mice developed more HCCs than their Tax1BP1+/+ littermates. We conclude that Tax1BP1 protects from liver cancer development by limiting proinflammatory signaling.
Queck, Alexander David Roger ; Bode, Hannah ; Uschner, Frank Erhard ; Brol, Maximilian ; Graf, Christiana ; Schulz, Martin ; Jansen, Christian ; Praktiknjo, Michael ; Schierwagen, Robert ; Klein, Sabine ; Trautwein, Christian ; Wasmuth, Hermann E. ; Berres, Marie-Luise ; Trebicka, Jonel ; Lehmann, Jennifer
Background and Aims: Monocyte chemotactic protein-1 (MCP-1) is a potent chemoattractant for monocytes. It is involved in pathogenesis of several inflammatory diseases. Hepatic MCP-1 is a readout of macrophage activation. While inflammation is a major driver of liver disease progression, the origin and role of circulating MCP-1 as a biomarker remains unclear.
Methods: Hepatic CC-chemokine ligand 2 (CCL2) expression and F4/80 staining for Kupffer cells were measured and correlated in a mouse model of chronic liver disease (inhalative CCl4 for 7 weeks). Next, hepatic RNA levels of CCL2 were measured in explanted livers of 39 patients after transplantation and correlated with severity of disease. Changes in MCP-1 were further evaluated in a rat model of experimental cirrhosis and acute-on-chronic liver failure (ACLF). Finally, we analyzed portal and hepatic vein levels of MCP-1 in patients receiving transjugular intrahepatic portosystemic shunt insertion for complications of portal hypertension.
Results: In this mouse model of fibrotic hepatitis, hepatic expression of CCL2 (P = 0.009) and the amount of F4/80 positive cells in the liver (P < 0.001) significantly increased after induction of hepatitis by CCl4 compared to control animals. Moreover, strong correlation of hepatic CCL2 expression and F4/80 positive cells were seen (P = 0.023). Furthermore, in human liver explants, hepatic transcription levels of CCL2 correlated with the MELD score of the patients, and thus disease severity (P = 0.007). The experimental model of ACLF in rats revealed significantly higher levels of MCP-1 plasma (P = 0.028) and correlation of hepatic CCL2 expression (R = 0.69, P = 0.003). Particularly, plasma MCP-1 levels did not correlate with peripheral blood monocyte CCL2 expression. Finally, higher levels of MCP-1 were observed in the hepatic compared to the portal vein (P = 0.01) in patients receiving TIPS. Similarly, a positive correlation of MCP-1 with Child-Pugh score was observed (P = 0.018). Further, in the presence of ACLF, portal and hepatic vein levels of MCP-1 were significantly higher compared to patients without ACLF (both P = 0.039).
Conclusion: Circulating levels of MCP-1 mainly derive from the injured liver and are associated with severity of liver disease. Therefore, liver macrophages contribute significantly to disease progression. Circulating MCP-1 may reflect the extent of hepatic macrophage activation.
Rumbaur, Christian ; Thevs, Niels ; Disse, Markus ; Ahlheim, Michael ; Brieden, Andreas ; Cyffka, Bernd ; Doluschitz, Reiner ; Düthmann, Doris ; Feike, Til ; Frör, Oliver ; Gärtner, Philipp ; Halik, Ümüt ; Hill, Joachim ; Hinnenthal, Marie ; Keilholz, Patrick ; Kleinschmit, Birgit ; Krysanova, Valentina ; Kuba, Martin ; Mader, Sebastian ; Menz, Christoph ; Othmanli, Hussein ; Pelz, Sonna ; Schroeder, Matthias ; Siew, Tuck Fatt ; Stender, Vivien ; Stahr, Karl ; Thomas, Frank M. ; Welp, Martin ; Wortmann, Michel ; Zhao, Xiaoning ; Chen, Xi ; Jiang, Tong ; Zhao, Chengyi ; Zhang, Xi ; Luo, Jing ; Yimit, Hamid ; Yu, Ruide
The Tarim River Basin, located in Xinjiang, NW China, is the largest endorheic river basin of China and one of the largest in whole Central Asia. Due to the extremely arid climate with an annual precipitation of less than 100 mm, the water supply along the Aksu and Tarim River solely depends on river water. This applies for anthropogenic activities (e.g. agriculture) as well as for the natural ecosystems so that both compete for water. The on-going increase of water consumption by agriculture and other human activities in this region has been enhancing the competition for water between human needs and nature. Against this background, 11 German and 6 Chinese universities and research institutes formed the consortium SuMaRiO (www.sumario.de), which aims at gaining a holistic picture of the availability of water resources in the Tarim River Basin and the impacts on anthropogenic activities and natural ecosystems caused by the water distribution within the Tarim River Basin. The discharge of the Aksu River, which is the major tributary to the Tarim, has been increasing over the past 6 decades due to enhanced glacier melt. Alone from 1989 to 2011, the area under agriculture more than doubled. Thereby, cotton became the major crop and there was a shift from small-scale farming to large-scale intensive farming. The major natural ecosystems along the Aksu and Tarim River are riparian ecosystems: Riparian (Tugai) forests, shrub vegetation, reed beds, and other grassland. Within the SuMaRiO Cluster the focus was laid on the Tugai forests, with Populus euphratica as dominant tree, because the most productive and species-rich natural ecosystems can be found among those forests. On sites with groundwater distance of less than 7.5 m the annual increments correlated with river runoffs of the previous year. But, the further downstream along the Tarim River, the more the natural river dynamics ceased, which impacts on the recruitment of Populus euphratica. Household surveys revealed that there is a considerable willingness to pay for conservation of those riparian forests with the mitigation of dust and sandstorms considered as the most important ecosystem service. This interdisciplinary project will result in a decision support tool (DST), build on the participation of regional stakeholders and models based on results and field experiments. This DST finally shall assist stakeholders in balancing the water competition acknowledging the major external effects of any water allocation.
Rumbaur, Christian ; Thevs, Niels ; Ahlheim, Michael ; Disse, Markus ; Brieden, Andreas ; Cyffka, Bernd ; Düthmann, Doris ; Feike, Til ; Frör, Oliver ; Gärtner, Philipp ; Halik, Ümüt ; Hill, Joachim ; Hinnenthal, Marie ; Keilholz, Patrick ; Kleinschmit, Birgit ; Krysanova, Valentina ; Kuba, Martin ; Mader, Sebastian ; Menz, Christoph ; Othmanli, Hussein ; Pelz, Sonna ; Schroeder, Matthias ; Siew, Tuck Fatt ; Stender, Vivien ; Stahr, Karl ; Thomas, Frank M. ; Welp, Martin ; Wortmann, Michel ; Zhao, Xiaoning ; Chen, Xi ; Jiang, Tong ; Luo, Jing ; Yimit, Hamid ; Yu, Ruide ; Zhang, Xi ; Zhao, Chengyi
The Tarim River basin, located in Xinjiang, NW China, is the largest endorheic river basin in China and one of the largest in all of Central Asia. Due to the extremely arid climate, with an annual precipitation of less than 100 mm, the water supply along the Aksu and Tarim rivers solely depends on river water. This is linked to anthropogenic activities (e.g., agriculture) and natural and semi-natural ecosystems as both compete for water. The ongoing increase in water consumption by agriculture and other human activities in this region has been enhancing the competition for water between human needs and nature. Against this background, 11 German and 6 Chinese universities and research institutes have formed the consortium SuMaRiO (Sustainable Management of River Oases along the Tarim River; http://www.sumario.de), which aims to create a holistic picture of the availability of water resources in the Tarim River basin and the impacts on anthropogenic activities and natural ecosystems caused by the water distribution within the Tarim River basin. On the basis of the results from field studies and modeling approaches as well as from suggestions by the relevant regional stakeholders, a decision support tool (DST) will be implemented that will then assist stakeholders in balancing the competition for water, acknowledging the major external effects of water allocation to agriculture and to natural ecosystems. This consortium was formed in 2011 and is funded by the German Federal Ministry of Education and Research. As the data collection phase was finished this year, the paper presented here brings together the results from the fields from the disciplines of climate modeling, cryology, hydrology, agricultural sciences, ecology, geoinformatics, and social sciences in order to present a comprehensive picture of the effects of different water availability schemes on anthropogenic activities and natural ecosystems along the Tarim River. The second objective is to present the project structure of the whole consortium, the current status of work (i.e., major new results and findings), explain the foundation of the decision support tool as a key product of this project, and conclude with application recommendations for the region. The discharge of the Aksu River, which is the major tributary of the Tarim, has been increasing over the past 6 decades. From 1989 to 2011, agricultural area more than doubled: cotton became the major crop and there was a shift from small-scale to large-scale intensive farming. The ongoing increase in irrigated agricultural land leads to the increased threat of salinization and soil degradation caused by increased evapotranspiration. Aside from agricultural land, the major natural and semi-natural ecosystems are riparian (Tugai) forests, shrub vegetation, reed beds, and other grassland, as well as urban and peri-urban vegetation. Within the SuMaRiO cluster, focus has been set on the Tugai forests, with Populus euphratica as the dominant tree species, because these forests belong to the most productive and species-rich natural ecosystems of the Tarim River basin. At sites close to the groundwater, the annual stem diameter increments of Populus euphratica correlated with the river runoffs of the previous year. However, the natural river dynamics cease along the downstream course and thus hamper the recruitment of Populus euphratica. A study on the willingness to pay for the conservation of the natural ecosystems was conducted to estimate the concern of the people in the region and in China's capital. These household surveys revealed that there is a considerable willingness to pay for conservation of the natural ecosystems, with mitigation of dust and sandstorms considered the most important ecosystem service. Stakeholder dialogues contributed to creating a scientific basis for a sustainable management in the future.
Janssen, Martin Wilhelm Walter ; Linxweiler, Johannes ; Terwey, S. ; Rugge, Sven ; Ohlmann, Carsten-Henning ; Becker, Frank ; Neisius, Andreas ; Thüroff, Joachim W. ; Siemer, Stefan ; Stöckle, Michael ; Roos, Frederik
Background: Does the dogma of nephron sparing surgery (NSS) still stand for large renal masses? Available studies dealing with that issue are considerably biased often mixing imperative with elective indications for NSS and also including less malignant variants or even benign renal tumors. Here, we analyzed the oncological long-term outcomes of patients undergoing elective NSS or radical tumor nephrectomy (RN) for non-endophytic, large (≥7cm) clear cell renal carcinoma (ccRCC).
Methods: Prospectively acquired, clinical databases from two academic high-volume centers were screened for patients from 1980 to 2010. The query was strictly limited to patients with elective indications. Surgical complications were retrospectively assessed and classified using the Clavien-Dindo-classification system (CDS). Overall survival (OS) and cancer specific survival (CSS) were analyzed using the Kaplan-Meier-method and the log-rank test.
Results: Out of in total 8664 patients in the databases, 123 patients were identified (elective NSS (n = 18) or elective RN (n = 105)) for ≥7cm ccRCC. The median follow-up over all was 102 months (range 3–367 months). Compared to the RN group, the NSS group had a significantly longer median OS (p = 0.014) and median CSS (p = 0.04).
Conclusions: In large renal masses, NSS can be performed safely with acceptable complication rates. In terms of long-term OS and CSS, NSS was at least not inferior to RN. Our findings suggest that NSS should also be performed in patients presenting with renal tumors ≥7cm whenever technically feasible. Limitations include its retrospective nature and the limited availability of data concerning long-term development of renal function in the two groups.
Agakishiev, Geydar ; Álvarez-Pol, Héctor ; Balanda, Andrzej ; Bassini, Roberto ; Böhmer, Michael ; Bokemeyer, Helmut ; Boyard, Jean-Louis ; Cabanelas Eiras, Pablo ; Chernenko, Sergey ; Christ, Tassilo ; Destefanis, Marco Giovanni Maria ; Dohrmann, Frank ; Dybczak, Adrian ; Eberl, Thomas ; Fabbietti, Laura ; Fateev, Oleg ; Finocchiaro, Paolo ; Friese, Jürgen ; Fröhlich, Ingo ; Galatyuk, Tetyana ; Garzón, Juan A. ; Gernhäuser, Roman ; Gilardi, Camilla ; Golubeva, Marina ; González-Díaz, Diégo ; Guber, Fedor ; Gumberidze, Malgorzata ; Hennino, Thierry ; Holzmann, Romain ; Ierusalimov, Alexander P. ; Iori, Ileana ; Ivashkin, Alexander ; Jurkovič, Martin ; Kämpfer, Burkhard ; Kanaki, Kalliopi ; Karavicheva, Tatiana L. ; Koenig, Ilse ; Koenig, Wolfgang ; Kolb, Burkhard W. ; Kotte, Roland ; Kozuch, Anna ; Krizek, Filip ; Kühn, Wolfgang ; Kugler, Andrej ; Kurepin, Alexei ; Lang, Simon Martin ; Lapidus, Kirill ; Liu, T. ; Maier, Ludwig W. ; Markert, Jochen ; Metag, Volker ; Michalska, Beata ; Morinière, Emilie ; Mousa, Jehad ; Münch, Mathias ; Müntz, Christian ; Naumann, Lothar ; Otwinowski, Jacek Tomasz ; Pachmayer, Yvonne C. ; Pechenov, Vladimir ; Pechenova, Olga ; Pérez Cavalcanti, Tiago ; Pietraszko, Jerzy ; Pospısil, Vladimir ; Przygoda, Witold ; Ramstein, Béatrice ; Reshetin, Andrey ; Roy-Stephan, M. ; Rustamov, Anar ; Sadovsky, Alexander ; Sailer, Benjamin ; Salabura, Piotr ; Sánchez, M. ; Schmah, Alexander ; Schwab, Erwin ; Sobolev, Yuri G. ; Spataro, Stefano ; Spruck, Björn ; Ströbele, Herbert ; Stroth, Joachim ; Sturm, Christian Thomas ; Tarantola Peloni, Attilio ; Teilab, Khaled ; Tlustý, Pavel ; Toia, Alberica ; Traxler, Michael ; Trebacz, Radoslaw ; Tsertos, Haralabos ; Wagner, Vladimir ; Wisniowski, Marcin ; Wojcik, Tomasz ; Wüstenfeld, Jörn ; Yurevich, Sergey ; Zanevsky, Yuri V. ; Zumbruch, Peter W.
We present measurements of exclusive ensuremathπ+,0 and η production in pp reactions at 1.25GeV and 2.2GeV beam kinetic energy in hadron and dielectron channels. In the case of π+ and π0 , high-statistics invariant-mass and angular distributions are obtained within the HADES acceptance as well as acceptance-corrected distributions, which are compared to a resonance model. The sensitivity of the data to the yield and production angular distribution of Δ (1232) and higher-lying baryon resonances is shown, and an improved parameterization is proposed. The extracted cross-sections are of special interest in the case of pp → pp η , since controversial data exist at 2.0GeV; we find \ensuremathσ=0.142±0.022 mb. Using the dielectron channels, the π0 and η Dalitz decay signals are reconstructed with yields fully consistent with the hadronic channels. The electron invariant masses and acceptance-corrected helicity angle distributions are found in good agreement with model predictions.
Camgoz, Aylin ; Paszkowski-Rogacz, Maciej ; Satpathy, Shankha ; Wermke, Martin ; Hamann, Martin V. ; Bonin, Malte von ; Choudhary, Chunaram ; Knapp, Stefan ; Buchholz, Frank
Acute myeloid leukemia (AML) is characterized by uncontrolled proliferation and accumulation of immature myeloblasts, which impair normal hematopoiesis. While this definition categorizes the disease into a distinctive group, the large number of different genetic and epigenetic alterations actually suggests that AML is not a single disease, but a plethora of malignancies. Still, most AML patients are not treated with targeted medication but rather by uniform approaches such as chemotherapy. The identification of novel treatment options likely requires the identification of cancer cell vulnerabilities that take into account the different genetic and epigenetic make-up of the individual tumors. Here we show that STK3 depletion by knock-down, knock-out or chemical inhibition results in apoptotic cells death in some but not all AML cell lines and primary cells tested. This effect is mediated by a premature activation of cyclin dependent kinase 1 (CDK1) in presence of elevated cyclin B1 levels. The anti-leukemic effects seen in both bulk and progenitor AML cells suggests that STK3 might be a promising target in a subset of AML patients.
Meintrup, David ; Borgmann, Stefan ; Seidl, Karlheinz ; Stecher, Melanie ; Jakob, Carolin Ellen Marianne ; Pilgram, Lisa ; Spinner, Christoph Daniel ; Rieg, Siegbert ; Isberner, Nora ; Hower, Martin ; Vehreschild, Maria J. G. T. ; Göpel, Siri ; Hanses, Frank ; Nowak-Machen, Martina
(1) Background: The aim of our study was to identify specific risk factors for fatal outcome in critically ill COVID-19 patients. (2) Methods: Our data set consisted of 840 patients enclosed in the LEOSS registry. Using lasso regression for variable selection, a multifactorial logistic regression model was fitted to the response variable survival. Specific risk factors and their odds ratios were derived. A nomogram was developed as a graphical representation of the model. (3) Results: 14 variables were identified as independent factors contributing to the risk of death for critically ill COVID-19 patients: age (OR 1.08, CI 1.06–1.10), cardiovascular disease (OR 1.64, CI 1.06–2.55), pulmonary disease (OR 1.87, CI 1.16–3.03), baseline Statin treatment (0.54, CI 0.33–0.87), oxygen saturation (unit = 1%, OR 0.94, CI 0.92–0.96), leukocytes (unit 1000/μL, OR 1.04, CI 1.01–1.07), lymphocytes (unit 100/μL, OR 0.96, CI 0.94–0.99), platelets (unit 100,000/μL, OR 0.70, CI 0.62–0.80), procalcitonin (unit ng/mL, OR 1.11, CI 1.05–1.18), kidney failure (OR 1.68, CI 1.05–2.70), congestive heart failure (OR 2.62, CI 1.11–6.21), severe liver failure (OR 4.93, CI 1.94–12.52), and a quick SOFA score of 3 (OR 1.78, CI 1.14–2.78). The nomogram graphically displays the importance of these 14 factors for mortality. (4) Conclusions: There are risk factors that are specific to the subpopulation of critically ill COVID-19 patients.
Prell, Tino ; Siebecker, Frank ; Lorrain, Michael ; Tönges, Lars ; Warnecke, Tobias ; Klucken, Jochen ; Wellach, Ingmar ; Buhmann, Carsten ; Wolz, Martin ; Lorenzl, Stefan ; Herbst, Heinz ; Eggers, Carsten ; Mai, Tobias
Access to specialized care is essential for people with Parkinson´s disease (PD). Given the growing number of people with PD and the lack of general practitioners and neurologists, particularly in rural areas in Germany, specialized PD staff (PDS), such as PD nurse specialists and Parkinson Assistants (PASS), will play an increasingly important role in the care of people with PD over the coming years. PDS have several tasks, such as having a role as an educator or adviser for other health professionals or an advocate for people with PD to represent and justify their needs. PD nurse specialists have been established for a long time in the Netherlands, England, the USA, and Scandinavia. In contrast, in Germany, distinct PDS models and projects have been established. However, these projects and models show substantial heterogeneity in terms of access requirements, education, theoretical and practical skills, principal workplace (inpatient vs. outpatient), and reimbursement. This review provides an overview of the existing forms and regional models for PDS in Germany. PDS reimbursement concepts must be established that will foster an implementation throughout Germany. Additionally, development of professional roles in nursing and more specialized care in Germany is needed.
Grillari, Johannes ; Ajuh, Paul ; Stadler, Guido ; Löscher, Marlies ; Voglauer, Regina ; Ernst, Wolfgang ; Chusainow, Janet ; Eisenhaber, Frank ; Pokar, Marion ; Fortschegger, Klaus ; Grey, Martin ; Lamond, Angus I. ; Katinger, Hermann
We have isolated the human protein SNEV as downregulated in replicatively senescent cells. Sequence homology to the yeast splicing factor Prp19 suggested that SNEV might be the orthologue of Prp19 and therefore might also be involved in pre-mRNA splicing. We have used various approaches including gene complementation studies in yeast using a temperature sensitive mutant with a pleiotropic phenotype and SNEV immunodepletion from human HeLa nuclear extracts to determine its function. A human–yeast chimera was indeed capable of restoring the wild-type phenotype of the yeast mutant strain. In addition, immunodepletion of SNEV from human nuclear extracts resulted in a decrease of in vitro pre-mRNA splicing efficiency. Furthermore, as part of our analysis of protein–protein interactions within the CDC5L complex, we found that SNEV interacts with itself. The self-interaction domain was mapped to amino acids 56–74 in the protein's sequence and synthetic peptides derived from this region inhibit in vitro splicing by surprisingly interfering with spliceosome formation and stability. These results indicate that SNEV is the human orthologue of yeast PRP19, functions in splicing and that homo-oligomerization of SNEV in HeLa nuclear extract is essential for spliceosome assembly and that it might also be important for spliceosome stability.
Rieke, Johanna Magdalena ; Zhang, Rong ; Braun, Doreen ; Yilmaz, Öznur ; Japp, Anna S. ; Lopes, Filipa M. ; Pleschka, Michael ; Hilger, Alina Christine ; Schneider, Sophia ; Newman, William G. ; Schneider, Sophia ; Newman, William G. ; Beaman, Glenda M. ; Nordenskjöld, Agneta ; Ebert, Anne-Karoline ; Promm, Martin ; Rösch, Wolfgang H. ; Stein, Raimund ; Hirsch, Karin ; Schäfer, Frank-Mattias ; Schmiedeke, Eberhard ; Boemers, Thomas M. ; Lacher, Martin ; Kluth, Dietrich ; Gosemann, Jan-Hendrik ; Anderberg, Magnus ; Barker, Gillian ; Holmdahl, Gundela ; Läckgren, Göran ; Keene, David ; Cervellione, Raimondo M. ; Giorgio, Elisa ; Di Grazia, Massimo ; Feitz, Wouter F. J. ; Marcelis, Carlo L. M. ; Rooij, Iris Antonia Leonarda Martina van ; Bökenkamp, Arend ; Beckers, Goedele M. A. ; Keegan, Catherine E. ; Sharma, Amit ; Dakal, Tikam Chand ; Wittler, Lars ; Grote, Phillip ; Zwink, Nadine ; Jenetzky, Ekkehart ; Brusco, Alfredo ; Thiele, Holger ; Ludwig, Michael ; Schweizer, Ulrich ; Woolf, Adrian S. ; Odermatt, Benjamin ; Reutter, Heiko
Previous studies in developing Xenopus and zebrafish reported that the phosphate transporter slc20a1a is expressed in pronephric kidneys. The recent identification of SLC20A1 as a monoallelic candidate gene for cloacal exstrophy further suggests its involvement in the urinary tract and urorectal development. However, little is known of the functional role of SLC20A1 in urinary tract development. Here, we investigated this using morpholino oligonucleotide knockdown of the zebrafish ortholog slc20a1a. This caused kidney cysts and malformations of the cloaca. Moreover, in morphants we demonstrated dysfunctional voiding and hindgut opening defects mimicking imperforate anus in human cloacal exstrophy. Furthermore, we performed immunohistochemistry of an unaffected 6-week-old human embryo and detected SLC20A1 in the urinary tract and the abdominal midline, structures implicated in the pathogenesis of cloacal exstrophy. Additionally, we resequenced SLC20A1 in 690 individuals with bladder exstrophy-epispadias complex (BEEC) including 84 individuals with cloacal exstrophy. We identified two additional monoallelic de novo variants. One was identified in a case-parent trio with classic bladder exstrophy, and one additional novel de novo variant was detected in an affected mother who transmitted this variant to her affected son. To study the potential cellular impact of SLC20A1 variants, we expressed them in HEK293 cells. Here, phosphate transport was not compromised, suggesting that it is not a disease mechanism. However, there was a tendency for lower levels of cleaved caspase-3, perhaps implicating apoptosis pathways in the disease. Our results suggest SLC20A1 is involved in urinary tract and urorectal development and implicate SLC20A1 as a disease-gene for BEEC.
Rose, Diana ; Gunthe, Sachin S. ; Jurányi, Zsófia ; Gysel, Martin ; Frank, Göran P. ; Schneider, Johannes ; Curtius, Joachim ; Pöschl, Ulrich
As part of the CLACE-6 campaign we performed size-resolved CCN measurements for a~supersaturation range of S = 0.079 % to 0.66% at the high-alpine research station Jungfraujoch, Switzerland, in March~2007. The derived effective hygroscopicity parameter κ describing the influence of particle composition on CCN activity was on average 0.23–0.30 for Aitken (50–100 nm) and 0.32–0.43 for accumulation mode particles (100–200 nm). The campaign average value of κ = 0.3 is similar to the average value of κ for other continental locations. When air masses came from southeasterly directions crossing the Po Valley in Italy, particles were much more hygroscopic (κ ≈ 0.42) due to large sulfate mass fractions. The κ values obtained at S = 0.079 % exhibited a good negative correlation with the organic mass fractions derived from PM1 aerosol mass spectrometer (AMS) measurements. Applying a simple mixing rule the organic and inorganic mass fractions observed by the AMS could be used to reproduce the temporal fluctuations of the hygroscopicity of accumulation mode particles quite well.
We show how during a cloud event the aerosol particles were activated as cloud droplets and then removed from the air by precipitation leaving behind only a small amount of accumulation mode particles consisting mainly of weakly CCN-active particles, most likely externally mixed unprocessed soot particles.
During the campaign we had the opportunity to directly compare two DMT CCN counters for a certain time. The total CCN concentration (NCCN,tot) obtained by the two instruments at equal supersaturations agreed well for both possible operating modes: detecting NCCN,tot directly by sampling the polydisperse aerosol with the CCNC, or indirectly by combining size-resolved measurements of the activated fraction with parallel measurements of the particle size distribution (e.g., by SMPS). However, some supersaturation setpoints differed between the two CCNCs by as much as 20% after applying the instrument calibrations, which resulted in differences of the corresponding NCCN,tot of up to 50%. This emphasizes that it is extremely important to carefully calibrate the supersaturation of the instrument, especially at low S.
Rabenhorst, Uta ; Thalheimer, Frederic Bastian ; Gerlach, Katharina ; Kijonka, Marek ; Böhm, Stefanie ; Krause, Daniela Sandra ; Vauti, Franz ; Arnold, Hans-Henning ; Schroeder, Timm ; Schnütgen, Frank ; Melchner, Harald von ; Rieger, Michael A. ; Zörnig, Martin
The ability of hematopoietic stem cells (HSCs) to self-renew is a prerequisite for the establishment of definitive hematopoiesis and life-long blood regeneration. Here, we report the single-stranded DNA-binding transcriptional regulator far upstream element (FUSE)-binding protein 1 (FUBP1) as an essential factor of HSC self-renewal. Functional inactivation of FUBP1 in two different mouse models resulted in embryonic lethal anemia at around E15.5 caused by severely diminished HSCs. Fetal and adult HSCs lacking FUBP1 revealed an HSC-intrinsic defect in their maintenance, expansion, and long-term blood reconstitution, but could differentiate into all hematopoietic lineages. FUBP1-deficient adult HSCs exhibit significant transcriptional changes, including upregulation of the cell-cycle inhibitor p21 and the pro-apoptotic Noxa molecule. These changes caused an increase in generation time and death of HSCs as determined by video-microscopy-based tracking. Our data establish FUBP1 and its recognition of single-stranded genomic DNA as an important element in the transcriptional regulation of HSC self-renewal.
Kandler, Konrad ; Worringen, Annette ; Benker, Nathalie ; Dirsch, Thomas ; Mertes, Stephan ; Schenk, Ludwig ; Kästner, Udo ; Frank, Fabian ; Nillius, Björn ; Bundke, Ulrich ; Rose, Diana ; Curtius, Joachim ; Kupiszewski, Piotr ; Weingartner, Ernest ; Vochezer, Paul ; Schneider, Johannes ; Schmidt, Susan ; Weinbruch, Stephan ; Ebert, Martin
During January/February 2013, at the High Alpine Research Station Jungfraujoch a measurement campaign was carried out, which was centered on atmospheric ice-nucleating particles (INP) and ice particle residuals (IPR). Three different techniques for separation of INP and IPR from the non-ice-active particles are compared. The Ice Selective Inlet (ISI) and the Ice Counterflow Virtual Impactor (Ice-CVI) sample ice particles from mixed phase clouds and allow for the analysis of the residuals. The combination of the Fast Ice Nucleus Chamber (FINCH) and the Ice Nuclei Pumped Counterflow Virtual Impactor (IN-PCVI) provides ice-activating conditions to aerosol particles and extracts the activated INP for analysis.Collected particles were analyzed by scanning electron microscopy and energy-dispersive X-ray microanalysis to determine size, chemical composition and mixing state. All INP/IPR-separating techniques had considerable abundances (median 20 – 70 %) of instrumental contamination artifacts (ISI: Si-O spheres, probably calibration aerosol; Ice-CVI: Al-O particles; FINCH+IN-PCVI: steel particles). Also, potential sampling artifacts (e.g., pure soluble material) occurred with a median abundance of < 20 %. While these could be explained as IPR by ice break-up, for INP their IN-ability pathway is less clear. After removal of the contamination artifacts, silicates and Ca-rich particles, carbonaceous material and metal oxides were the major INP/IPR particle types separated by all three techniques. Soot was a minor contributor. Lead was detected in less than 10 % of the particles, of which the majority were internal mixtures with other particle types. Sea-salt and sulfates were identified by all three methods as INP/IPR. Most samples showed a maximum of the INP/IPR size distribution at 400 nm geometric diameter. In a few cases, a second super-micron maximum was identified. Soot/carbonaceous material and metal oxides were present mainly in the submicron range. ISI and FINCH yielded silicates and Ca-rich particles mainly with diameters above 1 μm, while the Ice-CVI also separated many submicron IPR. As strictly parallel sampling could not be performed, a part of the discrepancies between the different techniques may result from variations in meteorological conditions and subsequent INP/IPR composition. The observed differences in the particle group abundances as well as in the mixing state of INP/IPR express the need for further studies to better understand the influence of the separating techniques on the INP/IPR chemical
composition.
Worringen, Annette ; Kandler, Konrad ; Benker, Nathalie ; Dirsch, Thomas ; Weinbruch, Stephan ; Mertes, Stephan ; Schenk, Ludwig ; Kästner, Udo ; Frank, Fabian ; Nillius, Björn ; Bundke, Ulrich ; Rose, Diana ; Curtius, Joachim ; Kupiszewski, Piotr ; Weingartner, Ernest ; Schneider, Johannes ; Schmidt, Susan ; Ebert, Martin
In the present work, three different techniques are used to separate ice-nucleating particles (INP) and ice particle residuals (IPR) from non-ice-active particles: the Ice Selective Inlet (ISI) and the Ice Counterflow Virtual Impactor (Ice-CVI), which sample ice particles from mixed phase clouds and allow for the analysis of the residuals, as well as the combination of the Fast Ice Nucleus Chamber (FINCH) and the Ice Nuclei Pumped Virtual Impactor (IN-PCVI), which provides ice-activating conditions to aerosol particles and extracts the activated ones for analysis. The collected particles were analyzed by scanning electron microscopy and energy-dispersive X-ray microanalysis to determine their size, chemical composition and mixing state. Samples were taken during January/February 2013 at the High Alpine Research Station Jungfraujoch. All INP/IPR-separating techniques had considerable abundances (median 20–70%) of contamination artifacts (ISI: Si-O spheres, probably calibration aerosol; Ice-CVI: Al-O particles; FINCH + IN-PCVI: steel particles). Also, potential measurement artifacts (soluble material) occurred (median abundance < 20%). After removal of the contamination particles, silicates and Ca-rich particles, carbonaceous material and metal oxides were the major INP/IPR particle types separated by all three techniques. Minor types include soot and Pb-bearing particles. Sea-salt and sulfates were identified by all three methods as INP/IPR. Lead was identified in less than 10% of the INP/IPR. It was mainly present as an internal mixture with other particle types, but also external lead-rich particles were found. Most samples showed a maximum of the INP/IPR size distribution at 400 nm geometric diameter. In a few cases, a second super-micron maximum was identified. Soot/carbonaceous material and metal oxides were present mainly in the submicron range. ISI and FINCH yielded silicates and Ca-rich particles mainly with diameters above 1 μm, while the Ice-CVI also sampled many submicron particles. Probably owing to the different meteorological conditions, the INP/IPR composition was highly variable on a sample to sample basis. Thus, some part of the discrepancies between the different techniques may result from the (unavoidable) non-parallel sampling. The observed differences of the particles group abundances as well as the mixing state of INP/IPR point to the need of further studies to better understand the influence of the separating techniques on the INP/IPR chemical composition.
Cremonese, Carla-Luisa Elsa ; Schierwagen, Robert ; Uschner, Frank Erhard ; Torres Núñez, Sandra ; Tyc, Olaf ; Ortiz, Cristina ; Schulz, Martin ; Queck, Alexander David Roger ; Kristiansen, Glen ; Bader, Michael ; Sauerbruch, Tilman ; Weiskirchen, Ralf ; Walther, Thomas ; Trebicka, Jonel ; Klein, Sabine
Non-alcoholic fatty liver disease (NAFLD) is gaining in importance and is linked to obesity. Especially,thedevelopmentoffibrosisandportalhypertensioninNAFLDpatientsrequirestreatment. Transgenic TGR(mREN2)27 rats overexpressing mouse renin spontaneously develop NAFLD with portal hypertension but without obesity. This study investigated the additional role of obesity in this model on the development of portal hypertension and fibrosis. Obesity was induced in twelve-week old TGR(mREN2)27 rats after receiving Western diet (WD) for two or four weeks. Liver fibrosis was assessed using standard techniques. Hepatic expression of transforming growth factor-β1 (TGF-β1), collagen type Iα1, α-smooth muscle actin, and the macrophage markers Emr1, as well as the chemoattractant Ccl2, interleukin-1β (IL1β) and tumor necrosis factor-α (TNFα) were analyzed. Assessment of portal and systemic hemodynamics was performed using the colored microsphere technique. Asexpected,WDinducedobesityandliverfibrosisasconfirmedbySiriusRedandOilRed O staining. The expression of the monocyte-macrophage markers, Emr1, Ccl2, IL1β and TNFα were increasedduringfeedingofWD,indicatinginfiltrationofmacrophagesintotheliver,eventhoughthis increase was statistically not significant for the EGF module-containing mucin-like receptor (Emr1) mRNA expression levels. Of note, portal pressure increased with the duration of WD compared to animals that received a normal chow. Besides obesity, WD feeding increased systemic vascular resistance reflecting systemic endothelial and splanchnic vascular dysfunction. We conclude that transgenic TGR(mREN2)27 rats are a suitable model to investigate NAFLD development with liver fibrosis and portal hypertension. Tendency towards elevated expression of Emr1 is associated with macrophage activity point to a significant role of macrophages in NAFLD pathogenesis, probably due to a shift of the renin–angiotensin system towards a higher activation of the classical pathway. The hepatic injury induced by WD in TGR(mREN2)27 rats is suitable to evaluate different stages of fibrosis and portal hypertension in NAFLD with obesity.
Wacker, Anna ; Weigand, Julia ; Akabayov, Sabine R. ; Altınçekiç, Nadide ; Bains, Jasleen Kaur ; Banijamali, Elnaz ; Binas, Oliver ; Castillo-Martinez, Jesus ; Çetiner, Erhan Can ; Ceylan, Betül ; Chiu, Liang-Yuan ; Davila-Calderon, Jesse ; Dhamotharan, Karthikeyan ; Duchardt-Ferner, Elke ; Ferner, Jan ; Frydman, Lucio ; Fürtig, Boris ; Gallego, José ; Grün, J. Tassilo ; Hacker, Carolin ; Haddad, Christina ; Hähnke, Martin Jens ; Hengesbach, Martin ; Hiller, Fabian ; Hohmann, Katharina Felicitas ; Hymon, Daniel ; de Jesus, Vanessa ; Jonker, Henry ; Keller, Heiko ; Knežić, Božana ; Landgraf, Tom ; Löhr, Frank ; Luo, Le ; Mertinkus, Klara Rebecca ; Muhs, Christina ; Novakovic, Mihajlo ; Oxenfarth, Andreas ; Palomino-Schätzlein, Martina ; Petzold, Katja ; Peter, Stephen ; Pyper, Dennis Joshua ; Qureshi, Nusrat ; Riad, Magdalena ; Richter, Christian ; Saxena, Krishna ; Schamber, Tatjana ; Scherf, Tali ; Schlagnitweit, Judith ; Schlundt, Andreas ; Schnieders, Robbin ; Schwalbe, Harald ; Simba-Lahuasi, Alvaro ; Sreeramulu, Sridhar ; Stirnal, Elke ; Sudakov, Alexey ; Tants, Jan-Niklas ; Tolbert, Blanton S. ; Vögele, Jennifer ; Weiß, Lena ; Wirmer-Bartoschek, Julia ; Wirtz Martin, Maria Alexandra ; Wöhnert, Jens ; Zetzsche, Heidi
The current pandemic situation caused by the Betacoronavirus SARS-CoV-2 (SCoV2) highlights the need for coordinated research to combat COVID-19. A particularly important aspect is the development of medication. In addition to viral proteins, structured RNA elements represent a potent alternative as drug targets. The search for drugs that target RNA requires their high-resolution structural characterization. Using nuclear magnetic resonance (NMR) spectroscopy, a worldwide consortium of NMR researchers aims to characterize potential RNA drug targets of SCoV2. Here, we report the characterization of 15 conserved RNA elements located at the 5′ end, the ribosomal frameshift segment and the 3′-untranslated region (3′-UTR) of the SCoV2 genome, their large-scale production and NMR-based secondary structure determination. The NMR data are corroborated with secondary structure probing by DMS footprinting experiments. The close agreement of NMR secondary structure determination of isolated RNA elements with DMS footprinting and NMR performed on larger RNA regions shows that the secondary structure elements fold independently. The NMR data reported here provide the basis for NMR investigations of RNA function, RNA interactions with viral and host proteins and screening campaigns to identify potential RNA binders for pharmaceutical intervention.
Aboona, Bassam ; Adam, Jaroslav ; Adamczyk, Leszek ; Adams, Joseph R. ; Aggarwal, Ishu ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Anderson, Derek M. ; Aschenauer, Elke Caroline ; Atchison, J. ; Bairathi, Vipul ; Baker, W. ; Ball Cap, Jonathan Gonzalo ; Barish, Kenneth ; Bellwied, Rene ; Bhagat, Pratibha ; Bhasin, Anju ; Bhatta, Somadutta ; Bielčík, Jaroslav ; Bielčíková, Jana ; Brandenburg, James D. ; Cai, X.Z. ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Cebra, Daniel A. ; Češka, Jakub ; Chakaberia, Irakli ; Chaloupka, Petr ; Chan, B.K. ; Chang, Z. ; Chen, D. ; Chen, J. ; Chen, J.H. ; Chen, Z. ; Cheng, J. ; Cheng, Y. ; Choudhury, Subikash ; Christie, William ; Chu, Xiaoxuan ; Crawford, Henry J. ; Csanád, Máté ; Dale-Gau, Gabriel ; Das, A. ; Daugherity, M. ; Deppner, Ingo Martin ; Dhamija, A. ; Di Carlo, L. ; Didenko, Lidia ; Dixit, Prabhupada ; Dong, X. ; Drachenberg, James Lucus ; Duckworth, Emilie ; Dunlop, James C. ; Engelage, Jon M. ; Eppley, Geary Wareham ; Esumi, ShinIchi ; Evdokimov, Olga Y. ; Ewigleben, A. ; Eyser, Kjeld Oleg ; Fatemi, Renee H. ; Fazio, Salvatore ; Feng, C.J. ; Feng, Yicheng ; Finch, Evan ; Fisyak, Yuri V. ; Flor, Fernando Antonio ; Fu, C. ; Gagliardi, Carl A. ; Galatyuk, Tetyana ; Geurts, Frank ; Ghimire, Navagyan ; Gibson, Adam ; Gopal, Krishan ; Gou, X. ; Grosnick, David P. ; Gupta, Anik ; Guryn, Włodzimierz ; Hamed, Ahmed M. ; Han, Y. ; Harabasz, Szymon ; Harasty, Matthew D. ; Harris, John W. ; Harrison, Hannah ; He, W. ; He, Xionghong ; He, Y. ; Herrmann, Norbert ; Holub, Lukáš ; Hu, C. ; Hu, Q. ; Hu, Yu ; Huang, H. ; Huang, Huan Zhong ; Huang, Shengli ; Huang, T. ; Huang, X. ; Huang, Y. ; Huang, Y. ; Humanic, Thomas J. ; Isenhower, D. ; Isshiki, M. ; Jacobs, William W. ; Jalotra, Ashish ; Jena, Chitrasen ; Jentsch, Alexander ; Ji, Yuanjing ; Jia, Jiangyong ; Jin, C. ; Ju, Xin-Yue ; Judd, Eleanor G. ; Kabana, Sonia ; Kabir, M.L. ; Kagamaster, Skipper ; Kalinkin, Dmitry ; Kang, K. ; Kapukchyan, David ; Kauder, Kolja ; Ke, Hongwei ; Keane, Declan ; Kelsey, Matthew ; Khyzhniak, Yevheniia V. ; Kikoła, Daniel P. ; Kimelman, B. ; Kincses, D. ; Kisel, Ivan ; Kiselev, A. ; Knospe, Anders Garritt ; Ko, H.S. ; Kosarzewski, Leszek Krzysztof ; Kramarik, L. ; Kumar, Lokesh ; Kumar, Shyam ; Kunnawalkam Elayavalli, Raghav ; Lacey, Roy Alphanso ; Landgraf, Jeffery M. ; Lauret, Jerome ; Lebedev, Alexei ; Lee, J.H. ; Leung, Yue Hang ; Lewis, N. ; Li, C. ; Li, C. ; Li, W. ; Li, X. ; Li, Y. ; Li, Y. ; Li, Z. ; Liang, X. ; Liang, Y. ; Licenik, Robert ; Lin, T. ; Lisa, Michael A. ; Liu, C. ; Liu, F. ; Liu, H. ; Liu, H. ; Liu, L. ; Liu, T. ; Liu, X. ; Liu, Y. ; Liu, Z. ; Ljubicic, Tonko A. ; Llope, William Joseph ; Lomicky, O. ; Longacre, Ronald S. ; Loyd, E. ; Lu, T. ; Lukow, N.S. ; Luo, X.F. ; Ma, L. ; Ma, R. ; Ma, Yu-Gang ; Magdy Abdelwahab Abdelrahman, Niseem ; Mallick, Dukhishyam ; Margetis, Spyridon ; Markert, Christina ; Matis, Howard S. ; Mazer, Joel Anthony ; McNamara, Grant ; Mi, K. ; Mioduszewski, Saskia ; Mohanty, Bedangadas ; Mooney, Isaac A. ; Mukherjee, A. ; Nagy, M.I. ; Nain, A.S. ; Nam, J.D. ; Nasim, Md. ; Neff, D. ; Nelson, John M. ; Nemes, Daniel B. ; Nie, M. ; Niida, Takafumi ; Nishitani, R. ; Nonaka, Toshihiro ; Nunes, A.S. ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Oh, Saehanseul ; Okubo, K. ; Page, Brian S. ; Pak, Robert ; Pan, Jinjin ; Pandav, Ashish ; Pandey, Ashutosh Kumar ; Pani, Tanmay ; Paul, A. ; Pawlik, Bogdan ; Pawłowska, Diana ; Perkins, Chris ; Pluta, Jan Marian ; Pokhrel, B.R. ; Posik, Matthew ; Protzman, Tristan ; Prozorova, V. ; Pruthi, Navneet Kumar ; Przybycien, Mariusz ; Putschke, Jörn H. ; Qin, Z. ; Qiu, H. ; Quintero, Amilkar ; Racz, Cameron ; Radhakrishnan, Sooraj Krishnan ; Raha, N. ; Ray, Robert L. ; Reed, Rosi Jan ; Ritter, Hans Georg ; Robertson, C.W. ; Robotkova, Monika ; Rosales Aguilar, M.A. ; Roy, D. ; Roy Chowdhury, P. ; Ruan, L. ; Sahoo, Aswini Kumar ; Sahoo, Nihar Ranjan ; Sako, H. ; Salur, Sevil ; Sato, Susumu ; Schmidke, William B. ; Schmitz, Norbert ; Seck, F.-J. ; Seger, Janet Elizabeth ; Seto, Richard ; Seyboth, Peter ; Shah, N. ; Shanmuganathan, Prashanth V. ; Shao, M. ; Shao, Tianhao ; Sharma, M. ; Sharma, Natasha ; Sharma, R. ; Sharma, S.R. ; Sheikh, Ashik Ikbal ; Shen, D.Y. ; Shen, K. ; Shi, Shusu ; Shi, Y. ; Shou, Q.Y. ; Si, F. ; Singh, J. ; Singha, Subhash ; Sinha, P. ; Skoby, Michael J. ; Smirnov, Nikolai ; Söhngen, Yannick ; Song, Y. ; Srivastava, B. ; Stanislaus, T. D. Shirvel ; Stefaniak, Maria ; Stewart, David J. ; Stringfellow, Blair ; Su, Y. ; Suaide, Alexandre Alarcon do Passo ; Šumbera, Michal ; Sun, C. ; Sun, X. ; Sun, Y. ; Sun, Y. ; Surrow, Bernd ; Sweger, Z.W. ; Szymański, Paweł ; Tamis, A. ; Tang, Aihong ; Tang, Zebo ; Tarnowsky, Terence J. ; Thomas, James H. ; Timmins, Anthony Robert ; Tlusty, David ; Todoroki, Takahito ; Tomkiel, C.A. ; Trentalange, Stephen ; Tribble, Robert E. ; Tribedy, Prithwish ; Truhlar, Tomas ; Trzeciak, Barbara Antonina ; Tsai, Oleg D. ; Tsang, C.Y. ; Tu, Zhoudunming ; Ullrich, Thomas ; Underwood, David G. ; Upsal, Isaac ; Van Buren, Gene ; Vanek, Jan ; Vassiliev, Iouri ; Verkest, Veronica ; Videbæk, Flemming ; Voloshin, Sergei ; Wang, F. ; Wang, G. ; Wang, J.S. ; Wang, X. ; Wang, Y. ; Wang, Y. ; Wang, Y. ; Wang, Z. ; Webb, Jason C. ; Weidenkaff, Philipp ; Westfall, Gary D. ; Wielanek, Daniel ; Wieman, Howard ; Wilks, G. ; Wissink, Scott W. ; Witt, Richard ; Wu, J. ; Wu, J. ; Wu, Xiao ; Wu, Y. ; Xi, B. ; Xiao, Z.G. ; Xie, W. ; Xu, H. ; Xu, N. ; Xu, Qinghua ; Xu, Y. ; Xu, Y. ; Xu, Z. ; Xu, Z. ; Yan, G. ; Yan, Z. ; Yang, C. ; Yang, Q. ; Yang, S. ; Yang, Y. ; Ye, Z. ; Ye, Z. ; Yi, L. ; Yip, K. ; Yu, Y. ; Zbroszczyk, Hanna Paulina ; Zha, Wangmei ; Zhang, C. ; Zhang, Dingwei ; Zhang, J. ; Zhang, S. ; Zhang, X. ; Zhang, Y. ; Zhang, Y. ; Zhang, Y. ; Zhang, Z.J. ; Zhang, Z. ; Zhang, Z. ; Zhao, F. ; Zhao, J. ; Zhao, M. ; Zhou, C. ; Zhou, J. ; Zhou, S. ; Zhou, Y. ; Zhu, X. ; Żurek, Maria Katarzyna ; Zyzak, Maksym
A decisive experimental test of the Chiral Magnetic Effect (CME) is considered one of the major scientific goals at the Relativistic Heavy-Ion Collider (RHIC) towards understanding the nontrivial topological fluctuations of the Quantum Chromodynamics vacuum. In heavy-ion collisions, the CME is expected to result in a charge separation phenomenon across the reaction plane, whose strength could be strongly energy dependent. The previous CME searches have been focused on top RHIC energy collisions. In this Letter, we present a low energy search for the CME in Au+Au collisions at sNN−−−√=27 GeV. We measure elliptic flow scaled charge-dependent correlators relative to the event planes that are defined at both mid-rapidity |η|<1.0 and at forward rapidity 2.1<|η|<5.1. We compare the results based on the directed flow plane (Ψ1) at forward rapidity and the elliptic flow plane (Ψ2) at both central and forward rapidity. The CME scenario is expected to result in a larger correlation relative to Ψ1 than to Ψ2, while a flow driven background scenario would lead to a consistent result for both event planes. In 10-50\% centrality, results using three different event planes are found to be consistent within experimental uncertainties, suggesting a flow driven background scenario dominating the measurement. We obtain an upper limit on the deviation from a flow driven background scenario at the 95\% confidence level. This work opens up a possible road map towards future CME search with the high statistics data from the RHIC Beam Energy Scan Phase-II.
Schutz und Pflege von Zwergstrauchheiden in Sachsen-Anhalt : am Beispiel der "Woltersdorfer Heide"
(2001)
Im Gegensatz zu den "Feuchten Zwergstrauchheiden des nordatlantischen Raumes", welche durch eine Dominanz der Glockenheide (Erica tetralix) geprägt sind und innerhalb Deutschlands ihre Schwerpunktvorkommen im nordwestdeutschen Tiefland besitzen, sind die hier näher betrachteten "Europäischen Trockenen Heiden" (NATURA-2000-Code 4030) vor allem in Nordostdeutschland verbreitet. Die Hauptvorkommen befinden sich im Süden Mecklenburg-Vorpommerns, in Brandenburg sowie im nördlichen und mittleren Sachsen-Anhalt. Sie sind durch das Vorherrschen der Besenheide (Calluna vulgaris) gekennzeichnet, deren Wuchsorte meist durch silikatischen und oberflächlich entkalkten Untergrund sowie schlechte Nährstoff- und Wasserhaushaltsverhältnisse geprägt sind (SSYMANK et al. 1998). In Sachsen-Anhalt sind die großflächigen Heide-Vorkommen in der Regel an glazial-fluviatile Sande gebunden.
Tony, Hans-Peter ; Burmester, Gerd-Rüdiger ; Schulze-Koops, Hendrik ; Grunke, Mathias ; Henes, Jörg Christoph ; Kötter, Ina ; Haas, Judith ; Unger, Leonore ; Lovric, Svjetlana ; Haubitz, Marion ; Fischer-Betz, Rebecca ; Chehab, Gamal ; Rubbert-Roth, Andrea ; Specker, Christof ; Weinerth, Jutta ; Holle, Julia Ulrike ; Müller-Ladner, Ulf ; König, Ramona ; Fiehn, Christoph ; Burgwinkel, Philip ; Budde, Klemens ; Sörensen, Helmut ; Meurer, Michael ; Aringer, Martin ; Kieseier, Bernd ; Erfurt-Berge, Cornelia ; Sticherling, Michael ; Veelken, Roland ; Ziemann, Ulf ; Strutz, Frank ; Wussow, Praxis von ; Meier, Florian Matthias Peter ; Hunzelmann, Nico ; Schmidt, Nico ; Bergner, Raoul ; Schwarting, Andreas ; Eming, Rüdiger ; Hertl, Michael ; Stadler, Rudolf ; Schwarz-Eywill, Michael ; Wassenberg, Siegfried ; Fleck, Martin ; Metzler, Claudia ; Zettl, Uwe Klaus ; Westphal, Jens ; Heitmann, Stefan ; Herzog, Anna Laura ; Wiendl, Heinz ; Jakob, Waltraud ; Schmidt, Enno ; Freivogel, Klaus ; Dörner, Thomas
Introduction: Evidence from a number of open-label, uncontrolled studies has suggested that rituximab may benefit patients with autoimmune diseases who are refractory to standard-of-care. The objective of this study was to evaluate the safety and clinical outcomes of rituximab in several standard-of-care-refractory autoimmune diseases (within rheumatology, nephrology, dermatology and neurology) other than rheumatoid arthritis or non-Hodgkin's lymphoma in a real-life clinical setting.
Methods: Patients who received rituximab having shown an inadequate response to standard-of-care had their safety and clinical outcomes data retrospectively analysed as part of the German Registry of Autoimmune Diseases. The main outcome measures were safety and clinical response, as judged at the discretion of the investigators.
Results: A total of 370 patients (299 patient-years) with various autoimmune diseases (23.0% with systemic lupus erythematosus, 15.7% antineutrophil cytoplasmic antibody-associated granulomatous vasculitides, 15.1% multiple sclerosis and 10.0% pemphigus) from 42 centres received a mean dose of 2,440 mg of rituximab over a median (range) of 194 (180 to 1,407) days. The overall rate of serious infections was 5.3 per 100 patient-years during rituximab therapy. Opportunistic infections were infrequent across the whole study population, and mostly occurred in patients with systemic lupus erythematosus. There were 11 deaths (3.0% of patients) after rituximab treatment (mean 11.6 months after first infusion, range 0.8 to 31.3 months), with most of the deaths caused by infections. Overall (n = 293), 13.3% of patients showed no response, 45.1% showed a partial response and 41.6% showed a complete response. Responses were also reflected by reduced use of glucocorticoids and various immunosuppressives during rituximab therapy and follow-up compared with before rituximab. Rituximab generally had a positive effect on patient well-being (physician's visual analogue scale; mean improvement from baseline of 12.1 mm).
Conclusions: Data from this registry indicate that rituximab is a commonly employed, well-tolerated therapy with potential beneficial effects in standard of care-refractory autoimmune diseases, and support the results from other open-label, uncontrolled studies.
Stenner, Frank ; Liewen, Heike ; Göttig, Stephan ; Henschler, Reinhard ; Markuly, Norbert ; Kleber, Sascha ; Faust, Michael ; Mischo, Axel ; Bauer, Stefan ; Zweifel, Martin ; Knuth, Alexander ; Renner, Christoph ; Wadle, Andreas
RP1 (synonym: MAPRE2, EB2) is a member of the microtubule binding EB1 protein family, which interacts with APC, a key regulatory molecule in the Wnt signalling pathway. While the other EB1 proteins are well characterized the cellular function and regulation of RP1 remain speculative to date. However, recently RP1 has been implicated in pancreatic cancerogenesis. CK2 is a pleiotropic kinase involved in adhesion, proliferation and anti-apoptosis. Overexpression of protein kinase CK2 is a hallmark of many cancers and supports the malignant phenotype of tumor cells. In this study we investigate the interaction of protein kinase CK2 with RP1 and demonstrate that CK2 phosphorylates RP1 at Ser236 in vitro. Stable RP1 expression in cell lines leads to a significant cleavage and down-regulation of N-cadherin and impaired adhesion. Cells expressing a Phospho-mimicking point mutant RP1-ASP236 show a marked decrease of adhesion to endothelial cells under shear stress. Inversely, we found that the cells under shear stress downregulate endogenous RP1, most likely to improve cellular adhesion. Accordingly, when RP1 expression is suppressed by shRNA, cells lacking RP1 display significantly increased cell adherence to surfaces. In summary, RP1 phosphorylation at Ser236 by CK2 seems to play a significant role in cell adhesion and might initiate new insights in the CK2 and EB1 family protein association.
Queck, Alexander David Roger ; Uschner, Frank Erhard ; Ferstl, Philip ; Schulz, Martin ; Brol, Maximilian ; Praktiknjo, Michael ; Schierwagen, Robert ; Klein, Sabine ; Straßburg, Christian P. ; Meyer, Carsten ; Jansen, Christian ; Berres, Marie-Luise ; Trebicka, Jonel
Background: Pathogenesis of portal hypertension is multifactorial and includes pathologic intrahepatic angiogenesis, whereby TIPS insertion is an effective therapy of portal hypertension associated complications. While angiogenin is a potent contributor to angiogenesis in general, little is known about its impact on TIPS function over time. Methods: In a total of 118 samples from 47 patients, angiogenin concentrations were measured in portal and inferior caval vein plasma at TIPS insertion (each blood compartment n = 23) or angiographic intervention after TIPS (each blood compartment n = 36) and its relationship with patient outcome was investigated. Results: Angiogenin levels in the inferior caval vein were significantly higher compared to the portal vein (P = 0.048). Ten to 14 days after TIPS, inferior caval vein angiogenin level correlated inversely with the portal systemic pressure gradient (P<0.001), measured invasively during control angiography. Moreover, patients with TIPS revision during this angiography, showed significantly lower angiogenin level in the inferior caval vein compared to patients without TIPS dysfunction (P = 0.01). Conclusion: In cirrhosis patients with complications of severe portal hypertension, circulating levels of angiogenin are derived from the injured liver. Moreover, angiogenin levels in the inferior caval vein after TIPS may predict TIPS dysfunction.
Adams, J. ; Adler, Clemens ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Amonett, John ; Anderson, Bryon D. ; Arkhipkin, Dmitry A. ; Averichev, Georgy S. ; Badyal, S. K. ; Balewski, Jan ; Barannikova, Olga ; Barnby, Lee Stuart ; Baudot, Jérome ; Bekele, Selemon ; Belaga, Victoria Vladimirovna ; Bellwied, Rene ; Berger, Jens ; Bezverkhny, B. I. ; Bhardwaj, S. ; Bhati, Ashok Kumar ; Bichsel, Hans ; Billmeier, Anja ; Bland, Leslie C. ; Blyth, Charles O. ; Bonner, Billy E. ; Botje, Michiel ; Boucham, Abdelkrim ; Brandin, Andrei V. ; Bravar, Alessandro ; Cadman, R. V. ; Cai, Xiang-Zhou ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Carroll, J. ; Castillo Castellanos, Javier Ernesto ; Cebra, Daniel A. ; Chaloupka, Petr ; Chattopadhyay, S. ; Chen, H. F. ; Chen, Y. ; Chernenko, S. P. ; Cherney, Michael Gerard ; Chikanian, Alexei ; Christie, William ; Coffin, Jean Pierre ; Cormier, Thomas Michael ; Cramer, John G. ; Crawford, Henry J. ; Das, Debasish ; Das, Supriya ; Derevschikov, Anatoly A. ; Didenko, Lidia ; Dietel, Thomas ; Dong, W. J. ; Dong, X. ; Draper, James E. ; Du, F. ; Dubey, Anand Kumar ; Dunin, V. B. ; Dunlop, James C. ; Majumdar, M. R. Dutta ; Eckardt, Volker ; Efimov, Leonid G. ; Emelianov, V. ; Engelage, Jon M. ; Eppley, Geary Wareham ; Erazmus, Barbara Ewa ; Estienne, Magali Danielle ; Fachini, Patricia ; Faine, V. ; Faivre, Julien ; Fatemi, Renee H. ; Filimonov, Kirill ; Filip, Peter ; Finch, Evan ; Fisyak, Yuri V. ; Flierl, Dominik Bernhard ; Foley, K. J. ; Fu, J. ; Gagliardi, Carl A. ; Gagunashvili, N. ; Gans, J. ; Ganti, Murthy S. ; Gaudichet, L. ; Geurts, Frank ; Ghazikhanian, Vahe ; Ghosh, Premomoy ; Gonzalez, Johan Enmanuel ; Grachov, Oleg A. ; Grebenyuk, Oleksandr ; Gronstal, S. ; Grosnick, David P. ; Guertin, Steven M. ; Gupta, Anik ; Gutierrez, Thomas Dominic ; Hallman, Timothy J. ; Hamed, Ahmed M. ; Hardtke, David H. ; Harris, John W. ; Heinz, Mark Thomas ; Henry, Thomas W. ; Heppelmann, Steven Francis ; Hippolyte, Boris ; Hirsch, Andrew S. ; Hjort, Eric ; Hoffmann, Gerald W. ; Horsley, M. ; Huang, Huan Zhong ; Huang, Shengli ; Hughes, E. ; Humanic, Thomas J. ; Igo, George J. ; Ishihara, A. ; Jacobs, Peter Martin ; Jacobs, William W. ; Janik, Michał ; Jiang, H. ; Johnson, I. ; Jones, Peter Graham ; Judd, Eleanor G. ; Kabana, Sonia ; Kaplan, Morton ; Keane, Declan ; Khodyrev, V. Yu. ; Kiryluk, Joanna ; Kisiel, Adam Ryszard ; Klay, Jennifer Lynn ; Klein, Spencer Robert ; Klyachko, A. ; Koetke, Donald D. ; Kollegger, Thorsten ; Kopytine, M. ; Kotchenda, L. ; Kovalenko, A. D. ; Kramer, M. ; Kravtsov, Peter ; Kravtsov, Vladimir I. ; Krueger, Keith William ; Kuhn, Christian Claude ; Kulikov, Anatoly I. ; Kumar, Ajay ; Kunde, Gerd J. ; Kunz, Christopher Lee ; Kutuev, R. Kh. ; Kuznetsov, A. A. ; Lamont, Matthew A. C. ; Landgraf, Jeffery M. ; Lange, S. ; Lasiuk, Brian ; Laue, Frank ; Lauret, Jerome ; Lebedev, Alexei ; Lednický, Richard ; LeVine, Micheal J. ; Li, C. ; Li, Q. ; Lindenbaum, Sam J. ; Lisa, Michael A. ; Liu, F. ; Liu, L. ; Liu, Z. ; Liu, Q. J. ; Ljubicic, Tonko A. ; Llope, William Joseph ; Long, H. ; Longacre, Ronald S. ; Lopez-Noriega, M. ; Love, William A. ; Ludlam, Thomas ; Lynn, David ; Ma, Jing-guo ; Ma, Yu-Gang ; Magestro, Daniel ; Mahajan, Sanjay ; Mangotra, Lalit K. ; Mahapatra, D. P. ; Majka, Richard Daniel ; Manweiler, Robert W. ; Margetis, Spyridon ; Markert, Christina ; Martin, L. ; Marx, Jay N. ; Matis, Howard S. ; Matulenko, Yuri A. ; McClain, C. J. ; McShane, Tom S. ; Meissner, F. ; Melnick, Yu. ; Meščanin, Aleksei P. ; Miller, M. L. ; Milosevich, Z. ; Minaev, Nikolai G. ; Mironov, Camelia ; Mischke, André ; Mishra, Debadeepti ; Mitchell, J. ; Mohanty, Bedangadas ; Molnar, Levente ; Moore, C. F. ; Mora-Corral, M. J. ; Morozov, Dmitry A. ; Morozov, V. ; de Moura, M. M. ; Munhoz, Marcelo Gameiro ; Nandi, Basanta Kumar ; Nayak, S. K. ; Nayak, Tapan Kumar ; Nelson, John M. ; Netrakanti, Pawan Kumar ; Nikitin, Vladimir A. ; Nogach, Larisa V. ; Norman, B. ; Nurušev, Sandibek B. ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Okorokov, Vitaly A. ; Oldenburg, Markus D. ; Olson, Douglas L. ; Paic, Guy ; Pal, Susanta Kumar ; Panebratsev, Yuri ; Panitkin, Sergei Yurievich ; Pavlinov, A. I. ; Pawlak, Tomasz Jan ; Peitzmann, Thomas ; Perevoztchikov, V. ; Perkins, Chris ; Peryt, Wiktor Stanislaw ; Petrov, V. A. ; Phatak, S. C. ; Picha, R. ; Planinic, Mirko ; Pluta, Jan Marian ; Porile, Norbert T. ; Porter, Jeffrey Brent ; Poskanzer, Arthur M. ; Potekhin, Maxim ; Potrebenikova, E. ; Potukuchi, B. V. K. S. ; Prindle, Duncan J. ; Pruneau, Claude A. ; Putschke, Jörn H. ; Rai, Gulshan ; Rakness, Gregory L. ; Raniwala, Rashmi ; Raniwala, Sudhir ; Ravel, Olivier ; Ray, Robert L. ; Razin, Sergej V. ; Reichhold, Dennis Michael ; Reid, Jeffrey G. ; Renault, G. ; Retiere, Fabrice ; Ridiger, Alexey ; Ritter, Hans Georg ; Roberts, Jabus B. ; Rogachevski, O. V. ; Romero, Juan L. ; Rose, A. ; Roy, Christelle Sophie ; Ruan, Lijuan ; Sahoo, Raghunath ; Sakrejda, Iwona ; Salur, Sevil ; Sandweiss, Jack H. ; Savin, Igor A. ; Schambach, Joachim ; Scharenberg, Rolf Paul ; Schmitz, Norbert ; Schroeder, Lee S. ; Schweda, Kai ; Seger, Janet Elizabeth ; Seyboth, Peter ; Shahaliev, Ehtiram ; Shao, M. ; Shao, W. ; Sharma, M. ; Shestermanov, Konstantin E. ; Shimanskii, S. S. ; Singaraju, Rama Narayana ; Simon, F. ; Skoro, Goran P. ; Smirnov, Nikolai ; Snellings, Raimond ; Sood, Gopika ; Sorensen, Paul Richard ; Sowinski, James ; Speltz, Jeff ; Spinka, Harold. M. ; Srivastava, Brijesh Kumar ; Stanislaus, T. D. Shirvel ; Stock, Reinhard ; Stolpovsky, Alexander ; Strichanov, Michail Nikolaevič ; Stringfellow, Blair ; Struck, Christof ; Suaide, Alexandre Alarcon do Passo ; Sugarbaker, Evan R. ; Suire, Christophe Pierre ; Šumbera, Michal ; Surrow, Bernd ; Symons, Timothy James MacNeil ; de Toledo, A. Szanto ; Szarwas, Piotr ; Tai, An ; Takahashi, Jun ; Tang, Aihong ; Thein, Dylan ; Thomas, James H. ; Timoshenko, Sergei ; Tokarev, Mikhail V. ; Tonjes, Marguerite Belt ; Trainor, Thomas A. ; Trentalange, Stephen ; Tribble, Robert E. ; Tsai, Oleg D. ; Ullrich, Thomas ; Underwood, David G. ; Van Buren, Gene ; VanderMolen, A. M. ; Varma, Raghava ; Vasilevski, I. ; Vasiliev, Alexander Nikolaevich ; Vernet, Renaud ; Vigdor, Steven E. ; Viyogi, Yogendra P. ; Voloshin, Sergei ; Vznuzdaev, Marat ; Waggoner, William T. ; Wang, F. ; Wang, G. ; Wang, G. ; Wang, X. L. ; Wang, Y. ; Wang, Z. M. ; Ward, H. ; Watson, J. W. ; Webb, Jason C. ; Wells, R. ; Westfall, Gary D. ; Whitten, Charles A. ; Wieman, Howard ; Willson, Robert ; Wissink, Scott W. ; Witt, Richard ; Wood, J. ; Wu, J. ; Xu, N. ; Xu, Z. ; Xu, Z. Z. ; Yamamoto, E. ; Yepes, Pablo P. ; Yurevich, Vladimir Yurevich ; Yuting, B. ; Zanevski, Y. V. ; Zhang, Haitao ; Zhang, W. M. ; Zhang, Z. P. ; Zhaomin, Z. P. ; Zizong, Z. P. ; Żołnierczuk, Piotr Adam ; Zoulkarneev, R. ; Zoulkarneeva, J. ; Zubarev, A. N.
We report results on rho (770)0--> pi + pi - production at midrapidity in p+p and peripheral Au+Au collisions at sqrt[sNN]=200 GeV. This is the first direct measurement of rho (770)0--> pi + pi - in heavy-ion collisions. The measured rho 0 peak in the invariant mass distribution is shifted by ~40 MeV/c2 in minimum bias p+p interactions and ~70 MeV/c2 in peripheral Au+Au collisions. The rho 0 mass shift is dependent on transverse momentum and multiplicity. The modification of the rho 0 meson mass, width, and shape due to phase space and dynamical effects are discussed.
Adam, Jaroslav ; Adamczyk, Leszek ; Adams, Joseph R. ; Adkins, J. Kevin ; Agakishiev, Geydar ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Alekseev, Igor G. ; Anderson, Derek M. ; Aparin, Alexey ; Aschenauer, Elke Caroline ; Ashraf, Muhammad Usman ; Atetalla, Fareha ; Attri, Anjali ; Averichev, Georgy S. ; Bairathi, Vipul ; Barish, Kenneth ; Behera, Arabinda ; Bellwied, Rene ; Bhasin, Anju ; Bielčík, Jaroslav ; Bielčíková, Jana ; Bland, Leslie C. ; Bordyuzhin, Igor G. ; Brandenburg, James D. ; Brandin, Andrei V. ; Bueltmann, S. ; Butterworth, Joseph ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Cebra, Daniel A. ; Chakaberia, Irakli ; Chaloupka, Petr ; Chan, B.K. ; Chang, F-H. ; Chang, Z. ; Chankova-Bunzarova, N. ; Chatterjee, A. ; Chen, D. ; Chen, J.H. ; Chen, X. ; Chen, Z. ; Cheng, J. ; Cherney, Michael Gerard ; Chevalier, M. ; Choudhury, Subikash ; Christie, William ; Chu, Xiaoxuan ; Crawford, Henry J. ; Csanád, Máté ; Daugherity, M. ; Dedovič, Tatiana G. ; Deppner, Ingo Martin ; Derevschikov, Anatoly A. ; Didenko, Lidia ; Dong, X. ; Drachenberg, James Lucus ; Dunlop, James C. ; Edmonds, Terrence ; Elsey, Nicholas ; Engelage, Jon M. ; Eppley, Geary Wareham ; Esumi, ShinIchi ; Evdokimov, Olga Y. ; Ewigleben, A. ; Eyser, Kjeld Oleg ; Fatemi, Renee H. ; Fazio, Salvatore ; Federič, Pavol ; Fedorišin, Jan ; Feng, C.J. ; Feng, Yicheng ; Filip, Peter ; Finch, Evan ; Fisyak, Yuri V. ; Francisco, Audrey ; Fulek, Łukasz ; Gagliardi, Carl A. ; Galatyuk, Tetyana ; Geurts, Frank ; Gibson, Adam ; Gopal, Krishan ; Grosnick, David P. ; Guryn, Włodzimierz ; Hamad, Ayman ; Hamed, Ahmed M. ; Harabasz, Szymon ; Harris, John W. ; He, S. ; He, W. ; He, Xionghong ; Heppelmann, Samuel ; Heppelmann, Steven Francis ; Herrmann, Norbert ; Hoffman, E. ; Holub, Lukáš ; Hong, Y. ; Horvat, S. ; Hu, Y. ; Huang, Huan Zhong ; Huang, Shengli ; Huang, T. ; Huang, X. ; Humanic, Thomas J. ; Huo, P. ; Igo, George J. ; Isenhower, D. ; Jacobs, William W. ; Jena, Chitrasen ; Jentsch, Alexander ; Ji, Yuanjing ; Jia, Jiangyong ; Jiang, K. ; Jowzaee, S. ; Ju, Xin-Yue ; Judd, Eleanor G. ; Kabana, Sonia ; Kabir, M.L. ; Kagamaster, Skipper ; Kalinkin, Dmitry ; Kang, K. ; Kapukchyan, David ; Kauder, Kolja ; Ke, Hongwei ; Keane, Declan ; Kechechyan, Armen ; Kelsey, Matthew ; Khyzhniak, Yevheniia V. ; Kikoła, Daniel P. ; Kim, C. ; Kimelman, B. ; Kincses, D. ; Kinghorn, Todd Adler ; Kisel, Ivan ; Kiselev, A. ; Kocan, Michal ; Kočenda, L. M. ; Kosarzewski, Leszek Krzysztof ; Kramárik, Lukáš ; Kravtsov, Peter ; Krueger, Keith William ; Kulathunga Mudiyanselage, Nalinda ; Kumar, Lokesh ; Kumar, Shyam ; Kunnawalkam Elayavalli, Raghav ; Kwasizur, Joseph H. ; Lacey, Roy Alphanso ; Lan, Shaowei ; Landgraf, Jeffery M. ; Lauret, Jerome ; Lebedev, Alexei ; Lednicky, Richard ; Lee, J.H. ; Leung, Yue Hang ; Li, C. ; Li, W. ; Li, W. ; Li, Xiaomei ; Li, Y. ; Liang, Y. ; Licenik, Robert ; Lin, T. ; Lin, Y. ; Lisa, Michael A. ; Liu, F. ; Liu, H. ; Liu, P. ; Liu, P. ; Liu, T. ; Liu, X. ; Liu, Y. ; Liu, Z. ; Ljubicic, Tonko A. ; Llope, William Joseph ; Longacre, Ronald S. ; Lukow, N.S. ; Luo, S. ; Luo, X. ; Ma, G.L. ; Ma, L. ; Ma, R. ; Ma, Yu-Gang ; Magdy Abdelwahab Abdelrahman, Niseem ; Majka, Richard Daniel ; Mallick, Dukhishyam ; Margetis, Spyridon ; Markert, Christina ; Matis, Howard S. ; Mazer, Joel Anthony ; Minaev, Nikolai G. ; Mioduszewski, Saskia ; Mohanty, Bedangadas ; Mooney, Isaac A. ; Moravcova, Zuzana ; Morozov, Dmitry A. ; Nagy, M. ; Nam, J.D. ; Nasim, Md. ; Nayak, Kishora ; Neff, D. ; Nelson, John M. ; Nemes, Daniel B. ; Nie, Maowu ; Nigmatkulov, Grigory A. ; Niida, Takafumi ; Nogach, Larisa V. ; Nonaka, Toshihiro ; Nunes, A.S. ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Oh, Saehanseul ; Okorokov, Vitaly A. ; Page, Brian S. ; Pak, Robert ; Pandav, Ashish ; Panebratsev, Yuri ; Pawlik, Bogdan ; Pawłowska, Diana ; Pei, Hua ; Perkins, Chris ; Pinsky, Lawrence ; Pintér, Roland Laszlo ; Pluta, Jan Marian ; Porter, Jeffrey Brent ; Posik, Matthew ; Pruthi, Navneet Kumar ; Przybycien, Mariusz ; Putschke, Jörn H. ; Qiu, H. ; Quintero, Amilkar ; Radhakrishnan, Sooraj Krishnan ; Ramachandran, Suvarna ; Ray, Robert L. ; Reed, Rosi Jan ; Ritter, Hans Georg ; Rogačevskij, Oleg V. ; Romero, Juan L. ; Ruan, Lijuan ; Rusnak, Jan ; Sahoo, Nihar Ranjan ; Sako, H. ; Salur, Sevil ; Sandweiss, Jack H. ; Sato, Susumu ; Schmidke, William B. ; Schmitz, Norbert ; Schweid, Benjamin R. ; Seck, Florian ; Seger, Janet Elizabeth ; Sergeeva, Maria ; Seto, Richard ; Seyboth, Peter ; Shah, N. ; Shahaliev, Ehtiram ; Shanmuganathan, Prashanth V. ; Shao, M. ; Sheikh, Ashik Ikbal ; Shen, F. ; Shen, W.Q. ; Shi, Shusu ; Shou, Q.Y. ; Sichtermann, Ernst P. ; Sikora, Rafał ; Šimko, Miroslav ; Singh, Jagbir ; Singha, Subhash ; Smirnov, Nikolai ; Solyst, William ; Sorensen, Paul Richard ; Spinka, Harold. M. ; Srivastava, Brijesh Kumar ; Stanislaus, T. D. Shirvel ; Stefaniak, Maria ; Stewart, David J. ; Strichanov, Michail Nikolaevič ; Stringfellow, Blair ; Suaide, Alexandre Alarcon do Passo ; Šumbera, Michal ; Summa, Branden ; Sun, X.M. ; Sun, X. ; Sun, Y. ; Sun, Y. ; Surrow, Bernd ; Svirida, Dmitry N. ; Szymański, Paweł ; Tang, Aihong ; Tang, Zebo ; Taranenko, Arkadiy ; Tarnowsky, Terence J. ; Thomas, James H. ; Timmins, Anthony Robert ; Tlusty, David ; Tokarev, Mikhail V. ; Tomkiel, Catherine A. ; Trentalange, Stephen ; Tribble, Robert E. ; Tribedy, Prithwish ; Tripathy, Srikanta Kumar ; Tsai, Oleg D. ; Tu, Zhoudunming ; Ullrich, Thomas ; Underwood, David G. ; Upsal, Isaac ; Van Buren, Gene ; Vanek, Jan ; Vasiliev, Alexander Nikolaevich ; Vassiliev, Iouri ; Videbæk, Flemming ; Vokal, Stanislav ; Voloshin, Sergei ; Wang, F. ; Wang, G. ; Wang, J.S. ; Wang, P. ; Wang, Y. ; Wang, Y. ; Wang, Z. ; Webb, Jason C. ; Weidenkaff, Philipp ; Wen, L. ; Westfall, Gary D. ; Wieman, Howard ; Wissink, Scott W. ; Witt, Richard ; Wu, Y. ; Xiao, Z.G. ; Xie, Guannan ; Xie, W. ; Xu, H. ; Xu, N. ; Xu, Qinghua ; Xu, Y.F. ; Xu, Y. ; Xu, Z. ; Xu, Z. ; Yang, C. ; Yang, Q. ; Yang, S. ; Yang, Y. ; Yang, Z. ; Ye, Z. ; Ye, Z. ; Yi, L. ; Yip, K. ; Zbroszczyk, Hanna Paulina ; Zha, Wangmei ; Zhang, C. ; Zhang, Dingwei ; Zhang, S. ; Zhang, S. ; Zhang, X.P. ; Zhang, Y. ; Zhang, Y. ; Zhang, Z.J. ; Zhang, Zuman ; Zhang, Zuman ; Zhao, J. ; Zhong, C. ; Zhou, C. ; Zhu, X. ; Zhu, Z. ; Zurek, Marian ; Zyzak, Maksym
We report results on the total and elastic cross sections in proton-proton collisions at √s = 200 GeV obtained with the Roman Pot setup of the STAR experiment at the Relativistic Heavy Ion Collider (RHIC). The elastic differential cross section was measured in the squared four-momentum transfer range 0.045 ≤ −t ≤ 0.135 GeV2. The value of the exponential slope parameter B of the elastic differential cross section dσ/dt ∼ e−Bt in the measured −t range was found to be B = 14.32 ± 0.09(stat.)+0.13 −0.28(syst.) GeV−2. The total cross section σtot, obtained from extrapolation of the dσ/dt to the optical point at −t = 0, is σtot = 54.67 ± 0.21(stat.)+1.28 −1.38(syst.) mb. We also present the values of the elastic cross section σel = 10.85 ± 0.03(stat.)+0..49 −0.41(syst.) mb, the elastic cross section integrated within the STAR t-range σ det el = 4.05 ± 0.01(stat.)+0.18−0.17(syst.) mb, and the inelastic cross section σinel = 43.82 ± 0.21(stat.)+1.37−1.44(syst.) mb. The results are compared with the world data
Abdulhamid, Muhammad Ibrahim ; Aboona, Bassam ; Adam, Jaroslav ; Adamczyk, Leszek ; Adams, Joseph R. ; Aggarwal, Ishu ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Aschenauer, Elke Caroline ; Aslam, Sameer ; Atchison, J. ; Bairathi, Vipul ; Ball Cap, Jonathan Gonzalo ; Barish, Kenneth ; Bellwied, Rene ; Bhagat, Pratibha ; Bhasin, Anju ; Bhatta, Somadutta ; Bhosale, Sneha ; Bielčík, Jaroslav ; Bielčíková, Jana ; Brandenburg, James D. ; Broodo, Caleb ; Cai, X.Z. ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Cebra, Daniel A. ; Češka, Jakub ; Chakaberia, Irakli ; Chaloupka, Petr ; Chan, B.K. ; Chang, Z. ; Chatterjee, A. ; Chen, D. ; Chen, J. ; Chen, J.H. ; Chen, Z. ; Cheng, J. ; Cheng, Y. ; Choudhury, Subikash ; Christie, William ; Chu, Xiaoxuan ; Crawford, Henry J. ; Csanád, Máté ; Dale-Gau, Gabriel ; Das, A. ; Deppner, Ingo Martin ; Dhamija, A. ; Dixit, Prabhupada ; Dong, X. ; Drachenberg, James Lucus ; Duckworth, Emilie ; Dunlop, James C. ; Engelage, Jon M. ; Eppley, Geary Wareham ; Esumi, ShinIchi ; Evdokimov, Olga Y. ; Eyser, Kjeld Oleg ; Fatemi, Renee H. ; Fazio, Salvatore ; Feng, C.J. ; Feng, Yicheng ; Finch, Evan ; Fisyak, Yuri V. ; Flor, Fernando Antonio ; Fu, C. ; Gagliardi, Carl A. ; Galatyuk, Tetyana ; Gao, T. ; Geurts, Frank ; Ghimire, Navagyan ; Gibson, Adam ; Gopal, Krishan ; Gou, X. ; Grosnick, David P. ; Gupta, Anik ; Guryn, Włodzimierz ; Hamed, Ahmed M. ; Han, Y. ; Harabasz, Szymon ; Harasty, Matthew D. ; Harris, John W. ; Harrison-Smith, Hannah ; He, W. ; He, Xionghong ; He, Y. ; Herrmann, Norbert ; Holub, Lukáš ; Hu, C. ; Hu, Q. ; Hu, Y. ; Huang, H. ; Huang, Huan Zhong ; Huang, Shengli ; Huang, T. ; Huang, X. ; Huang, Y. ; Huang, Y. ; Humanic, Thomas J. ; Isshiki, M. ; Jacobs, William W. ; Jalotra, Ashish ; Jena, Chitrasen ; Jentsch, Alexander ; Ji, Yuanjing ; Jia, Jiangyong ; Jin, C. ; Ju, Xin-Yue ; Judd, Eleanor G. ; Kabana, Sonia ; Kalinkin, Dmitry ; Kang, K. ; Kapukchyan, David ; Kauder, Kolja ; Keane, Declan ; Khanal, Aniket ; Khyzhniak, Yevheniia V. ; Kikoła, Daniel P. ; Kincses, D. ; Kisel, Ivan ; Kiselev, A. ; Knospe, Anders Garritt ; Ko, H.S. ; Kosarzewski, Leszek Krzysztof ; Kumar, Lokesh ; Labonte, Mathias C. ; Lacey, Roy Alphanso ; Landgraf, Jeffery M. ; Lauret, Jerome ; Lebedev, Alexei ; Lee, J.H. ; Leung, Yue Hang ; Lewis, N. ; Li, C. ; Li, D. ; Li, H-S. ; Li, H. ; Li, W. ; Li, X. ; Li, Y. ; Li, Y. ; Li, Z. ; Liang, X. ; Liang, Y. ; Licenik, Robert ; Lin, T. ; Lin, Y. ; Lisa, Michael A. ; Liu, C. ; Liu, G. ; Liu, H. ; Liu, L. ; Liu, T. ; Liu, X. ; Liu, Y. ; Liu, Z. ; Ljubicic, Tonko A. ; Lomicky, O. ; Longacre, Ronald S. ; Loyd, E.M. ; Lu, T. ; Luo, J. ; Luo, X.F. ; Ma, L. ; Ma, R. ; Ma, Yu-Gang ; Magdy Abdelwahab Abdelrahman, Niseem ; Mallick, Dukhishyam ; Manikandhan, Rutik ; Margetis, Spyridon ; Markert, Christina ; Matis, Howard S. ; McNamara, Grant ; Mezhanska, O. ; Mi, K. ; Mioduszewski, Saskia ; Mohanty, Bedangadas ; Mouli, Mriganka Mouli ; Mooney, Isaac A. ; Nagy, M.I. ; Nain, A.S. ; Nam, J.D. ; Nasim, M. ; Neff, D. ; Nelson, John M. ; Nemes, Daniel B. ; Nie, M. ; Nigmatkulov, Grigory A. ; Niida, Takafumi ; Nonaka, Toshihiro ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Oh, Saehanseul ; Okubo, K. ; Page, Brian S. ; Pak, Robert ; Pal, S. ; Pandav, Ashish ; Pani, Tanmay ; Paul, A. ; Pawlik, Bogdan ; Pawłowska, Diana ; Perkins, Chris ; Pluta, Jan Marian ; Pokhrel, B.R. ; Posik, Matthew ; Protzman, Tristan ; Prozorova, V. ; Pruthi, Navneet Kumar ; Przybycien, Mariusz ; Putschke, Jörn H. ; Qin, Z. ; Qiu, H. ; Racz, Cameron ; Radhakrishnan, Sooraj Krishnan ; Rana, Aditya ; Ray, Robert L. ; Reed, Rosi Jan ; Ritter, Hans Georg ; Robertson, C.W. ; Robotkova, Monika ; Rosales Aguilar, M.A. ; Roy, D. ; Roy Chowdhury, P. ; Ruan, L. ; Sahoo, Aswini Kumar ; Sahoo, Nihar Ranjan ; Sako, H. ; Salur, Sevil ; Sato, Susumu ; Schaefer, Brennan C. ; Schmidke, William B. ; Schmitz, Norbert ; Seck, F-J. ; Seger, Janet Elizabeth ; Seto, Richard ; Seyboth, Peter ; Shah, N. ; Shanmuganathan, Prashanth V. ; Shao, Tianhao ; Sharma, M. ; Sharma, Natasha ; Sharma, R. ; Sharma, S.R. ; Sheikh, Ashik Ikbal ; Shen, D. ; Shen, D.Y. ; Shen, K. ; Shi, Shusu ; Shi, Y. ; Shou, Q.Y. ; Si, F. ; Singh, J. ; Singha, Subhash ; Sinha, P. ; Skoby, Michael J. ; Smirnov, Nikolai ; Söhngen, Yannick ; Song, Y. ; Srivastava, B. ; Stanislaus, T. D. Shirvel ; Stefaniak, Maria ; Stewart, David J. ; Stringfellow, Blair ; Su, Y. ; Suaide, Alexandre Alarcon do Passo ; Šumbera, Michal ; Sun, C. ; Sun, X. ; Sun, Y. ; Sun, Y. ; Surrow, Bernd ; Sweger, Z.W. ; Tamis, A.C. ; Tang, Aihong ; Tang, Zebo ; Tarnowsky, Terence J. ; Thomas, James H. ; Timmins, Anthony Robert ; Tlusty, David ; Todoroki, Takahito ; Trentalange, Stephen ; Tribedy, Prithwish ; Tripathy, Srikanta Kumar ; Truhlar, Tomas ; Trzeciak, Barbara Antonina ; Tsai, Oleg D. ; Tsang, C.Y. ; Tu, Zhoudunming ; Tyler, J. ; Ullrich, Thomas ; Underwood, David G. ; Upsal, Isaac ; Van Buren, Gene ; Vanek, Jan ; Vassiliev, Iouri ; Verkest, Veronica ; Videbæk, Flemming ; Voloshin, Sergei ; Wang, F. ; Wang, G. ; Wang, J.S. ; Wang, J. ; Wang, K. ; Wang, X. ; Wang, Y. ; Wang, Y. ; Wang, Y. ; Wang, Z. ; Webb, Jason C. ; Weidenkaff, Philipp ; Westfall, Gary D. ; Wielanek, Daniel ; Wieman, Howard ; Wilks, G. ; Wissink, Scott W. ; Witt, Richard ; Wu, J. ; Wu, J. ; Wu, Xiao ; Wu, Xiao ; Xi, B. ; Xiao, Z.G. ; Xie, Guannan ; Xie, W. ; Xu, H. ; Xu, N. ; Xu, Qinghua ; Xu, Y. ; Xu, Y. ; Xu, Z. ; Xu, Z. ; Yan, G. ; Yan, Z. ; Yang, C. ; Yang, Q. ; Yang, S. ; Yang, Y. ; Ye, Z. ; Ye, Z. ; Yi, L. ; Yip, K. ; Yu, Y. ; Zbroszczyk, Hanna Paulina ; Zha, Wangmei ; Zhang, C. ; Zhang, Dingwei ; Zhang, J. ; Zhang, S. ; Zhang, W. ; Zhang, X. ; Zhang, Y. ; Zhang, Y. ; Zhang, Y. ; Zhang, Y. ; Zhang, Z.J. ; Zhang, Z. ; Zhang, Z. ; Zhao, F. ; Zhao, J. ; Zhao, M. ; Zhou, J. ; Zhou, S. ; Zhou, Y. ; Zhu, X. ; Żurek, Maria Katarzyna ; Zyzak, Maksym
We report results on an elastic cross section measurement in proton–proton collisions at a center-of-mass energy √𝑠 = 510 GeV, obtained with the Roman Pot setup of the STAR experiment at the Relativistic Heavy Ion Collider (RHIC). The elastic differential cross section is measured in the four-momentum transfer squared range 0.23 ≤ −𝑡 ≤ 0.67 GeV2. This is the only measurement of the proton-proton elastic cross section in this 𝑡 range for collision energies above the Intersecting Storage Rings (ISR) and below the Large Hadron Collider (LHC) colliders. We find that a constant slope 𝐵 does not fit the data in the aforementioned 𝑡 range, and we obtain a much better fit using a second-order polynomial for 𝐵(𝑡). This is the first measurement below the LHC energies for which the non-constant behavior 𝐵(𝑡) is observed. The 𝑡 dependence of 𝐵 is also determined using six subintervals of 𝑡 in the STAR measured 𝑡 range, and is in good agreement with the phenomenological models. The measured elastic differential cross section d𝜎∕dt agrees well with the results obtained at √𝑠 = 540 GeV for proton–antiproton collisions by the UA4 experiment. We also determine that the integrated elastic cross section within the STAR 𝑡-range is 𝜎f id el = 462.1 ± 0.9(stat.) ± 1.1(syst.) ± 11.6(scale) 𝜇b.
Duplissy, Jonathan ; Enghoff, Martin Bødker ; Aplin, Karen L. ; Arnold, Frank ; Aufmhoff, Heinfried ; Avngaard, Michael ; Baltensperger, Urs ; Bondo, Torsten ; Bingham, Robert ; Carslaw, Kenneth S. ; Curtius, Joachim ; David, André ; Fastrup, Bent ; Gagné, Stéphanie ; Hahn, F. ; Harrison, R. Giles ; Kellett, Barry ; Kirkby, Jasper ; Kulmala, Markku ; Laakso, Lauri ; Laaksonen, Ari ; Lillestol, Egil ; Lockwood, Michael ; Mäkelä, Jyrki ; Makhmutov, Vladimir ; Marsh, Nigel D. ; Nieminen, Tuomo ; Onnela, Antti ; Pedersen, E. ; Pedersen, Jens Olaf Pepke ; Polny, Josef ; Reichl, Ulrike ; Seinfeld, John H. ; Sipilä, Mikko ; Stozhkov, Yuri ; Stratmann, Frank ; Svensmark, Henrik ; Svensmark, J. ; Veenhof, Rob ; Verheggen, Bart ; Viisanen, Yrjö ; Wagner, Paul E. ; Wehrle, Günther ; Weingartner, Ernest ; Wex, Heike ; Wilhelmsson, Mats ; Winkler, Paul M.
During a 4-week run in October–November 2006, a pilot experiment was performed at the CERN Proton Synchrotron in preparation for the CLOUD1 experiment, whose aim is to study the possible influence of cosmic rays on clouds. The purpose of the pilot experiment was firstly to carry out exploratory measurements of the effect of ionising particle radiation on aerosol formation from trace H2SO4 vapour and secondly to provide technical input for the CLOUD design. A total of 44 nucleation bursts were produced and recorded, with formation rates of particles above the 3 nm detection threshold of between 0.1 and 100 cm−3s−1, and growth rates between 2 and 37 nm h−1. The corresponding H2SO4 concentrations were typically around 106 cm−3 or less. The experimentally-measured formation rates and H2SO4 concentrations are comparable to those found in the atmosphere, supporting the idea that sulphuric acid is involved in the nucleation of atmospheric aerosols. However, sulphuric acid alone is not able to explain the observed rapid growth rates, which suggests the presence of additional trace vapours in the aerosol chamber, whose identity is unknown. By analysing the charged fraction, a few of the aerosol bursts appear to have a contribution from ion-induced nucleation and ion-ion recombination to form neutral clusters. Some indications were also found for the accelerator beam timing and intensity to influence the aerosol particle formation rate at the highest experimental SO2 concentrations of 6 ppb, although none was found at lower concentrations. Overall, the exploratory measurements provide suggestive evidence for ion-induced nucleation or ion-ion recombination as sources of aerosol particles. However in order to quantify the conditions under which ion processes become significant, improvements are needed in controlling the experimental variables and in the reproducibility of the experiments. Finally, concerning technical aspects, the most important lessons for the CLOUD design include the stringent requirement of internal cleanliness of the aerosol chamber, as well as maintenance of extremely stable temperatures (variations below 0.1°C).
Duplissy, Jonathan ; Enghoff, Martin Bødker ; Aplin, Karen L. ; Arnold, Frank ; Aufmhoff, Heinfried ; Avngaard, Michael ; Baltensperger, Urs ; Bondo, Torsten ; Bingham, Robert ; Carslaw, Kenneth S. ; Curtius, Joachim ; David, André ; Fastrup, Bent ; Gagné, Stéphanie ; Hahn, F. ; Harrison, R. Giles ; Kellett, Barry ; Kirkby, Jasper ; Kulmala, Markku ; Laakso, Lauri ; Laaksonen, Ari ; Lillestol, Egil ; Lockwood, Michael ; Mäkelä, Jyrki ; Makhmutov, Vladimir ; Marsh, Nigel D. ; Nieminen, Tuomo ; Onnela, Antti ; Pedersen, E. ; Pedersen, Jens Olaf Pepke ; Polny, Josef ; Reichl, Ulrike ; Seinfeld, John H. ; Sipilä, Mikko ; Stozhkov, Yuri ; Stratmann, Frank ; Svensmark, Henrik ; Svensmark, J. ; Veenhof, Rob ; Verheggen, Bart ; Viisanen, Yrjö ; Wagner, Paul E. ; Wehrle, Günther ; Weingartner, Ernest ; Wex, Heike ; Wilhelmsson, Mats ; Winkler, Paul M.
During a 4-week run in October–November 2006, a pilot experiment was performed at the CERN Proton Synchrotron in preparation for the Cosmics Leaving OUtdoor Droplets (CLOUD) experiment, whose aim is to study the possible influence of cosmic rays on clouds. The purpose of the pilot experiment was firstly to carry out exploratory measurements of the effect of ionising particle radiation on aerosol formation from trace H2SO4 vapour and secondly to provide technical input for the CLOUD design. A total of 44 nucleation bursts were produced and recorded, with formation rates of particles above the 3 nm detection threshold of between 0.1 and 100 cm -3 s -1, and growth rates between 2 and 37 nm h -1. The corresponding H2O concentrations were typically around 106 cm -3 or less. The experimentally-measured formation rates and htwosofour concentrations are comparable to those found in the atmosphere, supporting the idea that sulphuric acid is involved in the nucleation of atmospheric aerosols. However, sulphuric acid alone is not able to explain the observed rapid growth rates, which suggests the presence of additional trace vapours in the aerosol chamber, whose identity is unknown. By analysing the charged fraction, a few of the aerosol bursts appear to have a contribution from ion-induced nucleation and ion-ion recombination to form neutral clusters. Some indications were also found for the accelerator beam timing and intensity to influence the aerosol particle formation rate at the highest experimental SO2 concentrations of 6 ppb, although none was found at lower concentrations. Overall, the exploratory measurements provide suggestive evidence for ion-induced nucleation or ion-ion recombination as sources of aerosol particles. However in order to quantify the conditions under which ion processes become significant, improvements are needed in controlling the experimental variables and in the reproducibility of the experiments. Finally, concerning technical aspects, the most important lessons for the CLOUD design include the stringent requirement of internal cleanliness of the aerosol chamber, as well as maintenance of extremely stable temperatures (variations below 0.1 °C)
Adams, John ; Adler, Clemens ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Amonett, John ; Anderson, Bryon D. ; Anderson, Mike ; Arkhipkin, Dmitry A. ; Averichev, Georgy S. ; Badyal, S. K. ; Balewski, Jan ; Barannikova, Olga ; Barnby, Lee Stuart ; Baudot, Jérome ; Bekele, Selemon ; Belaga, Victoria Vladimirovna ; Bellwied, Rene ; Berger, Jens ; Bezverkhny, B. I. ; Bhardwaj, S. ; Bhaskar, P. ; Bhati, Ashok Kumar ; Bichsel, Hans ; Billmeier, Anja ; Bland, Leslie C. ; Blyth, Charles O. ; Bonner, Billy E. ; Botje, Michiel ; Boucham, Abdelkrim ; Brandin, Andrei V. ; Bravar, Alessandro ; Cadman, R. V. ; Cai, Xiang-Zhou ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Cardenas, Andrés ; Carroll, J. ; Castillo Castellanos, Javier Ernesto ; Castro, M. ; Cebra, Daniel A. ; Chaloupka, Petr ; Chattopadhyay, S. ; Chen, H. F. ; Chen, Y. ; Chernenko, S. P. ; Cherney, Michael Gerard ; Chikanian, Alexei ; Choi, B. ; Christie, William ; Coffin, Jean Pierre ; Cormier, Thomas Michael ; Cramer, John G. ; Crawford, Henry J. ; Das, Debasish ; Das, Supriya ; Derevschikov, Anatoly A. ; Didenko, Lidia ; Dietel, Thomas ; Dong, X. ; Draper, James E. ; Du, F. ; Dubey, Anand Kumar ; Dunin, V. B. ; Dunlop, James C. ; Dutta Mazumdar, M. R. ; Eckardt, Volker ; Efimov, Leonid G. ; Emelianov, V. ; Engelage, Jon M. ; Eppley, Geary Wareham ; Erazmus, Barbara Ewa ; Fachini, Patricia ; Faine, V. ; Faivre, Julien ; Fatemi, Renee H. ; Filimonov, Kirill ; Filip, Peter ; Finch, Evan ; Fisyak, Yuri V. ; Flierl, Dominik Bernhard ; Foley, K. J. ; Fu, J. ; Gagliardi, Carl A. ; Ganti, Murthy S. ; Gutierrez, Thomas Dominic ; Gagunashvili, N. ; Gans, J. ; Gaudichet, L. ; Germain, Marie ; Geurts, Frank ; Ghazikhanian, Vahe ; Ghosh, Premomoy ; Gonzalez, Johan Enmanuel ; Grachov, Oleg A. ; Grigoriev, Vladislav A. ; Grosnick, David P. ; Guedon, M. ; Guertin, Steven M. ; Gupta, Anik ; Gushin, E. ; Hallman, Timothy J. ; Hardtke, David H. ; Harris, John W. ; Heinz, Mark Thomas ; Henry, Thomas W. ; Heppelmann, Steven Francis ; Herston, T. ; Hippolyte, Boris ; Hirsch, Andrew S. ; Hjort, Eric ; Hoffmann, Gerald W. ; Horsley, M. ; Huang, Huan Zhong ; Huang, Shengli ; Humanic, Thomas J. ; Igo, George J. ; Ishihara, A. ; Jacobs, Peter Martin ; Jacobs, William W. ; Janik, Michał ; Johnson, I. ; Jones, Peter Graham ; Judd, Eleanor G. ; Kabana, Sonia ; Kaneta, Kaneta ; Kaplan, Morton ; Keane, Declan ; Kiryluk, Joanna ; Kisiel, Adam Ryszard ; Klay, Jennifer Lynn ; Klein, Spencer Robert ; Klyachko, A. ; Koetke, Donald D. ; Kollegger, Thorsten ; Konstantinov, A. S. ; Kopytine, M. ; Kotchenda, L. ; Kovalenko, A. D. ; Kramer, M. ; Kravtsov, Peter ; Krueger, Keith William ; Kuhn, Christian Claude ; Kulikov, Anatoly I. ; Kumar, Ajay ; Kunde, Gerd J. ; Kunz, Christopher Lee ; Kutuev, R. Kh. ; Kuznetsov, A. A. ; Lamont, Matthew A. C. ; Landgraf, Jeffery M. ; Lange, S. ; Lansdell, Curtis Patrick Leon ; Lasiuk, Brian ; Laue, Frank ; Lauret, Jerome ; Lebedev, Alexei ; Lednický, Richard ; Leontiev, V. M. ; LeVine, Micheal J. ; Li, C. ; Li, Q. ; Lindenbaum, Sam J. ; Lisa, Michael A. ; Liu, F. ; Liu, L. ; Liu, Z. ; Liu, Q. J. ; Ljubicic, Tonko A. ; Llope, William Joseph ; Long, H. ; Longacre, Ronald S. ; Lopez-Noriega, M. ; Love, William A. ; Ludlam, Thomas ; Lynn, David ; Ma, Jing-guo ; Ma, Yu-Gang ; Magestro, Daniel ; Mahajan, Sanjay ; Mangotra, Lalit K. ; Mahapatra, A. P. ; Majka, Richard Daniel ; Manweiler, Robert W. ; Margetis, Spyridon ; Markert, Christina ; Martin, L. ; Marx, Jay N. ; Matis, Howard S. ; Matulenko, Yuri A. ; McShane, Tom S. ; Meissner, F. ; Melnick, Yu. ; Meščanin, Aleksei P. ; Messer, Matthias ; Miller, M. L. ; Milosevich, Z. ; Minaev, Nikolai G. ; Mironov, Camelia ; Mishra, Debadeepti ; Mitchell, J. ; Mohanty, Bedangadas ; Molnar, Levente ; Moore, C. F. ; Mora-Corral, M. J. ; Morozov, V. ; de Moura, M. M. ; Munhoz, Marcelo Gameiro ; Nandi, Basanta Kumar ; Nayak, S. K. ; Nayak, Tapan Kumar ; Nelson, John M. ; Nevski, P. ; Nikitin, Vladimir A. ; Nogach, Larisa V. ; Norman, B. ; Nurušev, Sandibek B. ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Okorokov, Vitaly A. ; Oldenburg, Markus D. ; Olson, Douglas L. ; Paic, Guy ; Pandey, S. U. ; Pal, S. ; Panebratsev, Yuri ; Panitkin, Sergei Yurievich ; Pavlinov, A. I. ; Pawlak, Tomasz Jan ; Perevoztchikov, V. ; Peryt, Wiktor Stanislaw ; Petrov, V. A. ; Phatak, S. C. ; Picha, R. ; Pluta, Jan Marian ; Porile, Norbert T. ; Porter, Jeffrey Brent ; Poskanzer, Arthur M. ; Potekhin, Maxim ; Potrebenikova, E. ; Potukuchi, B. V. K. S. ; Prindle, Duncan J. ; Pruneau, Claude A. ; Putschke, Jörn H. ; Rai, Gulshan ; Rakness, Gregory L. ; Raniwala, Rashmi ; Raniwala, Sudhir ; Ravel, Olivier ; Ray, Robert L. ; Razin, Sergej V. ; Reichhold, Dennis Michael ; Reid, Jeffrey G. ; Renault, G. ; Retiere, Fabrice ; Ridiger, Alexey ; Ritter, Hans Georg ; Roberts, Jabus B. ; Rogachevski, O. V. ; Romero, Juan L. ; Rose, A. ; Roy, Christelle Sophie ; Ruan, Lijuan ; Rykov, Vladimir L. ; Sahoo, Raghunath ; Sakrejda, Iwona ; Salur, Sevil ; Sandweiss, Jack H. ; Savin, Igor A. ; Schambach, Joachim ; Scharenberg, Rolf Paul ; Schmitz, Norbert ; Schroeder, Lee S. ; Schweda, Kai ; Seger, Janet Elizabeth ; Seliverstov, D. ; Seyboth, Peter ; Shahaliev, Ehtiram ; Shao, M. ; Sharma, M. ; Shestermanov, Konstantin E. ; Shimanskii, S. S. ; Singaraju, Rama Narayana ; Simon, F. ; Skoro, Goran P. ; Smirnov, Nikolai ; Snellings, Raimond ; Sood, Gopika ; Sorensen, Paul Richard ; Sowinski, James ; Spinka, Harold. M. ; Srivastava, Brijesh Kumar ; Stanislaus, S. ; Stephenson, Edward J. ; Stock, Reinhard ; Stolpovsky, Alexander ; Strichanov, Michail Nikolaevič ; Stringfellow, Blair ; Struck, Christof ; Suaide, Alexandre Alarcon do Passo ; Sugarbaker, Evan R. ; Suire, Christophe Pierre ; Šumbera, Michal ; Surrow, Bernd ; Symons, Timothy James MacNeil ; Toledo, Alejandro Szanto de ; Szarwas, Piotr ; Tai, An ; Takahashi, Jun ; Tang, Aihong ; Sorensen, Paul Richard ; Thein, Dylan ; Thomas, James H. ; Tikhomirov, V. ; Tokarev, Mikhail V. ; Tonjes, Marguerite Belt ; Trainor, Thomas A. ; Trentalange, Stephen ; Tribble, Robert E. ; Trivedi, M. D. ; Trofimov, V. ; Tsai, Oleg D. ; Ullrich, Thomas ; Underwood, David G. ; Van Buren, Gene ; Vander Molen, A. M. ; Vasiliev, Alexander Nikolaevich ; Vasiliev, M. ; Vigdor, Steven E. ; Viyogi, Yogendra P. ; Voloshin, Sergei ; Wang, F. ; Wang, G. ; Wang, X. L. ; Wang, Z. M. ; Ward, H. ; Watson, J. W. ; Wells, R. ; Westfall, Gary D. ; Whitten, Charles A. ; Wieman, Howard ; Willson, Robert ; Wissink, Scott W. ; Witt, Richard ; Wood, J. ; Wu, J. ; Xu, N. ; Xu, Z. ; Xu, Z. Z. ; Yakutin, A. E. ; Yamamoto, E. ; Yang, J. ; Yepes, Pablo P. ; Yurevich, Vladimir Yurevich ; Zanevski, Y. V. ; Zborovský, I. ; Zhang, Haitao ; Zhang, H. Y. ; Zhang, W. M. ; Zhang, Z. P. ; Żołnierczuk, Piotr Adam ; Zoulkarneev, R. ; Zoulkarneeva, J. ; Zubarev, A. N.
We report on the rapidity and centrality dependence of proton and antiproton transverse mass distributions from 197Au + 197Au collisions at sqrt[sNN ]=130 GeV as measured by the STAR experiment at the Relativistic Heavy Ion Collider (RHIC). Our results are from the rapidity and transverse momentum range of |y| <0.5 and 0.35< pt <1.00 GeV/c . For both protons and antiprotons, transverse mass distributions become more convex from peripheral to central collisions demonstrating characteristics of collective expansion. The measured rapidity distributions and the mean transverse momenta versus rapidity are flat within |y| <0.5 . Comparisons of our data with results from model calculations indicate that in order to obtain a consistent picture of the proton (antiproton) yields and transverse mass distributions the possibility of prehadronic collective expansion may have to be taken into account.