• Deutsch
Login

Open Access

  • Home
  • Search
  • Browse
  • Publish
  • FAQ

Refine

Author

  • Bojunga, Jörg (1)
  • Fokas, Emmanouil (1)
  • Franz, Kea (1)
  • Harter, Patrick Nikolaus (1)
  • Hattingen, Elke (1)
  • Imhoff, Detlef (1)
  • Pilatus, Ulrich (1)
  • Rieger, Johannes (1)
  • Rödel, Claus (1)
  • Steinbach, Joachim Peter (1)
+ more

Year of publication

  • 2020 (1) (remove)

Document Type

  • Article (1)

Language

  • English (1) (remove)

Has Fulltext

  • yes (1)

Is part of the Bibliography

  • no (1)

Keywords

  • glioblastoma (1) (remove)

Institute

  • Medizin (1)

1 search hit

  • 1 to 1
  • 10
  • 20
  • 50
  • 100
Maintenance of energy homeostasis during calorically restricted ketogenic diet and fasting-MR-spectroscopic insights from the ERGO2 trial (2020)
Wenger-Alakmeh, Katharina Johanna ; Wagner, Marlies ; Harter, Patrick Nikolaus ; Franz, Kea ; Bojunga, Jörg ; Fokas, Emmanouil ; Imhoff, Detlef ; Rödel, Claus ; Rieger, Johannes ; Hattingen, Elke ; Steinbach, Joachim Peter ; Pilatus, Ulrich ; Vos, Martin
Background: The ERGO2 (Ernaehrungsumstellung bei Patienten mit Rezidiv eines Glioblastoms) MR-spectroscopic imaging (MRSI) subtrial investigated metabolism in patients randomized to calorically restricted ketogenic diet/intermittent fasting (crKD-IF) versus standard diet (SD) in addition to re-irradiation (RT) for recurrent malignant glioma. Intracerebral concentrations of ketone bodies (KB), intracellular pH (pHi), and adenosine triphosphate (ATP) were non-invasively determined. Methods: 50 patients were randomized (1:1): Group A keeping a crKD-IF for nine days, and Group B a SD. RT was performed on day 4-8. Twenty-three patients received an extended MRSI-protocol (1H decoupled 31P MRSI with 3D chemical shift imaging (CSI) and 2D 1H point-resolved spectroscopy (PRESS)) at a 3T scanner at baseline and on day 6. Voxels were selected from the area of recurrent tumor and contralateral hemisphere. Spectra were analyzed with LCModel, adding simulated signals of 3-hydroxybutyrate (βOHB), acetone (Acn) and acetoacetate (AcAc) to the standard basis set. Results: Acn was the only reliably MRSI-detectable KB within tumor tissue and/or normal appearing white matter (NAWM). It was detected in 4/11 patients in Group A and in 0/8 patients in Group B. MRSI results showed no significant depletion of ATP in tumor tissue of patients at day 6 during crKD-IF, even though there were a significant difference in ketone serum levels between Group A and B at day 6 and a decline in fasting glucose in Group A from baseline to day 6. The tumor specific alkaline pHi was maintained. Conclusions: Our metabolic findings suggest that tumor cells maintain energy homeostasis even with reduced serum glucose levels and may generate additional ATP through other sources.r sources.
  • 1 to 1

OPUS4 Logo

  • Contact
  • Imprint
  • Sitelinks