Refine
Document Type
- Article (3)
- Part of Periodical (1)
Language
- English (4)
Has Fulltext
- yes (4)
Is part of the Bibliography
- no (4)
Keywords
- Chinese fauna (1)
- Dual targeting (1)
- Hydrachnidia (1)
- Torrenticolidae (1)
- Volmer–Weber growth (1)
- layer-by-layer (LbL) (1)
- metal–organic frameworks (1)
- new record (1)
- new species (1)
- plant protein distribution (1)
Institute
- Biochemie und Chemie (1)
- Biowissenschaften (1)
- Medizin (1)
Enzymes involved in tRNA maturation are essential for cytosolic, mitochondrial, and plastid protein synthesis and are therefore localized to these different compartments of the cell. Interestingly, only one isoform of tRNA nucleotidyltransferase (responsible for adding the 3′-terminal cytidine–cytidine–adenosine to tRNAs) has been identified in plants. The present study therefore explored how signals contained on this enzyme allow it to be distributed among the different cell compartments. It is demonstrated that the N-terminal portion of the protein acts as an organellar targeting signal and that differential use of multiple in-frame start codons alters the localization of the protein. Moreover, it is shown that the mature domain has a major impact on the distribution of the protein within the cell. These data indicate that regulation of dual localization involves not only specific N-terminal signals, but also additional factors within the protein or the cell.
The layer‐by‐layer (LbL) method is a well‐established method for the growth of surface‐attached metal–organic frameworks (SURMOFs). Various experimental parameters, such as surface functionalization or temperature, have been identified as essential in the past. In this study, inspired by these recent insights regarding the LbL SURMOF growth mechanism, the impact of reactant solutions concentration on LbL growth of the Cu2(F4bdc)2(dabco) SURMOF (F4bdc2−=tetrafluorobenzene‐1,4‐dicarboxylate and dabco=1,4‐diazabicyclo‐[2.2.2]octane) in situ by using quartz‐crystal microbalance and ex situ with a combination of spectroscopic, diffraction and microscopy techniques was investigated. It was found that number, size, and morphology of MOF crystallites are strongly influenced by the reagent concentration. By adjusting the interplay of nucleation and growth, we were able to produce densely packed, yet thin films, which are highly desired for a variety of SURMOF applications.
New data of Torrenticolidae Piersig, 1902 are presented in this paper from Wuyishan National Nature Reserve, P. R. China. Three new species, Torrenticola suptilisrostrum Gu & Guo sp. nov., Torrenticola spinextension Gu & Guo sp. nov. and Torrenticola wuyiensis Gu & Guo sp. nov. are described and illustrated in detail, and one new record for Chinese fauna is given, Torrenticola dentifera Wiles, 1991, which was originally described from Malaysia. In addition, an updated key is provided to all species of Torrenticolidae in China.
Background: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer's cases and 48,466 controls.
Principal findings: In addition to earlier reported genes, we detected genome-wide significant loci on chromosomes 8 (TP53INP1, p = 1.4×10−6) and 14 (IGHV1-67 p = 7.9×10−8) which indexed novel susceptibility loci.
Significance: The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimer's disease.