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  • Becker, Sven (1)
  • Holtrich, Uwe (1)
  • Karn, Thomas (1)
  • Müller, Volkmar (1)
  • Pusztai, Lajos (1)
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  • Schmidt, Marcus (1)

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  • 2014 (1)

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Control of dataset bias in combined affymetrix cohorts of triple negative breast cancer (2014)
Karn, Thomas ; Rody, Achim ; Müller, Volkmar ; Schmidt, Marcus ; Becker, Sven ; Holtrich, Uwe ; Pusztai, Lajos
Heterogenous subtypes of breast cancer need to be analyzed separately. Pooling of datasets can provide reasonable sample sizes but dataset bias is an important concern. We assembled a combined dataset of 579 Affymetrix microarrays from triple negative breast cancer (TNBC) in Gene Expression Omnibus (GEO) series GSE31519. We developed a method for selecting comparable datasets and to control for the amount of dataset bias of individual probesets.
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