Refine
Document Type
- Article (3)
- Working Paper (2)
Has Fulltext
- yes (5)
Is part of the Bibliography
- no (5)
Keywords
- Finance (2)
- Global Financial Class (2)
- Globalization (2)
- Pierre Bourdieu (2)
- Transnational Capitalist Class (2)
- Aspiration (1)
- COVID-19 (1)
- Cultural Omnivores (1)
- Cultural Omnivorousness (1)
- Exclusion (1)
The highly infectious disease COVID-19 caused by the Betacoronavirus SARS-CoV-2 poses a severe threat to humanity and demands the redirection of scientific efforts and criteria to organized research projects. The international COVID19-NMR consortium seeks to provide such new approaches by gathering scientific expertise worldwide. In particular, making available viral proteins and RNAs will pave the way to understanding the SARS-CoV-2 molecular components in detail. The research in COVID19-NMR and the resources provided through the consortium are fully disclosed to accelerate access and exploitation. NMR investigations of the viral molecular components are designated to provide the essential basis for further work, including macromolecular interaction studies and high-throughput drug screening. Here, we present the extensive catalog of a holistic SARS-CoV-2 protein preparation approach based on the consortium’s collective efforts. We provide protocols for the large-scale production of more than 80% of all SARS-CoV-2 proteins or essential parts of them. Several of the proteins were produced in more than one laboratory, demonstrating the high interoperability between NMR groups worldwide. For the majority of proteins, we can produce isotope-labeled samples of HSQC-grade. Together with several NMR chemical shift assignments made publicly available on covid19-nmr.com, we here provide highly valuable resources for the production of SARS-CoV-2 proteins in isotope-labeled form.
Sozialräume der Global Financial Class : Untersuchungen in den Finanzzentren Frankfurt und Sydney
(2016)
Dieses Working Paper untersucht die Bedeutung von Global Cities für die Formierung einer globalen Finanzklasse anhand der Finanzzentren Frankfurt und Sydney. In einer vergleichenden Ethnographie dieser beiden Städte werden urbane Räume und soziale Kontexte erforscht, die durch die kulturellen Praktiken und stilistischen Gemeinsamkeiten der modernen Finanzklasse geprägt sind. Es werden dabei vier charakteristische kulturelle Muster identifiziert: Dies sind die Muster der Repräsentation, der Exklusivität, der Aspiration und der sozialen Durchlässigkeit.
Im Muster der Repräsentation verbindet sich das Finanzwesen auf eine symbolische Weise mit Politik und Gesellschaft, während im Muster der Exklusivität der Kern ökonomischer Praktiken dem Zugriff der Allgemeinheit entzogen wird. Das Muster der Aspiration ermöglicht Praktiken der Herstellung und des Austestens von Zugehörigkeit, während der Modus sozialer Durchlässigkeit eine Auseinandersetzung mit anderen gesellschaftlichen Gruppen und die Aufnahme fremder kultureller Muster durch Praktiken der cultural omnivorousness ermöglicht.
Die Praktiken, die diese vier typischen Muster konstituieren, nehmen dabei jeweils lokale Eigenhei- ten auf, die in einen global verlaufenden Klassenbildungsprozess eingespeist werden und diese glo- bale Klasse in den Städten verankern.
This working paper gives insights on a theoretical perspective on class formation in the context of global financial markets and presents first empirical findings regarding the formation of a global financial class. It draws on numerous encounters with financial professionals that were inter- viewed in Frankfurt (Germany) and Sydney (Australia). As a preliminary conclusion from those inves- tigations on a micro-perspective, we state that acting on the market creates a sense of global socia- bility, whereby organizations only play a secondary role. Careers in finance follow internationally homogenized pathways. This process of global class formation is taking place prominently in global financial centers. Therefore we link the level of investigation on a micro-perspective (experience of financial professionals) with global city life and the fabric of the city. This results in empirical findings on a meso-level from an ethnography of the social and professional urban environment of finance in the two global cities. Symbolic struggles engraved in the built environment of Frankfurt and Sydney are traced and discussed against the background of every-day-practices of aspiration in the financial districts investigated.
Macrophages are highly versatile cells, which acquire, depending on their microenvironment, pro- (M1-like), or antiinflammatory (M2-like) phenotypes. Here, we studied the role of the G-protein coupled receptor G2A (GPR132), in chemotactic migration and polarization of macrophages, using the zymosan-model of acute inflammation. G2A-deficient mice showed a reduced zymosan-induced thermal hyperalgesia, which was reversed after macrophage depletion. Fittingly, the number of M1-like macrophages was reduced in the inflamed tissue in G2A-deficient mice. However, G2A activation was not sufficient to promote M1-polarization in bone marrow-derived macrophages. While the number of monocyte-derived macrophages in the inflamed paw was not altered, G2A-deficient mice had less macrophages in the direct vicinity of the origin of inflammation, an area marked by the presence of zymosan, neutrophil accumulation and proinflammatory cytokines. Fittingly neutrophil efferocytosis was decreased in G2A-deficient mice and several lipids, which are released by neutrophils and promote G2A-mediated chemotaxis, were increased in the inflamed tissue. Taken together, G2A is necessary to position macrophages in the proinflammatory microenvironment surrounding the center of inflammation. In absence of G2A the macrophages are localized in an antiinflammatory microenvironment and macrophage polarization is shifted toward M2-like macrophages.
The G2A receptor (GPR132) contributes to oxaliplatin-induced mechanical pain hypersensitivity
(2017)
Chemotherapy-induced peripheral neuropathic pain (CIPN) is a common and severe debilitating side effect of many widely used cytostatics. However, there is no approved pharmacological treatment for CIPN available. Among other substances, oxaliplatin causes CIPN in up to 80% of treated patients. Here, we report the involvement of the G-protein coupled receptor G2A (GPR132) in oxaliplatin-induced neuropathic pain in mice. We found that mice deficient in the G2A-receptor show decreased mechanical hypersensitivity after oxaliplatin treatment. Lipid ligands of G2A were found in increased concentrations in the sciatic nerve and dorsal root ganglia of oxaliplatin treated mice. Calcium imaging and patch-clamp experiments show that G2A activation sensitizes the ligand-gated ion channel TRPV1 in sensory neurons via activation of PKC. Based on these findings, we conclude that targeting G2A may be a promising approach to reduce oxaliplatin-induced TRPV1-sensitization and the hyperexcitability of sensory neurons and thereby to reduce pain in patients treated with this chemotherapeutic agent.