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Abelev, Betty ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Anderson, Bryon D. ; Arkhipkin, Dmitry A. ; Averichev, Georgy S. ; Balewski, Jan ; Barannikova, Olga ; Barnby, Lee Stuart ; Baudot, Jérome ; Baumgart, S. ; Beavis, D. R. ; Bellwied, Rene ; Benedosso, F. ; Betancourt, M. J. ; Betts, R. R. ; Bhasin, Anju ; Bhati, Ashok Kumar ; Bichsel, Hans ; Bielčík, Jaroslav ; Bielčíková, Jana ; Biritz, B. ; Bland, Leslie C. ; Bombara, Marek ; Bonner, Billy E. ; Botje, Michiel ; Bouchet, J. ; Braidot, E. ; Brandin, Andrei V. ; Bruna, Elena ; Bueltmann, S. ; Burton, T. P. ; Bystersky, M. ; Cai, Xiang-Zhou ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Catu, O. ; Cebra, Daniel A. ; Cendejas, R. ; Cervantes, M. C. ; Chajecki, Z. ; Chaloupka, Petr ; Chattopadhyay, S. ; Chen, H. F. ; Chen, J. H. ; Chen, J. Y. ; Cheng, J. ; Cherney, Michael Gerard ; Chikanian, Alexei ; Choi, K. E. ; Christie, William ; Clarke, R. F. ; Codrington, M. J. M. ; Corliss, R. ; Cormier, Thomas Michael ; Cosentino, Mauro Rogerio ; Cramer, John G. ; Crawford, Henry J. ; Das, Debasish ; Dash, Sadhana ; Daugherity, M. ; Silva, L. C. De ; Dedovich, T. G. ; DePhillips, M. ; Derevschikov, Anatoly A. ; de Souza, R. Derradi ; Didenko, Lidia ; Djawotho, P. ; Dogra, Sunil Manohar ; Dong, X. ; Drachenberg, James Lucus ; Draper, James E. ; Dunlop, James C. ; Mazumdar, M. R. Dutta ; Edwards, W. R. ; Efimov, Leonid G. ; Elhalhuli, E. ; Elnimr, M. ; Emelianov, V. ; Engelage, Jon M. ; Eppley, Geary Wareham ; Erazmus, Barbara Ewa ; Estienne, Magali Danielle ; Eun, L. ; Fachini, Patricia ; Fatemi, Renee H. ; Fedorišin, Jan ; Feng, A. ; Filip, Peter ; Finch, Evan ; Fine, Valeri ; Fisyak, Yuri V. ; Gagliardi, Carl A. ; Gaillard, L. ; Gangadharan, Dhevan Raja ; Ganti, Murthy S. ; Garcia-Solis, E. J. ; Geromitsos, A. ; Geurts, Frank ; Ghazikhanian, Vahe ; Ghosh, Premomoy ; Gorbunov, Y. N. ; Gordon, A. ; Grebenyuk, Oleksandr ; Grosnick, David P. ; Grube, B. ; Guertin, Steven M. ; Guimaraes, K. S. F. F. ; Gupta, Anik ; Gupta, N. ; Guryn, Włodzimierz ; Haag, B. ; Hallman, Timothy J. ; Hamed, Ahmed M. ; Harris, John W. ; He, W. ; Heinz, Mark Thomas ; Heppelmann, S. ; Hippolyte, Boris ; Hirsch, Andrew S. ; Hjort, Eric ; Hoffman, A. M. ; Hoffmann, Gerald W. ; Hofman, D. J. ; Hollis, R. S. ; Huang, Huan Zhong ; Humanic, Thomas J. ; Huo, L. ; Igo, George J. ; Iordanova, A. ; Jacobs, P. ; Jacobs, William W. ; Jakl, P. ; Jena, Chitrasen ; Jin, F. ; Jones, C. L. ; Jones, Peter Graham ; Joseph, J. ; Judd, Eleanor G. ; Kabana, Sonia ; Kajimoto, K. ; Kang, K. ; Kapitan, J. ; Keane, Declan ; Kechechyan, Armen ; Kettler, D. ; Khodyrev, V. Yu. ; Kikola, D. P. ; Kiryluk, Joanna ; Kisiel, Adam Ryszard ; Klein, Spencer Robert ; Knospe, Anders Garritt ; Kocoloski, A. ; Koetke, Donald D. ; Kopytine, M. ; Korsch, W. ; Kotchenda, L. ; Kouchpil, V. ; Kravtsov, Peter ; Kravtsov, Vladimir I. ; Krueger, Keith William ; Krus, M. ; Kuhn, Christian Claude ; Kumar, Lokesh ; Kurnadi, P. ; Lamont, Matthew A. C. ; Landgraf, Jeffery M. ; LaPointe, S. ; Lauret, Jerome ; Lebedev, Alexei ; Lednicky, Richard ; Lee, C. -H. ; Lee, J. H. ; Leight, W. ; LeVine, Micheal J. ; Li, C. ; Li, N. ; Li, Y. ; Lin, G. ; Lindenbaum, Sam J. ; Lisa, Michael A. ; Liu, F. ; Liu, J. ; Liu, L. ; Ljubicic, Tonko A. ; Llope, William Joseph ; Longacre, Ronald S. ; Love, William A. ; Lu, Y. ; Ludlam, Thomas ; Ma, G. L. ; Ma, Yu-Gang ; Mahapatra, Durga Prasad ; Majka, Richard Daniel ; Mall, O. I. ; Mangotra, Lalit K. ; Manweiler, Robert W. ; Margetis, Spyridon ; Markert, Christina ; Matis, Howard S. ; Matulenko, Yuri A. ; McDonald, Daniel ; McShane, Tom S. ; Meščanin, Aleksei P. ; Milner, R. ; Minaev, Nikolai G. ; Mioduszewski, Saskia ; Mischke, André ; Mohanty, Bedangadas ; Morozov, Dmitry A. ; Munhoz, Marcelo Gameiro ; Nandi, Basanta Kumar ; Nattrass, Christine ; Nayak, Tapan Kumar ; Nelson, John M. ; Netrakanti, Pawan Kumar ; Ng, M. J. ; Nogach, Larisa V. ; Nurušev, Sandibek B. ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Okada, H. ; Okorokov, Vitaly A. ; Olson, Douglas L. ; Pachr, Miloš ; Page, Brian S. ; Pal, Susanta Kumar ; Pandit, Y. ; Panebratsev, Yuri ; Pawlak, Tomasz Jan ; Peitzmann, Thomas ; Perevoztchikov, V. ; Perkins, Chris ; Peryt, Wiktor Stanislaw ; Phatak, S. C. ; Pile, P. ; Planinic, Mirko ; Pluta, Jan Marian ; Plyku, D. ; Poljak, Nikola ; Poskanzer, Arthur M. ; Potukuchi, B. V. K. S. ; Prindle, Duncan J. ; Pruneau, Claude A. ; Pruthi, Navneet Kumar ; Pujahari, P. R. ; Putschke, Jörn H. ; Raniwala, Rashmi ; Raniwala, Sudhir ; Ray, Robert L. ; Redwine, R. ; Reed, Rosi Jan ; Ridiger, Alexey ; Ritter, Hans Georg ; Roberts, Jabus B. ; Rogačevskij, Oleg V. ; Romero, Juan L. ; Rose, A. ; Roy, Christelle Sophie ; Ruan, L. ; Russcher, M. J. ; Sahoo, Raghunath ; Sakrejda, Iwona ; Sakuma, T. ; Salur, Sevil ; Sandweiss, Jack H. ; Sarsour, M. ; Schambach, Joachim ; Scharenberg, Rolf Paul ; Schmitz, Norbert ; Seger, Janet Elizabeth ; Selyuzhenkov, Ilya ; Seyboth, Peter ; Shabetai, Alexandre ; Shahaliev, Ehtiram ; Shao, M. ; Sharma, M. ; Shi, Shusu ; Shi, X. -H. ; Sichtermann, Ernst P. ; Simon, F. ; Singaraju, Rama Narayana ; Skoby, Michael J. ; Smirnov, Nikolai ; Snellings, Raimond ; Sorensen, Paul Richard ; Sowinski, James ; Spinka, Harold. M. ; Srivastava, B. ; Stadnik, A. ; Stanislaus, T. D. Shirvel ; Staszak, D. ; Strichanov, Michail Nikolaevič ; Stringfellow, Blair ; Suaide, Alexandre Alarcon do Passo ; Suarez, M. C. ; Subba, N. L. ; Šumbera, Michal ; Sun, X. M. ; Sun, Y. ; Sun, Z. ; Surrow, Bernd ; Symons, Timothy James MacNeil ; de Toledo, A. Szanto ; Takahashi, Jun ; Tang, Aihong ; Tang, Zebo ; Tarini, L. H. ; Tarnowsky, Terence J. ; Thein, Dylan ; Thomas, James H. ; Tian, J. ; Timmins, Anthony Robert ; Timoshenko, Sergei ; Tlusty, David ; Tokarev, Mikhail V. ; Trainor, Thomas A. ; Tram, V. N. ; Trattner, A. L. ; Trentalange, Stephen ; Tribble, Robert E. ; Tsai, Oleg D. ; Ulery, Jason Glyndwr ; Ullrich, Thomas ; Underwood, David G. ; Van Buren, Gene ; Leeuwen, Marco van ; Molen, A. M. Vander ; Vanfossen, J. A. ; Varma, Raghava ; Vasconcelos, G. M. S. ; Vasilevski, I. M. ; Vasiliev, Alexander Nikolaevich ; Videbæk, Flemming ; Vigdor, Steven E. ; Viyogi, Yogendra P. ; Vokal, Stanislav ; Voloshin, Sergei ; Wada, M. ; Walker, M. ; Wang, F. ; Wang, G. ; Wang, J. S. ; Wang, Q. ; Wang, X. ; Wang, X. L. ; Wang, Y. ; Webb, Grant ; Webb, Jason C. ; Westfall, Gary D. ; Whitten, Charles A. ; Wieman, Howard ; Wissink, Scott W. ; Witt, Richard ; Wu, Y. ; Xie, W. ; Xu, N. ; Xu, Qinghua ; Xu, Y. ; Xu, Z. ; Yang, Y. ; Yepes, Pablo P. ; Yip, K. ; Yoo, I. -K. ; Yue, Q. ; Zawisza, M. ; Zbroszczyk, Hanna Paulina ; Zhan, W. ; Zhang, S. ; Zhang, W. M. ; Zhang, X. P. ; Zhang, Y. ; Zhang, Z. P. ; Zhao, Y. ; Zhong, C. ; Zhou, J. ; Zoulkarneev, R. ; Zoulkarneeva, Youlia ; Zuo, J. X.
The STAR Collaboration at the Relativistic Heavy Ion Collider presents measurements of 𝐽/𝜓→𝑒+𝑒− at midrapidity and high transverse momentum (𝑝𝑇>5 GeV/𝑐) in 𝑝+𝑝 and central Cu+Cu collisions at √𝑠𝑁𝑁=200 GeV. The inclusive 𝐽/𝜓 production cross section for Cu+Cu collisions is found to be consistent at high 𝑝𝑇 with the binary collision-scaled cross section for 𝑝+𝑝 collisions. At a confidence level of 97%, this is in contrast to a suppression of 𝐽/𝜓 production observed at lower 𝑝𝑇. Azimuthal correlations of 𝐽/𝜓 with charged hadrons in 𝑝+𝑝 collisions provide an estimate of the contribution of 𝐵-hadron decays to 𝐽/𝜓 production of 13%±5%.
Belkum, Alex van ; Almeida, Carina ; Bardiaux, Benjamin ; Barrass, Sarah V. ; Butcher, Sarah J. ; Çaykara, Tuğçe ; Chowdhury, Sounak ; Datar, Rucha ; Eastwood, Ian ; Goldman, Adrian ; Goyal, Manisha ; Happonen, Lotta ; Izadi-Pruneyre, Nadia ; Jacobsen, Theis ; Johnson, Pirjo H. ; Kempf, Volkhard A. J. ; Kießling, Andreas ; Bueno, Juan Leva ; Malik, Anchal ; Malmström, Johan ; Meuskens, Ina ; Milner, Paul A. ; Nilges, Michael ; Pamme, Nicole ; Peyman, Sally A. ; Rodrigues, Ligia R. ; Rodriguez-Mateos, Pablo ; Sande, Maria G. ; Silva, Carla Joana ; Stasiak, Aleksandra Cecylia ; Stehle, Thilo ; Thibau, Arno ; Vaca Llerena, Diana Jaqueline ; Linke, Dirk
Infectious diseases are an existential health threat, potentiated by emerging and re-emerging viruses and increasing bacterial antibiotic resistance. Targeted treatment of infectious diseases requires precision diagnostics, especially in cases where broad-range therapeutics such as antibiotics fail. There is thus an increasing need for new approaches to develop sensitive and specific in vitro diagnostic (IVD) tests. Basic science and translational research are needed to identify key microbial molecules as diagnostic targets, to identify relevant host counterparts, and to use this knowledge in developing or improving IVD. In this regard, an overlooked feature is the capacity of pathogens to adhere specifically to host cells and tissues. The molecular entities relevant for pathogen–surface interaction are the so-called adhesins. Adhesins vary from protein compounds to (poly-)saccharides or lipid structures that interact with eukaryotic host cell matrix molecules and receptors. Such interactions co-define the specificity and sensitivity of a diagnostic test. Currently, adhesin-receptor binding is typically used in the pre-analytical phase of IVD tests, focusing on pathogen enrichment. Further exploration of adhesin–ligand interaction, supported by present high-throughput “omics” technologies, might stimulate a new generation of broadly applicable pathogen detection and characterization tools. This review describes recent results of novel structure-defining technologies allowing for detailed molecular analysis of adhesins, their receptors and complexes. Since the host ligands evolve slowly, the corresponding adhesin interaction is under selective pressure to maintain a constant receptor binding domain. IVD should exploit such conserved binding sites and, in particular, use the human ligand to enrich the pathogen. We provide an inventory of methods based on adhesion factors and pathogen attachment mechanisms, which can also be of relevance to currently emerging pathogens, including SARS-CoV-2, the causative agent of COVID-19.
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