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We have identified a mistake in how Fig. 1 is referenced in the text of the article Eur. Phys. J. C 77 (2017) no. 8, 569 which affected three paragraphs of the results section. The corrected three paragraphs as well as the unmodified accompanying figure are reproduced in this document with the correct labeling.
In addition, an editing issue led to a missing acknowledgements section. The missing section is reproduced at the end of this document in the manner in which it should have appeared in the published article.
Glioblastoma (GBM), WHO grade IV, is the most aggressive primary brain tumor in adults. The median survival time using standard therapy is only 12–15 months with a 5-year survival rate of around 5%. Thus, new and effective treatment modalities are of significant importance. Signal transducer and activator of transcription 3 (Stat3) is a key signaling protein driving major hallmarks of cancer and represents a promising target for the development of targeted glioblastoma therapies. Here we present data showing that the therapeutic application of siRNAs, formulated in nanoscale lipopolyplexes (LPP) based on polyethylenimine (PEI) and the phospholipid 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), represents a promising new approach to target Stat3 in glioma. We demonstrate that the LPP-mediated delivery of siRNA mediates efficient knockdown of Stat3, suppresses Stat3 activity and limits cell growth in murine (Tu2449) and human (U87, Mz18) glioma cells in vitro. In a therapeutic setting, intracranial application of the siRNA-containing LPP leads to knockdown of STAT3 target gene expression, decreased tumor growth and significantly prolonged survival in Tu2449 glioma-bearing mice compared to negative control-treated animals. This is a proof-of-concept study introducing PEI-based lipopolyplexes as an efficient strategy for therapeutically targeting oncoproteins with otherwise limited druggability.
Gekommen, um zu bleiben : der Fachinformationsdienst Germanistik als digitaler Forschungsbegleiter
(2019)
Aktuell erleben wissenschaftliche Bibliotheken in Deutschland einen Paradigmenwechsel, maßgeblich initiiert von der Deutschen Forschungsgemeinschaft als wichtigste bibliotheksrelevante Förderinstitution: "Fachinformationsdienste für die Wissenschaft (FID)" heißt das Infrastrukturprogramm der Stunde, das eine alte Förderlinie ersetzt. Das vorherige, am Gedanken einer Art "Universalbibliothek" angelehnte Programm ist nun stärker fachspezifisch ausgerichtet und bietet so Raum für neue Infrastrukturen im Fach, beispielsweise im Bereich einer auf das Fach zugeschnittenen Literaturrecherche. Diese bietet für Forschende einen erheblichen Mehrwert, denn jetzt gilt die Devise: Eine Bibliothek muss nicht mehr alles besitzen, aber (fast) alles soll man finden können. Dies gilt auch in der germanistischen Sprach- und Literaturwissenschaft. Verfolgt wird dieser Leitgedanke seit Juli 2018 im "Fachinformationsdienst (FID) Germanistik".
"Digitalisierung" bedeutet für die Germanistik weit mehr als die Entwicklung neuer digitaler Forschungsmethoden und die Identifizierung von Forschungsfeldern im Bereich der "Digital Humanities". Die Digitalisierung verändert das Fach vielmehr grundlegendund geht mit einem tiefgreifenden forschungskulturellen Wandel einher, der weitreichende Konsequenzen sowohl für das Selbstverständnis als auch für die Forschungs- und Kommunikationspraxis in der Germanistik hat.
We present first data on sub-threshold production of Ks0 mesons and Λ hyperons in Au+Au collisions at sNN=2.4 GeV. We observe an universal 〈Apart〉 scaling of hadrons containing strangeness, independent of their corresponding production thresholds. Comparing the yields, their 〈Apart〉 scaling, and the shapes of the rapidity and the pt spectra to state-of-the-art transport model (UrQMD, HSD, IQMD) predictions, we find that none of them can simultaneously describe these observables with reasonable χ2 values.
We investigate identical pion HBT intensity interferometry in central Au+Au collisions at 1.23A GeV. High-statistics π−π− and π+π+ data are measured with HADES at SIS18/GSI. The radius parameters, derived from the correlation function depending on relative momenta in the longitudinally comoving system and parametrized as three-dimensional Gaussian distribution, are studied as function of transverse momentum. A substantial charge-sign difference of the source radii is found, particularly pronounced at low transverse momentum. The extracted source parameters agree well with a smooth extrapolation of the center-of-mass energy dependence established at higher energies, extending the corresponding excitation functions down towards a very low energy.
We present the results of three-dimensional femtoscopic analyses for charged and neutral kaons recorded by ALICE in Pb-Pb collisions at sNN−−−√ = 2.76 TeV. Femtoscopy is used to measure the space-time characteristics of particle production from the effects of quantum statistics and final-state interactions in two-particle correlations. Kaon femtoscopy is an important supplement to that of pions because it allows one to distinguish between different model scenarios working equally well for pions. In particular, we compare the measured 3D kaon radii with a purely hydrodynamical calculation and a model where the hydrodynamic phase is followed by a hadronic rescattering stage. The former predicts an approximate transverse mass (mT) scaling of source radii obtained from pion and kaon correlations. This mT scaling appears to be broken in our data, which indicates the importance of the hadronic rescattering phase at LHC energies. A kT scaling of pion and kaon source radii is observed instead. The time of maximal emission of the system is estimated using the three-dimensional femtoscopic analysis for kaons. The measured emission time is larger than that of pions. Our observation is well supported by the hydrokinetic model predictions.