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Author

  • Kasama, Yuri (1)
  • Kohara, Michinori (1)
  • Kusunoki, Hideki (1)
  • Mizukami, Takuo (1)
  • Mizuochi, Toshiaki (1)
  • Nishito, Yasumasa (1)
  • Ozawa, Makoto (1)
  • Peveling-Oberhag, Jan Franz-Josef (1)
  • Tsukiyama-Kohara, Kyoko (1)

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  • 2014 (1)

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B-cell-intrinsic hepatitis C virus expression leads to B-cell-lymphomagenesis and induction of NF-κB signalling (2014)
Kasama, Yuri ; Mizukami, Takuo ; Kusunoki, Hideki ; Peveling-Oberhag, Jan Franz-Josef ; Nishito, Yasumasa ; Ozawa, Makoto ; Kohara, Michinori ; Mizuochi, Toshiaki ; Tsukiyama-Kohara, Kyoko
Hepatitis C virus (HCV) infection leads to the development of hepatic diseases, as well as extrahepatic disorders such as B-cell non-Hodgkin's lymphoma (B-NHL). To reveal the molecular signalling pathways responsible for HCV-associated B-NHL development, we utilised transgenic (Tg) mice that express the full-length HCV genome specifically in B cells and develop non-Hodgkin type B-cell lymphomas (BCLs). The gene expression profiles in B cells from BCL-developing HCV-Tg mice, from BCL-non-developing HCV-Tg mice, and from BCL-non-developing HCV-negative mice were analysed by genome-wide microarray. In BCLs from HCV-Tg mice, the expression of various genes was modified, and for some genes, expression was influenced by the gender of the animals. Markedly modified genes such as Fos, C3, LTβR, A20, NF-κB and miR-26b in BCLs were further characterised using specific assays. We propose that activation of both canonical and alternative NF-κB signalling pathways and down-regulation of miR-26b contribute to the development of HCV-associated B-NHL.
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