Institutes
Refine
Year of publication
Document Type
- Article (1852)
- Doctoral Thesis (447)
- Preprint (158)
- Conference Proceeding (108)
- Review (33)
- Book (17)
- Part of Periodical (12)
- Contribution to a Periodical (9)
- Part of a Book (7)
- Report (3)
Has Fulltext
- yes (2648)
Is part of the Bibliography
- no (2648)
Keywords
- COVID-19 (45)
- SARS-CoV-2 (37)
- inflammation (33)
- Epilepsy (20)
- Video (19)
- Inflammation (17)
- prostate cancer (17)
- ADHD (13)
- Cancer (12)
- autophagy (12)
- bladder cancer (12)
- cancer (12)
- Capsule endoscopy (11)
- Genetics (11)
- radical prostatectomy (11)
- Quality of life (10)
- Seizure (10)
- apoptosis (10)
- data science (10)
- microRNA (10)
- tumor microenvironment (10)
- Magnetic resonance imaging (9)
- Small bowel (9)
- Surgery (9)
- glioblastoma (9)
- hypoxia (9)
- macrophage (9)
- stroke (9)
- Apoptosis (8)
- Depression (8)
- EEG (8)
- Endoscopy (8)
- Mortality (8)
- TAVI (8)
- breast cancer (8)
- endothelial cells (8)
- epilepsy (8)
- fMRI (8)
- immunotherapy (8)
- mortality (8)
- survival (8)
- vaccination (8)
- Angiogenesis (7)
- Biomarker (7)
- Diagnostik (7)
- Immunological methods (7)
- Immunologische Methoden (7)
- Immunology (7)
- MRI (7)
- Outcome (7)
- Prostate cancer (7)
- Radiotherapy (7)
- Treatment (7)
- aging (7)
- angiogenesis (7)
- chemotherapy (7)
- children (7)
- oxidative stress (7)
- Balloon enteroscopy (6)
- Diagnostics (6)
- Enteroscopy (6)
- Epilepsie (6)
- Goethe-Universität Frankfurt am Main. Fachbereich Humanmedizin (6)
- Heart failure (6)
- Hepatitis C (6)
- Medical research (6)
- Medizin und Gesundheit (6)
- PCR (6)
- Sepsis (6)
- artificial intelligence (6)
- biomarker (6)
- colorectal cancer (6)
- glioma (6)
- mTOR (6)
- machine learning (6)
- miRNA (6)
- osteoarthritis (6)
- prevalence (6)
- proliferation (6)
- quality of life (6)
- risk factors (6)
- targeted therapy (6)
- thrombosis (6)
- AML (5)
- Autopsy (5)
- Bipolar disorder (5)
- Breast cancer (5)
- Calliphoridae (5)
- Comorbidity (5)
- ELISA (5)
- Epidemiology (5)
- Forensic entomology (5)
- HIV (5)
- Herb induced liver injury (5)
- Hypoxia (5)
- Immunotherapy (5)
- Machine learning (5)
- Macrophages (5)
- NADPH oxidase (5)
- Omicron (5)
- Osteoporosis (5)
- Pandemic (5)
- Physical activity (5)
- Polytrauma (5)
- Postural control (5)
- Rare diseases (5)
- Risk factors (5)
- Status epilepticus (5)
- coronavirus (5)
- depression (5)
- digital medicine (5)
- epidemiology (5)
- gene therapy (5)
- hippocampus (5)
- influenza (5)
- integrins (5)
- iron deficiency (5)
- lung cancer (5)
- machine-learning (5)
- outcome (5)
- pain (5)
- polypharmacy (5)
- reactive oxygen species (5)
- treatment (5)
- 177Lu-PSMA-617 (4)
- ACLF (4)
- Adenocarcinoma (4)
- Alcohol (4)
- Animal models (4)
- Antiviral therapy (4)
- Aortic stenosis (4)
- Ataxia telangiectasia (4)
- Bone density (4)
- Burden of illness (4)
- CRP (4)
- Cochlear implant (4)
- Computed tomography (4)
- Critical care (4)
- Diagnosis (4)
- Drug induced liver injury (4)
- Elderly (4)
- Endoscopic retrograde cholangiopancreatography (4)
- Endothelial cells (4)
- Epileptischer Anfall (4)
- Gesundheitsökonomie (4)
- Glioma (4)
- HCV (4)
- Health economics (4)
- Hepatotoxicity (4)
- Herbal hepatotoxicity (4)
- IntelliCage (4)
- Interleukin (4)
- Medizinstudenten (4)
- Medizinstudium (4)
- Melanoma (4)
- Neurology (4)
- Oncology (4)
- PSMA (4)
- Pain (4)
- Pandemie (4)
- Prevalence (4)
- Prostatakarzinom (4)
- Proteomics (4)
- Prävention (4)
- RNA (4)
- ROS (4)
- Registry (4)
- Rheumatoid arthritis (4)
- Sensitivity and Specificity (4)
- Sport (4)
- Stroke (4)
- Suicide (4)
- Transfusion (4)
- Trauma (4)
- Vaccination (4)
- acute myeloid leukemia (4)
- anemia (4)
- antiviral therapy (4)
- bibliometrics (4)
- child (4)
- cirrhosis (4)
- classification (4)
- colon cancer (4)
- cytokines (4)
- diabetes (4)
- drug resistance (4)
- elderly (4)
- epigenetics (4)
- external beam radiotherapy (4)
- extracellular matrix (4)
- fibrosis (4)
- growth (4)
- haemophilia treatment (4)
- hepatitis C virus (4)
- hepatocellular carcinoma (4)
- infection (4)
- iron (4)
- liver (4)
- long non-coding RNA (4)
- macrophage polarization (4)
- macrophages (4)
- medical students (4)
- metastasis (4)
- metastatic prostate cancer (4)
- microglia (4)
- mitochondria (4)
- multimorbidity (4)
- neuropathic pain (4)
- patients (4)
- phosphorylation (4)
- psoriasis (4)
- synaptic plasticity (4)
- systematic review (4)
- thrombolysis (4)
- tooth loss (4)
- treatment centres (4)
- 3D printing (3)
- ARDS (3)
- Acute kidney injury (3)
- Acute lymphoblastic leukemia (3)
- Acute myeloid leukemia (3)
- Adhesion (3)
- Anemia (3)
- Angiography (3)
- Antikörper (3)
- Artificial intelligence (3)
- Autism spectrum disorder (3)
- BMC (3)
- Biochemistry (3)
- Biographie (3)
- Brain (3)
- COMP (3)
- Cardiovascular diseases (3)
- Cell biology (3)
- Chronic hepatitis C (3)
- Cirrhosis (3)
- Classification (3)
- Clinical decision support systems (3)
- Cochlear implantation (3)
- Collagen (3)
- Colorectal cancer (3)
- Complications (3)
- Computer-assisted diagnosis (3)
- Corona (3)
- DMEK (3)
- Data science (3)
- Dental implant (3)
- Dental students (3)
- Diagnostic markers (3)
- Drugs (3)
- ER stress (3)
- Edema (3)
- Education (3)
- Emergency room (3)
- Encephalopathy (3)
- Endocrinology (3)
- Entscheidungsassistenz (3)
- Entzündung (3)
- Epigenetics (3)
- Evidence-based medicine (3)
- Extracellular vesicles (3)
- Fasting (3)
- Forensic medicine (3)
- Gene regulation (3)
- Glioblastoma (3)
- HBV (3)
- HCC (3)
- Health care (3)
- Healthcare costs (3)
- Healthy adults (3)
- HoLEP (3)
- Human behaviour (3)
- Hypertension (3)
- IFT (3)
- Immunohistochemistry (3)
- Immunsuppression (3)
- Incidence (3)
- Induction chemotherapy (3)
- Infections (3)
- Knochenersatzmaterial (3)
- Kommunikation (3)
- Lebensqualität (3)
- Lung failure (3)
- Major depressive disorder (3)
- Medizingeschichte (3)
- Medizinstudierende (3)
- Metabolomics (3)
- Microbiology (3)
- Microwave ablation (3)
- Molecular biology (3)
- Multianalyte detection (3)
- Multidetector computed tomography (3)
- Multiplate (3)
- Musculoskeletal system (3)
- NK cells (3)
- NSCLC (3)
- Neuroblastom (3)
- Neuroscience (3)
- Nierentransplantation (3)
- Non-coding RNA (3)
- Outcomes (3)
- Parkinson’s disease (3)
- Patient blood management (3)
- Patient safety (3)
- Peri-implantitis (3)
- Physiology (3)
- Platelet-rich fibrin (3)
- Pneumonia (3)
- Polypharmacy (3)
- Pre-analytics (3)
- Prevention (3)
- Prostataspezifisches Antigen (3)
- Pulmonary embolism (3)
- Pädiatrie (3)
- Qualitätssicherung (3)
- Radiomics (3)
- Rectal cancer (3)
- Rehabilitation (3)
- Reliability (3)
- Rezidiv (3)
- Rhabdomyosarcoma (3)
- SUDEP (3)
- Safety (3)
- Seltene Erkrankungen (3)
- Sensitivity (3)
- Sensitivität und Spezifität (3)
- Serodiagnosis (3)
- Sex (3)
- Spine (3)
- Surveillance (3)
- Survival (3)
- Systematic review (3)
- TIPS (3)
- Teaching (3)
- Therapie (3)
- Thrombozytenkonzentrat (3)
- Translational research (3)
- Treatment outcome (3)
- Tumor microenvironment (3)
- Tumormarker (3)
- Ultrasound (3)
- VEGF (3)
- Versorgungsqualität (3)
- Vitamin D (3)
- Western blot (3)
- adhesion (3)
- adult (3)
- adverse events (3)
- animal model (3)
- aortic stenosis (3)
- atherosclerosis (3)
- biomarkers (3)
- bleeding (3)
- brain metastases (3)
- cancer specific survival (3)
- cartilage (3)
- cervical cancer (3)
- chronic kidney disease (3)
- cognition (3)
- complication (3)
- critical care (3)
- curcumin (3)
- dental implant (3)
- dentate gyrus (3)
- diabetes mellitus (3)
- diagnosis (3)
- electrophysiology (3)
- ergonomics (3)
- exercise (3)
- exosomes (3)
- extracellular vesicles (3)
- flow cytometry (3)
- functional outcome (3)
- gene expression (3)
- haemophilia care (3)
- heart (3)
- heart failure (3)
- hematopoietic stem cell transplantation (3)
- hemorrhage (3)
- immune cells (3)
- immunity (3)
- immunohistochemistry (3)
- immunologische Methoden (3)
- innate immunity (3)
- liver cirrhosis (3)
- liver transplantation (3)
- lncRNA (3)
- magnetic resonance imaging (3)
- mesenchymal stromal/stem cells (3)
- metabolomics (3)
- multiple myeloma (3)
- multiple sclerosis (3)
- neurodegeneration (3)
- nociception (3)
- obesity (3)
- occupational infections (3)
- outcomes (3)
- overall survival (3)
- oxidative phosphorylation (3)
- p53 (3)
- pandemic (3)
- pediatric (3)
- periodontitis (3)
- platelets (3)
- polytrauma (3)
- portal hypertension (3)
- postoperative pain (3)
- pregnancy (3)
- prevention (3)
- primary care (3)
- proteomics (3)
- public health (3)
- qualitative research (3)
- quantitative MRI (3)
- radiotherapy (3)
- seizure (3)
- sphingolipids (3)
- sphingosine 1-phosphate (3)
- sphingosine-1-phosphate (3)
- stress (3)
- sulforaphane (3)
- supportive periodontal therapy (3)
- therapy (3)
- tissue engineering (3)
- toll-like receptor (3)
- trauma (3)
- traumatic brain injury (3)
- tyrosine kinase inhibitor (3)
- vaccine (3)
- yeast (3)
- 3D rapid prototyping (2)
- ADAM15 (2)
- ADHS (2)
- ALK (2)
- ATM (2)
- Abdominal aortic aneurysm (2)
- Abort (2)
- Accidental reaction (2)
- Acinetobacter baumannii (2)
- Acne inversa (2)
- Acuris (2)
- Acute seizure plan (2)
- Addiction (2)
- Affinity Labeling (2)
- Age estimation (2)
- Aging (2)
- Akuter Anfallsplan (2)
- Allergen avoidance (2)
- Alzheimer’s disease (2)
- Anandamide (2)
- Animal model (2)
- Anschlussheilbehandlung (2)
- Anti-IgE (2)
- Anti-seizure medication (2)
- Antibiotics (2)
- Anticonvulsants (2)
- Antigen test (2)
- Antikonvulsiva (2)
- Antikörpertest (2)
- Anxiety (2)
- Anämie (2)
- Arteriosklerose (2)
- Aspergillus (2)
- Ataxia-telangiectasia (2)
- Atrial fibrillation (2)
- Attention-deficit/hyperactivity disorder (2)
- Attitude (2)
- Auditory rehabilitation (2)
- Autismus (2)
- Autologous biomaterial (2)
- Autophagy (2)
- BA.1 (2)
- BAG3 (2)
- BCOR (2)
- BMI (2)
- BMNC (2)
- BNT162b2 (2)
- BPH (2)
- Bacterial infection (2)
- Bartonella henselae (2)
- Bauchaortenaneurysma (2)
- Behandlungsposition (2)
- Behavior (2)
- Betriebliche Gesundheitsförderung (2)
- Bibliometrics (2)
- Bile duct stone (2)
- Biological profile (2)
- Biomedical informatics (2)
- Biopsy (2)
- Biorecognition strategies (2)
- Bladder cancer (2)
- Bleeding (2)
- Blood (2)
- Blood loss estimation (2)
- Blow flies (2)
- Blutübertragbare Virusinfektionen (2)
- Body modification (2)
- Body posture (2)
- Bone marrow (2)
- Bone metastases (2)
- Borrelia (2)
- Bowel obstruction (2)
- C-reactive protein (2)
- CD14 (2)
- CMR (2)
- CMV (2)
- COVID 19 (2)
- COVID-19 surveillance (2)
- CRM (2)
- CSM (2)
- CT (2)
- Calpain (2)
- Calprotectin (2)
- Cancer therapy (2)
- Cancer-specific mortality (2)
- Candida (2)
- Cannabis (2)
- Carbapenemase (2)
- Cardiovascular magnetic resonance (2)
- Case report (2)
- Cell culture (2)
- Cell death (2)
- Cell death and immune response (2)
- Cerebellum (2)
- Cesarean section (2)
- Chemoprevention (2)
- Chemoradiotherapy (2)
- Child (2)
- Chirurgie (2)
- Cholangiography (2)
- Cholangiopancreatography (2)
- Chronic kidney disease (2)
- Clinical Trials and Observations (2)
- Cochleaimplantation (2)
- Cognition (2)
- Colonoscopy (2)
- Comparative analysis (2)
- Complex Formation (2)
- Computational models (2)
- Computed Tomography (2)
- Computer software (2)
- Connectivity (2)
- Consensus (2)
- Coronavirus (2)
- Covid-19 (2)
- Cre-recombinase (2)
- Cryoelectron microscopy (2)
- DAA (2)
- DNA (2)
- DNA methylation (2)
- Deep brain stimulation (2)
- Degradation (2)
- Dehydrogenases (2)
- Delegation (2)
- Dentists (2)
- Development (2)
- Diabetes mellitus (2)
- Diagnose (2)
- Diagnostic algorithm (2)
- Diagnostic imaging (2)
- Differential diagnosis (2)
- Digitalisierung (2)
- Directly acting antiviral agent (2)
- Dopamine (2)
- Double-balloon enteroscopy (2)
- Dravet syndrome (2)
- Drug hepatotoxicity (2)
- Dynamic MRI (2)
- EET (2)
- EGFR (2)
- EWSR1 (2)
- Emotion regulation (2)
- Endocannabinoid (2)
- Endocannabinoids (2)
- Endoscopic retrograde (2)
- Endothelium (2)
- Endovascular repair (2)
- Enterscopy (2)
- Environmental support (2)
- Enzyme-linked Immunosorbent Assay (2)
- EphB4 (2)
- Epicutaneous immunotherapy (2)
- Epidemiologie (2)
- Epidemiology and End Results (2)
- Epileptische Anfälle (2)
- Erwachsene (2)
- Erweiterter Suizid (2)
- Everolimus (2)
- Evidence-based (2)
- Evidenz (2)
- Exercise (2)
- Exosomes (2)
- Extended suicide (2)
- Extracellular matrix (2)
- FFLU (2)
- FHIR (2)
- FLT3-ITD (2)
- Feedback (2)
- Fibronectin (2)
- Follow-up treatment (2)
- Forensische Osteologie (2)
- Function (2)
- GEMs (2)
- GPCR (2)
- Gastroschisis (2)
- Gemeinschaftliche Selbsttötung (2)
- Gene Regulation (2)
- Gene expression (2)
- Gene fusion (2)
- Genetics research (2)
- Geographic variation (2)
- Geriatric patients (2)
- Germany (2)
- Geschichte (2)
- Geschlecht (2)
- Gesetz zur Verhütung erbkranken Nachwuchses (2)
- Gleason score (2)
- Glioblastom (2)
- Glucose (2)
- Guideline (2)
- H1N1 (2)
- HBsAg (2)
- HES (2)
- HL7 FHIR (2)
- HNSCC (2)
- Healthcare personnel (2)
- Healthcare resource utilization (2)
- Healthcare worker (2)
- Heart (2)
- Hepatitis (2)
- Hepatitis B (2)
- Hepatitis C virus (2)
- Hepatocellular carcinoma (2)
- Herpes Zoster Infektion (2)
- High oblique sagittal osteotomy (2)
- Hippocampus (2)
- Hörrehabilitation (2)
- ISR (2)
- Identification (2)
- Ileus (2)
- Immune cells (2)
- Immune system (2)
- Immunenzymtechniken (2)
- Immunoenzyme Techniques (2)
- Immunogenicity (2)
- Immunologic methods (2)
- Immunosuppression (2)
- Immunsystem (2)
- Immunturbidimetrie (2)
- Impfraten (2)
- Impfstoff (2)
- Impfung (2)
- Infection (2)
- Influenza (2)
- Innate Immunity (2)
- Insulin signalling (2)
- Integrin (2)
- Intensive care treatment (2)
- Intensive care units (2)
- Interferon (2)
- Interleukin-1 (2)
- Interleukin-6 (2)
- Iron (2)
- Ketogenic diet (2)
- Kinderwunsch (2)
- Klassifikation (2)
- Kolonkarzinom (2)
- Kolorektales Karzinom (2)
- Komplementsystem (2)
- Körperhaltung (2)
- L-DOPA (2)
- Labor and delivery (2)
- Labordiagnostik (2)
- Lactate Dehydrogenase (2)
- Legs (2)
- Lehre (2)
- Leitlinien (2)
- Leptin (2)
- Leukämie (2)
- Lipidomics (2)
- LncRNA (2)
- Local therapy (2)
- Long-COVID (2)
- Long-term potentiation (2)
- Low-molecular-weight heparin (2)
- Lucilia sericata (2)
- Lymphectasia (2)
- M2-PK (2)
- Machine-learning (2)
- Macrophage polarization (2)
- Makrophagen (2)
- Malnutrition (2)
- Medical consultation (2)
- Medical diagnostics (2)
- Medical risk factors (2)
- Memory (2)
- Mental health (2)
- Metabolic diseases (2)
- Migration (2)
- Mitochondria (2)
- Mitochondrial dysfunction (2)
- Model (2)
- Molecular autopsy (2)
- Molecular neuroscience (2)
- Monocytes (2)
- Morphology (2)
- Multimorbidity (2)
- Multiple Sklerose (2)
- Multiple sclerosis (2)
- Musculoskeletal diseases (2)
- Muskuloskeletale Erkrankungen (2)
- Myeloid Neoplasia (2)
- Myocardial infarction (2)
- Myocarditis (2)
- Myokarditis (2)
- NADH dehydrogenase (2)
- NAFLD (2)
- NASH (2)
- NCCN (2)
- NCoR1 (2)
- NF-κB (2)
- NS-Medizin (2)
- NS5A (2)
- Nachweismethoden (2)
- Nachweisverfahren (2)
- Nadelstichverletzungen (2)
- Neurodegeneration (2)
- Neuron (2)
- Neurotransmitter (2)
- Next-generation sequencing (2)
- Notaufnahme (2)
- Nrf2 (2)
- Nucleic acid biomarkers (2)
- OSCE (2)
- OXA-48 (2)
- Obesity (2)
- Occupational health (2)
- Offene Versorgung (2)
- Open repair (2)
- Optical phenomena (2)
- Oral immunotherapy (2)
- Orthognathic surgery (2)
- Osteoarthritis (2)
- Osteocalcin (2)
- Osteoporotic fractures (2)
- PD-L1 (2)
- PLGA (2)
- PRF (2)
- PSA (2)
- Pathogenesis (2)
- Pathologic complete response (2)
- Patient information (2)
- Patient needs (2)
- Patient*inneninformation (2)
- Patientenbedürfnisse (2)
- Patterns of care (2)
- Pediatric (2)
- Pediatrics (2)
- Pelargonium sidoides (2)
- Penile cancer (2)
- Penile carcinomas (2)
- Perikarditis (2)
- Periodontal treatment (2)
- Person-Umwelt-Passung (2)
- Person-environment fit (2)
- Phagocytosis (2)
- Pharmacology (2)
- Plasticity (2)
- Point-of-care testing (2)
- Portal hypertension (2)
- Positron emission tomography (2)
- Post-mortem interval (2)
- Preclinical research (2)
- Predictive coding (2)
- Predictive markers (2)
- Pregnancy (2)
- Preterm birth (2)
- Preventive medicine (2)
- Primary health care (2)
- Procalcitonin (2)
- Professional dance (2)
- Prognostic tool (2)
- Prophylaxis (2)
- Protein biomarkers (2)
- Pseudomonas aeruginosa (2)
- Psoriasis (2)
- Psychedelics (2)
- Psychology (2)
- Quality of care (2)
- Questionnaire (2)
- RCT (2)
- RNA therapeutics (2)
- RNAseq (2)
- Radiation (2)
- Radical prostatectomy (2)
- Reactive oxygen species (2)
- Reanimation (2)
- Rechtsmedizin (2)
- Redoxin (2)
- Rehabilitation outcome (2)
- Rehabilitationsergebnis (2)
- Remuneration (2)
- Rescue medication (2)
- Research Article (2)
- Respiratory distress syndrome (2)
- Reward (2)
- Ribavirin (2)
- Risikokommunikation (2)
- Risk communication (2)
- S1P receptors (2)
- SARS-CoV-2 monitoring (2)
- SARS-CoV-2 testing (2)
- SARS-CoV‑2 (2)
- SCC (2)
- SPM (2)
- SUMO (2)
- SV2A (2)
- SVR (2)
- Schilddrüsenknoten (2)
- Schizophrenia (2)
- Schwangerschaft (2)
- Screening (2)
- Seizures (2)
- Selbstmanagement (2)
- Self-management (2)
- Sensitivität (2)
- Serodiagnose (2)
- Signaling (2)
- Specificity (2)
- Speech discrimination (2)
- Spezifität (2)
- Sprache (2)
- Sprachstörung (2)
- Sprachverstehen (2)
- Sprechen (2)
- Sprechstörung (2)
- Squamous cell carcinoma (2)
- Standard endoscopy (2)
- Standard value (2)
- Standardization (2)
- Stem cell (2)
- Stereotaxie (2)
- Sudden death (2)
- Suicidality (2)
- Suicide pact (2)
- Superficial vein thrombosis (2)
- Supported decision making (2)
- Synaptic transmission (2)
- Systemic inflammation (2)
- Systemic therapy (2)
- T-cell (2)
- TACE (2)
- TGF-β (2)
- TSC (2)
- Telemedicine (2)
- Temozolomide (2)
- Therapy (2)
- Thrombose (2)
- Tight junctions (2)
- Todesart (2)
- Tomography (x-ray computed) (2)
- Tooth loss (2)
- Training (2)
- Transfusionsmedizin (2)
- Treatment position (2)
- Tumor marker (2)
- Type 2 diabetes (2)
- Undergraduate medical education (2)
- Universitätskliniken (2)
- Unterstützung der Umwelt (2)
- Upper body posture (2)
- Usability (2)
- Uteroglobin (2)
- VT (2)
- Vaccine uptake rate (2)
- Validierung (2)
- Validity (2)
- Variant histology (2)
- Vascular endothelial growth factor (VEGF) (2)
- Vasculitis (2)
- Vergütung (2)
- Versorgung (2)
- Virologie (2)
- Viruslast (2)
- Virussicherheit (2)
- Visual estimation (2)
- Volume therapy (2)
- Wearable cardioverter-defibrillator (2)
- Weiterbildung (2)
- Women (2)
- Wound healing (2)
- Wounds (2)
- Zigarette (2)
- Zink (2)
- acute coronary syndromes (2)
- adaptation (2)
- adipose-derived stromal/stem cells (2)
- adjuvant chemotherapy (2)
- age (2)
- alcohol use disorder (2)
- algorithm (2)
- alpha power (2)
- animal experiments (2)
- antibiotic resistance (2)
- antibody test (2)
- antiseizure medication (2)
- aortic valve stenosis (2)
- attention (2)
- automation (2)
- bacteria (2)
- biliary stricture (2)
- bioenergetics (2)
- biopsy cores (2)
- blood borne infection (2)
- blood pressure (2)
- blood transfusion (2)
- bloodborne viruses (2)
- blutübertragbare Infektionskrankheiten (2)
- bone (2)
- bone regeneration (2)
- bortezomib (2)
- brain cancer (2)
- brain metastasis (2)
- cabozantinib (2)
- callous-unemotional traits (2)
- calprotectin (2)
- campesterol (2)
- cancer treatment (2)
- cancer-specific mortality (2)
- cardiolipin (2)
- cardiovascular disease (2)
- caregivers (2)
- cell culture (2)
- cell cycle (2)
- cell death (2)
- cell migration (2)
- ceramides (2)
- cerebral hemorrhage (2)
- cerebral venous thrombosis (2)
- cerebrospinal fluid (2)
- cesarean section (2)
- chemoradiotherapy (2)
- childhood acute myeloid leukemia (2)
- cholestanol (2)
- cholesterol absorption (2)
- cholesterol synthesis (2)
- clinical isolates (2)
- clinical trial (2)
- clinical trials (2)
- co-infection (2)
- coagulopathy (2)
- cochlear implant (2)
- comorbidity (2)
- complementary medicine (2)
- complexome profiling (2)
- computed tomography (2)
- confinement (2)
- congenital diaphragmatic hernia (2)
- constipation (2)
- contemporary (2)
- counseling (2)
- critical size defect (2)
- critically ill patients (2)
- dance (2)
- deubiquitinase (DUB) (2)
- development (2)
- dexamethasone (2)
- diabetic nephropathy (2)
- diagnostic algorithm (2)
- diagnostics (2)
- disease burden (2)
- dopamine (2)
- dysphagia (2)
- efficacy (2)
- endodontic curriculum (2)
- endodontic education (2)
- endovascular treatment (2)
- ephrinB2 (2)
- epidermal growth factor receptor (2)
- epithelial to mesenchymal transition (2)
- erastin (2)
- everolimus (2)
- executive function (2)
- fall (2)
- fecal occult blood test (2)
- ferroptosis (2)
- fibroblasts (2)
- follow-up (2)
- furcation involvement class III (2)
- fusion biopsy (2)
- fäkaler okkulter Stuhltest (2)
- general practice (2)
- genetic variants (2)
- glycolysis (2)
- guided bone regeneration (2)
- healthcare worker (2)
- hepatitis C virus (HCV) (2)
- herpes zoster (2)
- histology (2)
- homeostatic plasticity (2)
- hyperglycemia (2)
- immune checkpoint inhibitors (2)
- immune response (2)
- immunosuppression (2)
- in vitro (2)
- infections (2)
- inflammatory bowel disease (2)
- insulin (2)
- integrative medicine (2)
- intermediate risk (2)
- invasion (2)
- iron metabolism (2)
- kidney (2)
- kidney cancer (2)
- kinematic analysis (2)
- laboratory testing (2)
- language (2)
- lathosterol (2)
- leptin (2)
- levetiracetam (2)
- lifestyle intervention (2)
- lipids (2)
- lipocalin-2 (2)
- lipoxygenase (2)
- liver fibrosis (2)
- localized prostate cancer (2)
- lockdown (2)
- long-term success (2)
- long-term tooth survival (2)
- low molecular weight heparin (2)
- low-glycaemic meal replacement (2)
- lung development (2)
- lymph node dissection (2)
- mRNA (2)
- mTORC1 (2)
- mast cells (2)
- medication management (2)
- melanoma (2)
- metabolism (2)
- metastatic castration-resistant prostate cancer (2)
- mice (2)
- monitoring (2)
- monoclonal antibody (2)
- monocytes (2)
- motility (2)
- multicentre study (2)
- multidetector computed tomography (2)
- musculoskeletal disorders (2)
- myocarditis (2)
- ncRNA (2)
- needlestick injury (2)
- nephropathy (2)
- neural oscillations (2)
- neurocognitive (2)
- neuropathy (2)
- neutralization (2)
- neutralizing antibodies (2)
- next-generation sequencing (2)
- niche (2)
- nitric oxide (2)
- nivolumab (2)
- olfaction (2)
- oligomerisation (2)
- online survey (2)
- other-cause mortality (2)
- out-patient paediatrics (2)
- patient blood management (2)
- pediatric patients (2)
- pediatric surgery (2)
- penile cancer (2)
- pentose phosphate pathway (2)
- perception (2)
- peri-implant diseases (2)
- peri-implantitis (2)
- pericarditis (2)
- periodontitis stage III and IV (2)
- pertussis (2)
- phagocytosis (2)
- pharmacokinetics (2)
- physical activity (2)
- pneumonia (2)
- post-translational modifications (2)
- prediction (2)
- predictive (2)
- predictive coding (2)
- predictor (2)
- preeclampsia (2)
- primary cilium (2)
- primary prostate cancer (2)
- process evaluation (2)
- prognosis (2)
- prognostic (2)
- prostaglandin E (2)
- prostaglandins (2)
- prostate carcinoma cells (2)
- proteasome (2)
- protein-protein interaction (2)
- protein-rich (2)
- psychiatric comorbidity (2)
- pulmonary embolism (2)
- quality assurance (2)
- questionnaire (2)
- radiation (2)
- radical cystectomy (2)
- radical prostatecomy (2)
- receptor (2)
- refractory (2)
- regenerative medicine (2)
- relapse (2)
- renal cell carcinoma (2)
- residual myometrial thickness (2)
- resistance mutation (2)
- resistant cell lines (2)
- resolution of inflammation (2)
- respiratory chain (2)
- respiratory infections (2)
- respiratory tract infection (2)
- resting-state (2)
- rheumatoid arthritis (2)
- risk group (2)
- salvage radical prostatectomy (2)
- salvage therapy (2)
- scaffold (2)
- schizophrenia (2)
- screening (2)
- second-line (2)
- serine protease (NS3-4A) (2)
- serum (2)
- sex differences (2)
- simulation training (2)
- sitosterol (2)
- smooth muscle cells (2)
- soft tissue (2)
- speech (2)
- speech and language disorder (2)
- speech perception (2)
- spinal dural leaks (2)
- spine head (2)
- stakeholder analysis (2)
- status epilepticus (2)
- stereotactic radiosurgery (2)
- strength training (2)
- stress granules (2)
- sub-lineage (2)
- subchondral bone (2)
- superficial siderosis (2)
- surgery (2)
- synaptopodin (2)
- systematic biopsy (2)
- systemic antibiotics (2)
- temozolomide (2)
- temporal lobe epilepsy (2)
- test methods (2)
- therapeutics (2)
- thymus (2)
- total hip replacement (2)
- transcription factor (2)
- triple-negative breast cancer (2)
- tumor necrosis factor (2)
- tumor-associated macrophages (2)
- tyrosine kinase inhibitors (2)
- ubiquitin (2)
- ubiquitination (2)
- upgrading (2)
- urinary incontinence (2)
- urological cancer (2)
- vaccine uptake rates (2)
- vascular biology (2)
- venous thrombosis (2)
- very high risk (2)
- viruses (2)
- waiting time (2)
- walking (2)
- weight reduction (2)
- white matter hyperintensity (2)
- working memory (2)
- Ärztliche Aufklärung (2)
- "NS"-Euthanasie (1)
- "alternative" technology (1)
- "conventional" analysis technics (1)
- (lyso)phospholipids (1)
- (sub-) luxation (1)
- 1-propanol (1)
- 177Lu-PSMA (1)
- 18-Hydroxycorticosteron (1)
- 18-OH corticosterone (1)
- 1H NMR; Conformational Properties (1)
- 2-AG (1)
- 2-Arachidonoyl glycerol (1)
- 2-deoxy-d-glucose (1)
- 223Radium-dichloride (1)
- 26 LncRNA (1)
- 2′,3′-cGAMP (1)
- 3 mm RAS instruments (1)
- 3 mm instruments (1)
- 3-hydroxyisovaleryl carnitine (1)
- 3-year survival (1)
- 3D culture (1)
- 3D gait analysis (1)
- 3D laparoscopy (1)
- 3D printing using composite resin (1)
- 3D printing using zirconia (1)
- 3D-Druck (1)
- 3D-models (1)
- 3D-printing (1)
- 3T3-L1 mouse fibroblasts (1)
- 4-fluoroamphetamine (1)
- 5-lipoxygenase (1)
- 8 weeks (1)
- 9-aminoacridine (1)
- 98/79/EC (1)
- A498 cells (1)
- AAA (1)
- AAA+ disaggregase (1)
- ABC transporter (1)
- ABCB5 (1)
- ACE inhibitor (1)
- ACKR (1)
- ACL (1)
- ACT-777991 (1)
- ACTH (1)
- ADAMTS13 (1)
- ADCC (1)
- ADGRE1 (1)
- AGMO (1)
- AIDS (1)
- AKT (1)
- AKT signaling (1)
- AKT-mTOR pathway (1)
- ALD (1)
- ALDH2 (1)
- ALL (1)
- ALLO (1)
- AMH (1)
- AMP-activated kinase (AMPK) (1)
- AO-PCCF (1)
- APT-CEST (1)
- ARFI (1)
- ASA (1)
- ASA-Klassifikation (1)
- ASPECTS (1)
- AT1 receptor antagonist (1)
- ATG3 (1)
- ATG4 (1)
- ATG8 (1)
- ATP (1)
- AU-rich element (1)
- Abdominelles Aortenaneurysma (1)
- Abductor pollicis longus (1)
- Ablation (1)
- Ablation Techniques (1)
- Abrasion (1)
- Abronia graminea (1)
- Abronia lythrochila (1)
- Abusive head trauma (AHT) (1)
- Access® immunoassay system (1)
- Access®-Immunoassaysystem (1)
- Accident (1)
- Accidents (1)
- Accumulated degree days (1)
- Acetabulumdefekt (1)
- Achtundsechzig (1)
- Achtundsechziger (1)
- Acide gamma-aminobutyrique (1)
- Acidic Dissociation (1)
- Acidic Amino Acids (1)
- Acquired resistance (1)
- Actaea cimicifuga (1)
- Activated partial thromboplastin time (1)
- Active middle ear implants (1)
- Activities of daily living (1)
- Acute (1)
- Acute Myeloid Leukemia (AML) (1)
- Acute appendicitis (1)
- Acute decompensation (1)
- Acute elbow dislocation (1)
- Acute inflammation (1)
- Acute injuries (1)
- Acute kidney failure (1)
- Acute myeloid leukaemia (1)
- Acute renal failure (1)
- Acute respiratory distress syndrom (1)
- Acute-on-chronic liver failure (1)
- Acute-on-chronic subdural hematoma (1)
- Adeno associated virus (1)
- Adenylate Kinase (1)
- Adherence (1)
- Adhesins (1)
- Adhesion Factor (1)
- Adhärenz (1)
- Adiposity (1)
- Adjuvant procedure (1)
- Adjuvantes Verfahren (1)
- Administrative claims data (1)
- Adrenal crisis (1)
- Adrenale Krise (1)
- Adrenocorticotropic hormone (1)
- Adrenokortikotropes Hormon (1)
- Adult neurogenesis (1)
- Adult-onset ADHD (1)
- Adults (1)
- Advanced stage (1)
- Adverse drug reaction (1)
- Adverse effects (1)
- Aedes aegypti (1)
- Aedes albopictus (1)
- Aeroplysinin-1 (1)
- Aerosolspektrometrie (1)
- Affect (1)
- Affective Misattribution Procedure (1)
- Affinity Chromatography (1)
- Afrikanische Schlafkrankheit (1)
- Ag-RDT (1)
- Aganglionosis (1)
- Agardiffusion (1)
- Age determination (1)
- Ageing (1)
- Aggression (1)
- Agitation (1)
- Airport-related emissions (1)
- Akkreditierung (1)
- Akt-mTOR pathway (1)
- Akt-mTOR signaling (1)
- Aktivierte partielle Thromboplastinzeit (1)
- Akute (1)
- Akute Niereninsuffizienz (1)
- Akute Nierenschädigung (1)
- Akute Verletzungen (1)
- Akute lymphatische Leukämie (1)
- Albumin (1)
- Albumin ratio (1)
- Algorithms (1)
- Alkaline phosphatase (1)
- Alkalische Phosphatase (1)
- Alkaloid (1)
- Alkylating NAD-Analogs (1)
- All-oral therapy (1)
- Allergie (1)
- Allergische Rhinitis (1)
- Allgemeinmedizin (1)
- Allgemeinmedizin Forschung (1)
- Allogeneic (1)
- Allopregnanolon (1)
- Allosteric inhibition (1)
- Alpha power (1)
- Alpha-fetoprotein (AFP) (1)
- Alte Medizin (1)
- Alzheimer's disease (1)
- Ambient air (1)
- Amblyopia (1)
- Ambulatory Assessment (1)
- Amino acids (1)
- Amisulpride (1)
- Amitriptyline (1)
- Amniotic fluid (1)
- Amphetamine (1)
- Anaemia (1)
- Anahuasca (1)
- Anakinra (1)
- Anal cancer (1)
- Analgesia (1)
- Analgesie (1)
- Analkarzinom (1)
- Analogue modelling (1)
- Analysis tool (1)
- Anamneseerhebung (1)
- Anatomy (1)
- Anderson–Fabry (1)
- Anemia management (1)
- Anerkennung (1)
- Anfall (1)
- Anfallsserie (1)
- Anfallsunterbrechende (1)
- Anfallsunterbrechende Medikamente (1)
- Angeborene Fehlbildungen (1)
- Angiectasia (1)
- Angiodysplasia (1)
- Angiomyolipoma (1)
- Angststörungen (1)
- Animal disease models (1)
- Animal experiment (1)
- Anion and Zwitterion Transport (1)
- Aniridia (1)
- Ankylosierende Spondylitis (1)
- Ankylosing spondylitis (1)
- Anomalous venous atrial connections (1)
- Anorexia Nervosa (1)
- Anterior cruciate ligament (1)
- Anti-inflammatory (1)
- Anti-rheumatic agents (1)
- Antibiotic steward-ship (1)
- Antibiotika (1)
- Antibiotikaresistenz (1)
- Antibodies (1)
- Antibody avidity (1)
- Antibody detection (1)
- Antibody therapy (1)
- Anticholinergic (1)
- Anticoagulant (1)
- Anticoagulation (1)
- Anticonvulsant (1)
- Antidepressiva (1)
- Antiepileptica (1)
- Antigen (1)
- Antigen- und Nukleinsäurenachweis (1)
- Antigene Virale/Immunologie (1)
- Antigennachweis (1)
- Antigens,Viral/immunology (1)
- Antikörpernachweis (1)
- Antimicrobial treatment (1)
- Antineoplastic agents (1)
- Antioxidant (1)
- Antioxidants (1)
- Antiproliferative (1)
- Antiretroviral therapy (1)
- Antiseizure medication (1)
- Antiseizure medication Instructions for action (1)
- Antiviral treatment (1)
- Antivirale Therapie (1)
- Anwendbarkeit (1)
- Anxiolytic pharmacological therapy (1)
- Aortendissektion (1)
- Aortic aneurysm (1)
- Aortic input function (1)
- Aperiodic (1)
- Aphakia (1)
- Aphantasia (1)
- Aphasia (1)
- Aphasie (1)
- Apixaban (1)
- Apoptotic cell death (1)
- Appendectomy (1)
- Appendizitis (1)
- Ara h2-specific IgE (1)
- Arbeitsbedingt erworbene Infektion (1)
- Arbeitsgedächtnis (1)
- ArchT (1)
- Archaebacterial Lipids (1)
- Arcuate fascicle (1)
- Aromatase inhibitors (1)
- Arrhythmia syndromes (1)
- Arteria ophthalmica (1)
- Arteriosclerosis (1)
- Arteriovenous malformation (1)
- Arthrodese (1)
- Arthroplasty (1)
- Arthroskopischer Bankart-Repair (1)
- Artificial Intelligence (1)
- Artificial feeding bioassays (1)
- Artificial iris (1)
- Asparaginase (1)
- Aspirin (1)
- Astrocytoma (1)
- Astrozyten (1)
- Ataxia (1)
- Ataxia score (1)
- Atherosklerose (1)
- Athlete (1)
- Atm (1)
- Atomoxetine (1)
- Atrial Fibrillation (1)
- Atrial fibrillation classification (1)
- Attention (1)
- Attention Deficit Hyperactivity Disorder (ADHD) (1)
- Attention deficit (1)
- Attention-Deficit/Hyperactivity Disorder (ADHD) (1)
- Attentional bias (1)
- Audiologie (1)
- Auditory system (1)
- Aufmerksamkeit (1)
- Aufmerksamkeitsleistung (1)
- Augenerkrankungen (1)
- Aurora kinase (1)
- Ausbildung (1)
- Autism (1)
- Autism Spectrum disorder (1)
- Autismus-Spektrum-Störungen (1)
- Autoimmun (1)
- Autoimmune response (1)
- Autoimmune vasculopathy (1)
- Autoimmunity (1)
- Automated sRNA analysis (1)
- Automation (1)
- Automatisation (1)
- Autonomes Nervensystem (1)
- Autophagie (1)
- Awareness campaign (1)
- Axial spondyloarthritis (1)
- Axiale Spondyloarthritis (1)
- Axiography (1)
- Ayahuasca (1)
- Ayurveda (1)
- Ayurvedic herbal products (1)
- Azan (1)
- B cell cancer (1)
- B cell differentiation (1)
- B cells (1)
- B-cell (1)
- B-cell transcription factors (1)
- B.1.1.529 (1)
- B.1.1.7 (1)
- B.1.617.1 (1)
- B.1.617.2 (1)
- B3GNT2 (1)
- BA.4 (1)
- BA.5 (1)
- BACTEC™ 9000 (1)
- BCG (1)
- BCORL1 (1)
- BCX7353 (1)
- BEACOPP (1)
- BET proteins (1)
- BEZ235 (1)
- BH3 mimetics (1)
- BMP4 (1)
- BNT2b2 (1)
- BPO (1)
- BPTF (1)
- BRD4 (1)
- BRD7 (1)
- BSP (1)
- Bachelorabschluss (1)
- Bachelor’s degree (1)
- Bacillus subtilis (1)
- Back pain (1)
- Back scan (1)
- Bacteraemia (1)
- Bacteremia/diagnosis (1)
- Bacteria (1)
- Bacteria-host interaction (1)
- Bacterial abundance (1)
- Bacterial adhesion (1)
- Bacterial leakage (1)
- Bacteriological techniques (1)
- Bagatelltrauma (1)
- Bakterien (1)
- Bakterientest (1)
- Bakteriologische Techniken (1)
- Bakteriämie/Diagnostik (1)
- Balance (1)
- Ballon-assisted enteroscopy (1)
- Balloon-expandable TAVI (1)
- Bamlanivimab (1)
- Bankart-Läsion (1)
- Barrier (1)
- Bartonella adhesin A (1)
- Bartonella grahamii (1)
- Bartonella schoenbuchensis (1)
- Basal ganglia (1)
- Basalzellkarzinom (1)
- Beck Depression Inventory (1)
- Beckwith–Wiedemann syndrome (1)
- Bedburg-Hau, Anstalt (1)
- Beginners (1)
- Begriffsbestimmung (1)
- Behandlungskontrolle (1)
- Behandlungspfad (1)
- Behavioral tests (1)
- Behavioural ecology (1)
- Behinderung (1)
- Bence Jones (BJ) proteinuria (1)
- Bence Jones-Proteinurie (1)
- Benign enlargement of the subarachnoid spaces (BESS) (1)
- Benign prostatic hyperplasia (1)
- Bentall operation (1)
- Berner, Friedrich (1)
- Berotralstat (1)
- Berufliche Gesundheit (1)
- Berufskrankheit (1)
- Berufszufriedenheit (1)
- Beschäftigte (1)
- Bestrahlung (1)
- Betriebliches Wiedereingliederungsmanagement (1)
- Bevacizumab (1)
- Bevölkerungsschutz (1)
- Bewegungsstörung (1)
- Biceps brachii (1)
- Big Five (1)
- Biglycan (1)
- Bilateral sagittal split osteotomy (1)
- Bildgebung (1)
- Bildqualität (1)
- Bilirubinbestimmung (1)
- Billroth II gastroenterostomy (1)
- Billroth papillotome (1)
- Billroth’s operation-II (1)
- Bio safety (1)
- Bioelektrische Impedanzanalyse (1)
- Bioenergetics (1)
- Biofilm (1)
- Biological sciences (1)
- Biologisches Profil (1)
- Biomarker Discovery Study (1)
- Biomarker Lipoprotein(a) (1)
- Biomarker TIMP‑2 und IGFBP7 (1)
- Biomarkers (1)
- Biomarkers TIMP‑2 and IGFBP7 (1)
- Biophysical models (1)
- Biophysics (1)
- Bipolar (1)
- Bipolare Störung (1)
- Birth (1)
- Birth weight (1)
- Bis-azido-NAD+ Analog (1)
- Black cohosh (1)
- Black cohosh induced liver injury (1)
- Bleeding Risk (1)
- Blindness (1)
- Blocked occlusion (1)
- Blog (1)
- Blood Banks/standards (1)
- Blood Transfusion, Autologous (1)
- Blood coagulation disorder (1)
- Blood loss (1)
- Blood loss calculator (1)
- Blood loss formula (1)
- Blood management (1)
- Blood parameters (1)
- Blood plasma (1)
- Blood pressure (1)
- Blood sample handling (1)
- Blood sampling (1)
- Bloodstream infections (1)
- Blot, Western (1)
- Blot, western (1)
- Blut- und Plasmaprodukte (1)
- Blutbanken/Standards (1)
- Blutkulturdiagnostik (1)
- Blutparameter (1)
- Blutpräparate (1)
- Blutspenderscreening (1)
- Bluttransfusion, Autologe (1)
- Blutung (1)
- Blutungskontrolle (1)
- Body Composition (1)
- Body image (1)
- Body measurements (1)
- Body sway (1)
- Bone Gla Protein (1)
- Bone cement implantation syndrome (1)
- Bone conduction devices (1)
- Bone defect (1)
- Bone disease (1)
- Bone diseases (1)
- Bone diseases, Metabolic (1)
- Bone dust (1)
- Bone marrow aspiration (1)
- Bone regeneration (1)
- Bone remodelling (1)
- Bone substitute (1)
- Bone tissue engineering (1)
- Bone tumor (1)
- Borrelia burgdorferi (1)
- Borrelien (1)
- Bovine Spongiforme Enzephalopathie (BSE) (1)
- Bovine spongiform, encephalopathy (BSE) (1)
- Brachial artery (1)
- Brachytherapy (1)
- Bradycardia (1)
- Brain DNA methylation (1)
- Brain asymmetry (1)
- Brain injuries (1)
- Brain metastasis (1)
- Brain tumor (1)
- Brain tumor surgery (1)
- Breast cancer survivers (1)
- Breast conserving surgery (1)
- Brodalumab (1)
- Bronchiolitis (1)
- Bronchiolitis obliterans (1)
- Browsertool (1)
- Brustkrebs (1)
- Burkholderia arboris (1)
- Burkitt’s lymphoma (1)
- Burns (1)
- Bühnentanz (1)
- Büroangestellte (1)
- Büroarbeit (1)
- C-reaktive protein (1)
- C-reäktives Protein (1)
- C1 inhibitor (1)
- CAC-DRS Score (1)
- CAD-CAM (1)
- CAD/ CAM crown (1)
- CAD/CAM (1)
- CAD/CAM crown (1)
- CAM (1)
- CAPON (1)
- CAR (1)
- CBC (1)
- CBCT (1)
- CCC-2 (1)
- CCL2 (1)
- CD107-Assay (1)
- CD16 (1)
- CD34+ cell enumeration (1)
- CD34 + cells (1)
- CD36 (1)
- CD4+ T cells (1)
- CD40 (1)
- CD44 (1)
- CD45RA Depletion (1)
- CD47 (1)
- CD62L (1)
- CD62p+Exosomes (1)
- CD8+ T cells (1)
- CD8+ zytotoxische T-Zellen (1)
- CDH13 (1)
- CDI (1)
- CDK-cyclin axis (1)
- CDK2 (1)
- CDK4/6 inhibitors (1)
- CDK9 (1)
- CE (1)
- CE marking (1)
- CE-Kennzeichnung (1)
- CEBPD (1)
- CEST EPI (1)
- CHAID-Analyse (1)
- CHAID-Analysis (1)
- CHEPs (1)
- CHRDL1 (1)
- CIM (1)
- CIOMS (1)
- CIRS (1)
- CK2α (1)
- CLIF-C ACLF score (1)
- CLIF-C ACLF-R score (1)
- CLOCC (1)
- CLS (1)
- CMV isolation (1)
- CMV risk groups are: pregnancy - blood transfusion - organ transplantation - prostitutes (1)
- CMV-Isolierung (1)
- CNDAC (1)
- CNS tumor (1)
- CNV (1)
- COPD (1)
- COVID (1)
- COVID 19 pandemic (1)
- COVID-19 epitope signatures (1)
- COVID-19 pandemic (1)
- COVID-19 vaccination (1)
- COVID-19, Primary care (1)
- COVID‐19 (1)
- CQL (1)
- CRBN (1)
- CRISPR screen (1)
- CRISPR/Cas (1)
- CRPC (1)
- CRT (1)
- CT dual-energy computed tomography (1)
- CTC (1)
- CTGF (1)
- CTLA-4 (1)
- CTX and NTX (1)
- CTX und NTX (1)
- CXCL12 (1)
- CXCL13 (1)
- CXCR3 antagonism (1)
- CXCR4 (1)
- CYP450 (1)
- CaMPARI (1)
- Cabozantinib (1)
- Caenorhabditis elegans (1)
- Calcium (1)
- Calcium calmodulin kinase (1)
- Calcium gluconate (1)
- Campylobacter (1)
- Cancer check up (1)
- Cancer development (1)
- Cancer genomics (1)
- Cancer progression (1)
- Cancer survivors (1)
- Cancer-specific survival (1)
- Cannabis-based Medicine (1)
- Capacity deficit (1)
- Capillary-Leak-Syndrom (1)
- Capnography (1)
- Capsaicin (1)
- Capsule endoscopy, video (1)
- Carcinoma (1)
- Cardiac arrest (1)
- Cardiac biomarkers (1)
- Cardiac implantable electronic devices (1)
- Cardiac infarction (1)
- Cardiac rehabilitation (1)
- Cardiac remodeling (1)
- Cardiac resynchronization therapy (1)
- Cardiavascular function (1)
- Cardio-oncology (1)
- Cardiology (1)
- Cardiotoxicity (1)
- Cardiovascular biology (1)
- Cardiovascular disease (1)
- Cardiovascular disease risk (1)
- Cardiovaskuläre Erkrankungen (1)
- Care centers (1)
- Care gaps (1)
- Care home (1)
- Caregiver burden (1)
- Carotid injury (1)
- Cartilage (1)
- Cartilage Biology (1)
- Cary-Blair medium (1)
- Cary-Blair-Medium (1)
- Casirivimab (1)
- Caspase-8 (1)
- Catel, Werner (1)
- Catheters (1)
- Catumaxomab (1)
- Causality assessment. (1)
- Cell Biology (1)
- Cell Death (1)
- Cell Metabolism (1)
- Cell Migration (1)
- Cell Signaling (1)
- Cell Surface Receptor (1)
- Cell division (1)
- Cell proliferation (1)
- Cell surface proteoglycans (1)
- Cell-based Assays (1)
- Cellular Immune Response (1)
- Cellular energy metabolism (1)
- Cellular network formation (1)
- Cement gap (1)
- Centers for Disease Control and Prevention (1)
- Central Europe (1)
- Cephalometry via electromagnetic induction (1)
- Cephalometry without x-rays (1)
- Ceramides (1)
- Cerebral hypoperfusion (1)
- Cerebral oxygen saturation (1)
- Cerebrospinal Fluid (1)
- Cerebrospinal fluid (1)
- Cerebrospinal fluid diagnostics (1)
- Cerebrovascular disorders (1)
- Cezanne (1)
- ChAdOx1-S (1)
- Chaperone (1)
- Checkliste (1)
- Checkpoint Inhibitor (1)
- Chemilumineszenz (1)
- Chemokines (1)
- Chemotherapie (1)
- Chemotherapy (1)
- Chikungunya (1)
- Child abuse (1)
- Child and adolescent psychotherapy (1)
- Children and adolescents (1)
- Chimeric Antigen Receptor (CAR) (1)
- Chimiothérapie (1)
- Chinese crocodile lizard (1)
- Chlamydia-Infections/urine (1)
- Chlamydien (1)
- Chlamydieninfektionen/Urin (1)
- Cholinergic (1)
- Chondrocytes (1)
- Chrna7 knockout (1)
- Chrom (1)
- Chromodomains (1)
- Chronic diseases (1)
- Chronic inflammation (1)
- Chronic lymphocytic leukemia (1)
- Chronisch aktive/Diagnostik (1)
- Chronische Fehl- und Überlastungsschäden (1)
- Cigarette (1)
- Cine (1)
- Circadian (1)
- Circulating MiRNA (1)
- Circulating markers (1)
- Cisplatinresistenz (1)
- Citrat (1)
- Civil protection (1)
- Clavien–Dindo classification (1)
- Click chemistry (1)
- Climate inequity (1)
- Clinical (1)
- Clinical Decision Support System (1)
- Clinical Global Impression of Change (1)
- Clinical efficacy (1)
- Clinical genetics (1)
- Clinical management (1)
- Clinical pathway (1)
- Clinical pharmacology (1)
- Clinical phenotype (1)
- Clinical practice guidelines (1)
- Clinical tasks (1)
- Clinical trial (1)
- Clinical trials (1)
- Clip (1)
- ClpB (1)
- Coagulation (1)
- Cochlear Implant (1)
- Coenzyme Analogue (1)
- Coenzyme Binding (1)
- Coeval folding and boudinage (1)
- Cognitive (1)
- Cognitive behavioural therapy (1)
- Cognitive dysfunction (1)
- Cognitive enhancers of exposure therapy (1)
- Cognitive impairment (1)
- Coherent infomax (1)
- Cohort studies (1)
- Cold hardiness (1)
- Cold tolerance (1)
- Collagen Maps (1)
- Collagen-based biomaterial (1)
- Colloids (1)
- Colonic neoplasms (1)
- Colony stimulating factor 1 receptor (1)
- Colorimetric blood loss estimation (1)
- Combined surgical therapy (1)
- Combustion (1)
- Commercial Immunoglobulins (1)
- Comorbidities (1)
- Complete response (1)
- Completed suicide (1)
- Complex decongestive therapy (1)
- Complex elbow fractures (1)
- Compliance (1)
- Compliance-Beobachtung (1)
- Complicated stage (1)
- Comprehensive complication index (1)
- Compression stocking (1)
- Computational biophysics (1)
- Computational neuroscience (1)
- Computational sRNA analysis (1)
- Computational science (1)
- Computed tomography imaging (1)
- Computed tomography, X-ray (1)
- Computer hardware (1)
- Computer science (1)
- Computer-Assisted (1)
- Computer-unterstützte (1)
- Concurrent CNS diseases (1)
- Conduct disorder (1)
- Cone-beam computed tomography (1)
- Confinement (1)
- Congenital (1)
- Congenital diaphragmatic hernia (1)
- Connective tissue (1)
- Connectomics (1)
- Conometric connection (1)
- Consensus document (1)
- Consensus statement (1)
- Conservative treatment (1)
- Constipation (1)
- Constitution (1)
- Constriction (1)
- Contingent Negative Variation, CNV (1)
- Continuous Performance Test, CPT (1)
- Continuous renal replacement therapy (1)
- Contraceptifs hormonaux (1)
- Contrast agent (1)
- Contrast-medium, injection rate, iodine concentration, hepatic malignancy, multiphasic CT (1)
- Control (1)
- Conventional and unconventional ubiquitination (1)
- Conventional dendritic cells (1)
- Convolutional Neural Networks (1)
- Cooperation (1)
- Copy number (1)
- Corneal tomography (1)
- Corona pandemic (1)
- Corona virus (1)
- Coronary CT (1)
- Coronary Heart Disease (1)
- Coronary Plaque Burden (1)
- Coronary artery disease (1)
- Coronary calcification (1)
- Coronary heart disease (1)
- Coronaviruses (1)
- Cortical degeneration (1)
- Cortical thickness (1)
- Corticotropic axis (1)
- Corucia zebrata (1)
- Cost-effectiveness (1)
- Costs (1)
- Course (1)
- Course evaluation (1)
- Craniomaxillofacial injuries (1)
- Creatinine (1)
- Crisis (1)
- Critical size (1)
- Crohn’s disease (1)
- Cross- sectional study (1)
- Cross-frequency coupling (1)
- Cue-P3 (1)
- Culex pipiens (1)
- Culex pipiens biotypes pipiens/molestus (1)
- Culicidae (1)
- Culture positive (1)
- Curcumis sativus (1)
- Curriculum (1)
- Cushing-Syndrom (1)
- Cushing’s syndrome (1)
- Custom-made mouthguard (1)
- Cuticular hydrocarbons (1)
- Cyanoacrylate (1)
- Cyclin T1 (1)
- Cyclosporin A (1)
- CysLTR1 (1)
- Cystatin C (1)
- Cystic fibrosis (1)
- Cytochrome P450 (1)
- Cytochrome P450 enzymes (1)
- Cytokine (1)
- Cytokines (1)
- Cytokines Induction (1)
- Cytomegalie (1)
- Cytomegalie-Virus (1)
- Cytomegalovirus (1)
- Cytomegalovirus Infection (1)
- Cytoreductive nephrectomy (1)
- Cytotoxicity (1)
- D-amino acid oxidase (1)
- DBS (1)
- DC-NK cell interaction (1)
- DCK (1)
- DECT (1)
- DIN EN ISO 15189 (1)
- DNA Adducts (1)
- DNA integrity (1)
- DNA mismatch repair (1)
- DNA, Virale/Blut (1)
- DNA-PK (1)
- DNA-based identification (1)
- DOMS (1)
- DOT1L (1)
- DPPIV (1)
- DRG (1)
- DST (1)
- DTI (1)
- DVI (1)
- DVT (1)
- DWI (1)
- Dance (1)
- Dark triad (1)
- Data Analysis (1)
- Data preprocessing (1)
- Data processing (1)
- Data reduction (1)
- Data structure detection (1)
- Daubert criteria (1)
- De-isolation (1)
- Dead space (1)
- Death certificate (1)
- Decay (1)
- Decision Confidence (1)
- Decision support (1)
- Decontamination (1)
- Decorin (1)
- Deep learning (1)
- Deep neural network (1)
- Deep vein thrombosis (1)
- Defibrillation (1)
- Deformation oblique layer (1)
- Degrader design (1)
- Dehnen (1)
- Dehntraining (1)
- Dehydrogenase (1)
- Delphi consensus (1)
- Dementia (1)
- Demenz (1)
- Dendritic Cells (1)
- Dengue (1)
- Density equalizing mapping (1)
- Density-equalizing mapping (1)
- Dental Tissues (1)
- Dental air (1)
- Dental assistants (1)
- Dental casts (1)
- Dental education (1)
- Dental implants (1)
- Dental practice (1)
- Dentale Implantate (1)
- Dentin adhesives (1)
- Dentistry (1)
- Depression stigma (1)
- Dermatitis (1)
- Detection (1)
- Detection workflow (1)
- Detraining (1)
- Deutsche Gesellschaft für Chirurgie (1)
- Deutsches Rotes Kreuz (1)
- Developmental Biology (1)
- Developmental and epileptic encephalopathy (1)
- Developmental programming (1)
- Developmental trajectory (1)
- Developmentally adapted cognitive processing therapy (1)
- Device (1)
- Dexamethasone (1)
- Dexterity (1)
- Diabetes (1)
- Diabetes mellitus Typ 1 und Typ 2 (1)
- Diagnosen ICD-10 Ziffern G41.0, G41.1, G41.2, G41.8, G41.9 (1)
- Diagnoses ICD-10 codes G41.0, G41.1, G41.2, G41.8, G41.9 (1)
- Diagnosezeitpunkt (1)
- Diagnosis related groups (1)
- Diagnostic accuracy (1)
- Diagnostic dye (1)
- Diagnostic error (1)
- Diagnostic test (1)
- Diagnostic tests (1)
- Dialyse (1)
- Diet (1)
- Dietary HDAC inhibitor (1)
- Dietary supplements (1)
- Dieulafoy’s lesion (1)
- Differential Thermoanalysis (1)
- Differenzierung (1)
- Difficult Airway Management (1)
- Diffusion MRI (1)
- Diffusion magnetic resonance imaging (1)
- Digital (1)
- Digital pathology (1)
- Digital subtraction angiography (1)
- Digital workshops (1)
- Digitale Volumen Tomographie (1)
- Digitalization (1)
- Digitization (1)
- Dimethyltryptamine (1)
- Diphtheria (1)
- Diptera (1)
- Direct costs (1)
- Direct measurement (1)
- Direct oral anticoagulation (1)
- Direct-acting antivirals (1)
- Disaster victim identification (1)
- Discitis (1)
- Disconnection (1)
- Discovery (1)
- Disease progression (1)
- Diseases (1)
- Disintegration (1)
- Diskonnektion (1)
- Dislocations of the knee (1)
- Distance learning (1)
- Distanzunterricht (1)
- Distribution limits (1)
- Dizygotic ectopic (1)
- Dome-and-basin structure (1)
- Donor screening (1)
- Dorsal root ganglia (1)
- Dose response (1)
- Dot-probe task (1)
- Double balloon enteroscopy (1)
- Double suicide (1)
- Double-blind placebo-controlled trial (1)
- Douleur (1)
- Downgrading (1)
- Dravet (1)
- Droplets (1)
- Drospirenon (1)
- Drug addiction (1)
- Drug resistance (1)
- Drug susceptibility testing (1)
- Drug targets (1)
- Drug therapy (1)
- Dual-energy computed tomography (1)
- Duodenum (1)
- Dural onlays (1)
- Dysfibrinogenämia (1)
- Dysfunctional social assumptions (1)
- Dysphagia (1)
- Désir d’enfant (1)
- D’Amico classification (1)
- E-health (1)
- EAA (1)
- EASI (1)
- EBM (1)
- EBRT (1)
- ECMO (1)
- EDOF (1)
- EGFRvIII mutation (1)
- EHL concentrates (1)
- EMR1 (1)
- EMT (1)
- EN ISO 15189 (1)
- ENIGMA (1)
- EP300 (1)
- EQ5D5L (1)
- EQA scheme (1)
- ER-phagy (1)
- ERAL1 (1)
- ERCP (1)
- ERK inhibitor (1)
- ERK1/2 signaling (1)
- ESBL (1)
- ESR Spectroscopy (1)
- ESR and Infrared Studies (1)
- EVAR (1)
- Early (prenatal and postnatal) life experiences (1)
- Early setting (1)
- Ebola (1)
- Eccentric fixation (1)
- Ecological Momentary Assessment (EMA) (1)
- Ectopic pregnancy (1)
- Ectopic varices (1)
- Edinger, Ludwig (1)
- Edoxaban (1)
- Effective half-life (1)
- Efficacy (1)
- Efficiency (1)
- Ego dissolution (1)
- Eicosanoide (1)
- Einstellungen zu Impfungen (1)
- Einwilligungsfähigkeit (1)
- Einzelzahnimplantate (1)
- Eisenbestimmung (1)
- Eisenmangel (1)
- Ejection fraction (1)
- Ektachem® (1)
- Elastographie (1)
- Elderly trauma patient (1)
- Electric stimulation (1)
- Electrical stimulation (1)
- Electroconvulsive Therapy (1)
- Electroencephalography (1)
- Electrophysiology (1)
- Elektrischer Sturm (1)
- Elektrophysilogie (1)
- Elite football (1)
- Ellipticine (1)
- Elternurteil (1)
- Embden, Gustav (1)
- Embolie (1)
- Emergency card (1)
- Emergency care (1)
- Emergency treatment (1)
- Emotional intelligence (1)
- Empathy (1)
- Empfindlichkeitstestung (1)
- Empty puparia (1)
- Ena/VASP proteins (1)
- Encephalitis Viruses (1)
- Endocrine system and metabolic diseases (1)
- Endocrine therapy (1)
- Endodontie (1)
- Endogenous retroviruses (ERV) (1)
- Endoluminal (1)
- Endometrial carcinoma (1)
- Endometriome (1)
- Endometriose (1)
- Endomicroscopy (1)
- Endométriomes (1)
- Endorectal (1)
- Endoscopic papillotomy (1)
- Endoscopic retrograde cholangiography (1)
- Endoscopic sphincterotomy (1)
- Endoscopic treatment (1)
- Endoscopic ultrasound (1)
- Endoskopie (1)
- Endothelial (1)
- Endothelial progenitor cells (1)
- Endothelial protein C receptor (1)
- Endothelial-to-mesenchymal transition (1)
- Endotoxin (1)
- Endotoxinaktivität (1)
- Endourologie (1)
- Endovascular aortic repair (1)
- Endovaskuläre Behandlung (1)
- Endovaskuläre Versorgung (1)
- Endpoint Urea determination (1)
- Endpunkt-Harnstoffbestimmung (1)
- Energiedefizit (1)
- Energy (1)
- Energy deficit (1)
- Energy metabolism (1)
- Energy-efficiency (1)
- Engraftment (1)
- Enterobacterales (1)
- Enterobacteriaceae (1)
- Environmental biotechnology (1)
- Environmental enrichment (1)
- Environmental impacts (1)
- Environmental sciences (1)
- Enzephalopathie (1)
- Enzymatic Behaviour (1)
- Enzymatic activity (1)
- Enzyme Linked Immunosorbent Assay (ELISA) (1)
- Enzyme Preparation (1)
- Enzymkinetik (1)
- Eosinophils (1)
- EpCAM positive tumor (1)
- Ephrin-B2–EphB4 (1)
- Epidemie (1)
- Epidemiologische Surveillance (1)
- Epidural abscess (1)
- Epigenetik (1)
- Epilepsiechirurgie (1)
- Epilepsiezentren (1)
- Epilepsy Acute seizure plan Antiseizure medication Instructions for action Self-management (1)
- Epilepsy center (1)
- Epilepsy centers (1)
- Epilepsy surgery (1)
- Epileptic seizure (1)
- Epileptic seizures (1)
- Epithelialization (1)
- Epithelioma Cells (1)
- Epsilon (1)
- Equity (1)
- ErbB-signaling (1)
- Erfolgsfaktoren (1)
- Ergebnisquantifizierung (1)
- Ergometrie (1)
- Ergometry (1)
- Ernährung (1)
- Erprobung (1)
- Erregernachweis (1)
- Erregerspektrum der Tonsillitis (1)
- Erste Hilfe (1)
- Erste-Hilfe-Kurs (1)
- Erythrophagocytosis (1)
- Erythropoetin (1)
- Erythrozytenkonzentrat (1)
- Erythrozytentransfusion (1)
- Estimated glomerular filtration rate (1)
- Estimation of height and sex determination (1)
- Etanercept (1)
- Eugenik (1)
- Eukaryotic sRNA (1)
- Europe (1)
- Euthanasie (1)
- Euthanasie <Nationalsozialismus> (1)
- Euthymic phase (1)
- Evaluation (1)
- Event related potentials (1)
- Event-related potential (1)
- Evidence based medicine (1)
- Evidence-based dentistry (1)
- Evidence-based drug discovery (1)
- Evidenzbasiert (1)
- Evidenzbasierte Medizin (1)
- Evidenzbasierung (1)
- Ewing sarcoma (1)
- Ewing-like (1)
- Exemestane (1)
- Exercise challenge (1)
- Exercise training (1)
- Exercise-induced asthma (1)
- Exertional angina and myocardial perfusion (1)
- Exhaled nitric oxide (1)
- Exoscope (1)
- Exosomal cytokines (1)
- Expansion (1)
- Expectation violation (1)
- Expert Systems (1)
- Expertensysteme (1)
- Explicit (1)
- External beam radiotherapy (1)
- Extracellular matrix proteins (1)
- Extracorporeal devices (1)
- Extracorporeal membrane oxygenation (1)
- Extraprostatic (1)
- Exudates and transudates (1)
- Eye diseases (1)
- EyesiNet (1)
- Ezrin (1)
- F4/80 (1)
- FABP (1)
- FAM134 (1)
- FAP (1)
- FAPI PET (1)
- FBK-R23 (1)
- FDG-PET/CT (1)
- FDM (1)
- FECD (1)
- FEV1 (1)
- FF-ATP synthase dimer (1)
- FFF (1)
- FFP3 respirator (1)
- FFPE (1)
- FGFR (1)
- FHIR Search (1)
- FIH1 (1)
- FOXO1 (1)
- FOXO3 (1)
- FPR (1)
- FSME-Virus (1)
- FTMT (1)
- FXR (1)
- Face masks (1)
- Facial nerve (1)
- FactorXIII Val34Leu polymorphism (1)
- Faktor V Leiden Mutation (1)
- Faktor XIII Val34Leu Polymorphismus (1)
- Faktorstruktur (1)
- Fall (1)
- Fall Leipzig (Kind Knauer) (1)
- Falls (1)
- Famines (1)
- Farbmuster (1)
- Fasciculus arcuatus (1)
- Fast Healthcare Interoperability Resources (1)
- Fatigue (1)
- Feasibility (1)
- Feasibility studies (1)
- Feinstaub (1)
- Female subjects (1)
- Fendrr (1)
- Ferritinophagy (1)
- Ferroptosis (1)
- Fertigkeit (1)
- Fertility counseling (1)
- Fertilität (1)
- Fertilité (1)
- Fetal heart (1)
- Fettleber (1)
- FibroMax (1)
- Fibroblast (1)
- Fibrous dysplasia (1)
- Field of View (1)
- Field study (1)
- Filariasis (1)
- Filariosis (1)
- Filgrastim (1)
- Filler (1)
- Filtermembranmethode (1)
- Finevo (1)
- Flaubert, Bouvard und Pécuchet (1)
- Flavin mononucleotide (1)
- Fluid overload (1)
- Fluid therapy (1)
- Fluorescence (1)
- Focal Adhesion Kinase (1)
- Focal onset seizure (1)
- Folgeerkrankungen (1)
- Follicular lymphoma (1)
- Follow-ups (1)
- Fondaparinux (1)
- Food and Drug Administration (1)
- Forced expiratory volume in 1 s (1)
- Forensic anthropology (1)
- Forensic examination (1)
- Forensic experts (1)
- Forensic osteology (1)
- Forensic pathology (1)
- Forensische Anthropologie (1)
- Forschung (1)
- Forschungspraxisnetz (1)
- Fracture (1)
- Fracture models (1)
- Fracture type (1)
- Fragebogen (1)
- Frameshift (1)
- Frankfurt am Main, Universität (1)
- Frankfurt am Main, Universitätsmedizin (1)
- Frankfurt, Anatomie (1)
- Frankfurt, Universität (1)
- Frankfurt, Universität, Seminar für Geschichte der Medizin (1)
- Frankfurt, Universitätsmedizin 1933-1945 (1)
- Frauen (1)
- Freie Atmung (1)
- Freud und die Psychoanalyse (1)
- Frontobasal (1)
- Fruit fly (1)
- Frühsommermeningoenzephalitis (1)
- Fuchs endothelial dystrophy (1)
- Fukushima (1)
- Functional characterization (1)
- Functional connectivity (1)
- Functional electrical stimulation (1)
- Functional outcomes (1)
- Fungemia/diagnosis (1)
- Fungämie/Diagnostik (1)
- Funktionelle Bildgebung (1)
- Further education (1)
- G-CSF (1)
- G207 (1)
- G2A (1)
- G3BP1 (1)
- GABA (1)
- GC–MS (1)
- GD2 (1)
- GDF11 (1)
- GFR (1)
- GIIb/IIIa-receptor (1)
- GLA deficiency (1)
- GMP (1)
- GPR4 (1)
- GRAND-SLAM (1)
- GSH (1)
- GTP cyclohydrolase (1)
- Gait analysis (1)
- Gallengangsstenose (1)
- Galvano (1)
- Ganglionic (1)
- Gan–Dou–Fu–Mu decoction (GDFMD) (1)
- Gastric adenoma (1)
- Gastric cancer (1)
- Gastric motility (1)
- Gastritis (1)
- Gastroenterology (1)
- Gastrointestinal (1)
- Gastrointestinal bleeding (1)
- Gaussian graphical models (1)
- Gefäßinflammation (1)
- Gefäßtonus (1)
- Gegenübertragung (1)
- Gehörlosigkeit (1)
- Gelastic seizures (1)
- Gelastische Anfälle (1)
- Genamplifikation (1)
- Gender (1)
- Gender Gap (1)
- Gender reassigning surgery (1)
- Gene (1)
- Gene ontology (1)
- Gene sequencing (1)
- Gene therapy (1)
- Gene-Amplification (1)
- Gene/Regulation (1)
- General Practitioner (1)
- General practice (1)
- Generalized procrustes analysis (1)
- Generation of reports on special findings in laboratory medicine (1)
- Genetic heart disease (1)
- Genetic loci (1)
- Genetic networks (1)
- Genetic syndromes (1)
- Genetic techniques (1)
- Genome editing (1)
- Genome-wide association study (1)
- Genomic medicine (1)
- Genu valgum (1)
- Geographical disparities (1)
- Gerinnungsfaktor XIII (1)
- German Society of Surgery (1)
- Gerontologic legal medicine (1)
- Gerontologische Rechtsmedizin (1)
- Gesamteiweißbestimmung im Harn (1)
- Geschichte 1914-2014 (1)
- Geschichte 1933-1945 (1)
- Geschichte 1938 (1)
- Geschichte der Medizin Frankfurt (1)
- Geschlechterdisparitäten (1)
- Gesprächsführung (1)
- Gestagen-Monopräparate (1)
- Gestationshyperthyreose (1)
- Gesundheitskommunikation (1)
- Gesundheitspersonal (1)
- Gesundheitspolitische Zuständigkeit (1)
- Gesundheitsversorgungseinrichtungen (1)
- Gezielte Therapie (1)
- Giftgas (Lost) (1)
- Glabella (1)
- Glaucoma (1)
- Gleason Grade Group (1)
- Gleason Grade group (1)
- Gleason grade group (1)
- Glia Maturation Factor (1)
- Glioblastoma survival (1)
- Global networking (1)
- Global warming (1)
- Glomerulosclerosis (1)
- Glyceraldehyde-3 Phosphate Dehydrogenase (1)
- Glyceraldehyde-3-phosphate Dehydrogenase (1)
- Glycolysis (1)
- Goldstein, Kurt (1)
- Gradient boosting (1)
- Grading (1)
- Graft (1)
- Graft quality (1)
- Gram-negative bacteria (1)
- Granulocytes (1)
- Graph theory (1)
- Graphical LASSO (1)
- Graves’ disease (1)
- Gravimetric method (1)
- Green Tobacco Sickness (GTS) (1)
- Green arboreal alligator lizard (1)
- Greenhouse effect (1)
- Groin pain (1)
- Grossesse (1)
- Guidance (1)
- Guide profession (1)
- Guided bone regeneration (GBR) (1)
- Guided tissue regeneration (GTR) (1)
- Guideline-based treatment (1)
- Guidelines (1)
- Guiding growth (1)
- Gut (1)
- Gut bacteria (1)
- GvL (1)
- Görden, Anstalt (1)
- Güntz, Eduard (1)
- Gütt, Arthur (1)
- HADS (1)
- HAE (1)
- HARS2 (1)
- HCC marker (1)
- HCMV (1)
- HCV-Core-Antigen (1)
- HDAC and BET inhibitor (1)
- HDAC inhibition (1)
- HDAC4 (1)
- HDR-Brachytherapie (1)
- HDR-brachytherapy (1)
- HEOR (1)
- HER2 (1)
- HEUS (1)
- HHUSD (1)
- HHV-8 (1)
- HIF (1)
- HIF-1α (1)
- HIF-2 (1)
- HIF-2α (1)
- HIF-2α, erythropoietin (1)
- HIPPO signalling (1)
- HIT (1)
- HIV protease inhibitors (1)
- HIV-1 Genotypisierung (1)
- HIV-1 genotyping (1)
- HIV-Antigen-Test (1)
- HIV-Antikörper (1)
- HIV-Infektion (1)
- HIV-Infektionen (1)
- HIV-antibodies (1)
- HIV-infection (1)
- HLA antibodies (1)
- HLHS (1)
- HNO (1)
- HNPCC (1)
- HOLEP (1)
- HOSO (1)
- HOTAIR (1)
- HPO (1)
- HPV infection (1)
- HPV-positive OPSCC (1)
- HRCT (1)
- HRM (1)
- HRV (1)
- HSC (1)
- HSCT (1)
- HSP (hereditary spastic paraplegia) (1)
- HSV type specific antibodies (1)
- HSV-1 (1)
- HSV-typenspezifische Antikörper (1)
- HT22 neurons (1)
- HVPG (1)
- Hadamar (1)
- Haematocrit (1)
- Haematologic diseases (1)
- Haemodialysis (1)
- Haemophilia (1)
- Haemophilie A (1)
- Half-of-the-Sites Reactivity (1)
- Halogenobenzimidazoles (1)
- Hals-Nasen-Ohren-Heilkunde (1)
- Handlungsanweisungen (1)
- Hard-tissue trauma (1)
- Hardware erosion (1)
- Harnsteinanalyse (1)
- Harnsteinkomponenten (1)
- Hausarztmangel (1)
- Hausarztpraxis (1)
- Hawaii Department of Health (1)
- HeLa cells (1)
- Head and neck cancer (1)
- Head bandage (1)
- Head neck cancer (1)
- Health Communication (1)
- Health care structures (1)
- Health care workers (1)
- Health facilities (1)
- Health personnel (1)
- Health policy (1)
- Health sciences (1)
- Health services (1)
- Health services research (1)
- Health surveys (1)
- Health technology assessment (1)
- Healthcare (1)
- Healthcare resource utilisation (1)
- Healthcare structure (1)
- Healthy Living Index (HLI) (1)
- Healthy men (1)
- Healthy stem cell donors (1)
- Health‑related quality of life (1)
- Heart defects (1)
- Heart rate (1)
- Heart transplantation (1)
- Heartrate (1)
- Heat Shock Protein (HSP) (1)
- Heat shock protein 27 (1)
- Heimtraining (1)
- Hematologic adverse events (1)
- Hematoma (1)
- Hematopoietic stem cell (1)
- Hematopoietic stem cell transplant (1)
- Hematotoxicity (1)
- Hemispheric specialization (1)
- Hemobilia (1)
- Hemodynamics (1)
- Hemosiderin (1)
- HepG2 Zellen (1)
- Heparan Sulfate (1)
- Heparin (1)
- Heparinsensitivität (1)
- Hepatectomy (1)
- Hepatic stellate cell (1)
- Hepatitis B Antibodies/serum (1)
- Hepatitis B Core-Antigene/Immunologie (1)
- Hepatitis B-Antikörper/Serum (1)
- Hepatitis B-Core-Antigens-immunology (1)
- Hepatitis C antibodies (1)
- Hepatitis C antigens (1)
- Hepatitis C-Virus (HCV) (1)
- Hepatitis C; DNA (1)
- Hepatitis G virus (1)
- Hepatitis G-Virus (1)
- Hepatitis, Chronic Active/diagnosis (1)
- Hepatoblastom (1)
- Hepatocellular Carcinoma (1)
- Hepatocellular carcinoma (HCC) (1)
- Herbal medicine (1)
- Herbalife products (1)
- Herbs induced liver injury (1)
- Hereditary angioedema (1)
- Hereditäre Thrombophilie (1)
- Herniated disk (1)
- Herpe-Viren (1)
- Herpes Simplex Virus/isolation and purification . (1)
- Herpes simplex Virus/Isolierung und Anreicherung (1)
- Herpes virus (1)
- Herpesvirus 1, Humanes (1)
- Herpesvirus 2, Human (1)
- Herpesvirus 2, Humanes (1)
- Herpesvirus1, Human (1)
- Herz-Kreislauffunktion (1)
- Herzchirurgie (1)
- Herzkatheteruntersuchung (1)
- Heterogeneity (1)
- Heterologous prime-boost (1)
- Heterotopic pregnancy (1)
- Hidradenitis suppurativa (1)
- Hierarchical drift-diffusion modeling (1)
- Hig1 (1)
- High altitude (1)
- High radon areas (1)
- High-risk prostate cancer (1)
- Highwire (1)
- Himalayas (1)
- Hip hemiarthroplasty (1)
- Hip revision (1)
- Hippocampal excitability (1)
- Hippokrates, Asteroid (1)
- Hirninfarkt (1)
- Hirnkrankheit (1)
- Hirnmetastasen (1)
- Hirschsprung disease (1)
- Hirt, August (1)
- Hispanic–Latino race/ethnicity (1)
- Histological analysis (1)
- Histology (1)
- Histonmethylierung (1)
- Hitachi 705 (1)
- HlV-Infections (1)
- Hochdurchsatz (1)
- Hodgkin lymphoma (1)
- Holmium laser enucleation (1)
- Home Care Services [MeSH] (1)
- Hometraining (1)
- Homicide (1)
- Homicide-suicide (1)
- Homizid-Suizid (1)
- Homogener Enzym Immunoassay (1)
- Homogenous enzymatic immunoassay (1)
- Honolulu Queen’s Medical Center (1)
- Hormonal (1)
- Hormone (1)
- Hormone receptor positive breast cancer (1)
- Hormonelle Kontrazeptiva (1)
- Hormones thyroïdiennes (1)
- Hornhauttransplantation (1)
- Hospital (1)
- Hospital case volume (1)
- HuR (1)
- Human Immunodeficiency Virus (1)
- Human chorionic villi mesenchymal stromal cells (1)
- Human pancreas (1)
- Human primary proximal tubular cells (1)
- Human retroelements (1)
- Human visual cortex (1)
- Hyaluronan (1)
- Hybrid Formation (1)
- Hydrocortison (1)
- Hydrocortisone (1)
- Hydrofluoric acid (1)
- Hydromineral (1)
- Hydroxyethyl starch (1)
- Hymenoptera venom allergy (1)
- Hyperactivity (1)
- Hyperlipidemia (1)
- Hyperlipidämie (1)
- Hyperscanning (1)
- Hypertensive disorders in pregnancy (1)
- Hyperthyroïdie gestationnelle (1)
- Hypokalzämie (1)
- Hypoparathyreoidismus (1)
- Hyposensibilisierung (1)
- Hypothyreose (1)
- Hypothyroïdie (1)
- Hypoxia inducible factor 1 alphal (1)
- Hypoxia-inducible factor-1α (HIF-1α) (1)
- Hämatotoxizität (1)
- Hämophile Arthropathie (1)
- Hämophilie (1)
- Händehygiene (1)
- Höchstrichterliche Rechtsprechung (1)
- IAP (1)
- IAP Proteins (1)
- IAP-IAP (1)
- ICAM-1 (1)
- ICD (1)
- ICG (1)
- ICH M13A draft guideline (1)
- ICL (1)
- ICL V4c (1)
- IDH mutation (1)
- IFN-β (1)
- IGF-1 (1)
- IGF1 (1)
- IL-17 (1)
- IL-17A (1)
- IL-1b (1)
- IL-1β (1)
- IL-33 (1)
- IL-38 (1)
- INR (1)
- IOL scleral Fixation (1)
- IPSS (1)
- IR (1)
- IRF-3 (1)
- IRIS (1)
- ISO (1)
- ISRS (1)
- IVD (1)
- IVD directive (1)
- IVD-Richtlinie (1)
- IVUS (1)
- Iatrogen (1)
- Iatrogenic (1)
- Idelalisib (1)
- Identifier (1)
- Identifikation (1)
- Identifizierung von Katastrophenopfern (1)
- Idiopathische Dystonie (1)
- Ig (sub)class-specific antibody determination (1)
- Ig- (sub)klassen-spezifische Antikörperbestimmung (1)
- IgA deficiency (1)
- IgM/Immunologie (1)
- IgM/immunology (1)
- Ileostomy (1)
- Image processing (1)
- Imagery (1)
- Imdevimab (1)
- Immunbiology (1)
- Immunchemie (1)
- Immune Complexes (1)
- Immune checkpoint inhibitors (1)
- Immune complex vasculitis (1)
- Immune paralysis (1)
- Immune status (1)
- Immunfixations-Elektrophorese (1)
- Immunglobulinklassen und -subklassen (1)
- Immunity (1)
- Immunität <Medizin> (1)
- Immunitätsbeurteilung (1)
- Immunkomplexe (1)
- Immunmodulation (1)
- Immunnephelometrie (1)
- Immunoassay (1)
- Immunodeficiency (1)
- Immunofluoreszenz (1)
- Immunogenetics (1)
- Immunoglobulin classes and -subclasses (1)
- Immunoglobulins (1)
- Immunologie (1)
- Immunologie Methods (1)
- Immunomodulatory agents (1)
- Immunonephelometry (1)
- Immunophenotyping (1)
- Immunoseneszenz (1)
- Immunoturbidimetry (1)
- Immuno‑histochemistry (1)
- Impedanzaggregometrie (1)
- Impella (1)
- Impfkurs (1)
- Impfquoten (1)
- Implant osseointegration (1)
- Implantable cardioverter-defibrillator (1)
- Implantat (1)
- Implicit (1)
- Implicit Processing (1)
- Implicit Association Test (1)
- Implicit motives (1)
- Impoverishment (1)
- Impräzision (1)
- Impulse generator (1)
- Imrt (1)
- In vitro (1)
- In vivo (1)
- In vivo electrophysiology (1)
- In-ASK Studie (1)
- In-Hospital Emergencies (1)
- In-TIPS thrombosis (1)
- Inactivation (1)
- IncX (1)
- Incidence rate (1)
- Incidental prostate cancer (1)
- Incontinence (1)
- Indication for fertility preservation (1)
- Indirect costs (1)
- Indirect treatment comparison (ITC) (1)
- Individual differences (1)
- Individualized therapy (1)
- Indocyanine green (1)
- Indonesia (1)
- Inducible nitric oxide synthase (iNOS) (1)
- Induction therapy (1)
- Inequality (1)
- Infektionen (1)
- Infektionsserologie (1)
- Inferior vena cava thrombus (1)
- Infertilität (1)
- Inflammasome (1)
- Inflammatory bowel disease (1)
- Inflammatory fibroid polyp (1)
- Inflammatory pattern (1)
- Influenza vaccination (1)
- Information theory (1)
- Informationstheorie (1)
- Informiertheit (1)
- Infrared Raman (1)
- Infrarotspektroskopie (1)
- Inguinal hernia (1)
- Inguinal pain (1)
- Inherited arrhythmic syndrome (1)
- Injuries (1)
- Injury (1)
- Injury Severity Score (ISS) (1)
- Innate immunity (1)
- Inpatient hospital cases (1)
- Instructions for action (1)
- Insulin (1)
- Insulin resistance (1)
- Integrated Pulmonary Index (1)
- Integration (1)
- Integrative Network Analysis (1)
- Intensive care (1)
- Intensivpatient (1)
- Intention attribution (1)
- Interaction (1)
- Interaktionsdatenbanken (1)
- Interferon alpha (1)
- Interferon-free (1)
- Interferon-α (1)
- Interferon-λ, (1)
- Interferonfrei (1)
- Interleukin-10 (1)
- Interleukin-22 (1)
- Interleukin-36 (1)
- Intermediate-risk (1)
- International normalized ratio (1)
- Internet-based therapy (1)
- Interoperability (1)
- Interposition (1)
- Interpretation Bias (1)
- Interrater Reliability (1)
- Interraterreliabilität (1)
- Intersectoral care (1)
- Interstitial pneumonia (1)
- Intervention (1)
- Intervention development (1)
- Interventional oncological treatment (1)
- Intervertebral disc displacement (1)
- Interview (1)
- Interviews (1)
- Intestinal fistula (1)
- Intestinal metaplasia (1)
- Intimal-medial thickness (1)
- Intoxication (1)
- Intoxikation (1)
- Intraoperative blood salvage (1)
- Intraoperative procedure (1)
- Intraoperative test (1)
- Intravenous antibiotic therapy (1)
- Intravenous antiepileptics (1)
- Intravenous iron (1)
- Intravenöse Antiepileptika (1)
- Intrinsic Disorder (1)
- Intrinsic resistance (1)
- Intubation (1)
- Intubation anesthesia (1)
- Intubationsnarkose (1)
- Ionization State (1)
- Iridium-192 (1)
- Iron deficiency (1)
- Iron estimation (1)
- Ischemia (1)
- Ischemic stroke (1)
- Isocitrate dehydrogenase (1)
- Isoflurane (1)
- Isoforms (1)
- Isolierung (1)
- Isothermal amplification (1)
- Ixodes (1)
- Ixodes ricinus (1)
- JAK2V617F (1)
- JNK (1)
- Jaw (1)
- Jaw surgery (1)
- Job satisfaction (1)
- Joint actions (1)
- Joint loading (1)
- Jurkat (1)
- Jüdische Dozenten Frankfurt (1)
- K-homology RNA-binding domain (1)
- K3EDTA plasma sampling (1)
- KCCQ (1)
- KCNH2 (1)
- KCNQ1 (1)
- KLHL11 (1)
- KPS (1)
- KSHV epidemiology (1)
- KSHV, Epidemiologie (1)
- Kachexie (1)
- Kaiserschnitt (1)
- Kallestad QM 300 (1)
- Kallestad QM 30 (1)
- Kallikrein inhibitor (1)
- Kanzlei des Führers (1)
- Kapazitätsdefizit (1)
- Kapnographie (1)
- Kappa (1)
- Kardiovaskuläres Risiko (1)
- Karzinom (1)
- Katheterablation (1)
- Kava (1)
- Kava hepatotoxicity (1)
- Keap1-Nrf2 (1)
- Kephalometrie mit Magnetinduktion (1)
- Kephalometrie ohne Röntgenstrahlen (1)
- Keratoplastik (1)
- Ki-67 (1)
- Kidney diseases (1)
- Kidneys (1)
- Kinases (1)
- Kind (1)
- Kinder und Jugendliche (1)
- Kinderchirurgie (1)
- Kindes- und Jugendalter (1)
- Klinische Aufgabengebiete (1)
- Klinische Ergebnisse (1)
- Knee joint (1)
- Knee joint sound (1)
- Knee osteoarthritis (1)
- Knee surgery (1)
- Knees (1)
- Kniegelenkinfekt (1)
- Knieinfekt (1)
- Knochen (1)
- Knochenabbau (1)
- Knochenevaluation (1)
- Knochenmetastasen (1)
- Knochenstoffwechselerkrankungen (1)
- Koch, Richard (1)
- Kognitiv (1)
- Kognitive Beeinträchtigungen (1)
- Kommerzielle Immunglobuline (1)
- Komorbidität (1)
- Komplementbindungsreaktion (KBR) (1)
- Komplikation allogene Stammzelltransplantation (1)
- Komplikationsrate (1)
- Komprimierte Abtastung (1)
- Konformitätsbewertung (1)
- Konsens (1)
- Kontaktallergie (1)
- Kontrazeption (1)
- Konusprothese (1)
- Konversion (1)
- Koronare Herzkrankheit (1)
- Kortikale Dicke (1)
- Kortikotrope Achse (1)
- Krankenhausfallaufkommen (1)
- Krankenversicherung (1)
- Krankheitskosten (1)
- Kreatinin (1)
- Krebs (1)
- Krebststammzelle (1)
- Kupfer (1)
- Kutner, Luis (1)
- Körperbild (1)
- Körpergrößenschätzung, Geschlechtsdiskrimination (1)
- Körperliche Aktivität (1)
- Körpermaße (1)
- Körpermodifizierung (1)
- L1-norm SVM (1)
- LAMTOR1 (1)
- LARS2 (1)
- LASS (1)
- LC-MS-Based Clinical Research (1)
- LC-MS-based lipid mediator analysis (1)
- LCD-Array (1)
- LD 2 Ringe (1)
- LD 2 rings (1)
- LDHB (1)
- LEOSS (1)
- LPS (1)
- LQTS (1)
- LSCC (1)
- LSD1 (1)
- LSEC (1)
- LU-102 (1)
- Labordiagnose (1)
- Labormedizinische Spezialbefundung (1)
- Labororganisation (1)
- Laborpersonal (1)
- Lacunar (1)
- Lagerungsbedingungen (1)
- Lakunär (1)
- Laminin (1)
- LanCL2 (1)
- Landarztprogramm (1)
- Landmark (1)
- Langstreckige Knochendefekte (1)
- Language delay (1)
- Langzeiteffekt (1)
- Laparoskopie (1)
- Large vessel occlusion (1)
- Laryngeal Tube (1)
- Laser interstitial thermal therapy (1)
- Lasers (1)
- Lateral flow antigen testing (1)
- Lateral flow immunoassay (1)
- Laufökonomie (1)
- Learning and memory (1)
- Lebenslimitierende Erkrankungen (1)
- Leberkrebs (1)
- Lebertransplantation (1)
- Leberzirrhose (1)
- Lee type, functional outcome (1)
- Lee-type (1)
- Left atrial appendage closure (1)
- Leg axis (1)
- Legal considerations (1)
- Legal medicine (1)
- Legionella pneumophila (1)
- Lehre im klinischen Alltag (1)
- Lehrforschung (1)
- Lehrveranstaltungsevaluation (1)
- Lehrvideos (1)
- Leichenschauschein (1)
- Leigh syndrome (1)
- Leipzig (1)
- Leipzig, Universitätskinderklinik (1)
- Leishmaniasis (1)
- Leistungsfähigkeit (1)
- Leitliniengerechte Behandlung (1)
- Leksell (1)
- Lemperle (1)
- Lennox-Gastaut syndrome (1)
- Lennox–Gastaut syndrome (1)
- Lernzuwachs (1)
- Leukaemic Cells (1)
- Leukemia (1)
- Leukocyte depletion filter (1)
- Leukozyt (1)
- Life-limiting conditions (1)
- Lifestyle (1)
- Ligand post-insertion (1)
- Limitation of therapy (1)
- Lipedema (1)
- Lipemia (1)
- Lipid Transition Temperature (1)
- Lipid peroxidation (1)
- Lipid solution (1)
- Lipocalin-2 (1)
- Lipoprotein(a)/Analytik (1)
- Lipoprotein(a)/analysis (1)
- Liposuction (1)
- Lippen-Kiefer-Gaumenspalte (1)
- Lipämie (1)
- Liquor cerebrospinalis (1)
- Liquordiagnostik (1)
- Liver (1)
- Liver Fibrosis (1)
- Liver Transplantation (1)
- Liver biopsy (1)
- Liver cancer (1)
- Liver disease (1)
- Liver fibrosis (1)
- Liver histology (1)
- Liver injury (1)
- Loa loa (1)
- Local field potential (1)
- Lockdown (1)
- Lokales IgE (1)
- Long QT syndrome (1)
- Long interspersed nuclear elements (LINE) (1)
- Long non-coding RNA (1)
- Long non-coding RNAs (1)
- Long noncoding RNA (1)
- Long-term continence (1)
- Long-term effect (1)
- Long-term follow-up (1)
- Long-term results (1)
- Long-term-measurements (1)
- Longchain polyunsaturated fatty acids (1)
- Low grade glioma (1)
- Low-dose radiation therapy (1)
- Low-virulent infection (1)
- Lower limb deformities (1)
- Lp(a)-Lipoproteinbestimmungen (1)
- Lp(a)-lipoprotein determinations (1)
- Lumbar Disk Degeneration (1)
- Luminex (1)
- Lung Neoplasms/serum (1)
- Lung cancer (1)
- Lung development (1)
- Lung function (1)
- Lung neoplasms (1)
- Lung ultrasound (1)
- Lungenneoplasma/Serum (1)
- Lyme Disease (1)
- Lyme borreliosis (1)
- Lyme disease (1)
- Lyme-Borreliose (1)
- Lymphangiectasia (1)
- Lymphocyte subpopulations (1)
- Lymphom (1)
- Lymphoma (1)
- Lymphoma Cells (1)
- Lymphopenia Mortality (1)
- Lymphozyt (1)
- Lysophosphatidic acids (1)
- Ländlicher Raum (1)
- M. Intracellulare (1)
- M. avium (1)
- M. avium complex (1)
- M. chimaera (1)
- MAP Kinases (MAPKs) (1)
- MAP kinase (1)
- MCH (1)
- MDD (1)
- MEIS (1)
- MEIS homeodomain protein (1)
- MEK inhibitor (1)
- MEN1 (1)
- MFA (1)
- MGMT (1)
- MGMT promoter (1)
- MID task (1)
- ML-IAP (1)
- MLH1 (1)
- MLKL (1)
- MMPs (1)
- MN1 (1)
- MR spectroscopy (1)
- MRI-negative epilepsy (1)
- MRT (1)
- MS (1)
- MSC (1)
- MT: Non-coding RNAs (1)
- MTHFR-Mutation (1)
- MTHFR-mutation (1)
- MTL30 (1)
- MTOR inhibitor (1)
- MTRasym (1)
- MTT assay (1)
- MUTARS® RS Cup (1)
- MUTARS® RS Cup System (1)
- MUTARS® RS cup system (1)
- MVPA (1)
- MYC (1)
- MYCBP2 (1)
- MYCN amplification (1)
- Machine Learning (1)
- Macrophage (1)
- Magnet dislocation (1)
- Magnetic resonance (1)
- Magnetic resonance Imaging (1)
- Magnetresonanztomographie (1)
- Maintenance therapy (1)
- Major Depressive Disorder (1)
- Malaria (1)
- Malate Dehydrogenases (1)
- Malignancy (1)
- Malignant meningioma (1)
- Mammakarzinom (1)
- Management (1)
- Manchester scar scale (1)
- Mandatory Vaccinations (1)
- Mandibula (1)
- Mandibular gland (1)
- Mandibular gland proteomics (1)
- Mangel (1)
- Manner of death (1)
- Manuelle Lymphdrainage (1)
- Marburg virus (1)
- Marginal integrity (1)
- Masking effect (1)
- Masquelet technique (1)
- Mass disaster (1)
- Massenkatastrophe (1)
- Massenspektrometrie (1)
- Mastectomy (1)
- Master Plan 2020 (1)
- Masterabschluss (1)
- Masterplan 2020 (1)
- Master’s degree (1)
- Mastoiditis (1)
- Matching-adjusted indirect comparison (MAIC) (1)
- Materials science (1)
- Maternal separation (1)
- Mathematical biosciences (1)
- Mathematical functions (1)
- Maxillofacial reconstruction (1)
- Maxillofacial surgery (1)
- Maxillofacial trauma (1)
- Mean erythrocyte volume (1)
- Mechanical ventilation (1)
- Mechanism of action (1)
- Median nerve (1)
- Medical Oncology (1)
- Medical Physics: Diagnostic (1)
- Medical education (1)
- Medical examiner (1)
- Medical history (1)
- Medical law (1)
- Medical studies (1)
- Medical study (1)
- Medikamente (1)
- Medikamente Handlungsanweisungen (1)
- Medizin (1)
- Medizingeschichte, Lehrbuch (1)
- Medizinische Ausbildung (1)
- Medizinisches Personal (1)
- Medizinkritik in der Literatur (1)
- Medizinrecht (1)
- Medizinstudenten 1968 (1)
- Meersseman test (1)
- Membrane proteins (1)
- Membrane-Phloretin Interaction (1)
- Mengele, Josef (1)
- Meningioma (1)
- Menschenversuche, verbrecherische (1)
- Mental disorder (1)
- Mental health and psychiatry (1)
- Mental health therapies (1)
- Meta-analysis (1)
- Metabolic (1)
- Metabolic dysfunction (1)
- Metabolic models (1)
- Metabolic syndrome (1)
- Metabolic vulnerabilities (1)
- Metabolism (1)
- Metabolomic profile (1)
- Metacognition (1)
- Metal clip (1)
- Metalloproteinases (1)
- Metastasen (1)
- Metastasis (1)
- Metastasis-directed therapy (1)
- Metastatic (1)
- Metastatic castration-resistant prostate cancer (1)
- Metastatic renal cell carcinoma (1)
- Metformin (1)
- Methanol (1)
- Methicillin-resistant Staphylococcus aureus (1)
- Method validation (1)
- Methodenvergleich (1)
- Methods (1)
- Methylation (1)
- Methylmercury Containing Inactivator (1)
- Methylphenidate (1)
- Mexican alligator lizards (1)
- MiR-29 (1)
- MiSpEx-network (1)
- Michael acceptor (1)
- Micro computed tomography (1)
- MicroRNAs (1)
- Microbiology and Infectious Disease (1)
- Microbiology, Virology & Host Pathogen Interaction (1)
- Microbiome (1)
- Microenvironment (1)
- Microfilaremia (1)
- Microgap (1)
- Microglia (1)
- Microparticles (1)
- Microplastic (1)
- Microstates (1)
- Microstructural impairment (1)
- Mid-intestinal bleeding (1)
- Migrant health (1)
- Mikroangiopathie (1)
- Mikroneutralisationstest (1)
- Mikropartikel (1)
- Mikrovesikel (1)
- Mikrowellenablation (1)
- Mild chronic inflammation (1)
- Mild hypoxia (1)
- Mindestmengen (1)
- Mindfulness (1)
- Mineralization (1)
- Mineralocorticoids (1)
- Mineralokortikoide (1)
- Mini-monovision (1)
- Minimal invasive dentistry (1)
- Minimal-invasiv (1)
- Minimally invasive (1)
- Minor injury (1)
- Mitochondrial Apoptosis (1)
- Mitochondrial Metabolism (1)
- Mitochondrial Permeability Transition (1)
- Mitochondrial ROS (1)
- Mitochondrial Transport (1)
- Mitochondrial and Cytoplasmic Malate Dehydrogenase (1)
- Mitochondrial complex I (1)
- Mitosis (1)
- Mitral regurgitation (1)
- Mitral valve (1)
- Mitralklappenrekonstruktion (1)
- Mixed Lipid Phases (1)
- Mixed hearing loss (1)
- Mmp12 (1)
- Mobilization (1)
- Model organisms (1)
- Moderne Medizin (1)
- Molecular Biology (1)
- Molecular Chaperone (1)
- Molecular diagnosis (1)
- Molecular diagnostics (1)
- Molecular glue (1)
- Molecular mimicry (1)
- Molecular subtypes (1)
- Moll, Albert (1)
- Molmassenverteilung (1)
- Monetary incentive delay (1)
- Mongolian spot (1)
- Monitoring (1)
- Monoacylglycerol lipase (1)
- Monoclonal antibody (mAb) (1)
- Monocyte gene expression (1)
- Monotherapie (1)
- Monozyten (1)
- Mood (1)
- Morbidity (1)
- Morbus Basedow (1)
- Morbus Cushing Syndrom (1)
- Morphologie (1)
- Mosquito (1)
- Mosquito crop (1)
- Mosquito-plant interaction (1)
- Motility (1)
- Motivation (1)
- Motivational situation (1)
- Motivationslage (1)
- Motor-cognitive (1)
- Mountain (1)
- Mouse (1)
- Mouse models (1)
- Multi-Omics (1)
- Multi-motive grid (1)
- Multi-stakeholder approach (1)
- Multi-syndrome classification (1)
- Multidrug-resistance (1)
- Multidrug-resistant organisms (1)
- Multiligament instability (1)
- Multimedication (1)
- Multimodal Modeling (1)
- Multimorbidität (1)
- Multiparametric MRI (1)
- Multiple Transport Systems (1)
- Multiple-indication review (1)
- Multiplex immunoassay (1)
- Multiresistente Erreger (1)
- Multisensorische Integrationsleistung (1)
- Multiset independent component analysis (1)
- Multivariate analysis (1)
- Mundhöhlenkarzinome (1)
- Muscle (1)
- Muscle analysis (1)
- Muscle damage (1)
- Muscle pain (1)
- Musculoskeletal abnormalities (1)
- Musculoskeletal mechanics (1)
- Musculoskeletal problems (1)
- Music (1)
- Mutations (1)
- Muttermilch (1)
- Myalgia (1)
- Mycobacteria (1)
- Mycobacterium avium complex (1)
- Mycophenolat Mofetil (1)
- Myiasis (1)
- Myocardial infarction (MI) (1)
- Myocardial injury (1)
- Myocardial perfusion (1)
- Myocardial remodeling (1)
- Myopia (1)
- Müdigkeit (1)
- N-glycosylation (1)
- N471D strumpellin knock-in mice (1)
- N501Y (1)
- NAD + Analogues (1)
- NAD Analogs (1)
- NAD+-Analogs (1)
- NADP+ Analogues (1)
- NAD⊕-Isomer (1)
- NAPS (1)
- NAT (1)
- NCOA4 (1)
- NDM (1)
- NET (1)
- NF-kB (1)
- NF-κB pathway (1)
- NFkB (1)
- NFκB (1)
- NGS sequencing (1)
- NIRS (1)
- NIS (1)
- NK Receptor (1)
- NK cell (1)
- NK cell subsets (1)
- NK-92 (1)
- NK-ZELL-BASIERTER IMMUNTHERAPIE (1)
- NK-ZELLEN (1)
- NLPHL (1)
- NLRP3 inflammasomes (1)
- NMOSD (1)
- NO (1)
- NOD (1)
- NOS-I (1)
- NOS1AP (1)
- NR4A2 (1)
- NR4A3 (1)
- NS-Kindereuthanasie (1)
- NS3/4A-Protease (1)
- NSBB (1)
- NTDs (1)
- NTM (1)
- NURF (1)
- NVBP (1)
- Nachteile (1)
- Nachtschattengewächs (1)
- Nachwuchsmangel (1)
- Nackenschmerzen (1)
- Nanoplastic (1)
- Natural Killer (NK) Cell (1)
- Natural killer cells (1)
- Nd:YAG laser capsulotomy (1)
- Nebennierenrinden-Adenom (1)
- Nebennierenrinden-Hyperplasie (1)
- Neck pain (1)
- Necroptosis (1)
- Necrosis (Necrotic Death) (1)
- Necrotizing enterocolitis (1)
- Needs Assessment [MeSH] (1)
- Negative appendectomy rate (1)
- Neglected tropical diseases (1)
- Negligence (1)
- Nek1 (1)
- Neoadjuvant systemic therapy (1)
- Neoadjuvant treatment (1)
- Neonatal surgery outcome (1)
- Neonatologie (1)
- Neoplasm staging (1)
- Nephelometrie und Turbidimetrie (1)
- Nephelometry and Turbidimetry (1)
- Nephrectomy (1)
- Nephropathie (1)
- Nervenkrankheit (1)
- Netzhaut (1)
- Neugeborene (1)
- Neural coding (1)
- Neural goal function (1)
- Neural stem cells (1)
- NeuroSAFE (1)
- Neuroblastom, SAMHD1, Chemoresistenz (1)
- Neurochirurgie (1)
- Neurodegenerative syndromes (1)
- Neurodevelopmental disorder (1)
- Neuroendocrine tumor (1)
- Neuroepithelial (1)
- Neuroepithelial tumor (1)
- Neurofeedback (1)
- Neurofilament light chain (1)
- Neurofilament light chains (1)
- Neurofilament-Leichtketten (1)
- Neuroligins (1)
- Neurologie (1)
- Neurologiegeschichte (1)
- Neuromodulatorisches Netzwerk (1)
- Neuromodulatory network (1)
- Neuromuscular exercise (1)
- Neuron-Specific Enolase/serum (1)
- Neuron-spezifische Enolase/Serum (1)
- Neuronales Netzwerk (1)
- Neuronspecific Enolase (1)
- Neuronspezifische-Enolase (1)
- Neurooncology (1)
- Neuropathie (1)
- Neuropathologie (1)
- Neuropilin (1)
- Neuropsychiatric disorders (1)
- Neuropsychiatrie (1)
- Neurostimulation (1)
- Neurosurgery (1)
- Neurotoxicity (1)
- Neurovascular damage (1)
- Neurovascular lesion (1)
- Nevus of Ito (1)
- Nevus of Ota (1)
- New E3-ligase ligands (1)
- NfL (1)
- Niche (1)
- Nicht-allergische Rhinitis (1)
- Nichtversicherung (1)
- Nicotine (1)
- Nicotine (Nicotiana tabacum/ Nicotiana rustica) (1)
- Nicotinic acetylcholine receptors (1)
- Nierendosimetrie (1)
- Nierentubulusepithelzellen (1)
- Nikotin (Nicotiana tabacum/ Nicotiana rustica) (1)
- Nikotinerge Acetylcholinrezeptoren (1)
- Nitric oxide (1)
- Nkx2-5 (1)
- Non-Hodgkin lymphoma (1)
- Non-abusive head trauma (NAHT) (1)
- Non-apoptotic functions (1)
- Non-cylindrical folds (1)
- Non-diffractive EDOF-IOL (1)
- Non-expert MRI (1)
- Non-small cell lung cancer (1)
- Non-tuberculous mycobacteria (1)
- Non-vitamin K antagonist oral anticoagulants (1)
- Nonaerosolizing treatment (1)
- Nonfermenter (1)
- Nonoperative management (1)
- Nonpenetrating (1)
- Nontuberculous mycobacteria (1)
- Noradrenergic (1)
- Norepinephrine (1)
- Normative modeling (1)
- Notch signaling (1)
- Notfallausweis (1)
- Notfallmedizin (1)
- Notfallversorgung (1)
- Nox (1)
- Nox inhibition (1)
- Nox4 (1)
- Nrf-2 (1)
- Nucleotide Triphosphate Analogue (1)
- Nuklearmedizin (1)
- Nukleinsäure-Amplifikations Testung (NAT) (1)
- Nukleinsäure-Amplifikationstechnik (NAT) (1)
- Nukleinsäureamplifikationstest (NAT) (1)
- Null responder (1)
- Number of platelets (1)
- Nursing (1)
- Nutrition (1)
- OA (1)
- OCT (1)
- OGR1 (1)
- OHIP-G14 (1)
- OHRQoL (1)
- OP capacity (1)
- OP-Kapazität (1)
- ORL (1)
- ORP (1)
- OSA (1)
- OSPE (1)
- OTSC Proctology (1)
- OTU domain-containing protein 7B (OTUD7B) (1)
- OXA-23 (1)
- OXA-484 (1)
- OXA-58 (1)
- OXPHOS (1)
- Obduktion (1)
- Oberflächenantigen-Mutante (1)
- Observational (1)
- Obsessive-compulsive disorder (1)
- Obstetrics and gynecology (1)
- Occlusion (1)
- Occlusion treatment (1)
- Occupational disease (1)
- Occupational reintegration management (1)
- Occupationally acquired infection (1)
- Oceanic boundlessness (1)
- Ocular trauma (1)
- Ocular tuberculosis (1)
- Office work (1)
- Ohrenheilkunde (1)
- Ohrenkrankheit (1)
- Older adult (1)
- Older patient (1)
- Older patients (1)
- Olfactory groove meningioma (1)
- Olfactory system (1)
- Oligodendroglioma (1)
- Oligometastatic (1)
- Omega lipids (1)
- Omicron variant BA.1 (1)
- Omphalocele (1)
- Omphalozele (1)
- Oncogenes (1)
- One-leg stand (1)
- Onkogene (1)
- Onkomodulation (1)
- Online Survey (1)
- Online education (1)
- Online-Magazin (1)
- Online-Umfrage (1)
- Open Science (1)
- Open pulmonary tuberculosis (1)
- Ophthalmoplegia (1)
- Opinion (1)
- Opioid system (1)
- Opioids (1)
- Opportunistic infections (1)
- Opsoclonus-myoclonus syndrome (1)
- Oral and maxillofacial surgery (1)
- Oral anticoagulation (1)
- Oral cancer (1)
- Oral food challenge (1)
- Oral immunotherapy (OIT) (1)
- Oral therapy (1)
- Orale Antikoagulanzien (1)
- Orbital fracture (1)
- Orexin (1)
- Organ failure (1)
- Organ injury (1)
- Organ preservation (1)
- Organ-confined (1)
- Orthodontic tooth movement (1)
- Orthopaedics (1)
- Oscillating saws (1)
- Ossifying fibroma (1)
- Osteoporose (1)
- Otorhinolaryngological (1)
- Otorhinolaryngology (1)
- Outcomes research (1)
- Outpatients (1)
- Ovarian cancer treatment (1)
- Ovarielle Reserve (1)
- Ovartoxizität (1)
- Over-the-scope clip (1)
- Overweight (1)
- Overwintering (1)
- Oxa1/YidC/Alb3 Membrane Insertases (1)
- Oxidative phosphorylation (1)
- OxyELITE Pro (1)
- Oxygen extraction fraction (1)
- P2X7 receptor (1)
- PAC-1 (1)
- PAD-test (1)
- PAM (1)
- PAPR (1)
- PATZ1 (1)
- PBBM (1)
- PBM (1)
- PBSC (1)
- PBX (1)
- PCA (1)
- PD-1 (1)
- PDPK1 (1)
- PFOA (1)
- PFOS (1)
- PGC-1α (1)
- PHGDH (1)
- PHR1 (1)
- PI3K (1)
- PI3K inhibitor (1)
- PI3K/mTor inhibition (1)
- PKCδ (1)
- PLAGL1 (1)
- PMA (1)
- PMI (1)
- PML (1)
- PMMA (1)
- POCT (1)
- POR (1)
- PPAR (1)
- PPAR-γ (1)
- PPTC7 (1)
- PRG5 (1)
- PRNT (1)
- PROTAC (1)
- PRRT (1)
- PSA screening (1)
- PSA-Screening (1)
- PTEN (1)
- PTEN inducible kinase 1 (1)
- PTM (1)
- PTSD (1)
- PV loop (1)
- PWI (1)
- PacBio SMRT sequencing (1)
- Pacemaker (1)
- Paediatric cancer (1)
- Paediatric trauma patients (1)
- Pain management (1)
- Pain prevalence (1)
- Pain scale MWA (1)
- Palacos reaction (1)
- Palliative Care [MeSH] (1)
- Palmitoylethanolamid (1)
- Pancreatic neuroendocrine tumor (1)
- Papillon-Lefèvre syndrome (1)
- Paracelsus, Asteroid (1)
- Paracoccus denitrificans (1)
- Paramyxoviridae (1)
- Paraneoplastic neurological syndromes (1)
- Parasympathetic (1)
- Parcellation (1)
- Parenteral nutrition (1)
- Parkinson's disease (1)
- Parodontitis (1)
- Parodontitistherapie (1)
- Particle load reduction (1)
- Particle number size distribution (1)
- Particle size distribution (1)
- Particle toxicity (1)
- Particulate matter (1)
- Particulates (1)
- Passivrauch (1)
- Pathogenicity (1)
- Pathogens (1)
- Pathology (1)
- Pathophysiology (1)
- Patient Blood Management (1)
- Patient Blood Management (PBM) (1)
- Patient Outcome Assessment [MeSH] (1)
- Patient Reported Outcome Measures [MeSH] (1)
- Patient and public Involvement (1)
- Patient care (1)
- Patient manikins (1)
- Patient outcome assessment (1)
- Patient participation (1)
- Patient perspective (1)
- Patient portals (1)
- Patient preference (1)
- Patienten (1)
- Patientenaufklärung (1)
- Patientenportale (1)
- Patientenverfügung (1)
- Pedagogue (1)
- Pediatric fracture (1)
- Pediatric oncology (1)
- Pediatric orthopedic (1)
- Pediatric stem cell transplantation (1)
- Pediatric surgery (1)
- Pelargonium sidoides questionable hepatotoxicity (1)
- Pelvic (1)
- Pentaglobin (1)
- Pentose Pathway (1)
- Per1−/−-mice (1)
- Perceived stigma (1)
- Percutaneous endoscopic gastrostomy (1)
- Percutaneous pinning (1)
- Percutaneous ultrasound (1)
- Performance (1)
- Peri-implant disease (1)
- Perifolliculitis capitis abscedens et suffodiens (1)
- Perinatalzentren (1)
- Periodic (1)
- Periodontal therapy (1)
- Periodontal trauma (1)
- Periodontitis (1)
- Periodontitis grades B and C (1)
- Peripheral arterial occlusive disease (1)
- Peripheral blood smears (1)
- Periphere arterielle Verschlusskrankheit (1)
- Periprocedural anticoagulation (1)
- Peritoneal macrophages (1)
- Peritumoural oedema (1)
- Peri‑implantitis (1)
- Peroxidase (1)
- Perrault syndrome (1)
- Persistence SARS-CoV-2 antibodies (1)
- Persistent organic pollutants (1)
- Persistierender Ductus arteriosus (1)
- Personal medicine (1)
- Personal protective equipment (1)
- Personal stigma (1)
- Personalbelastung (1)
- Personalisierte translationale Therapie (1)
- Personality inventory (1)
- Personalized Medicine (1)
- Personalized medicine (1)
- Personalmangel (1)
- Personnel shortage (1)
- Perspective forum (1)
- Perspektivforum (1)
- Pertussis (1)
- Petri net (1)
- Peutz–Jeghers syndrome (1)
- Pflege (1)
- Phakic (1)
- Phalangeal fractures (1)
- Phantoms (imaging) (1)
- Pharmacokinetics (1)
- Pharmacotherapy (1)
- Pharmacovigilance (1)
- Pharmaka (1)
- Phase 3 (1)
- Phase 3 trial (1)
- Phase I clinical trial (1)
- Phase-Proteine (1)
- Phase-reset (1)
- Phenotypic plasticity (1)
- Phenylketonuria (PKU) (1)
- Philadelphia chromosome-positive acute leukemia (1)
- Philemon and Baucis (1)
- Philemon und Baucis (1)
- Phlyctenule (1)
- Phosphohydrolases (1)
- Phospholipasen A2 (1)
- Phosphopyruvate Hydratase/serum (1)
- Phosphopyruvathydratase/Serum (1)
- Photoaffinity Labeling (1)
- Physical and mental health (1)
- Physical comorbidities (1)
- Physical self-perception (1)
- Physics (1)
- Physiologie (1)
- Physiotherapy (1)
- Pindar, Pythische Ode III (1)
- Pinhole IOL (1)
- Piriform cortex (1)
- Placental organoids (1)
- Plantagearbeiter (1)
- Plantation workers (1)
- Plasma (1)
- Plasma proteins (1)
- Plasmapheresis (1)
- Plasmapools (1)
- Plasmaprotein analyzer (1)
- Plasmaproteinanalysensysteme (1)
- Plasmaproteinbestimmung im Harn (1)
- Plasmaproteine (1)
- Plasmapräparate (1)
- Plastic pollution (1)
- Plastics (1)
- Plastikstent (1)
- Platelets (1)
- Plausibilität (1)
- Play (1)
- Pleasure (1)
- Pneumocystis jirovecii (1)
- Podospora anserina (1)
- Poe, Der wahre Sachverhalt im Falle Valdemar (1)
- Point of care (1)
- Point-of-Care Testing (POCT) (1)
- Point-of-care wound diagnostics (1)
- Polarisierung (1)
- Police (1)
- Polioviren (1)
- Polizei (1)
- Poly-Pore (1)
- Polygenic risk score (1)
- Polymerase Chain Reaction (1)
- Polymerase Kettenreaktion (PCR) (1)
- Polymerasekettenreaktion (1)
- Polymorphismen (1)
- Polyposis syndrome (1)
- Polyunsaturated fatty acid mediators (1)
- Polyunsaturated fatty acids (1)
- Ponatinib (1)
- Population dynamics (1)
- Portal veins (1)
- Portuguese population (1)
- Post mortem examination (1)
- Post mortem interval (1)
- Post-cesarean (1)
- Post-mortem genetic screening (1)
- Post-offence drinking (1)
- Post-processing (1)
- Post-thaw recovery (1)
- Post-traumatic stress disorder (1)
- Posterior cruciate ligament (1)
- Postmortem (1)
- Postmortem interval (1)
- Postoperative Complications (1)
- Postoperative anatomy (1)
- Posttraumatic stress disorder (1)
- Postural sway (1)
- Posture analysis (1)
- Postvention (1)
- Potassium iodide (1)
- Poverty (1)
- Powered air-purifying respirator (1)
- Practice-based Research Network (1)
- Praeklampsie (1)
- Praktische Lehre (1)
- Praktisches Jahr (1)
- Pre-operative radiotherapy (1)
- Precision medicine (1)
- Prediction (1)
- Prediction of locoregional recurrence (1)
- Predictive Modeling (1)
- Predictive model (1)
- Predictive processing (1)
- Predictors (1)
- Predominant polarity (1)
- Preeclampsia (1)
- Presbyopia (1)
- Pressure distribution (1)
- Pressure measuring plate (1)
- Primary Care Research Network (1)
- Primary care (1)
- Primary cilium (1)
- Primary molars (1)
- Primärversorgung (1)
- Principal component analysis (1)
- Prisoners (1)
- Prisons (1)
- Pro.M.D. (1)
- Probability density (1)
- Probability distribution (1)
- Probenidentifikation (1)
- Procedural skills (1)
- Professional dancers (1)
- Professioneller Fußball (1)
- Profi-Tänzer*innen (1)
- Proficiency testing (1)
- Progestatifs synthétiques (1)
- Prognose (1)
- Prognostic markers (1)
- Prognostic models (1)
- Prognostische Marker (1)
- Progranulin (1)
- Projekte Seltene Erkrankungen (1)
- Promoters (1)
- Propensity score matching (1)
- Propensity-Score Matching Analyse (1)
- Proposal (1)
- Propriozeption (1)
- Prostaglandine (1)
- Prostata-specific antigen (1)
- Prostate specific antigen (1)
- Prostatic specific antigen (1)
- Protease inhibitor therapy (1)
- Protein (1)
- Protein Domains (1)
- Protein Expression (1)
- Protein Folding (1)
- Protein Motifs (1)
- Protein Targeting (1)
- Protein Translocation (1)
- Protein interactions (1)
- Protein-Lipid Interaction (1)
- Protein-Protein Interactions (1)
- Protein-translocation (1)
- Proteinbestimmung (1)
- Proteinuria (1)
- Proteinurie (1)
- Proteomic analysis (1)
- Protestbewegung (1)
- Prothese (1)
- Prothrombinmutation (1)
- Protocol (1)
- Proton density (1)
- Proximal (1)
- Prä-B-Zellen (1)
- Prädiktive Validität (1)
- Präpulsinhibition (1)
- Präsenzdiagnostik (1)
- Prävalenz (1)
- Präzision und Richtigkeit (1)
- Pseudarthrosis (1)
- Pseudophakia (1)
- Pseudoprogression (1)
- Psoriatic arthritis (1)
- Psychiatric disorders (1)
- Psychiatric traits (1)
- Psychiatry (1)
- Psychoanalyse (1)
- Psychopharmaka (1)
- Psychophysics (1)
- Psychosomatik (1)
- Pteridine (1)
- Publikationen (1)
- Pulmonary edema (1)
- Pulmonary hypertension (1)
- Pulmonary hypoplasia (1)
- Pumpkin seeds (1)
- Purdue Pegboard (1)
- Pyogenic (1)
- Pyogenic spondylodiscitis (1)
- Pyruvate Kinase (1)
- Python (1)
- Pädagoge/in (1)
- Q80K (1)
- QT measurement (1)
- Qualifikationsmix (1)
- Qualitative Analyse (1)
- Qualitative Research [MeSH] (1)
- Qualitative analysis (1)
- Qualitative research (1)
- Qualitative study (1)
- Quality control (1)
- Quality indicators (1)
- Quality of Health Care [MeSH] (1)
- Quality standards (1)
- Qualitätsindikator (1)
- Qualitätsindikatoren (1)
- Qualitätsmanagement (1)
- Qualitätsstandards (1)
- Quantitative (q)T2 mapping (1)
- Quantitative Antikörpermessung (1)
- Quantitative Imaging (1)
- Quantitative MRI (1)
- Quantitative features (1)
- Quantitative magnetic resonance imaging (1)
- Quantra (1)
- Quarantine (1)
- Quasi-longitudinal study (1)
- Querschnittsstudie (1)
- Quinolones (1)
- R406 (1)
- RA-1000 (1)
- RAF (1)
- RARP (1)
- RAS (1)
- RAS pathway (1)
- RAS-ID-Gramneg (1)
- RBS-R (1)
- RCC (1)
- RDoC (1)
- RESLES (1)
- RET (1)
- RGAG1 (1)
- RIP (1)
- RIPK1 (1)
- RMS (1)
- RNA chaperone (1)
- RNA sequencing (1)
- RNA stability (1)
- RNA therapy (1)
- RNA turnover (1)
- RNA virus (1)
- RNA, Virale/ Blut (1)
- RNA-Bindeprotein (1)
- RNA-binding protein (1)
- RNA-sequencing (1)
- RNA/MicroRNA (1)
- RNAP II (1)
- RND (1)
- RNF4 (1)
- ROC analyses (1)
- ROC analysis (1)
- ROC-Analysen (1)
- ROS1 (1)
- ROSA (1)
- ROTEM (1)
- RRMS (1)
- RT-PCR (1)
- RT-PCR-detection (1)
- Rab7 (1)
- Rabbit (1)
- Race (1)
- Radiation Oncology (1)
- Radiation Protection Act (1)
- Radiation Protection Ordinance (1)
- Radiation necrosis (1)
- Radiochemotherapy (1)
- Radiofrequency ablation (1)
- Radiofrequenzablation (1)
- Radioiodine therapy (1)
- Radioiodine uptake test (1)
- Radioligandentherapie (1)
- Radiological assessment (1)
- Radiologie (1)
- Radiologie, Universität Frankfurt (1)
- Radiology (1)
- Radiosurgery (1)
- Radiothérapie (1)
- Radon action plan (1)
- Radonmaßnahmenplan (1)
- Radonvorsorgegebiete (1)
- Ragulator complex (1)
- Raketenimmunelektrophorese (1)
- Ramadan (1)
- Ramucirumab (1)
- Random forest (1)
- Randomisation (1)
- Randomized Controlled Trial (1)
- Randomized controlled trial (1)
- Randomized controlled trials (1)
- Rare Diseases/ Orphan Diseases (1)
- Raster (1)
- Rcf1 (1)
- Reactogenicity (1)
- Ready-made mouthguard (1)
- ReagentKits, -Diagnostic (1)
- Reagenzkits, Diagnostische (1)
- Real world (1)
- Real world study (1)
- Real-time MRI (1)
- Real-time polymerase chain reaction (PCR) tests (1)
- Receptors/Nuclear (1)
- Rechtliche Würdigung (1)
- Rechtsmediziner (1)
- Recognition (1)
- Rectal neoplasms (1)
- Recurrence (1)
- Recurrent episodes (1)
- Red-lipped arboreal alligator lizard (1)
- Redox dependent epigenetic modifications (1)
- Redox-sensitive transcription factor (1)
- Reduktion von Komplikationen (1)
- Redundancy (1)
- Reference values (1)
- Referenzwerte (1)
- Referral (1)
- Reflotron® (1)
- Refractive changes (1)
- Refractive lense exchange (1)
- Refractory ALL (1)
- Refractory AML (1)
- Refractory status epilepticus (1)
- Refraktärer Status epilepticus (1)
- RegJoint™ (1)
- Regeneration (1)
- Region (1)
- Region of Interest (1)
- Register (1)
- Registries (1)
- Regret (1)
- Regulatory agencies. (1)
- Rekonstruktion (1)
- Relapse surveillance (1)
- Relaxometrie (1)
- Relaxometry (1)
- Reliabilität (1)
- Remission (1)
- Renal cell carcinoma (1)
- Renal vein thrombus (1)
- Repetitives Verhalten (1)
- Representative survey (1)
- Reproducibility (1)
- Reproducibility/stability (1)
- Reproduzierbarkeit (1)
- Research (1)
- Research data (1)
- Research design (1)
- Research investment (1)
- Research patterns (1)
- Research validity (1)
- Resection (1)
- Residency (1)
- Residual myometrial thickness (1)
- Resilience (1)
- Resistenz (1)
- Resistenzprüfung (1)
- Resistenztestung (1)
- Respiratorische Infekte (1)
- Respiratory infections (1)
- Response control (1)
- Responsibility of healthcare policy (1)
- Restenosis (1)
- Resting-state (1)
- Restriktive und Repetitive Verhaltensweisen (1)
- Retikulozytenbestimmung (1)
- Retina (1)
- Retinal diseases (1)
- Retinoic acid (1)
- Retrospective study (1)
- Rettungsdienst (1)
- Return to work (1)
- Reverse electron transfer (1)
- Revisionsprothese (1)
- Reward anticipation (1)
- Reward system (1)
- Rezeptorsignalweg (1)
- Rh Antigens (1)
- Rhabdomyoma (1)
- Rheuma (1)
- Rho-kinase (1)
- Rhythmologie (1)
- Ribosomal RNA (1)
- Richtigkeit (1)
- Richtlinien (1)
- Ridge preservation (1)
- Riftia pachyptila (1)
- Ringversuch (1)
- Risikofaktoren (1)
- Risikogruppen sind: Schwangerschaft - Bluttransfusion - Organtransplantation - Prostituierte (1)
- Risk assessment (1)
- Risk factor (1)
- Risk stratification (1)
- Risk-stratification (1)
- Rivaroxaban (1)
- Roboter (1)
- Robotic-assisted radical prostatectomy (1)
- Robotik (1)
- Rocket immunoelectrophoresis (1)
- Rodents (1)
- Roussel Uclaf Causality Assess- ment Method (RUCAM) (1)
- Routinely Collected Health Data [MeSH] (1)
- Running Economy (1)
- Rural areas (1)
- Récidive (1)
- Réserve ovarienne (1)
- Röntgendiffraktion (1)
- Rückenschmerzen (1)
- S100A12 Hexamer (1)
- S1P (1)
- S1P lyase (1)
- S1P5 (1)
- S1PR5 (1)
- S63845 (1)
- SAH (1)
- SAMHD1 (1)
- SARS (1)
- SARS CoV 2 (1)
- SARS coronavirus (1)
- SARS-COV-2 (1)
- SARS-CoV-2 Pneumonia (1)
- SARS-CoV-2-specific T cells (1)
- SARS-CoV2 (1)
- SARS-CoV‑2 pandemic (1)
- SARS-CoV‑2-Pandemie (1)
- SCA2 (1)
- SCCHN (1)
- SCD14 (1)
- SCN5A (1)
- SEAP (1)
- SEC (1)
- SEC-ICP-DRC-MS (1)
- SEER (1)
- SELEX (1)
- SENP (1)
- SF-12 (1)
- SF-12 WOMAC KSS (1)
- SF-36 (1)
- SFR (1)
- SGPL1 (1)
- SGPL1 knockout cell line (1)
- SH- (S-S)-Groups (1)
- SH-SY5Y neuroblastoma cells (1)
- SIDS (1)
- SIRPalpha (1)
- SIRS (1)
- SIRT1 (1)
- SKALE score (1)
- SLAM-seq (1)
- SLC6a3 (1)
- SLC7A11 (1)
- SLUG (1)
- SMOC1 (1)
- SNORD95 (1)
- SNV (1)
- SOD (1)
- SPG8 (1)
- SPPL3 (1)
- SSRI (1)
- SSTI (1)
- STAT1 (1)
- STAT3 (1)
- SUD (1)
- Safety culture (1)
- Safety perspectives (1)
- Salivary gland cancer (1)
- Salivary gland carcinoma (1)
- Sampling protocol (1)
- Sandfly (1)
- Sanger Sequencing (1)
- Sapacitabine (1)
- Sarcoma (1)
- Sarcophagidae (1)
- Satisfaction (1)
- Saudi Arabia (1)
- Saure Dissoziation (1)
- Scaffold (1)
- Scalp defect (1)
- ScanWatch (1)
- Scanner models (1)
- Scheduling of radiotherapy (1)
- Scheimpflug imaging (1)
- Schilddrüse (1)
- Schilddrüsenfunktion (1)
- Schilddrüsenhormone (1)
- Schizophrenie (1)
- Schlaf (1)
- Schlafentzug (1)
- Schlaganfall (1)
- Schlaganfall-Sekundärprophylaxe (1)
- Schmerz (1)
- Schmerzprävalenz (1)
- Schulter (1)
- Schädel-MRT (1)
- Sclerotic glomeruli (1)
- Screening-ELISA (1)
- Screeningfragebogen (1)
- Scrofulous keratitis (1)
- Seasonal variation (1)
- Second donation (1)
- Second order regression curve (1)
- Secondhand Smoke (1)
- Sectio (1)
- Secular trend (1)
- Sedation (1)
- Sedatives (1)
- Sedierung (1)
- Seizure series (1)
- Sektion (1)
- Selbstmordpakt (1)
- Selbstvorstellung (1)
- Selektivmedien (1)
- Selen (1)
- Self-esteem (1)
- Self-expandable TAVI (1)
- Self-introduction (1)
- Self-renewal (1)
- Seltene Erkrankungen in der Lehre (1)
- Seminom (1)
- Senescence (1)
- Separation of ADP-Binding Enzymes (1)
- Sequelae (1)
- Sequencing (1)
- Seralyzer-System (1)
- Seralyzer® (1)
- Serin (1)
- Serious injured children (1)
- Seroconversion panels (1)
- Serodiagnostik (1)
- Serokonversionspanels (1)
- Serology (1)
- Serotonin (1)
- Serum (1)
- Serum biomarker (1)
- Shared information (1)
- Sharp injuries (1)
- Shinisaurus crocodilurus (1)
- Short bowel syndrome (1)
- Shortage of recruits (1)
- Shoulder luxation (1)
- Sialic acid (1)
- Sialinsäure (1)
- Side effect (1)
- Side effects (1)
- Siderosis (1)
- Signal Recognition Particle (1)
- Signal intensity (1)
- Signs and symptoms (1)
- Silver diamine fluoride (1)
- Simulated patients (1)
- Simulation training (1)
- Simulator (1)
- Single nucleotide polymorphism (1)
- Single positive core biopsy (1)
- Single-cell RNA sequencing (1)
- Single-leg hop for distance (1)
- Single-treatment (1)
- Sinus pilonidalis (1)
- Sirolimus (1)
- Sitting posture (1)
- Sitzhaltung (1)
- Skeletal health (1)
- Skeletal joints (1)
- Skeletal muscles (1)
- Skill- and grade mix (1)
- Skull base (1)
- Sleep (1)
- Slow Cortical Potentials, SCP (1)
- Smac mimetics (1)
- Smad (1)
- Small Cell/diagnosis (1)
- Small Leucine-rich Proteoglycan (SLRP) (1)
- Small RNA analysis (1)
- Small aperture IOL (1)
- Small variation coefficients (1)
- Small vessel disease (1)
- Small-bowel endoscopy (1)
- Smartwatch (1)
- Smoking habits (1)
- Smooth muscle cells (1)
- Social Media (1)
- Social Phobia (1)
- Social brain (1)
- Social cognition (1)
- Social decision-making (1)
- Social determinants (1)
- Social differences (1)
- Social neuroscience (1)
- Socio-economic analysis (1)
- Sociocognitive predictors (1)
- Sociodemographic characteristics (1)
- Socioeconomic analysis (1)
- Socioeconomic indices (1)
- Socket healing (1)
- Socket preservation (1)
- Sodium chloride (1)
- Soecificity (1)
- Sofortbelastung (1)
- Soft tissue healing (1)
- Soft tissue sarcoma (1)
- Software (1)
- Solanaceae (1)
- Solar insolation (1)
- Solomon Island skink (1)
- Soluble epoxide hydrolase (1)
- Sonication (1)
- Sonographie (1)
- Sonography (1)
- Sparse models (1)
- Spatial Attention (1)
- Specialist training (1)
- Specialized outpatient palliative care (1)
- Specific Synthesis (1)
- Speech (1)
- Speicherung (1)
- Spezialisierte ambulante Palliativversorgung (1)
- Speziesbarriere (1)
- Sphk1 (1)
- Sphk2 (1)
- Spinal cord (1)
- Spinal fractures (1)
- Spinal injuries (1)
- Spinal surgery (1)
- Spinalkanalstenose (1)
- Spine care (1)
- Spine fractures (1)
- Spine infection (1)
- Spinocerebellar ataxia type 2 (1)
- Spirochetes (1)
- Spondylitis (1)
- Spondylodiscitis (1)
- Spontan bakterielle Peritonitis (1)
- Sports and exercise medicine (1)
- Spread of Excitation (1)
- Spurenelemente (1)
- Sputum smear-negative (1)
- Stability (1)
- Staff load (1)
- Stage at presentation (1)
- Stakeholder participation (1)
- Stammzelltransplantation (1)
- Standard dataset (1)
- Standard reference values (1)
- Stark verwester Leichnam (1)
- Static MRI (1)
- Statin (1)
- Stationäre Krankenhausfälle (1)
- Statistical analysis (1)
- Status quo Seltene Erkrankungen (1)
- Steinfreiheit (1)
- Stem cell dose (1)
- Stem cell enumeration (1)
- Stereoelektroenzephalographie (1)
- Stereotactic ablative body radiotherapy (1)
- Sterilität (1)
- Sterols (1)
- Stickstoffmonoxid (1)
- Stigma (1)
- Stigma scale (1)
- Stimulant (1)
- Sting challenge (1)
- Stoppa approach (1)
- Strahlendosis (1)
- Strahlenschutzgesetz (1)
- Strahlenschutzverordnung (1)
- Straßburg, Reichsuniversität (1)
- Streptokokken (1)
- Streptomyces hydrogenans (1)
- Stress (1)
- Stress vulnerability/resilience genes (1)
- Stretch training (1)
- Streustrahlung (1)
- Striatum (1)
- Stroke Risk (1)
- Stroke genetics (1)
- Stroke unit (1)
- Structured written feedback (1)
- Student (1)
- Studentenproteste Frankfurt am Main (1)
- Störfaktoren in der serologischen Diagnostik (1)
- Sub-zero exposure (1)
- Subcortical (1)
- Subependymal giant cell astrocytoma (1)
- Subjective effects (1)
- Subjective health status (1)
- Subjektiver Gesundheitszustand (1)
- Subkortikal (1)
- Subregions (1)
- Substitution of Ribose (1)
- Subventricular zone (1)
- Sudden Cardiac Death (SCD) (1)
- Sudden cardiac death (1)
- Sudden infant death syndrome (1)
- Sugar feeding (1)
- Suicide attempt (1)
- Suizid (1)
- Suizidalität (1)
- Sulfhydryl Groups (1)
- Sulforaphane (1)
- Sulphoraphane (1)
- Sunlight (1)
- Supplementation (1)
- Support vector machine (1)
- Supported Decision-making (1)
- Supraglottic Airway Devices (1)
- Supratentorial (1)
- Supreme court ruling (1)
- Surgical APGAR Score (1)
- Surgical blood loss (1)
- Surgical education (1)
- Surgical oncology (1)
- Surgical site infection (1)
- Surgical therapy (1)
- Survey (1)
- Suspension (1)
- Sustained attention (1)
- Sustained virologic response (1)
- Sustained virological response (1)
- Swallowing (1)
- Syk Kinase (1)
- Symmetrical blocked occlusion (1)
- Sympathetic (1)
- Sympathetic nervous system (1)
- Synapse (1)
- Synaptic organizer (1)
- Synaptosomal preparation (1)
- Syndecan-1 (1)
- Synergy (1)
- Synovial sarcoma (1)
- Synthetic biology (1)
- Synthetische Gestagene (1)
- Synthetische Letalität (1)
- Syrian hamster (1)
- Systems & Computational Biology (1)
- Szientometrie (1)
- Säkularer Trend (1)
- Sérotonine (1)
- T Cell Biology (1)
- T cell (1)
- T cell receptor (1)
- T cell response (1)
- T cells (1)
- T helper cell differentiation (1)
- T-Zellen (1)
- T-bet (1)
- T-cell development (1)
- T-cell receptor (1)
- T-cell receptor (TCR) (1)
- T-cells (1)
- T2 (1)
- T4-Bestimmung (1)
- T4-analysis (1)
- TAM (1)
- TAMs (1)
- TAVI Vergleich transapikaler transfemoraler Zugangsweg (1)
- TAVI, Kardiologie, Klappen, Aortenklappenstenose, Prothesen, TTE, Frankfurt, Vergleich, Transkatheter, Mortalität, Herz (1)
- TB-therapy (1)
- TBI (1)
- TBK1 (1)
- TDAG8 (1)
- TDM (1)
- TEPT (1)
- TGF-α (1)
- TGF-β1 (1)
- TGFB-induced factor homeobox 1 (1)
- TGIF (1)
- TGR(mREN2)27 (1)
- THRLBCL (1)
- TIGAR (1)
- TIRADS (1)
- TLR2 (1)
- TLR4 (1)
- TME (1)
- TMT (1)
- TOR signalling (1)
- TRAIL (1)
- TRIMs (1)
- TRP Channels (1)
- TRP2 (1)
- TRPA1 (1)
- TRPM8 (1)
- TRPV4 (1)
- TSP-4 (1)
- TTFields (1)
- TTW nodules (1)
- TUR-P (1)
- TURP (1)
- TWNK (1)
- Tabak (1)
- Taekwondoka (1)
- Tailored therapy (1)
- Takotsubo Syndrome (1)
- Tamoxifen (1)
- Tanz (1)
- Tar (1)
- Targeted delivery (1)
- Targeted sequencing (1)
- Targeted therapies (1)
- Targeted therapy (1)
- Tattoo (1)
- Teaching in daily surgical routine (1)
- Technical data (1)
- Teilzeit (1)
- Tele-EEG (1)
- Tele-consultation (1)
- Telekonsil (1)
- Tempo-parietal junction (1)
- Temporomandibular joint (1)
- Temporomandibular joint dysfunction (1)
- Terminal ileitis (1)
- Terminology (1)
- Test assay (1)
- Testing (1)
- Teststreifenanalytik (1)
- Tetanus (1)
- Tetrahydro-Aldosteron (1)
- Tetrahydrobiopterin (1)
- Thalidomide (1)
- Theft (1)
- Theranostik (1)
- Therapeutic adherence (1)
- Therapeutic anticoagulation (1)
- Therapeutic competence (1)
- Therapiefreie Remission (1)
- Therapielimitierung (1)
- Therapiemonitoring (1)
- Therapies (1)
- Thermoablation (1)
- Thermogenesis (1)
- Thermoplasma acidophilum Membranes; Tetraetherlipids (1)
- Thoracic aortic aneurysm (1)
- Thoracic trauma (1)
- Thorax (1)
- Thromboembolische Ereignisse (1)
- Thrombophilie (1)
- Thrombotic thrombocytopenic purpura (1)
- Thrombozytentransfusion (1)
- Thumb carpometacarpal joint osteoarthritis (1)
- Thyreostatika (1)
- Thyroid (1)
- Thyroid Cancer Cells (1)
- Thyréostatiques (1)
- Tick (1)
- Tick-Borae (1)
- Tick-Born Diseases (1)
- Tick-borne diseases (1)
- Time of death (1)
- Time trend (1)
- Tissue Engineering (1)
- Tissue engineering (1)
- Tissue expander (1)
- Tissue microarray (1)
- Tissue-specificity (1)
- Tobacco (1)
- Tocilizumab (1)
- Toll-like Receptor (TLR) (1)
- Toll-like Rezeptor, Subcommissuralorgan; Circumventriculäre Organe (1)
- Toluidine blue (1)
- Tomography (1)
- Tonsillitis (1)
- Tooth Development (1)
- Tooth segmentation (1)
- Total Quality Managemen (1)
- Total elbow arthroplasty (1)
- Total hip arthroplasty (1)
- Touchscreen (1)
- Toxic liver disease (1)
- Toxicity (1)
- Toxicité ovarienne (1)
- Toxins (1)
- Traditional Chinese Medicine (TCM) (1)
- Traditional Indian Medicine (1)
- Trafficking (1)
- Trail (1)
- Traits of medical students (1)
- Trajectories (1)
- Tranexamsäure (1)
- Transarterial Chemoembolization (1)
- Transarterial chemoembolization (1)
- Transcatheter stage 1 (1)
- Transcranial direct current stimulation (1)
- Transcription (1)
- Transcription factor (1)
- Transcription regulation (1)
- Transcriptional regulatory elements (1)
- Transcriptomics (1)
- Transdifferentiation (1)
- Transfer learning (1)
- Transfusion practice (1)
- Transfusionsbedingte virale Infektionen (1)
- Transfusionszwischenfall (1)
- Transgender (1)
- Transgenic mice (1)
- Transiente Elastographie (1)
- Transitional fractures 3D printing (1)
- Transjugular Intrahepatic Portosystemic Shunt (1)
- Transjugular intrahepatic portosystemic shunt (1)
- Translation (1)
- Translation proteomics (1)
- Translationsregulation (1)
- Transplant logistics (1)
- Transplantation Centers (1)
- Transplantation/Immunologie (1)
- Transplantation/immunology (1)
- Transplantatnephrektomie (1)
- Transurethral resection of the prostate (1)
- Trauma centre (1)
- TraumaRegister DGU® (1)
- TraumaRegister DGU® (TR-DGU) (1)
- Traumatic brain injury (1)
- Traumatic dental injury (1)
- Traumatology (1)
- Travel regulations (1)
- Travel times (1)
- Treatment costs (1)
- Treatment effectiveness (1)
- Treatment management (1)
- Treatment rates (1)
- Treatment response (1)
- Treg (1)
- Treg cell (1)
- Trennhilfe (1)
- Trikuspidalklappenrekonstruktion (1)
- Trimeric autotransporter adhesins (1)
- Tripyridyltriazin (1)
- Tripyridyltriazin (TPTZ) (1)
- Tris-Teepol-Puffer (1)
- Tris-Teepol-buffer (1)
- Trisomy 21 (1)
- Troponin (1)
- TruGene (1)
- Truncating mutation (1)
- Truncus arteriosus (1)
- Trypanosoma brucei (1)
- Tuberkulose (1)
- Tuberous sclerosis complex (1)
- Tumor cell (1)
- Tumor subtype (1)
- Tumor therapy (1)
- Tumormikromilieu (1)
- Tumour immunology (1)
- Turbidimetric determination (1)
- Typ 1 Diabetes (1)
- Type 1 diabetes (1)
- Type of death (1)
- Type three hypersensitivity (1)
- Tyrosine kinase inhibitor (TKI) (1)
- Tyrosinemia (1)
- Tyrosinkinasen (1)
- Tödlicher Arbeitsunfall (1)
- Tötung (1)
- UBA domain (1)
- UGCG (1)
- UHPLC-MS (1)
- UKF-NB-2 (1)
- UKF-NB-2rVCR20 (1)
- ULK-Inhibition (1)
- UPR (1)
- URS (1)
- USA (1)
- USP28 (1)
- USP32 (1)
- UTUC (1)
- Ubiquitin Ligase (1)
- Ubiquitin ligase (1)
- Ubiquitin signaling (1)
- Ubiquitin-binding module (1)
- Ubiquitination (1)
- Ubiquitylation (1)
- Ulixertinib (1)
- Ultraschall (1)
- Umfassendes Qualitätsmanagement (1)
- Uncertainty (1)
- Undergraduate (1)
- Undergraduate education (1)
- Understanding (1)
- Undiagnosed patients (1)
- Unfall (1)
- Unfallchirurgie (1)
- Unfälle (1)
- Unique information (1)
- University hospitals (1)
- University medical centers (1)
- Universität Frankfurt (1)
- Universität Frankfurt am Main (1)
- Universität Frankfurt am Main, Geschichte (1)
- Universitätsmedizin Frankfurt am Main (1)
- Unterernährung (1)
- Untersuchungsangst (1)
- Upgrading (1)
- Upper airway infection (1)
- Urachal cancer (1)
- Urachus carcinoma (1)
- Ureterorenoskopie (1)
- Urethra/Mikrobiologie (1)
- Urethra/microbiology (1)
- Urethral cancer (1)
- Urinary continence (1)
- Urinary incontinence (1)
- Urine (1)
- Urologic tumors (1)
- Urological oncology (1)
- Urologie (1)
- Urothelkarzinom (1)
- Uterus (1)
- V4 (1)
- VEGF receptor 2 internalization and signaling (1)
- VEGF receptors (1)
- VF (1)
- VGAT-ChR2 (1)
- VHL (1)
- VIM (1)
- VMO (1)
- VR-Simulation (1)
- VRE (1)
- VUS (1)
- VX-2 (1)
- Vaccine (1)
- Vagus nerve (1)
- Vagus nerve stimulation (1)
- Vakzination (1)
- Validation (1)
- Valvular cardiomyopathy (1)
- Variant of concern (1)
- Variation (Genetics) (1)
- Variation (Genetik) (1)
- Variceal bleeding (1)
- Vascular cognitive disorder (VCD) – Paranoid hallucinatory syndrome – Late-onset trauma-related symptoms – Depression – Assertive community treatment (ACT) (1)
- Vascular disease (1)
- Vasospasm (1)
- Venous Thromboembolism (1)
- Venous thromboembolism (1)
- Venous thrombosis (1)
- Ventilators (1)
- Ventricular arrhythmia (1)
- Ventricular arrhythmias (1)
- Ventricular tachyarrhythmia (1)
- Venöse Thrombose/Genetik (1)
- Versorgungsforschung (1)
- Versorgungslücken (1)
- Versorgungsstruktur (1)
- Versorgungsstrukturen (1)
- Versorgungszentren (1)
- Vertebral body (1)
- Vertreibung jüdischer Dozenten (1)
- Vibroarthrography (1)
- Video rasterstereography (1)
- Videorasterstereography (1)
- Vincristin (1)
- Viral Load (1)
- Viral Matrix Proteins (1)
- Viral hepatitis (1)
- Viral infection (1)
- Viral load (1)
- Viral oncology (1)
- Viral/blood (1)
- Viral/blood; RNA (1)
- Virale Matrixproteine (1)
- Viremia-diagnosis (1)
- ViroSeq (1)
- Virological testing (1)
- Virology (1)
- Virtual noncalcium reconstructions (1)
- Virtual patients (1)
- Virulence (1)
- Virus (genom) nachweis (1)
- Virus infection (1)
- Virus trapping (1)
- Virusinfektionen (1)
- Virusisolierung (1)
- Virusnachweis (1)
- Viruspneumonien (1)
- Vision® (1)
- Visual Perception (1)
- Visual quality (1)
- Visual-field localizer (1)
- Vitamin D-Defizit (1)
- Volume reduction of thyroid nodules (1)
- Volumetrie (1)
- Volunteer donor (1)
- Von Hippel–Landau (1)
- Vorbeugemaßnahmen (1)
- Vorsorgeuntersuchung (1)
- Vorteile (1)
- WASH complex subunit 5 (1)
- WIPI2 (1)
- WIPI2b (1)
- Waldheim, Anstalt (1)
- Wastewater-based epidemiology (WBE) (1)
- Water contamination (1)
- Watertight Dural closure (1)
- Web 2.0 (1)
- Weight distribution (1)
- Western Blotting (1)
- Western diet (1)
- White blood cells (1)
- White matter hyperintensity (1)
- Whole slide images (1)
- Wilson disease (WD) (1)
- Winter survival (1)
- Wirkmechanismus (1)
- Withings (1)
- Wnt (1)
- Work health promotion (1)
- Working memory capacity (1)
- Workstation comparison (1)
- Wound care (1)
- Wounds and injuries (1)
- Wundversorgung (1)
- X-ray computed (1)
- X-ray crystallography (1)
- X-ray diffraction (1)
- XCL1/XCR1 axis (1)
- XIAP (1)
- Yamane (1)
- Year of practical training (1)
- Yeast-2-Hybrid (1)
- Yoga (1)
- Youtube (1)
- Zahnmedizin (1)
- Zahnmedizinische Fachangestellte (1)
- Zahnmedizinische Fakultäten (1)
- Zahnprothetik (1)
- Zahntechnik (1)
- Zahnärzte (1)
- Zebrafish (1)
- Zeckenübertragene Erkrankungen (1)
- Zellkultur (1)
- Zellproliferation (1)
- Zentralisierung (1)
- Zentrifugalanalysator (1)
- Zika Virus (1)
- Zika fever (1)
- Zone immunoelectrophoresis assay (1)
- Zonen-Immunelektrophorese- Assay (1)
- Zuckerkandl’s tubercle (1)
- Zwangssterilisation (1)
- Zwangssterilisierung (1)
- Zwiefalten, Anstalt (1)
- Zwischenanstalten der Aktion T 4 (1)
- Zymosan-induced peritonitis (1)
- Zytomegalievirus-IgG-Antikörper (1)
- Zöliakie (1)
- [18F]FET PET (1)
- aGVHD (1)
- abdominal aortic aneurysm (1)
- ablation (1)
- abscisic acid (1)
- abscopal effect (1)
- acarboxyprothrombin (1)
- accident (1)
- accreditation (1)
- accuracy (1)
- acetabular fracture (1)
- acetaminophen (1)
- acne inversa (1)
- acoustic radiation force impulse (1)
- acquired LQT syndrome (1)
- acriflavine (1)
- action (1)
- activated clotting time measurement (1)
- activated factor XIII (1)
- acute phase reactants (1)
- acute decompensation (1)
- acute infections (1)
- acute lymphoblastic leukemia (1)
- acute pain (1)
- acute respiratory distress syndrome (1)
- acute stroke (1)
- acute stroke care (1)
- acute-on-chronic liver failure (1)
- additive manufacturing (1)
- adenosine (1)
- adiabatic saturation (1)
- adipocytes (1)
- adipose-derived mesenchymal stem/stromal cells (1)
- adjuvante Krebstherapie (1)
- adolescence (1)
- adolescent (1)
- adolescents (1)
- adrenal adenomas (1)
- adrenergic therapy (1)
- adult neurogenesis (1)
- adults (1)
- advanced melanoma (1)
- advantages and shortcomings (1)
- adversity (1)
- agardiffusion (1)
- aged (1)
- agent-based modeling (1)
- agent-based models (1)
- agility (1)
- agreeableness (1)
- air abrasive (1)
- albumin (1)
- alcohol (1)
- alcohol use disorder (AUD) (1)
- alcoholic fatty liver disease (1)
- alcoholic hepatitis (1)
- alcoholic liver disease (1)
- aligners (1)
- allogeneic donor (1)
- allogeneic hematological stem cell transplantation (1)
- allogeneic hematopoietic stem cell transplantation (1)
- allogeneic stem cell transplant (1)
- allostasis (1)
- alpha band (1)
- alpha receptor (1)
- alpha-fetoprotein (1)
- alpha-galactosidase A deficiency (1)
- alpha-synuclein (1)
- alpha7 nicotinic acetylcholine receptor (1)
- alphaSynuclein (1)
- alteplase (1)
- alternative Analysentechniken (1)
- alternative matrices (1)
- alternative splicing (1)
- alveolar ridge augmentation (1)
- amide proton transfer (1)
- amino acids (1)
- amisulpride (1)
- amphiregulin (1)
- amygdalin (1)
- amyotrophic lateral sclerosis (1)
- amyotrophic lateral sclerosis (ALS) (1)
- anaemia walk-in clinic (1)
- analysis of urinary calculi (1)
- analysis of urinary calculi by a microscopic microchemical procedure (1)
- analysis of urinary calculi by chemical procedures (1)
- anaplastic large cell lymphoma (1)
- anesthesia (1)
- aneurysm (1)
- angioedema control test (1)
- angiography (1)
- angiokeratoma diffuse (1)
- animal models (1)
- anorectal malformation (1)
- anorexia nervosa (1)
- anti-CD3 antibody (1)
- anti-EGFR therapy (1)
- anti-HBc (1)
- anti-bacterial agents (1)
- anti-idiotypes (1)
- anti-inflammatory agent (1)
- anti-inflammatory drug (1)
- anti-neural autoantibodies (1)
- anti-p24-Antikörper (1)
- antiadhesive composites (1)
- antiangiogenic therapy (1)
- antiangiogenic therapy resistance (1)
- antibacterial composites (1)
- antibacterial therapy (1)
- antibiotic prophylactic therapy (1)
- antibiotic prophylaxis (1)
- antibiotics (1)
- antibody (1)
- anticipation (1)
- anticoagulant (1)
- anticoagulation (1)
- antiepileptic drug (1)
- antifungal agents (1)
- antifungal therapy (1)
- antigen (1)
- antigen detection (1)
- antihelix shaping (1)
- antimicrobial stewardship (1)
- antioxidant (1)
- antiviral agents (1)
- antiviral drugs (1)
- antiviral signaling (1)
- anxiety (1)
- anxiety disorders (1)
- aortic aneurysm (1)
- aortic root replacement (1)
- aortic valve repair (1)
- aortic valve-sparing (1)
- apex (1)
- aphrodisin (1)
- apical constriction (1)
- apical polarity (1)
- apolipoprotein B (1)
- aptamer (1)
- aptamer modeling (1)
- arachidonate 12/15-lipoxygenase (Alox12/15) (1)
- arachidonic acid (1)
- arachidonic acid (AA) (1)
- arbeitsbedingte Infektionen (1)
- arterial stiffness (1)
- arteriosclerosis (1)
- articular cartilage (1)
- articular chondrocytes (1)
- artifacts (1)
- artificial feeding (1)
- artificial intelligence (AI) (1)
- aryl hydrocarbon receptor (1)
- asparaginyl endopepdidase (AEP) (1)
- aspiration (1)
- aspirin (1)
- assembly (1)
- assembly factor (1)
- asthma (1)
- asymptomatic temporal encephaloceles (1)
- at-risk mental state (1)
- ataxia (1)
- atezolizumab (1)
- atomic power (1)
- atopic dermatitis (1)
- atrial fibrillation (1)
- attachment (1)
- attachment loss (1)
- attention deficit/hyperactivity disorder (ADHD) (1)
- attention-deficit/hyperactivity disorder (ADHD) (1)
- atypical EGFR mutations (1)
- auditory (1)
- auditory cortex (1)
- auditory fMRI (1)
- augmentation (1)
- autism (1)
- autism spectrum disorders (1)
- autoantibodies (1)
- autobiographical memories (1)
- autogenous tooth roots (1)
- autoimmune encephalitis (1)
- autoimmune-mediated psychosis (1)
- automatic scene classification (1)
- autophagy inhibition (1)
- autophagy-dependent cell death (1)
- avian flu (1)
- aviäre Influenza (1)
- awake surgery (1)
- azacitidine (1)
- azoospermia (1)
- bDNA; Hepatitis C-Virus (HCV) (1)
- bacteremia (1)
- bacterial leakage (1)
- bacterial viability (1)
- bacteriophages (1)
- ball (1)
- ballet (1)
- bariatric surgery (1)
- basilar artery occlusion (BAO) (1)
- bats (1)
- behavior (1)
- behavioral inhibition (1)
- behavioural rhythms (1)
- behördliche Anforderungen (1)
- benannte Stelle (1)
- benchmarking (1)
- benfooxythiamine (1)
- best medical treatment (1)
- beta-band activity (1)
- beta-blocker (1)
- beta-lactamases (1)
- beta2-adrenoceptor (1)
- bevacizumab (1)
- bibliometric analysis (1)
- bilateral (1)
- bile (1)
- bile acids (1)
- bilirubin determination (1)
- binocular vision (1)
- bio imaging (1)
- bioactive lipids (1)
- bioavailability (1)
- biochemical relapse free survival (1)
- biocompatibility (1)
- bioequivalence (1)
- biofilm (1)
- bioimaging (1)
- bioinformatics (1)
- biological networks (1)
- biologische Netzwerke (1)
- biologization (1)
- bioluminescence (1)
- biomolecular analysis (1)
- biorelevant dissolution (1)
- biotin deficiency (1)
- bipolar disorder (1)
- bipolare Störung (1)
- bladder neck stenosis (1)
- blended learning (1)
- blinatumomab (1)
- blood cell mutations (1)
- blood coagulation (1)
- blood coagulation factor XIII (1)
- blood components (1)
- blood concentrates (1)
- blood culture (1)
- blood culture diagnostic (1)
- blood donor screening (1)
- blood- and plasma products (1)
- blood-brain barrier (1)
- bloodstream infections (1)
- body plethysmography (1)
- body sway (1)
- body weight distribution (1)
- bone Gla protein (1)
- bone augmentation (1)
- bone barrow (1)
- bone marrow microenvironment (1)
- bone metastasis (1)
- bone tissue (1)
- bone tissue engineering (1)
- bone-regeneration (1)
- booster (1)
- bowel dysfunction (1)
- bowel management (1)
- brachytherapy (1)
- brain (1)
- brain disorders (1)
- brain function (1)
- brain imaging (1)
- brain infection (1)
- brain networks (1)
- brain shift (1)
- brain signal complexity (1)
- brain tumor (1)
- breast tumor (1)
- bromodomain and extraterminal (BET) protein (1)
- bronchial epithelium (1)
- bronchiolitis (1)
- bulimia nervosa (1)
- buparlisib (1)
- burden of disease (1)
- burden of illness (1)
- burkholderia (1)
- burkholderia cepacia complex infections (1)
- bypass (1)
- c-MET (1)
- c-MYC (1)
- c-tkl (1)
- cAMP (1)
- cCMV (1)
- cGMP (1)
- cabazitaxel (1)
- caesarean scar (1)
- caesarean section (1)
- calretinin (1)
- cancer cell metabolism (1)
- cancer immunotherapy (1)
- cancer information (1)
- cancer metastases (1)
- cancer surveillance (1)
- cancer therapy (1)
- cancer-associated fibroblasts (1)
- cancer-specific survival (1)
- cannabinoid receptors (1)
- cannabis (1)
- capillary leak syndrome (1)
- carbapenem resistance (1)
- carbapenemases (1)
- cardiac autonomic regulation (1)
- cardiac differentiation (1)
- cardiac magnetic resonance (1)
- cardiac regeneration (1)
- cardiac remodeling (1)
- cardiac reprogramming (1)
- cardiocerebral resuscitation (1)
- cardiomyocyte apoptosis (1)
- cardiomyocyte proliferation (1)
- cardiomyocytes (1)
- cardiopulmonary resuscitation (1)
- cardiothoracic surgery (1)
- cardiovascular management (1)
- cardiovascular system (1)
- casein kinase 2 (1)
- caspase-1 (1)
- castration resistance (1)
- cataract surgery (1)
- cataract surgery workflow (1)
- catecholamine excess (1)
- cathepsin L inhibitor (1)
- cell barrier integrity (1)
- cell differentiation (1)
- cell heterogeneity (1)
- cell lines (1)
- cell proliferation regulating inhibitor of protein phosphatase 2A (1)
- cellular heterogeneity (1)
- cellular inflammatory response (1)
- cellular therapies (1)
- cellular toxicity (1)
- central nervous system (1)
- central spasticity (1)
- ceramide synthase (1)
- cerebral imaging (1)
- cerebral ischemia (1)
- cerebral metastasis (1)
- cerebral palsy (1)
- cerebral pseudoprogression (1)
- cerebral sinus and vein thrombosis (CVT) (1)
- cerebral vasospasm (CVS) (1)
- cerebrovascular disease (1)
- cerumen (1)
- cetuximab (1)
- channelrhodopsin (1)
- chaperone-mediated autophagy (1)
- chelator (1)
- chemiluminescence (1)
- chemisches Harnsteinanalysenverfahren (1)
- chemokines (1)
- chemoprotection (1)
- chemorefractory metastatic colorectal cancer (1)
- chemoresistance (1)
- chemotaxis (1)
- chernobyl (1)
- childhood cancer (1)
- childhood epilepsy (1)
- children and adolescents (1)
- chimeric antigen receptor (CAR) (1)
- chlamydia (1)
- cholangiocarcinoma (1)
- cholesterol (1)
- cholinergic system (1)
- chromaffin cell (1)
- chromatin (1)
- chromium (1)
- chronic (1)
- chronic granulomatous disease (1)
- chronic hepatitis C (1)
- chronic hypoxia (1)
- chronic infections (1)
- chronic inflammation (1)
- chronic myeloid leukemia (1)
- chronische Herzinsuffizienz (1)
- circular RNA (1)
- citrate (1)
- classical Hodgkin lymphoma (1)
- clear cell renal cell carcinoma (1)
- clear cell sarcoma (1)
- clear lens exchange (1)
- climate change genomics (1)
- clindamycin (1)
- clinical communication (1)
- clinical decision support (1)
- clinical decision-making (1)
- clinical high at-risk mental state (1)
- clinical immunology (1)
- clinical node positive (1)
- clinical outcome (1)
- clinical research (1)
- clinical stage (1)
- clinical study (1)
- clinical teaching (1)
- clinically important restrictions and symptoms (1)
- clinically relevant dissolution specifications (1)
- clonal haematopoiesis (1)
- clonal transfer (1)
- cluster analysis (1)
- cluttering (1)
- coagulation (1)
- cochlear implants (1)
- cognitive ability (1)
- cognitive aging (1)
- cognitive impairment (CI) (1)
- cognitive interventions (1)
- cold atmospheric plasma (1)
- collagen (1)
- collagen membranes (1)
- collective cell migration (1)
- colon (1)
- colony formation (1)
- colorectal cancer (CRC) (1)
- colour pattern (1)
- combination therapy (1)
- combined modality therapy (1)
- comorbidities (1)
- comparison (1)
- competition ELISA (1)
- complement fixation assay (CF) (1)
- complementary/alternative medicine (CAM) (1)
- complete response (1)
- complex coronary interventions (1)
- complex systems (1)
- compound screen (1)
- compression bandage (1)
- computational knowledge-discovery (1)
- computational pathology (1)
- computer-assisted (1)
- concordance (1)
- conduct disorder (1)
- conformity assessment (1)
- congenital disorders of autophagy (1)
- congenital duodenal obstruction (1)
- conical coupling (1)
- connective tissue (1)
- connective tissue growth factor (1)
- connectivity (1)
- conometric connection (1)
- consensus (1)
- consensus classification (1)
- consensus data set (1)
- consensus paper (1)
- conservative dentistry (1)
- contamination (1)
- continuity of care (1)
- continuous performance test (1)
- contraception (1)
- control of menstrual bleeding (1)
- convulsive seizures (1)
- coping (1)
- copper (1)
- copper free strain-promoted azide alkyne cycloaddition (SPAAC) (1)
- core antigen (1)
- core expression (1)
- cornea donor (1)
- corona virus (1)
- coronally advanced flap (1)
- coronary heart disease (1)
- coronary imaging (1)
- corpus callosum (1)
- cortex (1)
- cortex-based alignment (1)
- cortical impact (1)
- corticospinal tracts (1)
- corticosteroid drugs (1)
- corticosteroids (1)
- cost analysis (1)
- cost containment (1)
- cost of illness (1)
- cost-effective (1)
- counselling (1)
- covalent drugs (1)
- criteria (1)
- critical-size defect (1)
- cross reactivity (1)
- cross-frequency coupling (1)
- cross-linking (1)
- cryoelectron microscopy (1)
- cryopreservation (1)
- culpa asociada a trauma (1)
- cyclic nucleotide analogues (1)
- cyclic nucleotide binding proteins (1)
- cyclin Y (1)
- cycling (1)
- cyclooxygenase 2 (1)
- cyclooxygenase-2 (1)
- cyclopentenone prostaglandins (1)
- cystic fibrosis (1)
- cytochrome P450 (1)
- cytochrome P450 enzymes (1)
- cytochrome P450 reductase (1)
- cytochrome c oxidase (complex IV) (1)
- cytochrome c oxidase I (COI) (1)
- cytokine (1)
- cytokine storm (1)
- cytokine(s) (1)
- cytomegalovirus-specific IgG (1)
- cytosolic free calcium (1)
- cytotoxic T lymphocyte (1)
- cytotoxic lymphocytes (1)
- cytotoxicity (1)
- dance teacher (1)
- data analysis (1)
- data management (1)
- data quality (1)
- data repositories (1)
- data sharing (1)
- de novo transcription (1)
- death rates (1)
- debris (1)
- decision tree (1)
- decompressive craniectomy (1)
- deep learning (1)
- deep vein thrombosis (1)
- default mode network (1)
- deferred treatment (1)
- deficiency (1)
- degradation (1)
- delay (1)
- delayed cerebral ischemia (DCI) (1)
- delayed diagnosis (1)
- delayed treatment (1)
- delirium (1)
- delivery mode (1)
- delta (1)
- demineralized bone matrix (1)
- demonstration of the infectious agent (1)
- dendrite morphogenesis (1)
- dendritic cell (1)
- dendritic cells (1)
- dengue vector (1)
- dental academic degrees (1)
- dental assistant (1)
- dental education (1)
- dental educationcation (1)
- dental implants (1)
- dental school (1)
- dental schools (1)
- dental treatment concept (1)
- dentist (1)
- dentist’s chair design (1)
- dentoalveolar surgery (1)
- deproteinized bovine bone matrix (DBBM) (1)
- depth perception (1)
- desensitization (1)
- detection of virus antigen and nucleic acid (1)
- detection task (1)
- deubiquitylation (deubiquitination) (1)
- diabetes complication (1)
- diabetes mellitus type 1 and type 2 (1)
- diagnostic imaging (1)
- diagnostic window (1)
- diagnostisches Fenster (1)
- diaphragm development (1)
- diet (1)
- differential expression (1)
- diffuse marrow involvement (1)
- diffusion-weighted magnetic resonance imaging (1)
- digital decision-support (1)
- digital one-piece casting (1)
- digital pressing technology (1)
- digital workflow (1)
- dihydrocannabidiol (1)
- diphtheria toxin (1)
- direct-acting antiviral (DAA) treatment (1)
- discontinuation (1)
- disease outbreaks (1)
- disease progression (1)
- disease vectors (1)
- dislocation (1)
- disordered iron metabolism (1)
- disorders of bone metabolism (1)
- distributed analysis (1)
- disturbing factors in serodiagnosis (1)
- dobutamine stress (1)
- docetaxel (1)
- docetaxel (DX) resistance (1)
- doctoral degrees (1)
- donor safety (1)
- dopamine transporter (1)
- dorsal attention network (1)
- double immune checkpoint inhibition (1)
- double negative (1)
- double-pigtail stents (1)
- downgrading (1)
- doxorubicin (1)
- doxycycline (1)
- drinking (1)
- drospirenone (1)
- drug (1)
- drug abstinence (1)
- drug discovery (1)
- drug repurposing (1)
- drugs (1)
- drug–drug interactions (1)
- drug–gene interactions (1)
- drug–g–gene interactions (1)
- dual-energy (1)
- dynamic causal modeling (1)
- dynamic system (1)
- dysbetalipoproteinemia (1)
- dysfibrinogenemia (1)
- early detection (1)
- early onset (1)
- early-onset prostate cancer (1)
- eating disorders (1)
- echo planar imaging (1)
- economic burden (1)
- edentulous (1)
- education (1)
- efferocytosis (1)
- efficiency (1)
- efflux pump (1)
- egg sampling (1)
- egr-1 (1)
- eicosanoid (1)
- elastin (1)
- elastische Verformung (1)
- electrical coupling (1)
- electroanatomical mapping (1)
- electrode design (1)
- electroencephalography (1)
- electroencephalography (EEG) (1)
- electrolytic cleaning (1)
- electron transfer (1)
- electron transfer chain (1)
- electronic adherence measurement (1)
- electronic diaries (1)
- electrophilic fatty acids (1)
- electrophoresis (1)
- element speciation (1)
- eligibility (1)
- elite athletes (1)
- emergency care (1)
- emicizumab (1)
- enamel matrix derivatives (1)
- encephalopathy (1)
- endodontics (1)
- endodontische Ausbildung (1)
- endodontischer Lehrplan (1)
- endodontology (1)
- endoscopic retrograde cholangiography (1)
- endoscopic retrograde cholangiopancreatography (1)
- endothelial dysfunction (1)
- endourology (1)
- endovascular recanalization (1)
- endovascular thrombectomy (1)
- ensemble cNN (1)
- enteral transmission (1)
- enterale Übertragung (1)
- enterobacter infections; pseudomonas aeruginosa; epidemiology (1)
- enterocytes (1)
- environmental tobacco smoke (1)
- enzyme activity assay (1)
- enzyme linked immunosorbent assay (ELISA) (1)
- epidemic (1)
- epidemics (1)
- epidemlology (1)
- epidermal growth factor (1)
- epidural (1)
- epilepsy surgery (1)
- epileptic encephalopathy (1)
- episodic memory (1)
- epithelial-to-mesenchymal transition (EMT) (1)
- epoxyeicosatrienoic acid (1)
- erectile dysfunction (1)
- erythropoiesis (1)
- essential thrombocythemia (ET) (1)
- essential tremor (1)
- estrogen (1)
- ethanol (1)
- ethnicity (1)
- euthymic (1)
- evaluation (1)
- everyday life (1)
- everyday tasks (1)
- evidence-based guideline (1)
- evolution (1)
- exclusion of very low profiles (1)
- executive functions (1)
- exosome (1)
- experimental pain models (1)
- expert witness statement (1)
- extracellular signal-regulated kinase (1)
- extraskeletal (1)
- eye movements (1)
- eye tracking (ET) (1)
- fMLP (1)
- fMRT (1)
- factor V Leiden mutation (1)
- factor XIII (1)
- faecal microbiota transfer (1)
- falsch negative Ergebnisse (1)
- falsch positive Ergebnisse (1)
- false negative results (1)
- false positive results (1)
- familial amyloid nephropathy with urticaria and deafness (1)
- famotidine (1)
- fasting insulin (1)
- fat grafting (1)
- fat pad resection (1)
- fatigue (1)
- fatty acid (1)
- fatty acid synthesis (1)
- feasibility study (1)
- febrile neutropenia (1)
- fecal incontinence (1)
- fecal microbiota transfer (1)
- federated feasibility queries (1)
- feedback control (1)
- female subjects (1)
- females (1)
- fenfluramine (1)
- ferric carboxymaltose (1)
- ferric derisomaltose (1)
- ferritin (1)
- ferritinophagy (1)
- ferroportin (1)
- ferumoxytol (1)
- fetal loss (1)
- fibrin-glue-spray technique (1)
- fibrinolysis (1)
- fibrosis imaging (1)
- filter membrane procedure (1)
- fimaporfin (1)
- first-time shoulder dislocation (1)
- fluorescence (1)
- fluorescence in situ hybridization (FISH) (1)
- focal cortical dysplasia (1)
- focal therapy (1)
- fondaparinux (1)
- fondaparinux sodium (1)
- foreign body reaction (1)
- formula diet (1)
- fractionation (1)
- fracture strength (1)
- fracture strength equation (1)
- fragile-X-associated tremor-ataxia syndrome (1)
- fragment screening (1)
- fragment-size analyses (ACE2; CQ11) (1)
- frequency of attacks (1)
- frontal fibrosierende Alopezie (1)
- fronto-temporal lobar dementia (1)
- fronto-temporal-lobar-dementia (1)
- frontotemporal dementia (1)
- full-arch restoration (1)
- function (1)
- functional connectivity (1)
- functional connectome acute (1)
- functional magnetic resonance imaging (1)
- fungal infection (1)
- fungal sinusitis (1)
- fungal sugar (1)
- fusion (1)
- fusion kinase (1)
- gait symmetry (1)
- gangliosides (1)
- gargle lavage (1)
- gasotransmitters (1)
- gastrointestinal (1)
- gastrointestinal stromal tumours (1)
- gefitinib (1)
- gel (1)
- gemcitabine (1)
- gender (1)
- gender differences (1)
- gene polymorphisms (1)
- gene regulation (1)
- gene signature (1)
- general practitioners (1)
- genetic diversity (1)
- genetic model (1)
- genetic variability (1)
- genetically caused iron imbalance (1)
- genetische Polymorphismen (1)
- genetische Varianten (1)
- genome (1)
- genomic instability (1)
- genotype G (1)
- geriatric patients (1)
- geriatrics (1)
- geriatrischer Ultraschall (1)
- gestational hypertension (1)
- gesundheitsbezogene Lebensqualität HIV (1)
- gingival recession therapy (1)
- glecaprevir (1)
- glioblastoma cells (1)
- glioblastoma survival (1)
- glioma microenvironment (1)
- glioma stem-like cells (1)
- global health (1)
- globosides (1)
- glomerulus (1)
- glucose and lipid metabolism (1)
- glucose-6-phosphate dehydrogenase (1)
- glucosylceramide (1)
- glucosylceramides (1)
- glutamate (1)
- glutathione peroxidase 4 (1)
- glycobiology (1)
- glycoconjugate (1)
- glycoproteins (1)
- glycosyltransferase (1)
- gp100 (1)
- graft-vs-host disease (1)
- granule polarization (1)
- graph theory (1)
- graphic 3D models (1)
- gravity (1)
- great height (1)
- grisel syndrome (1)
- growth inhibition (1)
- guided tissue regeneration (1)
- guideline (1)
- guidelines (1)
- haNK (1)
- habitat (1)
- haemophilia (1)
- haemophilia A (1)
- harmonization (1)
- harnwegspathogene Enterobacteriacae (1)
- hatching (1)
- head and neck neoplasms (1)
- head and neck squamous cell carcinoma (1)
- health behavior (1)
- health care (1)
- health data (1)
- health database (1)
- health education (1)
- health information interoperability (1)
- health services research (1)
- health-care personnel (1)
- health-related quality of life (1)
- health-relatedquality of life (1)
- healthcare personnel (1)
- healthcare system (1)
- healthcare workers (1)
- healthy control (1)
- hearing loss (1)
- heart neoplasms (1)
- heart rate (1)
- heart rate control (1)
- hematological (1)
- hematotoxicity (1)
- hemiepiphysiodesis plate (1)
- hemodialysis (1)
- hemophilia (1)
- hemophilia a (1)
- hemorrhagic transformation (1)
- heparan sulfate proteoglycans (1)
- heparin sensitivity (1)
- hepatic stellate cells (1)
- hepatitis (1)
- hepatitis B (1)
- hepatitis B surface antigen (1)
- hepatitis B virus (1)
- hepatitis C-virus (HCV) (1)
- hepatitis D (1)
- hepatocellular cancer (1)
- hepatotoxicity (1)
- herb-induced liver injury (HILI) (1)
- hereditary angioedema (1)
- hereditary dystopic lipidosis (1)
- hereditary thrombophilia (1)
- herpes simplex virus type 1 (1)
- herpes simplex virus type 2 (1)
- heterogeneity (1)
- hidradenitis suppurativa (1)
- hierarchical clustering (1)
- high risk (1)
- high sensitive C-reactive protein (1)
- high throughput screening (1)
- high-altitude adaptation (1)
- high-altitude pulmonary hypertension (1)
- high-content screen (1)
- high-fat-diet (1)
- high-risk (1)
- high-risk neuroblastoma (1)
- high-throughput (1)
- high-throughput screening (1)
- hip osteoarthritis (hip OA) (1)
- hippocampal sclerosis (1)
- histamine (1)
- histological outcomes (1)
- histone deacetylase (1)
- histopathological growth pattern (1)
- holistic treatment (1)
- home training (1)
- homeodomain protein (1)
- homeostasis (1)
- hormones (1)
- hospital admission (1)
- hospital length of stay (1)
- host matrix- pathogen interaction (1)
- host-microbe interaction (1)
- human MSCs (1)
- human allogeneic hematopoietic cell transplantation (1)
- human behaviour (1)
- human factors (1)
- human genomics (1)
- human immunodeficiency virus (1)
- human intestinal microbiota (1)
- human monoclonal antibody (1)
- human olfaction (1)
- human prion diseases (1)
- human research (1)
- human rhabdomyosarcoma (1)
- human subjects (1)
- human-liver chimeric mouse model (1)
- humans (1)
- hybrid abutment (1)
- hybrid materials (1)
- hybrid production (1)
- hybridization (1)
- hybrids (1)
- hydrogen peroxide (1)
- hydrogen sulfide (H2S) (1)
- hydroxylation (1)
- hyperactivity (1)
- hyperalgesia (1)
- hypercholesterolemia (1)
- hypersensitivity (1)
- hypertriglyceridemia (1)
- hypertrophy (1)
- hypnotics and sedatives (1)
- hypobaric hypoxia (1)
- hypocalcemia (1)
- hypoparathyreoidism (1)
- hypophosphatemia (1)
- hyposensitization (1)
- hypoxia inducible factor 1 alpha (1)
- hypoxia-inducible factor-2α (1)
- iCBT (1)
- ibrutinib (1)
- idiopathic pulmonary fibrosis (1)
- idiosyncratic drug-induced liver injury (DILI) (1)
- image-guided tissue acquisition (1)
- imaging (1)
- imaging genetics (1)
- imaging protocol (1)
- immobilization in external rotation and abduction (1)
- immun (1)
- immunchemische Bestimmungsmethoden (1)
- immune assessment (1)
- immune checkpoint (1)
- immune checkpoint blockade (1)
- immune checkpoint inhibitor (ICI) (1)
- immune checkpoint inhibitors (ICI) (1)
- immune defense (1)
- immune escape (1)
- immune host defense (1)
- immune infiltration (1)
- immune monitoring (1)
- immune related adverse events (irAE) (1)
- immune therapy (1)
- immuno-oncotherapy (1)
- immunoassay (1)
- immunofixation electrophoresis (1)
- immunological risk (1)
- immunosenescence (1)
- immunoturbidimetric inhibition technique (1)
- immunturbidimetrische Inhibitionstechnik (1)
- implant-mediated growth guidance (1)
- imprecision (1)
- impulsivity (1)
- in silico (1)
- in situ (1)
- in vitro models (1)
- in vivo (1)
- in vivo dosimetry (1)
- in-cabin exposure (1)
- inborn errors of immunity (1)
- incidence (1)
- incontinence (1)
- individual differences (1)
- indoor air (1)
- induction chemotherapy (1)
- induction regimen (1)
- induction therapy (1)
- inertial motion capture (1)
- inertial motion units (1)
- inertial sensors (1)
- infection control (1)
- infection precaution (1)
- infectious disease (1)
- infectivity (1)
- inferior frontal gyrus (1)
- inflammasome (1)
- inflammatory reaction (1)
- informal care (1)
- infrapatellar fat pad (1)
- infrared spectroscopy (1)
- inguinal hernia (1)
- inherited (1)
- inhibitor (1)
- inhibitors (1)
- inhibitory control (1)
- inhibitory interneurons (1)
- injury (1)
- injury pattern (1)
- injury prevention (1)
- inner membrane morphology (1)
- inosine (1)
- inositol signaling (1)
- instructional film and video (1)
- insula (1)
- insulin resistance (1)
- insulin sensitivity (1)
- insurance data (1)
- integrate-and-fire (1)
- integrated stress response (1)
- integrative neuromotor training (1)
- integrin (1)
- intellectual disability (1)
- intelligence (1)
- intensive care admission and mortality (1)
- inter-individual variability (1)
- interactions (1)
- interferon induction (1)
- interferon sensitivity (1)
- interferon type III (1)
- interim positron emissiontomography (1)
- interleukin-1beta (1)
- interleukin-22 (1)
- internal/external controls (1)
- international transport (1)
- interne/externe Kontrollen (1)
- internet (1)
- interstitial multicatheter brachytherapy (1)
- intervenciones cognitivas (1)
- intestinal iron loss (1)
- intestinal manipulation (1)
- intracellular (1)
- intracellular multiplication (1)
- intracerebral hemorrhage (ICH) (1)
- intracranial hemorrhage (1)
- intrahepatic cholangiocarcinoma (1)
- intranasal administration (1)
- intraoperatively molded (1)
- intraoral scanning (1)
- intrauterine Wachstumsretardierung (1)
- intrauterine growth restriction (1)
- intravenous iron (1)
- intravenous iron therapy (1)
- intrinsic and innate immune response (1)
- invasive fungal disease (1)
- invasive fungal infection (1)
- inverse spacer (1)
- inverse stage migration (1)
- investigational (1)
- inflammation (1)
- iron deficiency anemia (1)
- iron isomaltoside (1)
- iron-trafficking (1)
- irritable bowel syndrome (1)
- isolation (1)
- jejunoileal atresia (1)
- joint contact forces (1)
- joint innervation (1)
- joint load (1)
- juvenile myelomonocytic leukemia (1)
- kaffir lime (1)
- keratinized mucosa (1)
- kidney function (1)
- kidney neoplasm (1)
- kidney transplantation (1)
- kleinzelliges/Diagnostik (1)
- knee adduction moment (1)
- knee osteoarthritis (1)
- knowledge based systems (1)
- kolorektal (1)
- kompetitiver ELISA (1)
- konventionelle Analysentechniken (1)
- laboratory diagnosis (1)
- laboratory diagnostic (1)
- laboratory diagnostics (1)
- laboratory organization (1)
- laboratory worker (1)
- lacto/neo-lacto series GSLs (1)
- landrace pigs (1)
- language impairment (1)
- laparoscopic inguinal hernia repair (1)
- laparoscopische Cholezystektomie (1)
- laser-induced thermotherapy (1)
- lasso regression (1)
- late disease (1)
- latent factor mixed model (1)
- layer-specificity (1)
- learning and memory (1)
- left atrial appendage occlusion (1)
- leg axis malalignment (1)
- legislation (1)
- legumain (1)
- leisure-time activity (1)
- lenalidomide (1)
- length of stay (1)
- leptin receptor-deficient mouse (1)
- leucocytes (1)
- leukaemia (1)
- leukemia (1)
- leukocytes (1)
- leukodystrophy (1)
- leukotriene (1)
- lichen extracts (1)
- life table (1)
- life-expectancy (1)
- lifestyle (1)
- light irradiation (1)
- limitations (1)
- lipid droplets (1)
- lipidomics (1)
- lipofilling (1)
- lipofuscin (1)
- lipoproteins (1)
- lipoxin (1)
- lipoxin A4 (1)
- lipoxygenase inhibitor (1)
- liquid chromatography–mass spectrometry (1)
- live-cell imaging (1)
- live/dead staining (1)
- liver X receptor (1)
- liver damage (1)
- liver metastasis (1)
- liver steatosis (1)
- liver stiffness (1)
- liver volume (1)
- local antibiotics (1)
- local drug delivery (1)
- local preemptive analgesia (1)
- local recurrence (1)
- local treatment (1)
- location (1)
- locator (1)
- locusts (1)
- logistic models (1)
- long non-coding RNAs (1)
- long term (1)
- long-term outcome (1)
- long-term potentiation (1)
- long-term prophylaxis (1)
- long-term results (1)
- loss of B-cell phenotype (1)
- loss-of-function (1)
- loving-kindness meditation (1)
- low density lipoprotein receptor (1)
- low risk (1)
- low-back-pain (1)
- low-carbohydrate (1)
- low-dose irradiation (1)
- lower leg fracture (1)
- lower limb deformities (1)
- lppr5 (1)
- lung fibrosis (1)
- lung function (1)
- lung tumor heterogeneity (1)
- lungs (1)
- lymph node (1)
- lymph node metastases (1)
- lymphocytes (1)
- lysophospholipids (1)
- lysosomal-dependent cell death (1)
- lysosome (1)
- mCRPC (1)
- mRNA stability (1)
- mRNA-1273 (1)
- mRNA1273 (1)
- mTOR inhibitor (1)
- macaque (1)
- machine learning (ML) (1)
- magnetoencephalography (1)
- male (1)
- malignancies (1)
- malignancy (1)
- malignant melanoma (1)
- mammary carcinoma (1)
- manganese (1)
- mappers (1)
- mapping-algorithms (1)
- marginal fit (1)
- marked lymph node (1)
- marker (1)
- mass spectrometry (1)
- material characterization (1)
- maternity protection law (1)
- mathematical analysis (1)
- mathematical modeling (1)
- matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (1)
- mechanical accuracy (1)
- mechanical recanalization (1)
- mechanical ventilation (1)
- mechanotransduction (1)
- medical device (1)
- medical education (1)
- medical informatics (1)
- medical risk factors (1)
- medication adherence rate (1)
- medication review (1)
- meditación de bondad amorosa (1)
- medizinische Beschäftigte (1)
- medizinisches Personal (1)
- medulloblastoma (1)
- membrane protein complex (1)
- membrane remodeling (1)
- membrane-less organelles (1)
- membranous urethra (1)
- membranous urethral stricture (1)
- meningioma (1)
- menschliche Prionenerkrarikungen (1)
- mental distress (1)
- mental health (1)
- mesangial cells (1)
- mesenchymal stromal cell (1)
- mesenchymal stromal cells (1)
- mesenchymale Stammzellen (1)
- mesial temporal lobe epilepsy (1)
- meta-analysis (1)
- metabolic alterations (1)
- metabolic liver disease (1)
- metabolic rewiring (1)
- metastases (1)
- metastatic renal cell carcinoma (1)
- methacarn (1)
- miR (1)
- miR-122 (1)
- miR-142-3p (1)
- miR-181 (1)
- miR-21 (1)
- miR-6862-5p (1)
- michael acceptor (1)
- microangiopathy (1)
- microbial colonization (1)
- microbiologic agents (1)
- microbiology (1)
- microbiome (1)
- microcentrifugal analyzer (1)
- microdissection (1)
- microlaparoscopy (1)
- microneutralization assay (1)
- microsomal ethanol oxidizing system (1)
- microstates (1)
- microstimulation (1)
- microsurgery (1)
- microvesicles (1)
- microwave ablation (1)
- mid-IR spectroscopy (1)
- mid-term urinary continence (1)
- middle-aged (1)
- migration (1)
- mikrobiologische Erreger (Bakterien, Pilze, Protozoen) (1)
- mikroskopisch-mikrochemisches Harnsteinanalysenverfahren (1)
- mild cognitive impairment (1)
- mind wandering (1)
- mineralization (1)
- minimal invasive (1)
- minimal invasive surgery (1)
- minimal residual disease (1)
- minimally invasive surgery (1)
- minimally invasive therapy (1)
- minocycline (1)
- miscarriage (1)
- mitochondrial antiviral signaling protein (MAVS) (1)
- mitochondrial disease (1)
- mitochondrial metabolism (1)
- mitochondrial morphology (1)
- mitochondrial respiration (1)
- mitral regurgitation (1)
- mitral valve surgery (1)
- mixed infection (1)
- mixed lineage kinase domain-like (1)
- mobile air quality study (1)
- model builder software (1)
- modeling (1)
- modelling (1)
- models (1)
- molar mass distribution (1)
- mold (1)
- molecular adaptation (1)
- molecular biology (1)
- molecular diagnostic techniques (1)
- molecular dynamics (1)
- molecular marker (1)
- molecular modeling (1)
- molecular neuroscience (1)
- molecular subtyping (1)
- molecular surveillance (1)
- molecular typing (1)
- monkeypox (1)
- monoacylglycerol lipase (1)
- monoclonal antibodies (1)
- monoklonale Antikörper (1)
- monotherapy (1)
- monotype abutment (1)
- monsoon (1)
- mood (1)
- morbidity (1)
- morphometry (1)
- mortality analysis (1)
- mortality risk (1)
- motor activity (MA) (1)
- motor functions (1)
- motor-control-exercise (1)
- mouse (1)
- mouse models (1)
- mouse tumor model (1)
- mouthwash (1)
- mouthwash solution (1)
- mtLSU quality control (1)
- mucormycetes (1)
- mucormycosis (1)
- multi-material 3D printing (1)
- multi-scale models (1)
- multicenter study (1)
- multidisciplinary-therapy (1)
- multidrug resistance (1)
- multidrug resistance protein 4 (1)
- multiparametric magnetic resonance imaging (1)
- multiplex immunohistochemistry (1)
- multiplexed immunofluorescence (1)
- multisensory integration (1)
- multislice imaging (1)
- multispectral flow cytometry (1)
- multivoxel pattern analysis (1)
- musclin (1)
- musculoskeletal inflammation (1)
- musculoskeletal modeling (1)
- musculoskeletal repair (1)
- musculoskeletal system (1)
- mutation (1)
- mutism (1)
- myeloproliferative neoplasms (MPN) (1)
- myocardial efficiency (1)
- myocardial fibrosis (1)
- myocardial ischaemia (1)
- myocardial power (1)
- nNOS (1)
- nasal swab (1)
- natural killer (1)
- natural selection (1)
- natural sounds (1)
- necroptosis (1)
- neoadjuvant chemoradiotherapy (1)
- neoadjuvant chemotherapy (1)
- neoadjuvant immunochemotherapy (1)
- neoadjuvant therapy (1)
- neonate (1)
- neoplasm metastasis (1)
- neovascularization (1)
- nephrectomy (1)
- nephroblastoma (1)
- nephron sparing surgery (1)
- nephroureterectomy (1)
- nerve-sparing surgery (1)
- neue Rollenbilder der MFA (1)
- neural correlates (1)
- neural network (1)
- neuregulin 1 (1)
- neurexin (1)
- neuroblast (1)
- neuroblastoma (1)
- neurocognition (1)
- neurocognitive outcome (1)
- neurocritical care (1)
- neurodegenerative diseases (1)
- neurodevelopment (1)
- neurodevelopmental disorde (1)
- neuroendocrine (1)
- neuroendocrine tumor (1)
- neuroethology (1)
- neurogenic bowel (1)
- neuroimaging (1)
- neurological complication (1)
- neurological manifestations (1)
- neurological side effects (1)
- neurology (1)
- neuronal silencing (1)
- neurooncology (1)
- neuropeptide (1)
- neuropeptides (1)
- neuroprotection (1)
- neurotransmitter (1)
- neurysmal subarachnoid hemorrhage (aSAH) (1)
- neutralizing antibody (1)
- neutropenia (1)
- neutrophil elastase (1)
- newborn (1)
- newly diagnosed glioblastoma (1)
- nicht lineare Regressionskurve (1)
- niedermolekulares Heparin (1)
- nitroalkene (1)
- nitroalkylation (1)
- nitroglycerin (1)
- nociceptors (1)
- nodular lymphocyte-predominant Hodgkin lymphoma (1)
- noise (1)
- nomogram (1)
- non-alcoholic fatty liver disease (1)
- non-aneurysmal (1)
- non-aneurysmal SAH (1)
- non-coding RNA (1)
- non-contact injuries (1)
- non-fermenter (1)
- non-neutropenic episode (1)
- non-organ confined stage (1)
- non-perimesencephalic (1)
- non-small cell lung cancer (1)
- non-small-cell lung cancer (1)
- non-surgical periodontal therapy (1)
- noninvasive blood glucose analysis (1)
- nonsense-mediated mRNA decay (1)
- nontraumatic atlantoaxial rotatory subluxation (1)
- noradrenaline (1)
- norepinephrine (1)
- normal liver cells (1)
- notified body (1)
- novel technologies (1)
- nuclear cardiology (1)
- nuclear factor 2 (erythroid-derived 2-like factor) (NFE2L2) (Nrf2) (1)
- nuclear magnetic resonance (NMR) (1)
- nuclear power plant (1)
- nuclear receptor (1)
- nuclear receptor coactivator 4 (1)
- nuclear receptor-related 1 (1)
- nucleic acid amplification test(NAT) (1)
- nucleic acid amplification test (1)
- nucleic acid amplification test (NAT) (1)
- nucleic acid amplification testing (NAT) (1)
- nucleic acid docking (1)
- nucleic acid lateral flow immunoassay (1)
- nucleolus (1)
- nucleoredoxin (1)
- nutrient endocytosis (1)
- nutrition - clinical (1)
- nymphs (1)
- observational study (1)
- obstetric complications (1)
- obstetric pain (1)
- obstetrics (1)
- occupational immediate-type reactions (1)
- occupationally acquired viral infections (1)
- oedema (1)
- official requirements (1)
- olfactory testing (1)
- olive mill wastewater (OMWW) (1)
- oluble epoxide hydrolase (1)
- oncogenes (1)
- oncogenesis (1)
- oncogenic RAS (1)
- oncogenic signaling (1)
- oncological exercise therapy (1)
- oncomodulation (1)
- online intervention (1)
- online research (1)
- open (1)
- open field behavior (1)
- open science (1)
- open skill exercise (1)
- operating microscope (1)
- optogenetics (1)
- oral and maxillofacial surgery (1)
- oral cavity cancer (1)
- oral drug products (1)
- oral health (1)
- oral health burden (1)
- oral progestins (1)
- orale Gestagene (1)
- ordinary differential equation (1)
- ordinary differential equations (ODE) (1)
- organ preservation (1)
- organic nitrates (1)
- organoids (1)
- organotypic culture (1)
- orthopaedic patients (1)
- orthopoxvirus (1)
- osseoincorporation (1)
- osseointegration (1)
- osteoblast (1)
- osteoclasts (1)
- osteogenic differentiation (1)
- other cause mortality (1)
- otoplasty (1)
- outbreak (1)
- outpatient care (1)
- outpatients (1)
- outside-in signaling (1)
- ovarian cancer (1)
- overdenture (1)
- overtreatment (1)
- overweight (1)
- oviposition (1)
- oviposition substrate (1)
- ovitrap (1)
- oxaliplatin (1)
- oxidized low density lipoprotein (1)
- oxythiamine (1)
- oxytocin, articulation, over reading, affective prosody, neuromodulation (1)
- p-eIF2α (1)
- p16 (1)
- p21Cip1/CDKN1A (1)
- p24-antibodies (1)
- p38 MAPK (1)
- p53 pathway (1)
- pH (1)
- pH-dependent solubility (1)
- pIOL (1)
- pad-test (1)
- pain intensity (1)
- pain management (1)
- paired samples (1)
- palliative care (1)
- palliative care services (1)
- pancreatic ductal adenocarcinoma (1)
- pannexin-1 (1)
- paper-based detection (1)
- parabolic flight (1)
- paracrine signaling (1)
- paramyxoviridae. (1)
- parent rating (1)
- parenteral nutrition (1)
- partial differential equation (1)
- particle size distribution (1)
- particulate matter (1)
- passive smoke (1)
- pathogen (1)
- pathogenicity (1)
- pathology (1)
- patient blood management (PBM) (1)
- patient centered care (1)
- patient data (1)
- patient preferences (1)
- patient safety (1)
- patient-centred care (1)
- patient-reported outcomes (1)
- patient–doctor relationship (1)
- patient’s decree (1)
- pediatric intensive care (1)
- pediatric orthopedic (1)
- pediatric robotic surgery (1)
- pediatric solid tumors (1)
- pelvic trauma (1)
- pembrolizumab (1)
- pentaerythritol tetranitrate (1)
- peptide receptor radionuclide therapy (1)
- perceptual closure (1)
- percutaneous thermal ablation (1)
- perforant path transection (1)
- peri-implant disease (1)
- peri-implantitis treatment (1)
- pericytes (1)
- periimplantitis (1)
- perimesencephalic (1)
- perinatal (1)
- periodontal diseases (1)
- periodontal risk factors (1)
- periodontal treatment (1)
- periodontal– systemic disease interactions (1)
- peripartal (1)
- peripheral blood stem cell collection (1)
- peripheral injury (1)
- peritoneal macrophages (1)
- peritumoral edema (1)
- peritumoral edema zone (1)
- peroxisome proliferator-activated receptor (1)
- persistent periodontal pockets (1)
- personalized (1)
- phagocytes (1)
- phantom study (1)
- pharmaco-fMRI (1)
- pharmacodynamics (1)
- pharmacoepigenetics (1)
- pharmacogenetics (1)
- pharmacological data science (1)
- pharmacological plasticity (1)
- pharmacophore model (1)
- phase I (1)
- phase IV (1)
- phase separation (1)
- phenoconversion (1)
- phenotypic screening; (1)
- pheromone (1)
- phosphatidylethanolamines (1)
- phospholipase A2 (1)
- phospholipid (1)
- phosphoproteomics (1)
- photochemical internalization (1)
- photodynamic therapy (1)
- photothermal detection (1)
- physical performance (1)
- physiotherapy (1)
- phytosterols (1)
- pibrentasvir (1)
- pimozide (1)
- pitch (1)
- placenta (1)
- planimetric measurement (1)
- plasma (1)
- plasma C-peptide (1)
- plasma jet (1)
- plasma pools and products (1)
- plasma protein determination in urine (1)
- plasmid (1)
- platelet hyperactivity (1)
- platelet substitution (1)
- platelet-rich fibrin (1)
- platelet-rich-fibrin (1)
- platinum-based chemotherapy (1)
- plppr5 (1)
- pneumocystis (1)
- point of care (1)
- point-of-care diagnostics (1)
- point-of-care testing (POCT) (1)
- pole concept of goiter growth (1)
- poliovirus (1)
- polo-like kinases (1)
- poly(A)-tail (1)
- poly-LacNAc (1)
- polyQ (1)
- polyclonal antibody (1)
- polycythemia vera (PV) (1)
- polyklonale Antikörper (1)
- polymer infiltrated ceramic network (1)
- polymerase chain reaction (PCR) (1)
- polymeric micelle (1)
- polypept(o)ide (1)
- polyunsaturated fatty acid (1)
- portal pressure (1)
- portal vein (1)
- positron-emissions-tomography (1)
- post-caesarean uterus (1)
- post-exercise hypotension (1)
- post-infectious bronchiolitis obliterans (1)
- post-radiotherapy recurrence (1)
- post-transcriptional regulation (1)
- posterior circulation (1)
- posterior fossa tumor (1)
- posterior horn (1)
- posteroinferior horn (1)
- postgraduate edu (1)
- postinfectious bronchiolitis obliterans (1)
- postmonsoon (1)
- postmortem blood samples (1)
- postnatal care (1)
- postoperative complications (1)
- postoperative radiochemotherapy (1)
- postoperative radiotherapy (1)
- posttranslational modification (PTM) (1)
- potassium channel (1)
- poxvirus (1)
- pre-analytical system (1)
- pre-professional (1)
- precautions (1)
- precision and accuracy (1)
- precision medicine (1)
- precision weighting (1)
- preclinical (1)
- prediabetes and type 2 diabetes (1)
- predictive biomarker (1)
- predictive value (1)
- prefrontal cortex (1)
- prehabilitation (1)
- prenatal diagnostic (1)
- prepontine (1)
- preventive health services (1)
- preventive strategies (1)
- primary aldosteronism (1)
- primary biliary cholangitis (1)
- primary health care (1)
- primary immunodeficiency (1)
- primary myelofibrosis (PMF) (1)
- primary ovarian insufficiency (1)
- primärer Hyperaldosteronismus (1)
- print and press (1)
- prion-like (1)
- private brands (1)
- product performance (1)
- production (1)
- professional dance (1)
- professional soccer players (1)
- proficiency testing (1)
- progestin mono-preparation (1)
- prognostic marker (1)
- prognostic scores (1)
- progranulin (1)
- promyelocytic leukemia nuclear bodies (1)
- prone position (1)
- propensity score matching (1)
- prostaglandin (1)
- prostanoids (1)
- prostate cancer (PCa) (1)
- prostate neoplasia (1)
- prostate neoplasm (1)
- prostatectomy (1)
- protease inhibitor (1)
- proteasom inhibitor (1)
- proteasomal processing escape (1)
- protein aggregation (1)
- protein complexes (1)
- protein evolution (1)
- protein folding (1)
- protein phosphorylation (1)
- protein–protein interaction (1)
- proteoglycan (1)
- proteostasis (1)
- prothrombin induced by vitamin K absence-II (1)
- prothrombin mutation (1)
- proton pumping (1)
- proton-sensing GPCR (1)
- protruding ear (1)
- präanalytische Systeme (1)
- prädiktive Werte (1)
- pseudoaneurysm (1)
- pseudomonas aeruginosa (1)
- psoriatic arthritis (1)
- psychiatric disorder (1)
- psychiatric disorders (1)
- psychischer Stress (1)
- psychogenic non-epileptic seizures (1)
- psychosocial factors (1)
- publication output (1)
- pulmonary failure (1)
- pulmonary fibrosis (1)
- pulmonary hypertension (1)
- pulmonary hypoplasia (1)
- pulmonary ventilation (1)
- pulse wave velocity (1)
- pulsed SILAC (1)
- pulsed-field (1)
- purification (1)
- pädiatrische allogene Stammzelltransplantation (1)
- qRT-PCR (1)
- quality management (1)
- quantitative MRT (1)
- quantitative RUCAM (1)
- quantitative determination of viral antibodies (1)
- quantitative magnetic resonance imaging (1)
- quantum cascade laser (QCL) (1)
- query (1)
- quiescence (1)
- rRNA chaperone ERAL1 (1)
- race (1)
- race/ethnicity disparities (1)
- radiation dosage (1)
- radiation dosimetry (1)
- radiation protection (1)
- radiation-induced (1)
- radio sensitivity (1)
- radioimmunotherapy (1)
- radiomics (1)
- radiosensitization (1)
- randomized (1)
- randomized controlled trial (1)
- range expansion (1)
- rapid gastric emptying (1)
- rare disease (1)
- rare mendelian disorders (1)
- rat calvaria defect (1)
- rat femur critical size defect (1)
- rat model (1)
- rats (1)
- re-exposure (1)
- re-irradiation (1)
- reactive coordination (1)
- real time analysis (1)
- real world (1)
- real-world (1)
- realist synthesis (1)
- recall (1)
- rechallenge (1)
- recombinase polymerase amplification (1)
- recovery (1)
- recurrence pattern (1)
- recurrent cholangitis (1)
- recurrent urinary tract infections (1)
- red cells (1)
- redox status (1)
- reduced kidney function (1)
- reduction potential (1)
- refractive lens exchange (1)
- refractive surgery (1)
- regenerative therapy (1)
- regulatory T cell (1)
- regulatory T helper cells (1)
- reintroduction (1)
- relapsing–remitting multiple sclerosis (1)
- relaxometry (1)
- remodeling (1)
- renal dysfunction (1)
- renal failure (1)
- renal fibroblasts (1)
- renal inflammation (1)
- renal transplantation (1)
- renal tubular epithelial cells (1)
- replicative fitness (1)
- reproducibility (1)
- research database (1)
- research funding (1)
- research incentives (1)
- resectability (1)
- resin nano ceramics (1)
- resistance (1)
- resistance analysis (1)
- resistance testing (1)
- resistant epilepsy (1)
- resolution (1)
- resolution of inflammation (1)
- resolvin (1)
- respiratorische Infektion (1)
- respiratorische Insuffizienz (1)
- respiratory failure (1)
- respiratory infection (1)
- respiratory insufficiency (1)
- response (1)
- response inhibition (1)
- response to therapy (1)
- rest period (1)
- resting-state fMRI (1)
- result quantitation; (1)
- resveratrol (1)
- reticulocyte count (1)
- reticulocyte haemoglobin (1)
- reticulocyte hemoglobin equivalent (1)
- retinoic acid (1)
- retrospective studies (1)
- retrovirus (1)
- reverberation (1)
- revision knee arthroplasty (1)
- reward (1)
- reward probabilities (1)
- rhabdomyosarcoma (1)
- rhinovirus (1)
- ribonucleotide reductase (1)
- rifampicin (1)
- rifampin (1)
- risk assessment (1)
- risk factor (1)
- risk of malignancy (1)
- risk stratification (1)
- rituximab (1)
- robot-guided stereotaxy (1)
- robotic-assisted (1)
- robotically assisted surgery (1)
- robotics (1)
- room simulation (1)
- rotary ATPase mechanism (1)
- rotational thromboelastometry (1)
- sE-Cadherin (1)
- sEH (1)
- sRNA (1)
- sRNA tool (1)
- safety attitudes questionnaire (1)
- salience network (1)
- saliva (1)
- salvage mastectomy (1)
- sample Identification (1)
- sampling (1)
- sarcoma (1)
- scanner noise (1)
- scar (1)
- schwangerschaftsdepression (1)
- schwangerschaftsinduzierter Hypertonus (1)
- screening ELISA (1)
- screening questionnaire (1)
- sealing zone (1)
- searchlight analysis (1)
- seasonal adaption (1)
- second line therapy (1)
- second-line immunotherapy (1)
- second-line treatment / 2L treatment (1)
- secondary data analysis (1)
- secondary progressive multiple sclerosis (1)
- secreted Ly-6/uPAR-related protein 1 (1)
- secretory phospholipase A (1)
- seed and soil (1)
- segmental ureteral resection (1)
- seizures (1)
- selection (1)
- selective media (1)
- selenium (1)
- self-collected samples (1)
- seminoma (1)
- semiquinone (1)
- sensitivity (1)
- sensorineural hearing loss (1)
- sensory loss (1)
- sensory organ development (1)
- septicemia (1)
- seroconversion (1)
- serologic screening (1)
- serological markers of disease (1)
- serological testing for infectious diseases (1)
- serologische Prognosefaktoren (1)
- serum separator (1)
- severe acute respiratory syndrome coronavirus 2 (1)
- severely injured (1)
- severely injured patient (1)
- sex (1)
- sexual arousal (1)
- sexual dysfunction (1)
- sexual rehabilitation (1)
- shape (1)
- shared decision-making (1)
- shear stress (1)
- shikonin (SHI) (1)
- short bowel (1)
- short linear motif (1)
- short-course antibiotic therapy (1)
- short-term (1)
- shoulder instability (1)
- shoulder stabilization (1)
- siRNA analysis (1)
- siRNA lipid nanoparticles (LNPs) (1)
- siRNA quantification (1)
- sialic acid (1)
- signal transduction (1)
- signaling (1)
- simulation (1)
- single-cell RNA sequencing (1)
- single-cell proteomics (1)
- skin diseases (1)
- sleep (1)
- sleep deprivation (1)
- sleep disordered breathing (1)
- sleep quality (1)
- small bowel (1)
- small leucine-rich proteoglycans (1)
- small ubiquitin-related modifier (1)
- smoking behavior (1)
- smooth muscle cell (1)
- social anxiety (1)
- social communication (1)
- social recognition (1)
- socio-economic influences (1)
- socioeconomic factors (1)
- soft tissue sarcoma (1)
- software (1)
- solid phase reagent chemistry (1)
- solid tumor (1)
- sonoSens (1)
- sonography (1)
- sorafenib (1)
- sound localization (1)
- sound-induced flash illusion (1)
- spared nerve injury (1)
- sparse imaging (1)
- spatial learning (1)
- spatial specificity (1)
- specialized pro-resolving lipid mediators (SPMs) (1)
- species barrier (1)
- specificity (1)
- speech and language pathologist (1)
- sphingosine (1)
- sphingosine 1-phosphate homologues (1)
- sphingosine 1-phosphate receptor (1)
- sphingosine kinase (1)
- spike mutation (1)
- spike protein (1)
- spina bifida (1)
- spinal bone metastasis (1)
- spinal infection (1)
- spinal metastasis (1)
- spine injury (1)
- spinocerebellar ataxia (1)
- splicing (1)
- split-mouth (1)
- sport (1)
- spreading (1)
- sprouting (1)
- sprouting angiogenesis (1)
- squamous cell carcinoma (1)
- stage (1)
- stage migration (1)
- stairs (1)
- standard value (1)
- starvation (1)
- statin (1)
- statin treatment (1)
- statins (1)
- statistics (1)
- steady-state condition (1)
- steatosis (1)
- stem cell transplantation (1)
- stem cells (1)
- stent patency (1)
- stereotactic frame (1)
- stereotactic neurosurgery (1)
- stoma (1)
- stomach neoplasms (1)
- storage (1)
- store brands (1)
- stress period (1)
- structure constraints (1)
- structure-function (1)
- structured care program (1)
- strumpellin (1)
- student abuse (1)
- student mistreatment (1)
- study protocol (1)
- stuttering (1)
- subarachnoid hemorrhage (1)
- subdural hematoma (1)
- subgrouping (1)
- subpopulation (1)
- sudden cardiac death (1)
- sulfatides (1)
- sulfur-oxidizing symbiont (1)
- sunitinib (1)
- superficial vein (1)
- superparamagnetic iron oxide nanoparticles (1)
- supplementation (1)
- supply (1)
- support (1)
- suprachiasmatic nucleus (1)
- surface antigen mutant (1)
- surgical complications (1)
- surgical oncology (1)
- surgical procedures (1)
- surrogate ELISA (1)
- susceptibility testing (1)
- swallowing (1)
- swarming (1)
- symbiosis (1)
- sympathetic (1)
- sympathetic nervous system (1)
- symptoms (1)
- synaesthesia (1)
- synoviocytes (1)
- synovitis (1)
- synovium (1)
- tDCS (1)
- tVNS (1)
- tZVK (1)
- tachycardia (1)
- taller-than-wide (1)
- target (1)
- targeted axillary dissection (1)
- targeted sequencing (1)
- taste buds (1)
- tauopathies (1)
- tauopathy (1)
- teambasierte Intervention (1)
- temporal encephaloceles (1)
- tension band plate (1)
- testosterone (1)
- tetracycline (1)
- tetrahydroaldosterone (1)
- tetrahydrobiopterin (1)
- tetrahydrocannabinol (1)
- theory of mind (1)
- therapeutic anticoagulation (1)
- therapy monitoring (1)
- therapy response (1)
- thermal ablation (1)
- theta band (1)
- thrombectomy (1)
- thrombin (1)
- thrombin injection (1)
- thromboembolism (1)
- thrombophilia (1)
- thrombospondins (1)
- thromboxane (1)
- thymic selection (1)
- thyroid functioning (1)
- tibial fracture (1)
- tight junctions (1)
- tip cell filopodia formation (1)
- tissue microstructure (1)
- tissue reconstruction (1)
- tissue segmentation (1)
- tivantinib (1)
- toddler’s fracture (1)
- tolerability (1)
- tolerance (1)
- tooth transplantation (1)
- topical administration (1)
- topographical pattern (1)
- topoisomerase inhibitor (1)
- toric intraocular lens (1)
- torticollis (1)
- total knee replacement (1)
- total protein determination in urine (1)
- total thyroidectomy (1)
- total urinary protein (1)
- totale Thyreoidektomie (1)
- toxic milk mice (TX mice) (1)
- toxicity (1)
- trabecular metal (1)
- trace elements (1)
- tracking (1)
- traditional Chinese medicine (TCM) (1)
- traffic emissions (1)
- trafficking (1)
- training (1)
- trans (1)
- transarterielle Chemoembolisation (1)
- transcription (1)
- transcription factors (1)
- transcriptional cyclin-dependent kinase (1)
- transcriptome (1)
- transcriptomics (1)
- transduction (1)
- transfer entropy (1)
- transferrin (1)
- transforming growth factor-β (1)
- transfusion medicine (1)
- transgenic mice (1)
- transglutaminase (1)
- transient elastography (1)
- transjugular intrahepatic portosystemic shunt (1)
- translation (1)
- translational investigation (1)
- translational study (1)
- translatome (1)
- translatomics (1)
- transmission (1)
- transovarial transmission (1)
- transplant-free survival (1)
- transplantation (1)
- transstadial transmission (1)
- trauma registry (1)
- trauma-related guilt (1)
- trauma-related shame (1)
- traumatic injury (1)
- traumaticbraininjury(TBI) (1)
- treatment outcome (1)
- treatment resistance (1)
- treatment response (1)
- trials registry (1)
- triglycerides (1)
- trimeric autotransporters adhesin (1)
- triplex (1)
- trophoblast organoids (1)
- trophoblasts (1)
- trough levels (1)
- tuberous sclerosis complex (1)
- tumor (1)
- tumor growth (1)
- tumor immunity (1)
- tumor immunology (1)
- tumor marker (1)
- tumor spheroids (1)
- tumor stroma (1)
- tumor therapy (1)
- tumor-associated macrophages (TAM) (1)
- tunnel technique (1)
- type 1 diabetes (1)
- type 2 diabetes (1)
- tyrosin kinases (1)
- tyrosine hydroxylase (1)
- tyrosine kinase inhibitor (TKI) (1)
- tyrosine kinase receptor signaling (1)
- ubiquitin hydrolase (1)
- ubiquitin ligase (1)
- ultra-high risk for psychosis (1)
- ultrasonic cleaning (1)
- ultrasound (1)
- unacceptable antigen mismatches (1)
- unangemessene Behandlung (1)
- unconventional T cell (1)
- undifferentiated pleomorphic sarcoma (1)
- unilateral (1)
- unilateral hip osteoarthritis (1)
- unmethylated MGMT (1)
- upper tract urothelial carcinoma (1)
- upstaging (1)
- ureteroscopy (1)
- urethal stricture (1)
- urethral stricture (1)
- urethroplasty (1)
- uropathogenic enterobacteriacae (1)
- urothelial carcinoma (1)
- ursodeoxycholic acid (1)
- uterine wall (1)
- uveal melanoma (1)
- v-ATPase (1)
- vaccination rates (1)
- vaccine uptake rate (1)
- vaccine, (1)
- vaccine-induced immune thrombotic thrombocytopenia (VITT) (1)
- vaginal breech (1)
- vaginal hysterectomy (1)
- validation (1)
- variable silent delay (1)
- variant of concern (1)
- variants of concern (1)
- vascular disease (1)
- vascular integrity (1)
- vasodilation (1)
- vector (1)
- vemurafenib (1)
- venous thromboembolic events (1)
- venous thromboembolism (1)
- ventral otoplasty (1)
- ventral striatum (1)
- ventral tegmental area (1)
- ventralis intermedius nucleus (1)
- ventricular tachycardia (1)
- venöse Thromboembolie (1)
- vergence (1)
- vergüenza asociada a trauma (1)
- vertical transmission (1)
- vertigo (1)
- very high-risk (1)
- very low density lipoproteins (1)
- vestibular function (1)
- viral contamination (1)
- viral fitness (1)
- viral load (1)
- viral replication (1)
- virologic agents (1)
- virologic failure (1)
- virologische Erreger (1)
- virology (1)
- virus (1)
- virus (genome) detection. (1)
- virus detection (1)
- virus isolation (1)
- virus pneumonia (1)
- virus-safety (1)
- visual cortex (1)
- visual search (VS) (1)
- vitamin d (1)
- vitamin d-deficiency (1)
- vitamin k antagonists (1)
- vocational (1)
- volumetric measurement technology (1)
- von Willebrand disease (1)
- von Willebrand's disease (1)
- von-Willebrand-Syndrom (1)
- voxel-wise analyses (1)
- wastewater-based epidemiology (WBE) (1)
- wearable sensors (1)
- wearable-cardioverter defibrillator (1)
- whole genome pooled sequencing (1)
- whole-genome sequencing (1)
- wissensbasierte Systeme (1)
- wochenbettdepression (1)
- women (1)
- work place evaluation (1)
- workflow development (1)
- wound exudate (1)
- wound healing (1)
- wound infection (1)
- wound repair (1)
- xenograft (1)
- yellow fever mosquito (1)
- yellow flags (1)
- younger (1)
- zinc (1)
- zinc protoporphyrin (1)
- zirkulierende Tumorzellen (1)
- Öffentlichkeit (1)
- Übergewicht (1)
- Übertragung (1)
- ß-amyloid (1)
- β-HCG (1)
- β-ᴅ-2′-Deoxyribosides (1)
- β2-adrenoceptor (1)
- fibrogenesis (1)
- fingolimod (1)
Institute
- Medizin (2648) (remove)
Einfluss eines Erste-Hilfe-Kurses für Medizinstudierende auf notfallmedizinische Basiskompetenzen
(2021)
Medizinstudierende sind bereits in der Vorklinik häufig mit Situationen konfrontiert, in denen medizinische Notfälle passieren, die unter anderem wegen der Lage des Universitätscampus und den damit verbundenen Kontakt zu Patientinnen und Patienten oder in den Pflegepraktika. Tritt in diesen Situationen ein medizinischer Notfall ein, müssen sie Erste Hilfe leisten können. Das Ziel der vorliegenden Arbeit ist daher die Erfassung notfallmedizinischer Basiskompetenzen von Medizinstudierenden der Vorklinik und die Frage, ob diese ausreichend sind, um den Anforderungen ihres Umfeldes gerecht zu werden. Des Weiteren wurde ein Erste-Hilfe-Kurs speziell für Vorklinikstudierende basierend auf dem ABCDE-Schema konzipiert, implementiert und evaluiert, ob die erfassten Kompetenzdefizite behoben werden konnten.
In einem Pre-Post-Design wurde die theoretische Kompetenz anhand eines 10 Items Multiple-Choice-Tests und die praktischen Kompetenzen anhand von 3 OSCE-/OSPE-Stationen (je 5 min) erfasst. Sowohl der MC-Test als auch die OSCE-/OSPE-Stationen wurden in Probeläufen getestet und überarbeitet. Soziodemographische Daten wurden mittels Fragebogen erhoben. Der entwickelte Kurs umfasst 9 UE (davon 6 UE praktische Übungen) in denen die zu erlernenden Erste-Hilfe-Maßnahmen strukturiert und in logischer Reihenfolge anhand des etablierten ABCDE-Schemas vermittelt werden. Jeweils 8 Teilnehmende werden von zwei geschulten Peer-Dozierenden unterrichtet. Im Anschluss an das Training erfolgte eine erneute Erhebung der theoretischen und praktischen Kompetenzen. Die Eingabe der Rohdaten erfolgte in Microsoft Excel (Microsoft Inc., Redmond, WA, USA). Die weitere Auswertung erfolgte mittels SPSS (SPSS Inc., Chicago, IL, USA).
160 Studierende aus den ersten beiden Studienjahren konnten in die Studie eingeschlossen werden. Im Basis-Assessment demonstrierten nur 25% der Studierenden zwei Minuten lang eine suffiziente Kompression mit richtiger Frequenz und Drucktiefe, nur 29% überstreckten am Ende der Seitenlage den Kopf des Patienten und öffneten den Mund. Im Anschluss an das Training erzielten die Studierenden an allen OSCE/OSPE-Stationen signifikant bessere Ergebnisse: Bei der stabilen Seitenlage steigerten sie sich durchschnittlich um 5,3 Punkte (max. 14), bei der Reanimation um 6,8 Punkte (max. 18). Während sich vor dem Kurs 33% der Studierenden in der Lage fühlten, Wiederbelebungsmaßnahmen durchzuführen, waren dies nach dem Kurs 98%. Die Kursevaluation war durchweg positiv.
Die Erfassung notfallmedizinischer Basiskompetenzen von Medizinstudierenden der Vorklinik zeigte, dass diese nicht ausreichend geschult sind, um Notfallsituationen adäquat zu bewältigen. Vor diesem Hintergrund muss eine dem Anforderungsprofil entsprechende Ausbildung in Erster Hilfe bereits in der Vorklinik an der Universität gewährleistet werden. Die vorliegenden Ergebnisse zeigen, dass mithilfe eines speziell auf Medizinstudierende ausgerichteten Erste-Hilfe-Kurs eine deutliche Steigerung notfallmedizinischer Basiskompetenzen erfolgen kann.
Trehalose, a sugar from fungi, mimics starvation due to a block of glucose transport and induces Transcription Factor EB- mediated autophagy, likely supported by the upregulation of progranulin. The pro-autophagy effects help to remove pathological proteins and thereby prevent neurodegenerative diseases such as Alzheimer’s disease. Enhancing autophagy also contributes to the resolution of neuropathic pain in mice. Therefore, we here assessed the effects of continuous trehalose administration via drinking water using the mouse Spared Nerve Injury model of neuropathic pain. Trehalose had no effect on drinking, feeding, voluntary wheel running, motor coordination, locomotion, and open field, elevated plus maze, and Barnes Maze behavior, showing that it was well tolerated. However, trehalose reduced nerve injury-evoked nociceptive mechanical and thermal hypersensitivity as compared to vehicle. Trehalose had no effect on calcium currents in primary somatosensory neurons, pointing to central mechanisms of the antinociceptive effects. In IntelliCages, trehalose-treated mice showed reduced activity, in particular, a low frequency of nosepokes, which was associated with a reduced proportion of correct trials and flat learning curves in place preference learning tasks. Mice failed to switch corner preferences and stuck to spontaneously preferred corners. The behavior in IntelliCages is suggestive of sedative effects as a 'side effect' of a continuous protracted trehalose treatment, leading to impairment of learning flexibility. Hence, trehalose diet supplements might reduce chronic pain but likely at the expense of alertness.
Einleitung: OTSC Proctology ist ein Verfahren in der Analfistelchirurgie dessen Erfolgsaussichten auch 9 Jahre nach der ersten klinischen Anwendung nicht abschließend beurteilt werden können. Die wenigen bisher publizierten Studien zeigen sehr divergente Ergebnisse mit Heilungsraten von 10 bis 90%.
Material und Methoden: Wir führten eine retrospektive Auswertung der Behandlungsergebnisse aller konsekutiven Patienten, die in dem Zeitraum vom 01.03.2014 bis 31.03.2017 in der koloproktologischen Abteilung der DKD Helios Klinik Wiesbaden mittels OTSC-Verfahren wegen Analfisteln operiert wurden, durch. Erfasst wurden Alter, Geschlecht, OP- und Aufenthaltsdauer, Operateur, Fistelart und –lokalisation, Vorhandensein von Stoma und CED, plastischer Fistelverschluss (PFV) in der Anamnese, Clipverbleib nach der OP, Dauer des Follow-ups, Komplikationen sowie postoperative Schmerzsituation. Die Datenauswertung erfolgte mittels deskriptiver Statistik bei Subgruppenanalyse unter Verwendung der Statistiksoftware SPSS 20.
Ergebnisse: Es wurden insgesamt 68 Fälle eingeschlossen, davon 37% weiblich und 63% männlich. Das durchschnittliche Alter betrug 52 Jahre (25 – 81). 19 (28%) Patienten litten an CED, 11 (16%) Patienten hatten ein Stoma. 34 (50%) der Patienten hatten plastischen Fistelverschluss in der Anamnese. Die Verteilung nach Fisteltyp war wie folgt: 58 (85%) transsphinktär, 4 (6%) suprasphinktär, 3 (4%) intersphinktär, 1 (1,5%) rektovaginal, 1 (1,5%) rektourethral und 1 (1,5%) Pouchfistel. Die häufigsten Fistelokalisationen waren bei 6 h (N = 26, 38%), 12 h (N = 14, 21%), 7 h (N = 7, 10%) und 3h (N = 5, 7%) SSL. Die durchschnittlichen OP-Dauer und stationärer Aufenthalt betrugen 25 min (6 – 90) und 7 Tage (1 – 14 Tage) entsprechend. Die durchschnittliche Dauer des Follow-ups betrug 29 Monate (10 – 36).
Die Fistelheilung im Gesamtkollektiv lag bei 48,5%, 1 (1,5%) Patient war lost-tofollow-up. In der weiblichen (N = 25) und männlichen (N = 43) Kohorte fand die Heilung in 40% und 53% der Fälle entsprechend statt. Die Heilungsraten bei intersphinktären (N = 3), transsphinktären (N = 58) und suprasphinktären (N = 4) Fisteln lagen bei 100%, 46,5% und 50% entsprechend, eine rektovaginale und eine rektourethrale Fistel sind nicht geheilt. Eine Pouchfistel ist geheilt.
Die Heilungsraten bei 6h und 12h SSL lagen bei 58% und 14% entsprechend mit deutlichem Vorteil bei posteriorer Fistellage. Dieser Vorteil blieb nach der Aufteilung der Fisteln in anteriore (N = 30) und posteriore (N = 38), mit
Heilungsraten von 33% und 60,5% entsprechend, bestehen. In den Subgruppen ohne CED (N = 49) und mit CED (N = 19) lagen die Heilungsraten bei 53% und 35% entsprechend. In den Subgruppen ohne PFV (N = 34) und mit PFV (N = 34) lagen die Heilungsraten bei 59% und 38% entsprechend. In der Subgruppe ohne Stoma (N = 57) wurde eine Heilung in 47% der Fälle, in der Subgruppe mit Stoma (N = 11) in 55% beobachtet. In der Subgruppe mit den kryploglandulären Fisteln (N = 47) war die Heilung in 55,3% zu sehen und in der Subgruppe mit
kryptoglandulären Fisteln ohne PFV (N = 27) bei 63%.
In 48 (70,6%) Fällen wurde der Clip aktiv entfernt, in 11 (16,2%) Fällen kam es zum Spontanverlust und in 8 (11,8%) Fällen blieb der Clip in situ. Die durchschnittliche Zeit bis zur Klammerentfernung betrug 4 Monate. Die Heilungsraten bei Clipentfernung, Clipverbleib und Clipspontanabgang lagen bei 42%, 100% und 45% entsprechend.
Der maximale Schmerz nach NRS 0 – 2 bei 61% der Patienten, NRS 3 – 4 bei 28% und NRS 5 – 7 nur bei 11%. Bei 50% der Fälle war kein Opiat erforderlich und bei 39% der Fälle erfolgte die Opiateinnahme nicht länger als 2 Tage.
Die Komplikationen waren sehr selten: eine Nachblutung mit Clipdislokation (1,5%), ein Analabszess (1,5%), 2 Fälle (3%) der neuaufgetretenen Stuhlschmieren und 1 (1,5%) Wundheilungsstörung intraanal, die spontan abheilte. In 4 (6%) Fällen kam es zur Klammerdislokation vom inneren
Fistelostium mit konsekutiver Fistelpersistenz.
Fazit: OTSC ist ein komplikationsarmes und schmerzarmes Verfahren mit kurzer OP-Zeit und könnte einen festen Platz in der Analfistelchirurgie einnehmen. Die bestmöglichen Ergebnisse lassen sich bei dorsal gelegenen Analfisteln in
nichtvoroperierten Patienten ohne CED erzielen.
In humans, alterations of circadian rhythms and autophagy are linked to metabolic, cardiovascular and neurological dysfunction. Autophagy constitutes a specific form of cell recycling in many eukaryotic cells. Aging is the principal risk factor for the development of neurodegenerative diseases. Thus, we assume that both the circadian clock and autophagy are indispensable to counteract aging. We have previously shown that the hippocampus of Per1−/−-mice exhibits a reduced autophagy and higher neuronal susceptibility to ischemic insults compared to wild type (WT). Therefore, we chose to study the link between aging and loss of clock gene Per1−/−-mice. Young and aged C3H- and Per1−/−-mice were used as models to analyze the hippocampal distribution of Aβ42, lipofuscin, presenilin, microglia, synaptophysin and doublecortin. We detected several changes in the hippocampus of aged Per1−/−-mice compared to their wild type littermates. Our results show significant alterations of microglia morphology, an increase in Aβ42 deposition, overexpression of presenilin, decrease in synaptophysin levels and massive accumulation of lipofuscin in the hippocampus of 24-month-old Per1−/−-mice, without alteration of adult neurogenesis. We suggest that the marked lipofuscin accumulation, Aβ42 deposition, and overexpression of presenilin-2 observed in our experiments may be some of the consequences of the slowed autophagy in the hippocampus of aged Per1−/−-mice. This may lead during aging to excessive accumulation of misfolded proteins which may, consequently, result in higher neuronal vulnerability.
The group of proton-sensing G-protein coupled receptors (GPCRs) consists of the four receptors GPR4, TDAG8 (GPR65), OGR1 (GPR68), and G2A (GPR132). These receptors are cellular sensors of acidification, a property that has been attributed to the presence of crucial histidine residues. However, the pH detection varies considerably among the group of proton-sensing GPCRs and ranges from pH of 5.5 to 7.8. While the proton-sensing GPCRs were initially considered to detect acidic cellular environments in the context of inflammation, recent observations have expanded our knowledge about their physiological and pathophysiological functions and many additional individual and unique features have been discovered that suggest a more differentiated role of these receptors in health and disease. It is known that all four receptors contribute to different aspects of tumor biology, cardiovascular physiology, and asthma. However, apart from their overlapping functions, they seem to have individual properties, and recent publications identify potential roles of individual GPCRs in mechanosensation, intestinal inflammation, oncoimmunological interactions, hematopoiesis, as well as inflammatory and neuropathic pain. Here, we put together the knowledge about the biological functions and structural features of the four proton-sensing GPCRs and discuss the biological role of each of the four receptors individually. We explore all currently known pharmacological modulators of the four receptors and highlight potential use. Finally, we point out knowledge gaps in the biological and pharmacological context of proton-sensing GPCRs that should be addressed by future studies.
Exogenous adenosine and its metabolite inosine exert anti-inflammatory effects in synoviocytes of osteoarthritis (OA) and rheumatoid arthritis (RA) patients. We analyzed whether these cells are able to synthesize adenosine/inosine and which adenosine receptors (ARs) contribute to anti-inflammatory effects. The functionality of synthesizing enzymes and ARs was tested using agonists/antagonists. Both OA and RA cells expressed CD39 (converts ATP to AMP), CD73 (converts AMP to adenosine), ADA (converts adenosine to inosine), ENT1/2 (adenosine transporters), all AR subtypes (A1, A2A, A2B and A3) and synthesized predominantly adenosine. The CD73 inhibitor AMPCP significantly increased IL-6 and decreased IL-10 in both cell types, while TNF only increased in RA cells. The ADA inhibitor DAA significantly reduced IL-6 and induced IL-10 in both OA and RA cells. The A2AAR agonist CGS 21680 significantly inhibited IL-6 and induced TNF and IL-10 only in RA, while the A2BAR agonist BAY 60-6583 had the same effect in both OA and RA. Taken together, OA and RA synoviocytes express the complete enzymatic machinery to synthesize adenosine/inosine; however, mainly adenosine is responsible for the anti- (IL-6 and IL-10) or pro-inflammatory (TNF) effects mediated by A2A- and A2BAR. Stimulating CD39/CD73 with simultaneous ADA blockage in addition to TNF inhibition might represent a promising therapeutic strategy.
The purpose of the study was to investigate the bacterial viability of the initial biofilm on the surface of experimental modified dental resin composites. Twenty-five healthy individuals with good oral hygiene were included in this study. In a split-mouth design, they received acrylic splints with five experimental composite resin specimens. Four of them were modified with either a novel polymeric hollow-bead delivery system or methacrylated polymerizable Irgasan (Antibacterial B), while one specimen served as an unmodified control (ST). A delivery system based on Poly-Pore® was loaded with one of the active agents: Tego® Protect 5000 (Antiadhesive A), Dimethicone (Antiadhesive B), or Irgasan (Antibacterial A). All study subjects refrained from toothbrushing during the study period. Specimens were detached from the splints after 8 h and given a live/dead staining before fluorescence microscopy. A Friedman test and a post hoc Nemenyi test were applied with a significance level at p < 0.05. In summary, all materials but Antibacterial B showed a significant antibacterial effect compared to ST. The results suggested the role of the materials’ chemistry in the dominance of cell adhesion. In conclusion, dental resin composites with Poly-Pore-loaded active agents showed antibacterial effectiveness in situ.
Cancer is the major cause of death besides cardiovascular disease. Leukaemia represents the most prevalent malignancy in children with a frequency of 30 % and is one of the ten leading types of cancer in adults. Philadelphia Chromosome-positive B-ALL (Ph+ B-ALL) is driven by the cytogenetic aberration of the reciprocal chromosomal translocation t(9;22)(q34;q11) leading to the formation of the Philadelphia chromosome with a BCR-ABL1 fusion gene. This fusion gene encodes a BCR-ABL1 oncoprotein which is characterized by a constitutively enhanced tyrosine kinase activity promoting amplified proliferation, differentiation arrest and resistance to cell death. Ph+ B-ALL is considered the most aggressive ALL subtype with a long-term survival rate in the range of only 30 % despite intensive standard of care including chemotherapy in combination with a tyrosine kinase inhibitor (TKI) followed by allogeneic stem cell transplantation after remission for clinically fit patients.
The efficacy of chemotherapy has long been mainly attributed to tumour cell toxicity while immune modulating effects have been overlooked, especially in light of known immunosuppressive properties. Accumulative evidence, however, emphasizes the ability of chemotherapeutic agents, including TKIs, to normalise or re-educate a dysfunctional tumour microenvironment (TME) resulting in enhanced anti-tumour immunity. One of the underlying mechanisms of immune modulation is the induction of immunogenic cell death (ICD). ICD is an anti-tumour agent-induced cell death modality determined by the capacity to convert cancer cells into anti-cancer vaccines. The induction of ICD relies on the release of damage-associated molecular patterns (DAMPs) from dying tumour cells succumbing to ICD. Translocation of CALR to the cell surface, extracellular secretion of ATP and release of HMGB1 from the nucleus are key hallmarks of ICD that mediate anti-tumour immunity upon binding to antigen presenting cells resulting in a tumour antigen-specific immune response. Besides these molecular determinants, ICD is functionally defined by the inhibition of tumour growth in a vaccination assay in which mice are injected with tumour cells exposed to the potential ICD inducer in-vitro and then re-challenged with live tumour cells of the same cancer type. Both molecular and functional criteria determine the gold standard approach to assess ICD. By increasing the immunogenicity of cancer cells, ICD contributes to the restoration of immunosurveillance as an essential feature of tumour rejection, which is clinically reflected by improved therapeutic efficacy and disease outcome in patients. Therefore, identifying novel ICD inducers is an objective of interest in the context of cancer therapy.
In respect of these considerations, the aim addressed in the present work is the examination of the second-generation TKI Nilotinib for the ability to induce ICD. The thesis is set in the context of the group's research on the role of Gas6/TAM signalling within the TME regarding the pathogenesis of acute leukaemia. In in-vivo experiments of our research group it has been consistently observed that the use of Nilotinib enhances the anti-leukaemic immunity mediated by a deletion of Gas6. Against the background of increasing importance of chemotherapeutic agents as potent modulators of a dysregulated TME, it was hypothesized that Nilotinib may synergize with a Gas6-deficient environment by inducing ICD in Ph+ B-ALL cells.
In growth inhibition and Annexin V/Propidium iodide cell death assays Nilotinib was shown to induce cell death in concentration-dependent manner that occurs bimodally in terms of cell death modality ranging between apoptosis and necrosis. By ICD marker analysis, comprising flow-cytometric detection of CALR exposure, chemoluminescence-based ATP measurement and immunoblotting for HMGB1, it was found that Nilotinib-induced cell death is not accompanied by CALR exposure and ATP secretion, but is associated with the release of HMGB1. In macrophages co-culture experiments with Nilotinib-treated leukaemic cells, no relevant shift in terms of macrophages activation and polarisation was observed in either a juxtacrine or paracrine setup. In consistency with the results obtained in the in-vitro experiments, Nilotinib was not potent to elicit a protective immune response in mice within a vaccination assay.
Conclusively, Nilotinib was identified to not qualify as bona fide ICD inducer. The role of Nilotinib-induced cell death and HMGB1 release are proposed as objective for further investigation concerning the synergistic interplay between Nilotinib and a Gas6-deficient environment. Efforts addressing exploration and optimisation of the immunological potential of chemotherapeutic agents are a promising approach aimed at providing cancer patients with the best possible treatment in future.
Purpose This study aims to define the extent of additional surgical procedures after abdominal wall closure (AWC) in patients with gastroschisis (GS) and omphalocele (OC) with special focus on gastrointestinal related operations. Methods A retrospective chart review was performed including all operations in GS and OC patients in the first year after AWC (2010–2019). The risk for surgery was calculated using the one-year cumulative incidence (CI). Results 33 GS patients (18 simple GS, 15 complex) and 24 OC patients (12 without (= OCL), 12 OC patients with liver pro-trusion (= OCL +)) were eligible for analysis. 43 secondary operations (23 in GS, 20 in OC patients) occurred after a median time of 84 days (16–824) in GS and 114.5 days (12–4368) in OC. Patients with complex versus simple GS had a significantly higher risk of undergoing a secondary operation (one-year CI 64.3% vs. 24.4%; p = 0.05). 86.5% of surgical procedures in complex GS and 36.3% in OCL + were related to gastrointestinal complications. Complex GS had a significantly higher risk for GI-related surgery than simple GS. Bowel obstruction was a risk factor for surgery in complex GS (one-year CI 35.7%). Conclusion Complex GS and OCL + patients had the highest risk of undergoing secondary operations, especially those with gastrointestinal complications
Background: Excessive alcohol intake is associated with adverse immune response-related effects, however, acute and chronic abuse differently modulate monocyte activation. In this study, we have evaluated the phenotypic and functional changes of monocytes in acutely intoxicated healthy volunteers (HV).
Methods: Twenty-two HV consumed individually adjusted amounts of alcoholic beverages until reaching a blood alcohol level of 1‰ after 4h (T4). Peripheral blood was withdrawn before and 2h (T2), 4h (T4), 6h (T6), 24h (T24), and 48h (T48) after starting the experiment and stained for CD14, CD16 and TLR4. CD14brightCD16-, CD14brightCD16+ and CD14dimCD16+ monocyte subsets and their TLR4 expression were analyzed by flow cytometry. Inflammasome activation via caspase-1 in CD14+ monocytes was measured upon an ex vivo in vitro LPS stimulation. Systemic IL-1β and adhesion capacity of isolated CD14+ monocytes upon LPS stimulation were evaluated.
Results: The percentage of CD14+ monocyte did not change following alcohol intoxication, whereas CD14brightCD16- monocyte subset significantly increased at T2 and T24, CD14brightCD16+ at T2, T4 and T6 and CD14dimCD16+ at T4 and T6. The relative fraction of TLR4 expressing CD14+ monocytes as well as the density of TLR4 surface presentation increased at T2 and decreased at T48 significantly. TLR4+CD14+ monocytes were significantly enhanced in all subsets at T2. TLR4 expression significantly decreased in CD14brightCD16- at T48, in CD14brightCD16+ at T24 and T48, increased in CD14dimCD16+ at T2. IL-1β release upon LPS stimulation decreased at T48, correlating with TLR4 receptor expression. Alcohol downregulated inflammasome activation following ex vivo in vitro stimulation with LPS between T2 and T48 vs. T0. The adhesion capacity of CD14+ monocytes decreased from T2 with significance at T4, T6 and T48. Following LPS administration, a significant reduction of adhesion was observed at T4 and T6.
Conclusions: Alcohol intoxication immediately redistributes monocyte subsets toward the pro-inflammatory phenotype with their subsequent differentiation into the anti-inflammatory phenotype. This is paralleled by a significant functional depression, suggesting an alcohol-induced time-dependent hyporesponsiveness of monocytes to pathogenic triggers.
Kinase fusions are considered oncogenic drivers in numerous types of cancer. In lung adenocarcinoma 5–10% of patients harbor kinase fusions. The most frequently detected kinase fusion involves the Anaplastic Lymphoma Kinase (ALK) and Echinoderm Microtubule-associated protein-Like 4 (EML4). In addition, oncogenic kinase fusions involving the tyrosine kinases RET and ROS1 are found in smaller subsets of patients. In this study, we employed quantitative mass spectrometry-based phosphoproteomics to define the cellular tyrosine phosphorylation patterns induced by different oncogenic kinase fusions identified in patients with lung adenocarcinoma. We show that exogenous expression of the kinase fusions in HEK 293T cells leads to widespread tyrosine phosphorylation. Direct comparison of different kinase fusions demonstrates that the kinase part and not the fusion partner primarily defines the phosphorylation pattern. The tyrosine phosphorylation patterns differed between ALK, ROS1, and RET fusions, suggesting that oncogenic signaling induced by these kinases involves the modulation of different cellular processes.
Traditional ergonomic risk assessment tools such as the Rapid Upper Limb Assessment (RULA) are often not sensitive enough to evaluate well-optimized work routines. An implementation of kinematic data captured by inertial sensors is applied to compare two work routines in dentistry. The surgical dental treatment was performed in two different conditions, which were recorded by means of inertial sensors (Xsens MVN Link). For this purpose, 15 (12 males/3 females) oral and maxillofacial surgeons took part in the study. Data were post processed with costume written MATLAB® routines, including a full implementation of RULA (slightly adjusted to dentistry). For an in-depth comparison, five newly introduced levels of complexity of the RULA analysis were applied, i.e., from lowest complexity to highest: (1) RULA score, (2) relative RULA score distribution, (3) RULA steps score, (4) relative RULA steps score occurrence, and (5) relative angle distribution. With increasing complexity, the number of variables times (the number of resolvable units per variable) increased. In our example, only significant differences between the treatment concepts were observed at levels that are more complex: the relative RULA step score occurrence and the relative angle distribution (level 4 + 5). With the presented approach, an objective and detailed ergonomic analysis is possible. The data-driven approach adds significant additional context to the RULA score evaluation. The presented method captures data, evaluates the full task cycle, and allows different levels of analysis. These points are a clear benefit to a standard, manual assessment of one main body position during a working task.
Sulforaphane (SFN) is a natural glucosinolate found in cruciferous vegetables that acts as a chemopreventive agent, but its mechanism of action is not clear. Due to antioxidative mechanisms being thought central in preventing cancer progression, SFN could play a role in oxidative processes. Since redox imbalance with increased levels of reactive oxygen species (ROS) is involved in the initiation and progression of bladder cancer, this mechanism might be involved when chemoresistance occurs. This review summarizes current understanding regarding the influence of SFN on ROS and ROS-related pathways and appraises a possible role of SFN in bladder cancer treatment.
Background and Aims. Systemic treatment with sorafenib has been the standard of care (SOC) in patients with advanced Barcelona Clinic Liver Cancer (BCLC) stage C hepatocellular carcinoma (HCC) for more than a decade. TACE has been reported to allow better local tumor control in selected patients with BCLC stage C HCC. Methods. A retrospective analysis of patients with BCLC stage C HCC that were treated with sorafenib and TACE was conducted; they were compared to BCLC stage C patients treated either with TACE or sorafenib in the same period of time outside a clinical trial. Results. A total of 201 patients with BCLC stage C were identified, who were treated with either sorafenib and TACE (group A; n = 54), sorafenib (group B; n = 82) or TACE (group C; n = 65). No significant difference in baseline characteristics was observed. Time to progression was 7.0 months (95% CI: 4.3–9.7), 4.1 months (95% CI: 3.6–4.7) and 5.0 months (95% CI: 2.9–7.1) in groups A, B and C, respectively, and overall survival was 16.5 months (95% CI: 15.0–18.1), 8.4 months (95% CI: 6.0–10.8) and 10.5 months (95% CI: 7.5–13.6), respectively (group A vs. group B: p < 0.001; group A vs. group C: p = 0.0023). Adverse events of grade 3/4 occurred in 34% of patients in group A. Conclusions. Although sorafenib is a SOC in patients with BCLC stage C HCC, TACE is frequently used as an additional locoregional treatment in selected patients. This combined approach resulted in a significant overall survival benefit in selected patients, although randomized trials have not yet proven this benefit.
Adapting movements rapidly to unanticipated external stimuli is paramount for athletic performance and to prevent injuries. We investigated the effects of a 4-week open-skill choice-reaction training intervention on unanticipated jump-landings. Physically active adults (n = 37; mean age 27, standard deviation 2.7 years, 16 females, 21 males) were randomly allocated to one of two interventions or a control group (CG). Participants in the two intervention groups performed a 4-week visuomotor open skill choice reaction training, one for the upper and one for the lower extremities. Before and after the intervention, two different types of countermovement jumps with landings in split stance position were performed. In the (1) pre-planned condition, we informed the participants regarding the landing position (left or right foot in front position) before the jump. In the (2) unanticipated condition, this information was displayed after take-off (350–600 ms reaction time before landing). Outcomes were landing stability [peak vertical ground reaction force (pGRF) and time to stabilization (TTS)], and landing-related decision-making quality (measured by the number of landing errors). To measure extremity-specific effects, we documented the number of correct hits during the trained drills. A two-factorial (four repeated measures: two conditions, two time factors; three groups) ANCOVA was carried out; conditions = unanticipated versus pre-planned condition, time factors = pre versus post measurement, grouping variable = intervention allocation, co-variates = jumping time and self-report arousal. The training improved performance over the intervention period (upper extremity group: mean of correct choice reaction hits during 5 s drill: +3.0 hits, 95% confidence interval: 2.2–3.9 hits; lower extremity group: +1.6 hits, 0.6–2.6 hits). For pGRF (F = 8.4, p < 0.001) and landing errors (F = 17.1, p < 0.001) repeated measures effect occurred. Significantly more landing errors occurred within the unanticipated condition for all groups and measurement days. The effect in pGRF is mostly impacted by between-condition differences in the CG. No between-group or interaction effect was seen for these outcomes: pGRF (F = 0.4, p = 0.9; F = 2.3, p = 0.1) landing errors (F = 0.5, p = 0.6; F = 2.3, p = 0.1). TTS displayed a repeated measures (F = 4.9, p < 0.001, worse values under the unanticipated condition, improvement over time) and an interaction effect (F = 2.4, p = 0.03). Healthy adults can improve their choice reaction task performance by training. As almost no transfer to unanticipated landing successfulness or movement quality occurred, the effect seems to be task-specific. Lower-extremity reactions to unanticipated stimuli may be improved by more specific training regimens.
Magnetic resonance-guided laser interstitial laser therapy (MRgLITT) and radiofrequency ablation (RFA) represent two minimally invasive methods for the treatment of drug-refractory mesial temporal lobe epilepsy (mTLE). We performed a systematic review and a meta-analysis to compare outcomes and complications between MRgLITT, RFA, and conventional surgical approaches to the temporal lobe (i.e., anterior temporal lobe resection [ATL] or selective amygdalohippocampectomy [sAHE]). Forty-three studies (13 MRgLITT, 6 RFA, and 24 surgery studies) involved 554, 123, 1504, and 1326 patients treated by MRgLITT, RFA, ATL, or sAHE, respectively. Engel Class I (Engel-I) outcomes were achieved after MRgLITT in 57% (315/554, range = 33.3%–67.4%), RFA in 44% (54/123, range = 0%–67.2%), ATL in 69% (1032/1504, range = 40%–92.9%), and sAHE in 66% (887/1326, range = 21.4%–93.3%). Meta-analysis revealed no significant difference in seizure outcome between MRgLITT and RFA (Q = 2.74, p = .098), whereas ATL and sAHE were both superior to MRgLITT (ATL: Q = 8.92, p = .002; sAHE: Q = 4.33, p = .037) and RFA (ATL: Q = 6.42, p = .0113; sAHE: Q = 5.04, p = .0247), with better outcome in patients at follow-up of 60 months or more. Mesial hippocampal sclerosis (mTLE + hippocampal sclerosis) was associated with significantly better outcome after MRgLITT (Engel-I outcome in 64%; Q = 8.55, p = .0035). The rate of major complications was 3.8% for MRgLITT, 3.7% for RFA, 10.9% for ATL, and 7.4% for sAHE; the differences did not show statistical significance. Neuropsychological deficits occurred after all procedures, with left-sided surgeries having a higher rate of verbal memory impairment. Lateral functions such as naming or object recognition may be more preserved in MRgLITT. Thermal therapies are effective techniques but show a significantly lower rate of Engel-I outcome in comparison to ATL and sAHE. Between MRgLITT and RFA there were no significant differences in Engel-I outcome, whereby the success of treatment seems to depend on the approach used (e.g., occipital approach). MRgLITT shows a similar rate of complications compared to RFA, whereas patients undergoing MRgLITT may experience fewer major complications compared to ATL or sAHE and might have a more beneficial neuropsychological outcome.
Background: We hypothesized that lymph node dissection (LND) at salvage radical prostatectomy may be associated with lower cancer-specific mortality (CSM) and we tested this hypothesis.
Methods: We relied on surveillance, epidemiology, and end results (2004–2016) to identify all salvage radical prostatectomy patients. Categorical, as well as univariate and multivariate Cox regression models tested the effect of LND (LND performed vs. not), as well as at its extent (log-transformed lymph node count) on CSM.
Results: Of 427 salvage radical prostatectomy patients, 120 (28.1%) underwent LND with a median lymph node count of 6 (interquartile range [IQR], 3–11). According to LND status, no significant or clinically meaningful differences were recorded in PSA at diagnosis, stage and biopsy Gleason score at diagnosis, except for age at prostate cancer diagnosis (LND performed 63 vs. 68 years LND not performed, p < .001). LND status (performed) was an independent predictor of lower CSM (hazard ratio [HR] 0.47; p = .03). Similarly, lymph node count (log transformed) also independently predicted lower CSM (HR: 0.60; p = .01). After the 7th removed lymph node, the effect of CSM became marginal. The effect of N-stage on CSM could not be tested due to insufficient number of observations.
Conclusions: Salvage radical prostatectomy is rarely performed and LND at salvage radical prostatectomy is performed in a minority of patients. However, LND at salvage radical prostatectomy is associated with lower CSM. Moreover, LND extent also exerts a protective effect on CSM. These observations should be considered in salvage radical prostatectomy candidates.
Purpose: Dexamethasone (Dex) is the most common corticosteroid to treat edema in glioblastoma (GBM) patients. Recent studies identified the addition of Dex to radiation therapy (RT) to be associated with poor survival. Independently, Tumor Treating Fields (TTFields) provides a novel anti-cancer modality for patients with primary and recurrent GBM. Whether Dex influences the efficacy of TTFields, however, remains elusive. Methods: Human GBM cell lines MZ54 and U251 were treated with RT or TTFields in combination with Dex and the effects on cell counts and cell death were determined via flow cytometry. We further performed a retrospective analysis of GBM patients with TTFields treatment +/- concomitant Dex and analysed its impact on progression-free (PFS) and overall survival (OS). Results: The addition of Dex significantly reduced the efficacy of RT in U251, but not in MZ54 cells. TTFields (200 kHz/250 kHz) induced massive cell death in both cell lines. Concomitant treatment of TTFields and Dex did not reduce the overall efficacy of TTFields. Further, in our retrospective clinical analysis, we found that the addition of Dex to TTFields therapy did not influence PFS nor OS. Conclusion: Our translational investigation indicates that the efficacy of TTFields therapy in patients with GBM and GBM cell lines is not affected by the addition of Dex.
Objectives: To evaluate peri-implant tissue dimensions following nonsurgical (NS) and surgical therapy (S) employing different decontamination protocols of advanced ligature-induced peri-implantitis in dogs.
Material & Methods: Peri-implantitis defects (n = 5 dogs, n = 30 implants) were randomly and equally allocated in a split-mouth design to NS or S treatment using either an Er:YAG laser (ERL), an ultrasonic device (VUS), or plastic curettes + local application of metronidazole gel (PCM), respectively. Horizontal bone thickness (hBT) and soft tissue thickness (hMT) were measured at different reference points: (v0) at the marginal portion of the peri-implant mucosa (PM); (v1) at 50% of the distance from PM to bone crest (BC); (v2) at the BC; (v3) at the most coronal extension of the bone-to-implant contact. Vertical peri-implant tissue height was calculated from PM to BC.
Results: All of the treatment groups showed a gradual hMT increase from v0 to the v2 reference point, followed by a reduction from v2 to the v3 region. The S-VUS subgroup tended to be associated with higher hMT values at the v0 region than the NS-VUS subgroup (0.44 mm versus 0.31 mm). PM-BC distance varied from 2.22 to 2.83 mm in the NS group, and from 2.07 to 2.38 in the S group.
Conclusion: Vertical and horizontal peri-implant tissue dimensions were similar in different treatment groups.
Background: Facial skin cancer lesions in close proximity to critical organs require further development of radiotherapeutic techniques for highly conformal treatment, especially when treating elderly frail patients. We report on our treatment technique and first clinical experience for patients with perinasal/periorbital skin cancer treated with individualized epithetic mold high-dose-rate brachytherapy (BRT).
Methods: From January 2019, patients with complex shaped or unfavorably located skin cancer not eligible for surgery or external beam radiotherapy (RT) were screened for mold-based BRT. Six patients were identified. Toxicity and clinical response were documented during therapy and posttreatment follow-up.
Results: Median patient age was 80 years (74–92 years). Median prescription dose was 42 Gy (range, 33–44 Gy) delivered in once-daily fractions of 3 or 4 Gy. Two patients had treatment interruptions caused by acute conjunctivitis grade 2 and a nontreatment-related cardiac event, respectively. At a median follow-up of 335 days (96–628 days), no ≥ grade 2 late toxicity was documented with all patients showing complete clinical response.
Conclusions: High-dose-rate BRT with individualized epithetic molds for perinasal/periorbital skin cancer is a well-tolerated and safe treatment option for patients not eligible for primary surgery or definitive external beam RT because of comorbidities or tumor location.
Objective: This study was undertaken to identify temporal encephaloceles (TEs) and examine their characteristics in patients with temporal lobe epilepsy (TLE) and ex- tratemporal lobe epilepsy (ETLE), as well as in asymptomatic cases.
Methods: Four hundred fifty-eight magnetic resonance imaging scans were exam- ined retrospectively to identify TE in 157 patients with TLE, 150 patients with ETLE, and 151 healthy controls (HCs).
Results: At least one TE was identified in 9.6% of the TLE patients (n = 15, 95% confidence interval [CI] = 5.3%–15.3%), in 3.3% of patients with ETLE (n = 5, 95% CI = 1.1%–7.6%), and in 2.0% of the HCs (n = 3, 95% CI = .4%–5.7%), indicating a significantly higher frequency in patients with TLE compared to ETLE and HC sub- jects (p = .027, p = .005). Examining the characteristics of TEs in both asymptomatic and epilepsy patients, we found that TEs with a diameter of less than 6.25 mm were more likely to be asymptomatic, with a sensitivity of 91.7% and a specificity of 73.3% (area under the curve = .867, 95% CI = .723–1.00, p = .001).
Significance: Temporal encephaloceles may occur without presenting any clinical symp- toms. Patients with TLE show a higher frequency of TEs compared to the ETLE and HC groups. According to our study, TE size could be used to suggest potential epileptogenicity.
Treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute leukemia (Ph+ ALL) has been revolutionized with the advent of tyrosine kinase inhibitors (TKIs). Most patients with CML achieve long-term survival similar to individuals without CML due to treatment with TKIs not only in frontline but also in further lines of therapy. The third-generation TKI ponatinib has demonstrated efficacy in patients with refractory CML and Ph+ ALL. Ponatinib is currently the most potent TKI in this setting demonstrating activity against T315I mutant clones. However, ponatinib’s safety data revealed a dose-dependent, increased risk of serious cardiovascular (CV) events. Guidance is needed to evaluate the benefit–risk profile of TKIs, such as ponatinib, and safety measures to prevent treatment-associated CV events. An expert panel of German hematologists and cardiologists summarize current evidence regarding ponatinib’s efficacy and CV safety profile. We propose CV management strategies for patients who are candidates for ponatinib.
Alkylglycerol monooxygenase (AGMO) is a tetrahydrobiopterin (BH4)-dependent enzyme with major expression in the liver and white adipose tissue that cleaves alkyl ether glycerolipids. The present study describes the disclosure and biological characterization of a candidate compound (Cp6), which inhibits AGMO with an IC50 of 30–100 µM and 5–20-fold preference of AGMO relative to other BH4-dependent enzymes, i.e., phenylalanine-hydroxylase and nitric oxide synthase. The viability and metabolic activity of mouse 3T3-L1 fibroblasts, HepG2 human hepatocytes and mouse RAW264.7 macrophages were not affected up to 10-fold of the IC50. However, Cp6 reversibly inhibited the differentiation of 3T3-L1 cells towards adipocytes, in which AGMO expression was upregulated upon differentiation. Cp6 reduced the accumulation of lipid droplets in adipocytes upon differentiation and in HepG2 cells exposed to free fatty acids. Cp6 also inhibited IL-4-driven differentiation of RAW264.7 macrophages towards M2-like macrophages, which serve as adipocyte progenitors in adipose tissue. Collectively, the data suggest that pharmacologic AGMO inhibition may affect lipid storage.
Simple Summary:
CDK9, in combination with Cyclin T1, is one of the major regulators of RNA Polymerase II mediated productive transcription of critical genes in any cell. The activity of CDK9 is significantly up-regulated in a wide variety of cancer entities, to aid in the overexpression of genes responsible for the regulation of functions, which are beneficial to the cancer cells, like proliferation, survival, cell cycle regulation, DNA damage repair and metastasis. Enhanced CDK9 activity, therefore, leads to poorer prognosis in many cancer types, offering the rationale to target it using small-molecule inhibitors. Several, increasingly specific inhibitors, have been developed, some of which are presently in clinical trials. Other approaches being tested involve combining inhibitors against CDK9 activity with those against CDK9’s upstream regulators like BRD4, SEC and HSP90; or downstream effectors like cMYC and MCL-1. The inhibition of CDK9’s activity holds the potential to be a highly effective anti-cancer therapeutic.
Abstract:
Cyclin Dependent Kinase 9 (CDK9) is one of the most important transcription regulatory members of the CDK family. In conjunction with its main cyclin partner—Cyclin T1, it forms the Positive Transcription Elongation Factor b (P-TEFb) whose primary function in eukaryotic cells is to mediate the positive transcription elongation of nascent mRNA strands, by phosphorylating the S2 residues of the YSPTSPS tandem repeats at the C-terminus domain (CTD) of RNA Polymerase II (RNAP II). To aid in this process, P-TEFb also simultaneously phosphorylates and inactivates a number of negative transcription regulators like 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole (DRB) Sensitivity-Inducing Factor (DSIF) and Negative Elongation Factor (NELF). Significantly enhanced activity of CDK9 is observed in multiple cancer types, which is universally associated with significantly shortened Overall Survival (OS) of the patients. In these cancer types, CDK9 regulates a plethora of cellular functions including proliferation, survival, cell cycle regulation, DNA damage repair and metastasis. Due to the extremely critical role of CDK9 in cancer cells, inhibiting its functions has been the subject of intense research, resulting the development of multiple, increasingly specific small-molecule inhibitors, some of which are presently in clinical trials. The search for newer generation CDK9 inhibitors with higher specificity and lower potential toxicities and suitable combination therapies continues. In fact, the Phase I clinical trials of the latest, highly specific CDK9 inhibitor BAY1251152, against different solid tumors have shown good anti-tumor and on-target activities and pharmacokinetics, combined with manageable safety profile while the phase I and II clinical trials of another inhibitor AT-7519 have been undertaken or are undergoing. To enhance the effectiveness and target diversity and reduce potential drug-resistance, the future of CDK9 inhibition would likely involve combining CDK9 inhibitors with inhibitors like those against BRD4, SEC, MYC, MCL-1 and HSP90.
Die vorliegende Studie befasst sich mit dem Einfluss minimalinvasiver Zugangswege zur Mitralklappe auf den Herzrhythmus, den Erfolg einer perioperativ durchgeführten Ablation und die postoperative Notwendigkeit eines Herzschrittmachers.
Mitralklappenvitien und deren herzchirurgische Versorgung sind in vielen Fällen mit präoperativ bestehendem oder postoperativ neu auftretendem Vorhofflimmern assoziiert. In den vergangenen Jahrzehnten haben sich neben der medikamentösen Therapie des Vorhofflimmerns und der durch die Mitralklappeninsuffizienz induzierten Herzinsuffizienz verschiedene minimalinvasive chirurgische Zugangswege zur Mitralklappe sowie Ablationsverfahren etabliert und einen kurativen Therapieansatz gebildet.
Die Ablation im Zuge einer Mitralklappenchirurgie ist zu einem alltäglich durchgeführten Verfahren geworden.
Neu auftretendes Vorhofflimmern im Rahmen der Mitralklappenchirurgie kann perioperativ begrenzt sein und konvertiert häufig innerhalb der ersten 6 Wochen spontan in den Sinusrhythmus. Es geht aber mit einer erhöhten Mortalität und Hospitalisierungszeit einher. Das neu auftretende Vorhofflimmern kann jedoch auch persistieren oder erst im Langzeitverlauf entstehen. Auch die Notwendigkeit eines Herzschrittmachers kann durch Mitralklappeneingriffe insbesondere mit additiver Ablation aufgrund der anatomischen Gegebenheiten erhöht sein.
In unserer Arbeit ist von Interesse, ob sich die unten genannten Zugangswege im Hinblick auf das Neuauftreten von Vorhofflimmern im Langzeitverlauf, die Vorhofflimmerrezidivrate nach Ablation und die Schrittmacherrate mit und ohne durchgeführte Ablation unterscheiden.
Die vorliegende Studie umfasst alle Mitralklappenoperationen, die zwischen 1998 und 2015 in der Klinik für Thorax-, Herz- und thorakale Gefäßchirurgie der Universitätsklinik Frankfurt am Main über die folgenden drei minimalinvasiven Zugangswege, durchgeführt wurden: Gruppe A bildeten 300 Patienten, die im genannten Zeitraum über eine anterolaterale Minithorakotomie mittels Chitwood-Klemme operiert wurden. Gruppe B bestand aus 687 Patienten, die über eine partielle obere Sternotomie mit superiorem transseptalem Zugang operiert wurden. Die 219 Patienten, bei denen eine partielle obere Sternotomie mit transcavalem Zugang angewandt wurde, bildeten Gruppe C.
Die Auswertung erfolgte anhand von Patientenakten, internen und externen Untersuchungsbefunden und eines standardisierten Fragebogens im Follow-up. Es erfolgte eine zweite Auswertung nach Propensity Matching, um präoperative signifikante Unterschiede der Gruppen zu egalisieren.
Im Ergebnis konnte in unserer Studie gezeigt werden, dass die atriale Inzision einen entscheidenden Einfluss auf den Ablationserfolg sowie auf die Schrittmacherinzidenz hat. Bekannt war dabei ein höheres Risiko für postoperatives Vorhofflimmern und Schrittmacherimplantationen aufgrund der anatomischen Gegebenheiten bei Gruppe B. Dass jedoch Gruppe C ein signifikant noch höheres Risiko für Schrittmacherimplantationen mit sich bringt, war überraschend und ist derzeit nicht in der Literatur beschrieben.
In der multivariaten Analyse nach Matching waren Gruppe C, eine additive Ablation und das Alter signifikante unabhängige Prädiktoren für Schrittmacherimplantationen. In der logistischen Regression war Gruppe A ein unabhängiger Prädiktor für den Ablationserfolg zum Zeitpunkt der Entlassung. In der Langzeitbeobachtung trat Gruppe C an Stelle von Gruppe A, möglicherweise aufgrund der bei Gruppe A vorliegenden längsten Follow-up-Zeit. Wie schon in der vorliegenden Literatur diskutiert waren auch in unserer Auswertung hohes Alter und eine präoperative linksatriale Vergrößerung unabhängige Prädiktoren für den langfristigen Ablationserfolg.
Es bedarf weiterer vergleichender Studien mit einheitlichen Follow-up-Zeiten, um die hier gezeigten Ergebnisse zu überprüfen. Insbesondere der transcavale Zugang, der sich im negativen Sinne auf die Zahl der Schrittmacherimplantationen auszuwirken scheint, gibt Anlass für weitere Untersuchungen.
Popular media now often present 3D printing as a widely employed technology for the production of dental prostheses. This article aims to show, based on factual information, to what extent 3D printing can be used in dental laboratories and dental practices at present. It attempts to present a rational evaluation of todays´ applications of 3D printing technology in the context of dental restorations. In addition, the article discusses future perspectives and examines the ongoing viability of traditional dental laboratory services and manufacturing processes. It also shows which expertise is needed for the digital additive manufacturing of dental restorations.
Survival following relapse in children with Acute Myeloid leukemia: a report from AML-BFM and COG
(2021)
Simple Summary: Acute myeloid leukemia in children remains a difficult disease to cure despite intensive therapies that push the limits of tolerability. Though the intent of initial therapy should be the prevention of relapse, about 30% of all patients experience a relapse. Hence, relapse therapy remains critically important for survival. This retrospective analysis of two large international study groups (COG and BFM) was undertaken to describe the current survival, response rates and clinical features that predict outcomes. We demonstrate that children with relapsed AML may be cured with cytotoxic therapy followed by HSCT. High-risk features at initial diagnosis and early relapse remain prognostic for post-relapse survival. Current response criteria are not aligned with the standards of care for children, nor are the count recovery thresholds meaningful for prognosis in children with relapsed AML. Our data provide a new baseline for future treatment planning and will allow an updated stratification in upcoming studies.
Abstract: Post-relapse therapy remains critical for survival in children with acute myeloid leukemia (AML). We evaluated survival, response and prognostic variables following relapse in independent cooperative group studies conducted by COG and the population-based AML-BFM study group. BFM included 197 patients who relapsed after closure of the last I-BFM relapse trial until 2017, while COG included 852 patients who relapsed on the last Phase 3 trials (AAML0531, AAML1031). Overall survival at 5 years (OS) was 42 ± 4% (BFM) and 35 ± 2% (COG). Initial high-risk features (BFM 32 ± 6%, COG 26 ± 4%) and short time to relapse (BFM 29 ± 4%, COG 25 ± 2%) predicted diminished survival. In the BFM dataset, there was no difference in OS for patients who had a complete remission with full hematopoietic recovery (CR) following post-relapse re-induction compared to those with partial neutrophil and platelet recovery (CRp and CRi) only (52 ± 7% vs. 63 ± 10%, p = 0.39). Among 90 patients alive at last follow-up, 87 had received a post-relapse hematopoietic stem cell transplant (HSCT). OS for patients with post-relapse HSCT was 54 ± 4%. In conclusion, initial high-risk features and early relapse remain prognostic. Response assessment with full hematopoietic recovery following initial relapse therapy does not predict survival. These data indicate the need for post-relapse risk stratification in future studies of relapse therapies.
Diabetes is associated with platelet hyper-reactivity and enhanced risk of thrombosis development. Here we compared protein expression in platelets from healthy donors and diabetic patients to identify differentially expressed proteins and their possible function in platelet activation. Mass spectrometry analyses identified cyclin Y (CCNY) in platelets and its reduced expression in platelets from diabetic patients, a phenomenon that could be attributed to the increased activity of calpains. To determine the role of CCNY in platelets, mice globally lacking the protein were studied. CCNY-/- mice demonstrated lower numbers of circulating platelets but platelet responsiveness to thrombin and a thromboxane A2 analogue were comparable with that of wild-type mice, as was agonist-induced α and dense granule secretion. CCNY-deficient platelets demonstrated enhanced adhesion to fibronectin and collagen as well as an attenuated spreading and clot retraction, indicating an alteration in “outside in” integrin signalling. This phenotype was accompanied by a significant reduction in the agonist-induced tyrosine phosphorylation of β3 integrin. Taken together we have shown that CCNY is present in anucleated platelets where it is involved in the regulation of integrin-mediated outside in signalling associated with thrombin stimulation.
Hintergrund. Ziel dieser Studie war es, zu bewerten, ob die Datenübertragung während peripherer endovaskulärer Eingriffe durch ein sprachgesteuertes, optisches Head-Mounted Display verwirklicht, und ob hierdurch der Arbeitsablauf der Intervention verbessert werden kann.
Methoden. Wir benutzten die Google Glass® Explorer Edition in Verbindung mit einer eigens entwickelten Glass App, um vorhandene Grafiken über die Datenbrille durch Sprachbefehle zugänglich zu machen. 40 Medizinstudenten im letzten Drittel des Medizinstudiums wurden in zwei Gruppen randomisiert.
Jeder Proband erhielt die Aufgabe eine PTA der A. femoralis superficialis an einem High-Fidelity-VR-Simulator (ANGIO-Mentor®, 3D Systems) durchzuführen. Während Gruppe A hierfür nötige Informationen über einen zusätzlich installierten Monitor erhielt, verwendete Gruppe B Google Glass®, um jeweilige Informationen durch zuvor definierte Sprachbefehle aufzurufen. Die objektive Bewertung der erbrachten Leistung erfolgte durch standardisierte Bewertungsbögen in dichotomer Nominalskalierung und durch die Messung der für die Aufgaben benötigten Zeit. Am Ende jeder Simulation erfolgte die subjektive Bewertung seitens der Probanden durch standardisierte Fragebögen mit 5-Level-Likert-Skalierung.
Ergebnisse. Eine maximale Punktzahl von 10 Punkten war erreichbar. Der in Gruppe A und Gruppe B gefundene Median lag bei 9 Punkten mit nicht signifikanten Abweichungen (p = 0,91). Die Gesamtdauer des Eingriffs betrug zwischen 12 und 14 Minuten. Gruppe B war unter Verwendung von Google Glass®, aufgrund technischer Schwierigkeiten mit der getesteten App, im Schnitt um 1:07 Minuten signifikant langsamer (p = 0,01). Dennoch konnte nachgewiesen werden, dass Google Glass® bei dem Transfer einfacher Informationen schneller oder zumindest gleichwertig gegenüber dem klassischen Monitoring war.
In diesem Kontext erachteten 92,5% der Probanden die Digitalisierung im klinischen Alltag als sinnvoll. 17 von 20 Teilnehmern (85%) empfanden die Handhabung von Google Glass® als einfach bis sehr einfach. Alle Teilnehmer waren der Ansicht, dass Augmented Reality bei peripheren endovaskulären Eingriffen im Katheterlabor nützlich sein könnte.
Schlussfolgerung. Google Glass® war dem klassischen Monitoring im Katheterlabor hinsichtlich der Gesamtinterventionszeit nur geringfügig unterlegen und behinderte den Arbeitsablauf während einer simulierten PTA der A. femoralis superficialis nicht. Unsere Studie offenbarte hierbei technische Schwierigkeiten bei der Genauigkeit der Spracherkennung und der Bildqualität von Google Glass®. Trotzdem konnten einzelne Aufgaben durch die Nutzung der Google Glass® signifikant schneller durchgeführt werden. Wir erwarten, dass nach Überwindung dieser technischen Probleme der Arbeitsablauf während endovaskulären Eingriffen mit einem optischen Head-Mounted Display verbessert werden kann.
Polo-like kinases (PLKs) belong to a five-membered family of highly conserved serine/threonine kinases (PLK1-5) that play differentiated and essential roles as key mitotic kinases and cell cycle regulators and with this in proliferation and cellular growth. Besides, evidence is accumulating for complex and vital non-mitotic functions of PLKs. Dysregulation of PLKs is widely associated with tumorigenesis and by this, PLKs have gained increasing significance as attractive targets in cancer with diagnostic, prognostic and therapeutic potential. PLK1 has proved to have strong clinical relevance as it was found to be over-expressed in different cancer types and linked to poor patient prognosis. Targeting the diverse functions of PLKs (tumor suppressor, oncogenic) are currently at the center of numerous investigations in particular with the inhibition of PLK1 and PLK4, respectively in multiple cancer trials. Functions of PLKs and the effects of their inhibition have been extensively studied in cancer cell culture models but information is rare on how these drugs affect benign tissues and organs. As a step further towards clinical application as cancer targets, mouse models therefore play a central role. Modelling PLK function in animal models, e.g., by gene disruption or by treatment with small molecule PLK inhibitors offers promising possibilities to unveil the biological significance of PLKs in cancer maintenance and progression and give important information on PLKs’ applicability as cancer targets. In this review we aim at summarizing the approaches of modelling PLK function in mice so far with a special glimpse on the significance of PLKs in ovarian cancer and of orthotopic cancer models used in this fatal malignancy.
Simple Summary: Penile cancer is a rare but aggressive malignancy characterized by rapid tumor growth as well as prompt metastasis in groin lymphatics. While localized diseases can be successfully cured by surgery in most cases, no truly effective treatment options have been established for metastatic diseases as of yet. In the current investigation, we assessed the value of selected members of the PI3K/mTOR/AKT pathway to serve as tumor markers or therapeutic targets for this disease. Higher expression of AKT was significantly more prevalent in high-grade tumors and independently predictive of the worse survival parameters, while increased expression of pmTOR was associated with an inferior prognosis as well. Treatment with the pan-AKT inhibitor capivasertib in PeCa cell lines induced significant reduction of cell viability and movement capacity. These findings might aid in the understanding of the molecular tumor background as well as development of novel treatment options for advanced penile cancer.
Abstract: The PI3K/mTOR/AKT pathway might represent an intriguing option for treatment of penile cancer (PeCa). We aimed to assess whether members of this pathway might serve as biomarkers and targets for systemic therapy. Tissue of primary cancer from treatment-naïve PeCa patients was used for tissue microarray analysis. Immunohistochemical staining was performed with antibodies against AKT, pAKT, mTOR, pmTOR, pS6, pPRAS, p4EBP1, S6K1 and pp70S6K. Protein expression was correlated with clinicopathological characteristics as well as overall survival (OS), disease-specific survival (DSS), recurrence-free survival (RFS) and metastasis-free survival (MFS). AKT inhibition was tested in two primarily established, treatment-naïve PeCa cell lines by treatment with capivasertib and analysis of cell viability and chemotaxis. A total of 76 patients surgically treated for invasive PeCa were included. Higher expression of AKT was significantly more prevalent in high-grade tumors and predictive of DSS and OS in the Kaplan–Meier analysis, and an independent predictor of worse OS and DSS in the multivariate regression analysis. Treatment with pan-AKT inhibitor capivasertib in PeCa cell lines induced a significant downregulation of both total AKT and pAKT as well as decreased cell viability and chemotaxis. Selected protein candidates of the mTOR/AKT signaling pathway demonstrate association with histological and survival parameters of PeCa patients, whereas AKT appears to be the most promising one.
Simple Summary: The introduction of BRAF/MEK-directed targeted therapy (TT) has significantly improved the management of patients with advanced BRAF-V600-mutant melanoma. Although resistance occurs, there is a subgroup of patients showing a complete response (CR) to TT and who maintain durable disease control. For these patients with durable CR, it is not clear whether it is safe to cease therapy. In this retrospective, multicenter study we have analyzed 37 patients who received TT and achieved a CR upon treatment. We identified 15 patients with a durable CR to TT. Overall, patients who discontinued TT (n = 26) were at higher risk of tumor progression compared to patients receiving ongoing TT. Sustained CR was however not restricted to patients with ongoing TT (n = 11) but was also found in patients who ceased TT (n = 4). Finally, our analysis indicated which patients with an initial CR might be most likely to maintain durable CR upon discontinuation of TT.
Abstract: The advent of BRAF/MEK inhibitors (BRAFi/MEKi) has significantly improved progression-free (PFS) and overall survival (OS) for patients with advanced BRAF-V600-mutant melanoma. Long-term survivors have been identified particularly among patients with a complete response (CR) to BRAF/MEK-directed targeted therapy (TT). However, it remains unclear which patients who achieved a CR maintain a durable response and whether treatment cessation might be a safe option in these patients. Therefore, this study investigated the impact of treatment cessation on the clinical course of patients with a CR upon BRAF/MEK-directed-TT. We retrospectively selected patients with BRAF-V600-mutant advanced non-resectable melanoma who had been treated with BRAFi ± MEKi therapy and achieved a CR upon treatment out of the multicentric skin cancer registry ADOReg. Data on baseline patient characteristics, duration of TT, treatment cessation, tumor progression (TP) and response to second-line treatments were collected and analyzed. Of 461 patients who received BRAF/MEK-directed TT 37 achieved a CR. TP after initial CR was observed in 22 patients (60%) mainly affecting patients who discontinued TT (n = 22/26), whereas all patients with ongoing TT (n = 11) maintained their CR. Accordingly, patients who discontinued TT had a higher risk of TP compared to patients with ongoing treatment (p < 0.001). However, our data also show that patients who received TT for more than 16 months and who discontinued TT for other reasons than TP or toxicity did not have a shorter PFS compared to patients with ongoing treatment. Response rates to second-line treatment being initiated in 21 patients, varied between 27% for immune-checkpoint inhibitors (ICI) and 60% for BRAFi/MEKi rechallenge. In summary, we identified a considerable number of patients who achieved a CR upon BRAF/MEK-directed TT in this contemporary real-world cohort of patients with BRAF-V600-mutant melanoma. Sustained PFS was not restricted to ongoing TT but was also found in patients who discontinued TT.
Simple Summary: Early and accurate diagnosis of breast cancer that has spread to other organs and tissues is crucial, as therapeutic decisions and outcome expectations might change. Computed tomography (CT) is often used to detect breast cancer’s spread, but this method has its weaknesses. The computer-assisted technique “radiomics” extracts grey-level patterns, so-called radiomic features, from medical images, which may reflect underlying biological processes. Our retrospective study therefore evaluated whether breast cancer spread can be predicted by radiomic features derived from iodine maps, an application on a new generation of CT scanners visualizing tissue blood flow. Based on 77 patients with newly diagnosed breast cancer, we found that this approach might indeed predict cancer spread to other organs/tissues. In the future, radiomics may serve as an additional tool for cancer detection and risk assessment.
Abstract: Dual-energy CT (DECT) iodine maps enable quantification of iodine concentrations as a marker for tissue vascularization. We investigated whether iodine map radiomic features derived from staging DECT enable prediction of breast cancer metastatic status, and whether textural differ- ences exist between primary breast cancers and metastases. Seventy-seven treatment-naïve patients with biopsy-proven breast cancers were included retrospectively (41 non-metastatic, 36 metastatic). Radiomic features including first-, second-, and higher-order metrics as well as shape descriptors were extracted from volumes of interest on iodine maps. Following principal component analysis, a multilayer perceptron artificial neural network (MLP-NN) was used for classification (70% of cases for training, 30% validation). Histopathology served as reference standard. MLP-NN predicted metastatic status with AUCs of up to 0.94, and accuracies of up to 92.6 in the training and 82.6 in the validation datasets. The separation of primary tumor and metastatic tissue yielded AUCs of up to 0.87, with accuracies of up to 82.8 in the training, and 85.7 in the validation dataset. DECT iodine map-based radiomic signatures may therefore predict metastatic status in breast cancer patients. In addition, microstructural differences between primary and metastatic breast cancer tissue may be reflected by differences in DECT radiomic features.
Simple Summary: Treatment of metastatic renal cell carcinoma (mRCC) remains a challenge due to the lack of biomarkers indicating the optimal drug for each patient. This study analyzed blood samples of patients with predominant clear cell mRCC who were treated with the mTOR inhibitor everolimus after failure of one prior tumor therapy. In an exploratory approach, predictive blood biomarkers were searched. We found lower levels of the protein thrombospondin-2 (TSP-2) at the start of the therapy and higher lactate dehydrogenase (LDH) levels in serum two weeks after therapy initiation to be associated with therapy response. Of note, these blood biomarkers had a higher predictive value than baseline patient parameters or risk classifications. Polymorphisms in the mTOR gene appeared to be associated with therapy response, but were not significant. To conclude, it seems feasible to identify patients showing longtime responses to everolimus and possible to increase tumor therapy response rates based on biomarkers for individual therapy selection.
Abstract: There is an unmet need for predictive biomarkers in metastatic renal cell carcinoma (mRCC) therapy. The phase IV MARC-2 trial searched for predictive blood biomarkers in patients with predominant clear cell mRCC who benefit from second-line treatment with everolimus. In an exploratory approach, potential biomarkers were assessed employing proteomics, ELISA, and polymorphism analyses. Lower levels of angiogenesis-related protein thrombospondin-2 (TSP-2) at baseline (≤665 parts per billion, ppb) identified therapy responders with longer median progression-free survival (PFS; ≤665 ppb at baseline: 6.9 months vs. 1.8, p = 0.005). Responders had higher lactate dehydrogenase (LDH) levels in serum two weeks after therapy initiation (>27.14 nmol/L), associated with a longer median PFS (3.8 months vs. 2.2, p = 0.013) and improved overall survival (OS; 31.0 months vs. 14.0 months, p < 0.001). Baseline TSP-2 levels had a stronger relation to PFS (HR 0.36, p = 0.008) than baseline patient parameters, including IMDC score. Increased serum LDH levels two weeks after therapy initiation were the best predictor for OS (HR 0.21, p < 0.001). mTOR polymorphisms appeared to be associated with therapy response but were not significant. Hence, we identified TSP-2 and LDH as promising predictive biomarkers for therapy response on everolimus after failure of one VEGF-targeted therapy in patients with clear cell mRCC.
Falls from a height are a common cause of polytrauma care in Level I Trauma Centers worldwide. The expected injury consequences depend on the height of the fall and the associated acceleration, as well as the condition of the ground. In addition, we further hypothesize a correlation between the cause of the fall, the age of the patient, and the patient’s outcome. A total of 178 trauma patients without age restriction who were treated in our hospital after a fall >3 m within a 5-year period were retrospectively analyzed. The primary objective was a clinically and radiologically quantifiable increase in the severity of injuries after falls from different relevant heights (>3 m, >6 m, and >9 m). The cause of the fall, either accidental or suicidal; age and duration of intensive care unit stay, including duration of ventilation; and total hospital stay were analyzed. Additionally, the frequency of urgent operations, such as, external fixation of fractures or hemi-craniectomies, laboratory parameters; and clinical outcomes were also among the secondary objectives. Sustaining a thoracic trauma or pelvis fractures increases significantly with height, and vital parameters are significantly compromised. We also found significant differences in urgent pre- and in-hospital emergency interventions, as well as organ complications and outcome parameters depending on the fall’s height.
Vaginal breech delivery is becoming an extinct art although national guidelines underline its safety and vaginal breech delivery in an upright position has been shown to be a safe birth mode option. In order to spread clinical knowledge and be able to implement vaginal breech delivery into obstetricians’ daily practice, we need to gather knowledge from facilities who teach specialized obstetrical management. Methods: We performed a prospective cohort study on 140 vaginal deliveries out of breech presentation solely-managed by seven newly-trained physicians and compared fetal outcome as well as rates of manual assistance in respect to preexisting experience. Results: Fetal morbidity rate measured with a modified PREMODA score was not significantly different in three sub-cohorts sorted by preexisting expertise levels of managing obstetricians (experience groups EG, EG0: 2, 5%; EG1: 3, 7.5%; EG2: 1, 1.7%; p = 0.357). Manual assistance rate was significantly higher in EG1 (low experience level in breech delivery and only in dorsal position) compared to EG0 and EG2 (EG1 28, 70%; EG0: 14, 25%; EG2: 21, 35%; p = 0.0008). Conclusions: Our study shows that vaginal breech delivery with newly-trained obstetricians is a safe option whether or not they have advanced preexisting expertise in breech delivery. These data should encourage implementing vaginal breech delivery in clinical routine.
The plaque reduction neutralization test (PRNT) is a preferred method for the detection of functional, SARS-CoV-2 specific neutralizing antibodies from serum samples. Alternatively, surrogate enzyme-linked immunosorbent assays (ELISAs) using ACE2 as the target structure for the detection of neutralization-competent antibodies have been developed. They are capable of high throughput, have a short turnaround time, and can be performed under standard laboratory safety conditions. However, there are very limited data on their clinical performance and how they compare to the PRNT. We evaluated three surrogate immunoassays (GenScript SARS-CoV-2 Surrogate Virus Neutralization Test Kit (GenScript Biotech, Piscataway Township, NJ, USA), the TECO® SARS-CoV-2 Neutralization Antibody Assay (TECOmedical AG, Sissach, Switzerland), and the Leinco COVID-19 ImmunoRank™ Neutralization MICRO-ELISA (Leinco Technologies, Fenton, MO, USA)) and one automated quantitative SARS-CoV-2 Spike protein-based IgG antibody assay (Abbott GmbH, Wiesbaden, Germany) by testing 78 clinical samples, including several follow-up samples of six BNT162b2 (BioNTech/Pfizer, Mainz, Germany/New York, NY, USA) vaccinated individuals. Using the PRNT as a reference method, the overall sensitivity of the examined assays ranged from 93.8 to 100% and specificity ranged from 73.9 to 91.3%. Weighted kappa demonstrated a substantial to almost perfect agreement. The findings of our study allow these assays to be considered when a PRNT is not available. However, the latter still should be the preferred choice. For optimal clinical performance, the cut-off value of the TECO assay should be individually adapted.
Sleep disordered breathing (SDB) is a frequent comorbidity in cardiac disease patients. Nevertheless, the prevalence and relationship between SDB and severe primary mitral regurgitation (PMR) has not been well investigated to date. Methods: A cohort of 121 patients with significant PMR undergoing mitral valve surgery were prospectively enrolled and received a cardiorespiratory single night polygraphy screening using ApneaLink before surgery. Eighty-two of them underwent a follow-up examination including a follow-up single-night sleep study 3 months after surgery. Results: The mean age of patients was 65.3 ± 12.0 years. Sixty patients (49.6%) were female. The mean EuroSCORE II was 2.5 ± 2.4%. Initially, 91 (75.2%) patients presented with SDB, among whom 50.4% (46 patients, 38.0% of total cohort) were classified as moderate to severe. These patients tended to require significantly longer postoperative intensive care and mechanical ventilation. Among the 82 patients who completed follow-up exams, mitral valve surgery led to a significant reduction in relevant SDB (20.7%). The apnea-hypopnea index (from 11/h [4;18] to 4/h [3;14] (p = 0.04)), the oxygenation-desaturation index (from 8/h [3;18] to 5/h [3;12] (p = 0.008)) as well as the saturation time below 90% (from 32 min [13;86] to 18 min [5;36] (p = 0.005)), were all shown to be improved significantly. Conclusion: The prevalence of SDB is very high in patients with severe primary mitral regurgitation and may contribute to postoperative complications and prolonged intensive care. A significantly reduced but still high prevalence of SDB was observed 3 months after mitral valve surgery, highlighting the bidirectional relationship between SDB and heart failure.
Drug interactions are a well-known cause of adverse drug events, and drug interaction databases can help the clinician to recognize and avoid such interactions and their adverse events. However, not every interaction leads to an adverse drug event. This is because the clinical relevance of drug–drug interactions also depends on the genetic profile of the patient. If inhibitors or inducers of drug metabolising enzymes (e.g., CYP and UGT) are added to the drug therapy, phenoconcversion can occur. This leads to a genetic phenotype that mismatches the observable phenotype. Drug–drug–gene and drug–gene–gene interactions influence the toxicity and/or ineffectivness of the drug therapy. To date, there have been limited published studies on the impact of genetic variations on drug–drug interactions. This review discusses the current evidence of drug–drug–gene interactions, as well as drug–gene–gene interactions. Phenoconversion is explained, the and methods to calculate the phenotypes are described. Clinical recommendations are given regarding the integratation of the PGx results in the assessment of the relevance of drug interactions in the future.
Aims: In primary central nervous system tumours, epithelial-to-mesenchymal transition (EMT) gene expression is associated with increased malignancy. However, it has also been shown that EMT factors in gliomas are almost exclusively expressed by glioma vessel-associated pericytes (GA-Peris). In this study, we aimed to identify the mechanism of EMT in GA-Peris and its impact on angiogenic processes.
Methods; In glioma patients, vascular density and the expression of the pericytic markers platelet derived growth factor receptor (PDGFR)-β and smooth muscle actin (αSMA) were examined in relation to the expression of the EMT transcription factor SLUG and were correlated with survival of patients with glioblastoma (GBM). Functional mechanisms of SLUG regulation and the effects on primary human brain vascular pericytes (HBVP) were studied in vitro by measuring proliferation, cell motility and growth characteristics.
Results: The number of PDGFR-β- and αSMA-positive pericytes did not change with increased malignancy nor showed an association with the survival of GBM patients. However, SLUG-expressing pericytes displayed considerable morphological changes in GBM-associated vessels, and TGF-β induced SLUG upregulation led to enhanced proliferation, motility and altered growth patterns in HBVP. Downregulation of SLUG or addition of a TGF-β antagonising antibody abolished these effects.
Conclusions: We provide evidence that in GA-Peris, elevated SLUG expression is mediated by TGF-β, a cytokine secreted by most glioma cells, indicating that the latter actively modulate neovascularisation not only by modulating endothelial cells, but also by influencing pericytes. This process might be responsible for the formation of an unstructured tumour vasculature as well as for the breakdown of the blood–brain barrier in GBM.
Sex differences in psychiatric comorbidity and clinical presentation in youths with conduct disorder
(2021)
Background: Conduct disorder (CD) rarely occurs alone but is typically accompanied by comorbid psychiatric disorders, which complicates the clinical presentation and treatment of affected youths. The aim of this study was to investigate sex differences in comorbidity pattern in CD and to systematically explore the ‘gender paradox’ and ‘delayed-onset pathway’ hypotheses of female CD.
Methods: As part of the FemNAT-CD multisite study, semistructured clinical interviews and rating scales were used to perform a comprehensive phenotypic characterization of 454 girls and 295 boys with CD (9–18 years), compared to 864 sex- and age-matched typically developing controls.
Results: Girls with CD exhibited higher rates of current major depression, anxiety disorders, post-traumatic stress disorder and borderline personality disorder, whereas boys with CD had higher rates of current attention-deficit/hyperactivity disorder. In line with the ‘gender paradox’ hypothesis, relative to boys, girls with CD showed significantly more lifetime psychiatric comorbidities (incl. Alcohol Use Disorder), which were accompanied by more severe CD symptoms. Female and male youths with CD also differed significantly in their CD symptom profiles and distribution of age-of-onset subtypes of CD (i.e. fewer girls with childhood-onset CD). In line with the ‘delayed-onset pathway’ hypothesis, girls with adolescent-onset CD showed similar levels of dimensional psychopathology like boys with childhood-onset CD, while boys with adolescent-onset CD had the lowest levels of internalizing psychopathology.
Conclusions: Within the largest study of CD in girls performed to date, we found compelling evidence for sex differences in comorbidity patterns and clinical presentation of CD. Our findings further support aspects of the ‘gender paradox’ and ‘delayed-onset pathway’ hypotheses by showing that girls with CD had higher rates of comorbid lifetime mental disorders and functional impairments, and they usually developed CD during adolescence. These novel data on sex-specific clinical profiles of CD will be critical in informing intervention and prevention programmes.
Aims: Somatic mutations in haematopoietic stem cells can lead to the clonal expansion of mutated blood cells, known as clonal haematopoiesis (CH). Mutations in the most prevalent driver genes DNMT3A and TET2 with a variant allele frequency (VAF) ≥ 2% have been associated with atherosclerosis and chronic heart failure of ischemic origin (CHF). However, the effects of mutations in other driver genes for CH with low VAF (<2%) on CHF are still unknown.
Methods and results: Therefore, we analysed mononuclear bone marrow and blood cells from 399 CHF patients by deep error-corrected targeted sequencing of 56 genes and associated mutations with the long-term mortality in these patients (3.95 years median follow-up). We detected 1113 mutations with a VAF ≥ 0.5% in 347 of 399 patients, and only 13% had no detectable CH. Despite a high prevalence of mutations in the most frequently mutated genes DNMT3A (165 patients) and TET2 (107 patients), mutations in CBL, CEBPA, EZH2, GNB1, PHF6, SMC1A, and SRSF2 were associated with increased death compared with the average death rate of all patients. To avoid confounding effects, we excluded patients with DNMT3A-related, TET2-related, and other clonal haematopoiesis of indeterminate potential (CHIP)-related mutations with a VAF ≥ 2% for further analyses. Kaplan–Meier survival analyses revealed a significantly higher mortality in patients with mutations in either of the seven genes (53 patients), combined as the CH-risk gene set for CHF. Baseline patient characteristics showed no significant differences in any parameter including patient age, confounding diseases, severity of CHF, or blood cell parameters except for a reduced number of platelets in patients with mutations in the risk gene set in comparison with patients without. However, carrying a mutation in any of the risk genes remained significant after multivariate cox regression analysis (hazard ratio, 3.1; 95% confidence interval, 1.8–5.4; P < 0.001), whereas platelet numbers did not.
Conclusions: Somatic mutations with low VAF in a distinct set of genes, namely, in CBL, CEBPA, EZH2, GNB1, PHF6, SMC1A, and SRSF2, are significantly associated with mortality in CHF, independently of the most prevalent CHIP-mutations in DNMT3A and TET2. Mutations in these genes are prevalent in young CHF patients and comprise an independent risk factor for the outcome of CHF, potentially providing a novel tool for risk assessment in CHF.
Ein professioneller Orchestermusiker verbringt die meiste Zeit in körperlich ungünstiger Sitzhaltung beim Spielen. Die Folge ist ein Anstieg des Risikos für die Entwicklung von muskuloskelettalen Beschwerden [44, 127, 128]. Eine Verbesserung der Arbeitsbedingungen lässt sich u.a. durch den Einsatz von ergonomischen Stühlen erzielen, da sie einen Einfluss auf die Körperhaltung des Orchestermusikers besitzen. Im Mittelpunkt der vorliegenden Arbeit standen daher sechs unterschiedliche von der Firma Mey für Orchestermusiker konzipierte Stühle. Die Studie beinhaltete eine Untersuchung des Einflusses der Stühle auf die Oberkörperstatik und die Sitzdruckverteilung von Orchestermusikern und den Einfluss auf ihr Instrumentalspiel im Vergleich zur habituellen Sitzhaltung. Das Probandenkollektiv umfasste 24 Berufsmusiker des Polizeiorchesters Mainz (Rheinland-Pfalz, Deutschland) und bestand zum größten Teil aus Blasinstrumentalisten (3 Frauen, 21 Männer). Das Durchschnittsalter betrug 45 Jahre. Die Überprüfung der Oberkörperstatik erfolgte durch einen 3D-Rückenscanner (ABW GmbH, Frickenhausen, Deutschland), eine Evaluation der Druckverhältnisse im Gesäß durch eine Druckmessmatte (GeBioM GmbH, Münster, Deutschland), womit sich bei jedem Stuhl ein bestimmtes Druckmuster kennzeichnen ließ. Die Messung erfolgte pro Stuhl und Messgerät stets im Wechsel zwischen der statischen Position ohne Instrument (oI) und der statischen Position mit Instrument (mI). Bei der statistischen Auswertung kam es zur Verwendung nicht parametrischer Tests (Friedman-, Wilcoxon Matched- Pairs-Test), wobei das Signifikanzniveau bei ≤0,05 lag. Es erfolgte eine Unterteilung in einen Inter- und einen Intrastuhlvergleich.
Die Ergebnisse des Interstuhlvergleichs zeigten bezüglich der Schulterregion keine signifikanten Veränderungen, wohingegen im Hinblick auf die WS-Parameter Signifikanzen zwischen Stuhl 2 und 5 verzeichnet wurden: in der habituellen Position offenbarte die Rumpflänge D die größte Abweichung mit einem Längenunterschied von 14mm (p≤0,001), so auch die Rumpflänge S (16 mm; p≤0,001). Bezüglich dieser Stühle wiesen die restlichen WS-Parameter Abweichungen von max. 4° bzw. 3mm auf. Zwischen Stuhl 2 und 3 ergaben sich m.I. im Hinblick auf den thorakalen (p≤0,01) und lumbalen Biegungswinkel (p≤0,001) max. Diskrepanzen von 2,5°. Die größten Unterschiede in der Beckenregion zeigten sich beim Beckenabstand zwischen Stuhl 3 und 5 o.I. (7mm) und m.I. (4mm), (beide Bedingungen p≤0,001). Im Hinblick auf die Druckparameter fand sich eine Abhängigkeit zwischen belasteter Fläche und Sitzbeinhöckerdruck (SBH): eine kleine Fläche bedeutete eine schlechte Druckverteilung und umgekehrt. Stühle 1 und 4 besaßen den geringsten SBH (p≤0,001). Im Intrastuhlvergleich zeigten die Bereiche der WS, Schultern und Becken jeweils mindestens einen signifikanten Parameter auf, wie z.B. Schulterblattabstand, sagittale Rumpfneigung und Beckenabstand. Korrelationen zwischen den Parametern waren nicht zu erkennen. M.I. kommt es hinsichtlich des SBH auf der linken Hälfte im Schnitt auf allen Stühlen zu einer Druckerhöhung von 8,46%, auf der rechten zu einer von 11,11%. Im Hinblick auf den Oberschenkeldruck (OS) vollzieht sich die größte Veränderung (7,4bar) der rechten Gesäßhälfte auf Stuhl 2 mit p≤0,001. Der Interstuhlvergleich zeigt also, dass die Wahl eines Stuhls keine Auswirkung auf die Körperhaltung hat. Ursache für Diskrepanzen hinsichtlich des SBH ist die unterschiedliche Polsterung und Größe der Sitzfläche, welche eine hohe Relevanz in Bezug auf die Umverteilung des Drucks und den subjektiven Komfort besitzt. Eine gepolsterte und große Oberfläche ist gleichzusetzen mit einer günstigen Druckverteilung und einem angenehmen individuellen Sitzgefühl. Der Intrastuhlvergleich offenbart ebenfalls keine klinisch relevanten Veränderungen im Oberkörper. Ausschließlich in der Druckverteilung ist eine signifikante Variabilität hinsichtlich des OS rechts bei Stuhl 2 vorhanden (p≤0,001). Die Sitzposition der Probanden ist symmetrisch. Die Symmetrie bezieht sich sowohl auf den Schulter-, WS- und Beckenbereich, als auch auf die Druckverhältnisse im Gesäßbereich.
In der vorliegenden Studie konnte belegt werden, dass gepolsterte und breite Sitzoberflächen mit gleichmäßiger Druckverteilung und gleichzeitig hohem Komfort einhergehen. Im Hinblick auf das Musizieren über einen längeren Zeitraum ist das Vorhandensein eines hohen Komforts für den Orchestermusiker von Bedeutung. Diese Erkenntnisse sind bei der Weiterentwicklung von ergonomischen Stühlen zu berücksichtigen. Eine Analyse der Schulter- und Rumpfmuskulatur und Messung des Beckenwinkels ist in weiteren Studien zusätzlich erforderlich, um zu erforschen, inwieweit die Stühle die Fehlfunktionen des Bewegungsapparates beeinflussen.
Die Therapie langstreckiger Knochendefekte stellt auch weiterhin eine große Herausforderung dar. Dies beruht unter anderem darauf, dass der therapeutische Goldstandard - die Verwendung von autogener Knochensubstanz aus dem Beckenkamm - neben der begrenzten Verfügbarkeit vor allem Komplikationen im Bereich der Entnahmestelle mit sich bringen kann. Es wurde bisher aber noch kein durchschlagendes Ergebnis in der Entwicklung neuer Scaffolds zum Einsatz bei langstreckigen Knochendefekten erreicht. Dies kann eine Vielzahl an Ursachen haben, die sich von der verwendeten Ausgangssubstanz, bis hin zum verwendeten Design erstrecken können. Neben dem Ausgangsmaterial spielen vor
allem die Formgebung und physikalische Eigenschaften, wie Porosität und Mikroarchitektur, eine wichtige Rolle.
Ein aktueller Ansatz zur Nutzung als alternatives Knochenersatzmaterial ist das Knochen-Tissue-Engineering. Hierbei werden körpereigene, knochen-regenerative Zellen mit einem dreidimensionalen Gerüststoff (Knochenersatzmaterial oder -scaffold) kombiniert und in den Knochendefekt implantiert. In dieser Arbeit wurde der Fokus auf die Designentwicklung eines neuen Kochenersatz-Scaffolds gelegt. Nach Vorbild schon vorgestellter Knochenersatzdesigns und unter Berücksichtigung einer Grundstruktur, die auch Phasen der Knochenheilung wie die Frakturhämatomausbreitung und initiale Nährstoffversorgung einbeziehen sollte, wurden mehrere Designs (Raster, Tempel, Zwiebel) entwickelt. Mithilfe des additiv extrusionsbasierten Schmelzschichtverfahrens (Fused Filament Fabrication) wurden die in Computer-Aided Design entworfenen Scaffolds realisiert.
Dieser Ansatz beinhaltet, unter Verwendung des resorbierbaren und biokompatiblen Trägerpolymers Polylaktat, mehrstufige Designs, die kleine biologisch funktionelle Einheiten in eine tragende, kompressionsfeste Rahmenstruktur einbetten. Hierdurch entsteht einerseits die nötige mechanische Belastbarkeit und andererseits eine offene Architektur mit Poren, die Diffusion von Sauerstoff und
Nährstoffen in die inneren Bereiche des Implantats ermöglicht. Es wurden verschiedene Designs entwickelt, gedruckt und mechanisch sowie in vitro in den Kernbereichen Zelladhäsion, Zellaktivität und osteogene Differenzierung nach Besiedelung mit Saos-2-Zellen charakterisiert.
Ein weiterer Entwicklungsschritt stellte das Einführen eines neuartigen, innerhalb der Designs kompatiblen Baukastensystems dar. Hierdurch wird nicht nur die Anpassbarkeit an den Knochendefekt verbessert, es sind auch weitere Funktionen ergänzbar und die unterschiedlichen Designs untereinander kombinierbar.
Die Ergebnisse dieser Dissertationsarbeit dienen als Basis für einen völlig neuen Ansatz von Knochenersatzmaterialien mit positiven biologischen sowie biophysikalischen Eigenschaften.
Background & Aims: HBV genotype G (HBV/G) is mainly found in co-infections with other HBV genotypes and was identified as an independent risk factor for liver fibrosis. This study aimed to analyse the prevalence of HBV/G co-infections in healthy European HBV carriers and to characterize the crosstalk of HBV/G with other genotypes.
Methods: A total of 560 European HBV carriers were tested via HBV/G-specific PCR for HBV/G co-infections. Quasispecies distribution was analysed via deep sequencing, and the clinical phenotype was characterized regarding qHBsAg-/HBV-DNA levels and frequent mutations. Replicative capacity and expression of HBsAg/core was studied in hepatoma cells co-expressing HBV/G with either HBV/A, HBV/D or HBV/E using bicistronic vectors.
Results: Although no HBV/G co-infection was found by routine genotyping PCR, HBV/G was detected by specific PCR in 4%-8% of patients infected with either HBV/A or HBV/E but only infrequently in other genotypes. In contrast to HBV/E, HBV/G was found as the quasispecies major variant in co-infections with HBV/A. No differences in the clinical phenotype were observed for HBV/G co-infections. In vitro RNA and DNA levels were comparable among all genotypes, but expression and release of HBsAg was reduced in co-expression of HBV/G with HBV/E. In co-expression with HBV/A and HBV/E expression of HBV/G-specific core was enhanced while core expression from the corresponding genotype was markedly diminished.
Conclusions: HBV/G co-infections are common in European inactive carriers with HBV/A and HBV/E infection, but sufficient detection depends strongly on the assay. HBV/G regulated core expression might play a critical role for survival of HBV/G in co-infections.
Background: A link between attention-deficit/hyperactivity disorder (ADHD) and alcohol use disorder (AUD) has been widely demonstrated. In this study, we used neuroimaging to investigate the connectivity traits that may contribute to the comorbidity of these disorders.
Methods: The study included an AUD group (N = 18), an ADHD group (N = 17), a group with AUD + ADHD comorbidity (N = 12) and a control group (N = 18). We used resting-state functional connectivity in a seed-based approach in the default mode networks, the dorsal attention network, and the salience network.
Results: Within the default mode networks, all affected groups shared greater connectivity toward the temporal gyrus when compared to the control group. Regarding the dorsal attention network, the Brodmann area 6 presented greater connectivity for each affected group in comparison with the control group, displaying the strongest aberrations in the AUD + ADHD group. In the salience network, the prefrontal cortex showed decreased connectivity in each affected group compared to the control group.
Conclusions: Despite the small and unequal sample sizes, our findings show evidence of common neurobiological alterations in AUD and ADHD, supporting the hypothesis that ADHD could be a risk factor for the development of AUD. The results highlight the importance of an early ADHD diagnosis and treatment to reduce the risk of a subsequent AUD.
Verletzungen der Fingerkuppen stellen einen häufigen Grund für die Vorstellung in der Notaufnahme dar. Während viele Verletzungen konservativ behandelt werden können, benötigen einige Patienten eine operative Versorgung. Dabei kommen verschiedene operative Verfahren zur Anwendung, darunter eine Fingerkuppenrekonstruktion mit einer neurovaskulären Insel-Lappenplastik.
Ziel der neurovaskulären Insel-Lappenplastik ist die Wiederherstellung einer taktil sensiblen und wieder belastungsfähigen Fingerkuppe ohne ein Längendefizit des Fingers.
In der vorliegenden Studie wurden Langzeit-Behandlungsergebnisse mit einer mittleren Nachuntersuchungsdauer von 105 Monaten bei 28 Patienten mit 29 durch neurovaskuläre Insel-Lappenplastiken rekonstruierten Fingerkuppen in der Berufsgenossenschaftlichen Unfallklinik Frankfurt am Main erfasst. Die untersuchten Patienten hatten zum Zeitpunkt der Verletzung ein Durchschnittsalter von 38,4 Jahren. Es handelte sich überwiegend um männliche und berufstätige Patienten.
Es wurden nur Fingerkuppenverletzungen mit freiliegenden Knochen (Allen-Klassifikation Zone III und IV) operativ versorgt. In unserer Studie traten am häufigsten die Verletzungen am Mittelfinger, Zeigefinger und Ringfinger auf. Die Mehrheit der Fingerkuppenverletzungen geschah in Folge eines Arbeitsunfalls, die Arbeitsunfähigkeitsdauer betrug ca. 6,1 Wochen. Die maximale Größe eines neurovaskulären Insel-Lappen lag bei 6 x 3,5 cm.
Alle Patienten waren mit den Behandlungsergebnissen anhand der numerischen Rating-Skala und des DASH Fragebogens bezüglich Funktionalität sowie dem ästhetischen Outcome zufrieden und würden sich wieder operieren lassen.
Die Sensibilität konnte anhand der Zwei-Punkte-Diskrimination sowie Semmes-Weinstein Monofilament-Testes als gut bewertet werden und normale physiologische Werte erreichen. Die Narbe war überwiegend weich und in der Mehrheit der Fälle entsprach sie anhand der Vancouver Scar Scale Werte annähend der normalen Haut. Zwei Drittel der Patienten gaben keine Schmerzen in Ruhe an. Die Hälfte der Patienten gaben Schmerzen unter Belastung anhand der numerischen Rating-Scala an.
Trotz der hohen Anzahl von Krallennagelbildungen in 56,5 % und einer Differenz der Nagellänge bzw. Form waren alle Patienten mit dem Erhalt des Nagels zufrieden und haben dies subjektiv nicht als störend empfunden.
Als besonders beeinträchtigend wurde eine Kälteempfindlichkeit von 48,3 % Patienten beschrieben.
Der Mittelwert der Fingerkraft im Schlüsselgriff mit Hilfe des Pinch-Gauge zwischen Daumen und den vier Fingerspitzen im Wechsel wurde bei fast allen Messungen an den gesunden Fingern gering größer gemessen ohne eine statistisch signifikante Differenz. Die Messung der Handkraft mittels Jamar-Dynamometer ergab ein Defizit von 8,8 % (Vergleich betroffene zur gesunden Hand).
Bei drei von 24 Patienten hat sich eine Beugekontraktur im Interphalangealgelenk von 5°, 15°, 20° und bei einem von 22 Patienten im distalen Interphalangealgelenk von 10° gebildet. Zum Nachuntersuchungszeitpunkt wurden durch die Untersucherin ein Hoffmann-Tinel- Zeichen in 24,1 % und Druckschmerz in 17,2 % im Bereich der verletzten Fingerkuppe festgestellt. Subjektiv empfand kein Patient diese Symptome als störend und alle berufstätigen Patienten konnten ihre vor dem Unfall ausgeübte Tätigkeit wieder aufnehmen. Diese Studie konnte belegen, dass die Defektdeckung der Fingerkuppenverletzungen mit Hilfe von neurovaskulären Insel-Lappenplastiken ein sehr gutes ästhetisches und funktionelles Ergebnis mit einer fast identischen Hautqualität erzielt. Mit dieser Methode konnte eine Wiederherstellung des Weichteilgewebes der sensiblen Fingerkuppe auch bei großflächigen Defekten der Fingerkuppe erreicht werden. Die subjektive Patientenzufriedenheit mit dieser Rekonstruktionsmethode ist hoch.
Fokale idiopathische Dystonien stellen die häufigste Dystonieform im Erwachse-nenalter dar. Die Pathophysiologie dieser Erkrankungsgruppe ist weitestgehend unverstanden, wobei die Basalganglien, der Thalamus und das Cerebellum eine zentrale Rolle in der Genese dystoner Bewegungen zu spielen scheinen. Unklar ist, ob Patienten mit fokaler idiopathischer Dystonie mikrostrukturelle Verände-rungen in den oben genannten Arealen aufweisen, die das Störungsbild bedingen könnten.
In dieser Arbeit wurde mittels Methoden der quantitativen Magnetresonanztomographie (qMRT) der Versuch unternommen, Änderungen von Struktur und Eigenschaften des Hirngewebes bei idiopathischen Dystonien im Vergleich zu einer gesunden Kontrollkohorte zu identifizieren. Vorangegangen bildgebende Studien erbrachten bislang widersprüchliche Ergebnisse. Insbesondere der Frage nach möglichen Veränderungen des Eisengehaltes sollte mittels Messung der T2*-Re-laxationszeit nachgegangen werden. Weiterhin wurden Areale der motorischen Kontrolle (Basalganglien, Thalamus, Cerebellum und zerebraler Kortex) auf mög-liche Volumenveränderungen untersucht.
Insgesamt wurden 30 Patienten mit fokaler idiopathischer Dystonie sowie 30 alters- und geschlechtsgematchte Kontrollprobanden mittels multimodaler qMRT untersucht und Parameterkarten für die T1- und T2/T2*-Relaxationszeiten sowie der Protonendichte berechnet. Die Parameterkarten wurden sowohl voxelweise als auch regionenbasiert mit der Frage nach Dystonie-spezifischen Veränderungen statistisch ausgewertet. Zusätzlich erfolgte eine Subgruppenanalyse der ge-nannten Parameter von 17 Patienten mit zervikaler Dystonie im Vergleich zu ei-ner verkleinerten Kontrollgruppe.
Für keinen der untersuchten qMRT-Parameter konnte in der voxelweisen oder der regionenbasierten Analyse signifikante Gruppenunterschiede zwischen Patienten mit fokaler idiopathischer Dystonie und gesunden Kontrollprobanden nachgewiesen werden (p ≥ 0,05). Auch unterschieden sich die untersuchten Hirnregionen nicht hinsichtlich ihres Volumens (p ≥ 0,31). Ebenfalls ausschließlich negative Ergebnisse ergab die Subgruppenanalyse für Patienten mit zervikaler Dystonie (Gewebeparameter p ≥ 0,05, Volumen p ≥ 0,21).
Somit fanden sich entgegen der ursprünglichen Hypothese keine mittels qMRT detektierbaren krankheitsspezifischen mikrostrukturellen Gewebeveränderungen bei Patienten mit fokaler idiopathischer Dystonie. Unter Berücksichtigung der me-thodischen Limitationen und der kleinen Fallzahl ergaben sich keine Hinweise auf Dystonie-assoziierte neurodegenerative Prozesse, erhöhte Eisenablagerungen, Demyelinisierung oder Veränderungen des Wassergehaltes. Die Ergebnisse dieser Studie sind kompatibel mit der Sichtweise, dass idiopathische Dystonien am ehesten aufgrund einer reinen neurofunktionellen Netzwerkstörung der Ba-salganglien und deren kortikalen sowie cerebellären Projektionsareale entstehen. Hierbei ist zu berücksichtigen, dass sehr kleine, feingewebliche Veränderungen, die unterhalb des Auflösungsvermögens der hier verwendeten Bildge-bungsmethode liegen, nicht sicher ausgeschlossen werden können. Weitere quantitativ histologische Untersuchungen in Kombination mit quantitativ bildgebenden Verfahren werden benötigt, um die Pathophysiologie dieser Erkrankungsgruppe besser verstehen zu können.