Refine
Author
- Bereiter-Hahn, Jürgen (7)
- Wittig, Ilka (6)
- Auburger, Georg (5)
- Gispert, Suzana (5)
- Matthess, Yves (5)
- Raab, Monika (5)
- Strebhardt, Klaus (5)
- Bernd, August (4)
- Brandt, Ulrich (4)
- Kaufmann, Roland (4)
- Kippenberger, Stefan (4)
- Lausen, Jörn (4)
- Reichert, Andreas (4)
- Becker, Sven (3)
- Bönig, Halvard-Björn (3)
- Hofmann, Matthias (3)
- Jendrach, Marina (3)
- Lausen, Olga Nikolaevna (3)
- Meyer, Annekarin (3)
- Osiewacz, Heinz D. (3)
- Rotter, Björn (3)
- Rödel, Franz (3)
- Sanhaji, Mourad (3)
- Schneider, Lucas (3)
- Seifried, Erhard (3)
- Waidmann, Oliver (3)
- Zeuzem, Stefan (3)
- Ansari, Nariman (2)
- Bode, Helge Björn (2)
- Botti, Valentina (2)
- Brehm, Nadine (2)
- Canet Pons, Júlia (2)
- Cuntz, Hermann (2)
- Das, Saumya (2)
- Deller, Thomas (2)
- Dröse, Stefan (2)
- Ebersberger, Ingo (2)
- Ferreirós Bouzas, Nerea (2)
- Fulda, Simone (2)
- Helmke, Christina (2)
- Herkt, Stefanie (2)
- Kraiczy, Peter (2)
- Meyer-Hermann, Michael (2)
- Momma, Stefan (2)
- Müller, Sören (2)
- Müller-McNicoll, Michaela (2)
- Neugebauer, Karla M. (2)
- Niesel, Katja Anne (2)
- Oellerich, Thomas (2)
- Pampaloni, Francesco (2)
- Pfeilschifter, Josef (2)
- Pleli, Thomas (2)
- Poser, Ina (2)
- Rödel, Claus (2)
- Schulz, Michael (2)
- Schwich, Oliver Daniel (2)
- Sevenich, Lisa (2)
- Steiner, Christina Michaela (2)
- Stelzer, Ernst H. K. (2)
- Urlaub, Henning (2)
- Wiig, Helge (2)
- Winter, Peter (2)
- Yillah, Jasmin (2)
- Zarnack, Katharina (2)
- Zawada, Adam M. (2)
- Đikić, Ivan (2)
- Şen, Nesli Ece (2)
- Abdel Malik, Randa (1)
- Abhari, Behnaz (1)
- Acker, Till (1)
- Acker-Palmer, Amparo (1)
- Adelstein, Robert S. (1)
- Adihou, Hélène (1)
- Afonso-Grunz, Fabian (1)
- Ahrens, Bodo (1)
- Alekseeva, Tijna (1)
- Allen, Claire E. (1)
- Altmann, Christian F. (1)
- Arsović, Aleksandar (1)
- Atas, Hakan (1)
- Aygören-Pürsün, Emel (1)
- Babuke, Tanja (1)
- Bachmann, Malte (1)
- Badiou, Jacquie (1)
- Balat, Ahmed el- (1)
- Balermpas, Panagiotis (1)
- Balkom, Bastiaan Wilhelmus Maria van (1)
- Bandmann, Oliver (1)
- Banning, Antje (1)
- Bartel, Sabine (1)
- Başak, Ayşe Nazlı (1)
- Becker, Walter (1)
- Beetz, Marcel Jerome (1)
- Beining, Marcel (1)
- Benner, Christopher (1)
- Berger, Jürgen (1)
- Bergs, Judith (1)
- Bernstein, Jonathan A. (1)
- Betschel, Stephen (1)
- Bhagwat, Aditya M. (1)
- Bhattacharyya, Suvendra N. (1)
- Binkley, Karen (1)
- Biondi, Ricardo M. (1)
- Bittl, Verena (1)
- Blaheta, Roman A. (1)
- Bliek, Alexander van der (1)
- Boehncke, Wolf-Henning (1)
- Bon, Dimitra (1)
- Bonatto, Diego (1)
- Bonzelius, Frank (1)
- Borici-Mazi, Rozita (1)
- Bork, Konrad (1)
- Bowen, Tom (1)
- Boysen, Henrik B. (1)
- Bracher, Franz (1)
- Braig, Simone (1)
- Brandes, Ralf (1)
- Brandl, Holger (1)
- Bratzke, Hansjürgen (1)
- Bremm, Anja (1)
- Bretaud, Sandrine (1)
- Brill, Boris (1)
- Brodesser, Susanne (1)
- Brose, Nils (1)
- Brown, Lucy (1)
- Bruyn, Rahel de (1)
- Buck, Amy H. (1)
- Busch, Karin (1)
- Buzás, Edit I. (1)
- Büttner, Carmen (1)
- Caballero, Teresa (1)
- Cabral-Calderı́n, Yuranny (1)
- Cerwenka, Adelheid (1)
- Chae, Woon Hyung (1)
- Chaikuad, Apirat (1)
- Chen-Wichmann, Linping (1)
- Chimi, Marthe A. (1)
- Chow, Franklin W. N. (1)
- Chun, Felix (1)
- Cicardi, Marco (1)
- Cinatl, Jindrich (1)
- Costa, Wagner Steuer (1)
- Craig, Timothy (1)
- Curk, Tomaz (1)
- Dallas, Karen (1)
- Damrath, Ewa (1)
- Darvishi, Tahmineh (1)
- Das, Avash (1)
- De Felice, Elena (1)
- Dean, John (1)
- Deckmann, Klaus (1)
- Demolli, Shemsi (1)
- Depboylu, Candan (1)
- Dhimal, Meghnath (1)
- Di Liegro, Italia (1)
- Dias, Matheus H. (1)
- Diehl, Valentina (1)
- Dikov, Daniel (1)
- Djahanschiri, Bardya (1)
- Domínguez Bautista, Jorge Antolio (1)
- Domínguez-Bautista, Jorge (1)
- Dowling, Andrea (1)
- Driedonks, Tom A. P. (1)
- Dunnen, Wilfred F. A. den (1)
- Dvorak, Karel (1)
- Dötsch, Christina (1)
- Effenberger, Felix (1)
- Elshorst-Schmidt, Thomas (1)
- Enders, Giulia (1)
- Engels, Knut (1)
- Ernst, Andreas (1)
- Fan, Wei (1)
- Farin, Henner (1)
- Farkas, Henriette (1)
- Fernandes, Carolina Gonçalves (1)
- Fernandes, Denise C. (1)
- Fernández-Messina, Lola (1)
- Figge, Marc Thilo (1)
- Firestein, Ron (1)
- Fischer, Elisabeth (1)
- Fißlthaler, Beate (1)
- Fleming, Ingrid (1)
- Flinn, Laura J. (1)
- Fliser, Danilo (1)
- Fokas, Emmanouil (1)
- Frangakis, Achilleas S. (1)
- Freitag, Christine M. (1)
- French-Constant, Richard (1)
- Frömel, Timo (1)
- Fu, Ting (1)
- Gaese, Bernhard (1)
- Galuske, Ralf (1)
- García Rosales, Francisco (1)
- Garvalov, Boyan K. (1)
- Geburtig-Chiocchetti, Andreas (1)
- Geisslinger, Gerd (1)
- Geist, Miriam M. (1)
- Gerlach, Katharina (1)
- Giannattasio, Ariane (1)
- Gjertsen, Bjørn Tore (1)
- Golinski, Peter Anton (1)
- Gomes, Ligia G. (1)
- Gottschalk, Alexander (1)
- Grammatikos, Georgios (1)
- Graumann, Johannes (1)
- Grebbin, Britta Moyo (1)
- Grohmann, Beate (1)
- Grösch, Sabine (1)
- Guillemin, Gilles J. (1)
- Gunawan, Felix (1)
- Guschel, Maike (1)
- Győrffy, Balázs (1)
- Göttig, Stephan (1)
- Günther, Andreas (1)
- Günther, Stefan (1)
- Gürdal, Ece (1)
- Haapanen, Outi (1)
- Haase, Winfried (1)
- Habbe, Nils (1)
- Habib, Anowarul (1)
- Hackmann, Karl (1)
- Haderk, Franziska (1)
- Halbach, Melanie Vanessa (1)
- Hallström, Teresia (1)
- Hammerschmidt, Sven (1)
- Hansmann, Martin-Leo (1)
- Haslinger, Denise (1)
- Hausmann, Johannes (1)
- Hayes, Michael G. B. (1)
- Head, Brian (1)
- Heath, Paul Roy (1)
- Hebel, Marie (1)
- Hechavarria-Cueria, Julio C. (1)
- Heide, Heinrich (1)
- Heidler, Juliana (1)
- Heine, Gunnar H. (1)
- Heinemann, Linda Verena (1)
- Heinz, Sven (1)
- Herglotz, Julia (1)
- Herrmann, Eva (1)
- Hetzel, Miriam (1)
- Hildebrand, Sven (1)
- Hill, Andrew F. (1)
- Hipp, Katharina (1)
- Hori, Katsutoshi (1)
- Humpe, Andreas (1)
- Hébert, Jacques (1)
- Hörlin, Albrecht (1)
- Ingham, Philip W. (1)
- Iruegas, Ruben (1)
- Ishikawa, Masahito (1)
- Jin, Young-June (1)
- Jo, Hanjoong (1)
- Johnson, Madrid (1)
- Jones, Jennifer C. (1)
- Joos, Friederike (1)
- Joyce, Johanna A. (1)
- Jungenitz, Tassilo (1)
- Jüngel, Eva (1)
- Kaderali, Lars (1)
- Kahl, Günter (1)
- Kaiser, Jochen (1)
- Kaiser, Marcel (1)
- Kajihara, Daniela (1)
- Kanani, Amin (1)
- Kaulich, Manuel (1)
- Kaya, Zeynep-Ece (1)
- Kazmaier, Uli (1)
- Keatinge, Marcus (1)
- Keith, Paul K. (1)
- Kellner, Christian (1)
- Kempf, Volkhard A. J. (1)
- Key, Jana (1)
- Kieß, Stefan (1)
- Kim, Hyun-Taek (1)
- Kitz, Julia (1)
- Kleinhans, Martin (1)
- Klemm, Florian (1)
- Klemmt, Petra (1)
- Klinkenberg, Michael (1)
- Klöß, Stephan (1)
- Knapp, Stefan (1)
- Koch, Alexander (1)
- Koch, Ina (1)
- Koch, Joachim (1)
- Kohl, Wladislaw (1)
- Kohrs, Nicole (1)
- Koob, Sebastian (1)
- Kostin, Sawa (1)
- Kowal, Emma (1)
- Kowald, Axel (1)
- Krause, Daniela Sandra (1)
- Krezdorn, Nicolas (1)
- Kronenberger, Bernd (1)
- Krämer, Andrea (1)
- Kubisch, Rebekka (1)
- Kuch, Ulrich (1)
- Kur, Ivan-Maximiliano (1)
- Kurrle, Nina Susanne (1)
- Kurunci-Csacsko, Elisabeth (1)
- Kurz, Alexander (1)
- Kvasnicka, Hans Michael (1)
- Köberich, Vanessa Carena (1)
- Köfeler, Harald (1)
- Köhl, Ulrike (1)
- Köhler, Gunther (1)
- Köhler, Karsten (1)
- Kössl, Manfred (1)
- Köster, Reinhard W. (1)
- Kühlbrandt, Werner (1)
- La Marca, Enrique (1)
- Lacuesta, Gina (1)
- Lahut, Suna (1)
- Lai, Charles P. (1)
- Lang-Robertson, Kelly (1)
- Lange, Christian (1)
- Laramée, Benoît (1)
- Laurindo, Francisco Rafael Martins (1)
- Lehr, Matthias (1)
- Leisegang, Matthias (1)
- Leith, Eric (1)
- Leube, Barbara (1)
- Leukert, Laura (1)
- Liebers, Julia (1)
- Liebl, Johanna (1)
- Lim, Chai K. (1)
- Lindlar, Silvia (1)
- Linke, Dirk (1)
- Longhurst, Hilary (1)
- Looso, Mario (1)
- Lorenowicz, Magdalena J. (1)
- Lorenz, Ioana (1)
- Lu, Yuning (1)
- Luce, Karin (1)
- Ludwig, Petra (1)
- Lunavat, Taral Rameshchand (1)
- Lässer, Cecilia (1)
- Lötters, Stefan (1)
- Ma, Xuefei (1)
- Maas, Sybren L. N. (1)
- Mace, Sean (1)
- Mack, Sandra J. (1)
- Mai, Sören (1)
- Makarević, Jasmina (1)
- Mandal, Ranadip (1)
- Maring, Alisa (1)
- Marschalek, Rolf (1)
- Martin, Daniel (1)
- Martin, Lisa M. (1)
- Mateescu, Bogdan (1)
- Matschiavelli, Nicole (1)
- Matsui, Hideaki (1)
- Mattheyer, Christian (1)
- Maxeiner, Sebastian (1)
- McCormack, Emmet (1)
- McCusker, Christine (1)
- McNicoll, François (1)
- McTighe, Aimee (1)
- Mebs, Dietrich (1)
- Meierhofer, David (1)
- Meister, Melanie (1)
- Menke, Henrik (1)
- Meyer zu Heringdorf, Dagmar (1)
- Michels, Birgitta E. (1)
- Mills, Deryck J. (1)
- Milo, Marta (1)
- Mittelbronn, Michel Guy André (1)
- Mittelbrunn, Maria (1)
- Mondorf, Antonia Maria (1)
- Moote, Bill (1)
- Moretti, Ana Beatriz Silveira (1)
- Mortiboys, Heather (1)
- Mosa, Mohammed Hossameldin (1)
- Muellerleile, Julia (1)
- Mujić, Maja (1)
- Mukherjee, Kamalika (1)
- Muqit, Miratul M. K. (1)
- Muster, Britta (1)
- Mäger, Imre (1)
- Mühl, Heiko (1)
- Müller-Braun, Felicia (1)
- Müller-Esterl, Werner (1)
- Müller-Tidow, Carsten (1)
- Nawaz, Muhammed (1)
- Noack, Sabrina (1)
- Nolasco, Patrícia (1)
- Nollmann, Friederike I. (1)
- Nolte-’t Hoen, Esther N. M. (1)
- Oberschmidt, Carola (1)
- Odedra, Devang (1)
- Oertel, Wolfgang H. (1)
- Offermanns, Stefan (1)
- Ömür, Özgür (1)
- Panza, Paolo (1)
- Parey, Kristian Kurt (1)
- Parganlija, Dajana (1)
- Pavanelli, Jessyca C. (1)
- Pegtel, Dirk Michiel (1)
- Pfaff, Michael W. (1)
- Pflanzer, Ralph (1)
- Piiper, Albrecht (1)
- Pilatus, Ulrich (1)
- Pirkevi, Caroline (1)
- Pirschtat, Nina (1)
- Pohl, Christian (1)
- Polen, Tino (1)
- Pommerenke, Claudia (1)
- Poon, Man-Chiu (1)
- Preussner, Jens (1)
- Prinz, Simone (1)
- Prouvot, Pierre-Hugues (1)
- Prümmer, Marcus (1)
- Radić, Tijana (1)
- Rahm, Benjamin (1)
- Rave-Fränk, Margret (1)
- Reetz, Kathrin (1)
- Reim, Kerstin (1)
- Reisinger, Kerstin (1)
- Resch, Eduard (1)
- Ricciardi, Filomena (1)
- Richter, Florian Martin (1)
- Riedel-Christ, Sara (1)
- Rieger, Michael A. (1)
- Ries, Vincent (1)
- Riesbeck, Kristian (1)
- Ritchie, Bruce (1)
- Roebroeck, Alard F. (1)
- Roeper, Jochen (1)
- Rogacev, Kyrill S. (1)
- Rother, Michael (1)
- Rothweiler, Florian (1)
- Roßberg, Maila (1)
- Rudd, Christopher E. (1)
- Ruonala, Mika O. (1)
- Ruppert, Clemens (1)
- Rutz, Jochen (1)
- Rüb, Udo (1)
- Rycak, Lukas (1)
- Rüben, Katharina (1)
- Sader, Robert Alexander (1)
- Salamero-Boix, Anna (1)
- Salinas-Riester, Gabriela (1)
- Sandhoff, Konrad (1)
- Schaubeck, Simone (1)
- Scheckhuber, Christian Quintus (1)
- Scheider, Jessica (1)
- Schiffelers, Raymond M. (1)
- Schindewolf, Marc (1)
- Schmäh, Juliane (1)
- Schneider, Ines (1)
- Schreiner, Laura (1)
- Schrempf, Wiebke (1)
- Schroeter, Sirkka (1)
- Schröck, Evelin (1)
- Schueth, Anna (1)
- Schwarzacher, Stephan (1)
- Schweitzer, Jens (1)
- Schüler, Christina (1)
- Seidel, Kay (1)
- Serve, Hubert (1)
- Shaltiel, Lior (1)
- Sharma, Vivek (1)
- Shelke, Amit (1)
- Siegmund, Karin (1)
- Singer, M. (1)
- Singer, Mathias (1)
- Singh, Birendra (1)
- Sippl, Wolfgang (1)
- Skerka, Christine (1)
- Smith, Xin (1)
- Smyrek, Isabell (1)
- Sokol, Anna (1)
- Solovyeva, Anfisa (1)
- Soppa, Jörg (1)
- Stainier, Didier (1)
- Stark, Donald (1)
- Starzinski-Powitz, Anna (1)
- Steiner, Marlene (1)
- Steinle, Alexander (1)
- Steinmetz, Helmuth (1)
- Strecker, Valentina (1)
- Strobel, Ingmar (1)
- Stroh, Albrecht (1)
- Sukhorukov, Valerii M. (1)
- Sussman, Gordon (1)
- Söllner, Rosemarie Waltraud (1)
- Süß, Beatrix (1)
- Tahara, Hidetoshi (1)
- Tanaka, Leonardo Yuji (1)
- Teodorescu-Branzeu, Dragos Gabriel (1)
- Thomas, Dominique Jeanette (1)
- Théry, Clotilde (1)
- Tikkanen, Ritva (1)
- Tireli, Hülya (1)
- Torres-Odio, Sylvia (1)
- Tosar, Juan Pablo (1)
- Tran, Ngoc-Vinh (1)
- Tsai, Meng-Miao (1)
- Tsaur, Igor (1)
- Vadasz, David (1)
- Van Keuren-Jensen, Kendall R. (1)
- Vargas, Joseph (1)
- Vlachos, Andreas (1)
- Vollmar, Angelika (1)
- Vonck, Janet (1)
- Vormberg, Alexandra (1)
- Wagner, Ernst (1)
- Waibler, Zoe (1)
- Waltes, Regina (1)
- Walzog, Barbara (1)
- Wangenheim, Klaus von (1)
- Waserman, Susan (1)
- Wauben, Marca H. M. (1)
- Weber, Tobias Alexander (1)
- Wegener, Marius (1)
- Wegner, Martin (1)
- Weidensdorfer, Marko (1)
- Weigand, Julia E. (1)
- Weil, Andrea (1)
- Weil, Sandra (1)
- Wendisch, Volker F. (1)
- Wesche, Frank (1)
- Wichelhaus, Thomas Alexander (1)
- Wichmann, Christian (1)
- Wiechmann, Svenja (1)
- Wiedmann, Romina Madeleine (1)
- Wieland, Ulrike (1)
- Windisch, Roland (1)
- Wingert, Susanne (1)
- Witwer, Kenneth W. (1)
- Wolf, Zsuzsanna (1)
- Woodroof, Helen I. (1)
- Wosniak, João (1)
- Wurzel, Patrick (1)
- Wurzlbauer, Anne (1)
- Yang, Bill (1)
- Yepes, Diego (1)
- Yin, Wenguang (1)
- Young, Peter (1)
- Yousaf, Afsheen (1)
- Zerulla, Karolin (1)
- Zickermann, Volker (1)
- Zimmermann, Herbert (1)
- Zipfel, Peter F. (1)
- Zippel, Nina (1)
- Zukunft, Sven (1)
- Zuraw, Bruce (1)
- Zöller, Nadja Nicole (1)
- Zörnig, Martin (1)
- Züllig, Thomas (1)
- de Jesus Domingues, Antonio M. (1)
- de-Candia, Paola (1)
Year of publication
Document Type
- Article (68)
- Book (6)
- Conference Proceeding (4)
Has Fulltext
- yes (78)
Is part of the Bibliography
- no (78)
Keywords
- Cancer (2)
- Cell differentiation (2)
- Gene expression (2)
- Parkinson’s disease (2)
- Podospora anserina (2)
- aging (2)
- autophagy (2)
- brain metastases (2)
- caspase-8 (2)
- epigenetics (2)
Institute
- Biowissenschaften (78) (remove)
Wurzlbauer, Anne ; Rüben, Katharina ; Gürdal, Ece ; Chaikuad, Apirat ; Knapp, Stefan ; Sippl, Wolfgang ; Becker, Walter ; Bracher, Franz
The β-carboline alkaloid harmine is a potent DYRK1A inhibitor, but suffers from undesired potent inhibition of MAO-A, which strongly limits its application. We synthesized more than 60 analogues of harmine, either by direct modification of the alkaloid or by de novo synthesis of β-carboline and related scaffolds aimed at learning about structure-activity relationships for inhibition of both DYRK1A and MAO-A, with the ultimate goal of separating desired DYRK1A inhibition from undesired MAO-A inhibition. Based on evidence from published crystal structures of harmine bound to each of these enzymes, we performed systematic structure modifications of harmine yielding DYRK1A-selective inhibitors characterized by small polar substituents at N-9 (which preserve DYRK1A inhibition and eliminate MAO-A inhibition) and beneficial residues at C-1 (methyl or chlorine). The top compound AnnH75 remains a potent DYRK1A inhibitor, and it is devoid of MAO-A inhibition. Its binding mode to DYRK1A was elucidated by crystal structure analysis, and docking experiments provided additional insights for this attractive series of DYRK1A and MAO-A inhibitors.