Domain organization of long autotransporter signal sequences
Bacterial autotransporters represent a diverse family of proteins that autonomously translocate across the inner membrane of Gram-negative bacteria via the Sec complex and across the outer bacterial membrane. They often possess exceptionally long N-terminal signal sequences. We analyzed 90 long signal sequences of bacterial autotransporters and members of the two-partner secretion pathway in silico and describe common domain organization found in 79 of these sequences. The domains are in agreement with previously published experimental data. Our algorithmic approach allows for the systematic identification of functionally different domains in long signal sequences. Keywords: bacterial autotransporter, sequence analysis, pattern, protein targeting, signal peptide, protein trafficking
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| Author: | Jan Alexander Hiß, Gisbert Schneider |
|---|---|
| URN: | urn:nbn:de:hebis:30-82650 |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 19.10.2010 |
| Year of first Publication: | 2009 |
| Publishing Institution: | Univ.-Bibliothek Frankfurt am Main |
| Tag: | bacterial autotransporter ; pattern ; protein targeting ; protein trafficking; sequence analysis ; signal peptide |
| Source: | Bioinformatics and Biology Insights 2009:3, pp. 189–204 |
| HeBIS PPN: | 229315801 |
| Institutes: | Biowissenschaften |
| Dewey Decimal Classification: | 570 Biowissenschaften; Biologie |
| Sammlungen: | Universitätspublikationen |
| Sondersammelgebiets-Volltexte Biologie | |
| Note: | This article is available from http://www.la-press.com. © the authors, licensee Libertas Academica Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://www.creativecommons.org/licenses/by/2.0) which permits unrestricted use, distribution and reproduction provided the original work is properly cited. |
| Licence (German): |  Veröffentlichungsvertrag für Publikationen ohne Print on Demand |
