PaCATB, a secreted catalase protecting Podospora anserina against exogenous oxidative stress

A differential mass spectrometry analysis of secreted proteins from juvenile and senescentPodospora anserina cultures revealed age-related differences in protein profiles. Among other proteins with decreased abundance in
A differential mass spectrometry analysis of secreted proteins from juvenile and senescentPodospora anserina cultures revealed age-related differences in protein profiles. Among other proteins with decreased abundance in the secretome of senescent cultures a catalase, termed PaCATB, was identified. Genetic modulation of the abundance of PaCATB identified differential effects on the phenotype of the corresponding strains. Deletion of PaCatB resulted in decreased resistance, over-expression in increased resistance against hydrogen peroxide. While the lifespan of the genetically modified strains was found to be unaffected under standard growth conditions, increased exogenous hydrogen peroxide stress in the growth medium markedly reduced the lifespan of the PaCatB deletion strain but extended the lifespan of PaCatB over-expressors. Overall our data identify a component of the secretome of P. anserina as a new effective factor to cope with environmental stress, stress that under natural conditions is constantly applied on organisms and influences aging processes.
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Metadaten
Author:Sandra Zintel, Dominik Bernhardt, Adelina Rogowska-Wrzesinska, Heinz D. Osiewacz
URN:urn:nbn:de:hebis:30:3-259401
ISSN:1945-4589
Parent Title (English):Aging
Publisher:Impact Journals, LLC
Place of publication:[S.l.]
Document Type:Article
Language:English
Date of Publication (online):2011/08/14
Date of first Publication:2011/08/14
Publishing Institution:Univ.-Bibliothek Frankfurt am Main
Release Date:2012/08/31
Tag:Podospora anserina; aging and catalases; oxidative stress; secreted proteins
Volume:3
Issue:8
Pagenumber:14
First Page:768
Last Page:781
Institutes:Biowissenschaften
Dewey Decimal Classification:570 Biowissenschaften; Biologie
Sammlungen:Universitätspublikationen
Sondersammelgebiets-Volltexte
Licence (German):License LogoCreative Commons - Namensnennung 3.0

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